Asia-Pacific Journal of Oncology Nursing最新文献

{"title":"Summary of the best evidence for prehabilitation management of patients with non-small cell lung cancer","authors":"Wenfang Wu,&nbsp;Huayan Li,&nbsp;Rongrong Fan","doi":"10.1016/j.apjon.2024.100516","DOIUrl":"10.1016/j.apjon.2024.100516","url":null,"abstract":"<div><h3>Objective</h3><p>This study adopts an evidence-based methodology to establish a comprehensive theory foundation for preoperative prehabilitation management in non-small cell lung cancer (NSCLC) patients.</p></div><div><h3>Methods</h3><p>A systematic literature review linked to prehabilitation management for NSCLC patients was conducted, utilizing reputable databases such as UpToDate, BMJ Best Practice, UK NICE, SIGN, GIN, Joanna Briggs Institute Library, Cochrane Library, Web of Science, Embase, OVID evidence-based database, PubMed, Chinese Wanfang database, CNKI, CBM, ATS, BTS, AACVPR, and EACTS. The search encompassed articles, including clinical decision-making, guidelines, evidence summaries, expert consensuses, and systematic reviews, from the inception of databases up to March 31st, 2023. Two researchers performed quality assessment of the literature and subsequent evidence extraction.</p></div><div><h3>Results</h3><p>Nineteen articles were included, comprising five guidelines, three expert consensuses, seven systematic reviews, and four randomized controlled trials. A total of 41 pieces of evidence were summarized, addressing key aspects such as the multidisciplinary team, appropriate patient population, prehabilitation modes, timing of prehabilitation, prehabilitation assessment, prehabilitation content, quality control, and effectiveness evaluation.</p></div><div><h3>Conclusions</h3><p>The synthesis of the best evidence for prehabilitation management in NSCLC patients provides a solid evidence-based foundation for its implementation. It is recommended that healthcare professionals conduct thorough patient evaluations, optimize and integrate medical resources, and collaboratively engage in interdisciplinarity efforts to develop and implement personalized and multimodal prehabilitation plans.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 7","pages":"Article 100516"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001380/pdfft?md5=09f921044efa822b8b6922d2fd20e73d&pid=1-s2.0-S2347562524001380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a nurse navigation program for cancer pain","authors":"Miyoung Yoo ,&nbsp;Eunyoung E. Suh ,&nbsp;Mi Jang ,&nbsp;Sunsil Kang","doi":"10.1016/j.apjon.2024.100528","DOIUrl":"https://doi.org/10.1016/j.apjon.2024.100528","url":null,"abstract":"<div><h3>Objective</h3><p>Cancer pain significantly impacts the overall quality of life of cancer patients, necessitating proactive management. The manifestations of cancer pain vary individually and require tailored interventions to address each patient's unique characteristics. Therefore, this study aims to develop a nurse navigation program for cancer pain (NNP-CP) tailored to the needs of cancer patients requiring pain control, aiming to establish evidence-based clinical nursing practices and promote effective cancer pain management.</p></div><div><h3>Methods</h3><p>This study is a methodological research into developing a pain management program led by nurses for cancer patients requiring pain control, based on a professional navigation framework. The development of the program relied on three out of the five stages of the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model.</p></div><div><h3>Results</h3><p>A literature review was conducted to select the content and rationale to be included in the intervention program. Publications within the last 10 years in English or Korean were identified and screened based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 literature selection flow, 17 articles were included. Standardized information regarding cancer pain control was based on the 7th edition of 'Cancer Pain Management Guidelines'. The initial draft of the pain management intervention program was developed by organizing and structuring the derived content based on the professional navigation framework. Subsequently, the final intervention program was confirmed through the review by six clinical experts specializing in cancer pain.</p></div><div><h3>Conclusions</h3><p>Cancer pain is a significant factor that profoundly influences the quality of life and survival duration of cancer patients. While appropriate management methods offer the prospect of control, insufficient intervention is the current reality. Through the pain management intervention program based on the expert navigation framework that promotes continuity of care and empowers the recipients, this study anticipates not only pain reduction in cancer patients but also an enhancement in their quality of life.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 7","pages":"Article 100528"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001501/pdfft?md5=606358ba5112b4d73e8c3241c6c8291c&pid=1-s2.0-S2347562524001501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141595965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence trends and spatial distribution of thyroid cancer in the Chinese female population from 1990 to 2019","authors":"Xiaowei Qiao ,&nbsp;Yunshang Cui ,&nbsp;Changgeng Ma ,&nbsp;Chunxiao Ma ,&nbsp;Bingyu Bai ,&nbsp;Chunping Wang","doi":"10.1016/j.apjon.2024.100529","DOIUrl":"10.1016/j.apjon.2024.100529","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to analyze the incidence trends and spatial distribution characteristics of thyroid cancer among Chinese females from 1990 to 2019, thereby providing a scientific foundation and data support for the development of prevention and control policies.</p></div><div><h3>Methods</h3><p>Thyroid cancer incidence data from the Global Burden of Disease (GBD) research and the annual report from the Chinese Tumor Registration were utilized. The standardized thyroid cancer incidence rate among Chinese females 1990 to 2019 was described to understand the changes in developmental trends. The JoinPoint Regression Model was employed using Excel 2019, GraphPad Prism 8, JoinPoint Regression Program 4.8.0.1, and ArcGIS 10.2.</p></div><div><h3>Results</h3><p>Thyroid cancer's standardized incidence among female Chinese continued to increase at 1.7% per year (annual average percentage change [AAPC] = 1.7, <em>P</em> &lt; 0.001), and the spatial distribution was clustered. The main high-incidence areas were North, East, and Northwest China.</p></div><div><h3>Conclusions</h3><p>Thyroid cancer incidence in Chinese women is rapidly increasing, and its spatial distribution is concentrated. Strengthening monitoring, prevention, and control efforts in the relevant areas is warranted.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 7","pages":"Article 100529"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001513/pdfft?md5=876dfedb3ca048874629cc459b4349b4&pid=1-s2.0-S2347562524001513-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and results of virtual nursing intervention for cancer patients: A systematic review and meta-analysis","authors":"Hui Fang,&nbsp;Yajun Sun,&nbsp;Dongfeng Yu,&nbsp;Yuhong Xu","doi":"10.1016/j.apjon.2024.100515","DOIUrl":"10.1016/j.apjon.2024.100515","url":null,"abstract":"<div><h3>Objective</h3><p>Virtual nursing interventions, which use virtual reality and artificial intelligence technology to provide remote care for patients, have become increasingly common in cancer treatment, especially during the COVID-19 pandemic. This study was to evaluate the efficacy of virtual nursing interventions for cancer patients in contrast to conventional, in-person care.</p></div><div><h3>Methods</h3><p>Eight randomized controlled trials (RCTs) contrasted virtual nursing with conventional techniques that satisfied the inclusion criteria were found after a thorough search across databases including PubMed, Web of Science, CINAHL, EMBASE, the Cochrane Library, Scopus, and APA PsycINFO. RevMan 5.3 software was utilized for data analysis after the included literature's quality was assessed and the intended consequence indicators were extracted.</p></div><div><h3>Results</h3><p>Virtual nurse interventions enhanced the quality of life of cancer patients (standardized mean difference [SMD] = 0.22, 95% confidence interval [CI] 0.01 to 0.43, <em>P</em> = 0.04). Virtual nurse interventions provide cancer patients with important support, particularly when access to in-person care is limited. In light of the many demands that cancer patients have, further research is required to overcome implementation issues and provide fair access to virtual treatment.</p></div><div><h3>Conclusions</h3><p>All things considered, virtual nursing shows potential as an adjunctive element of all-inclusive cancer care delivery models, deserving of further investigation and thoughtful incorporation into healthcare systems.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 7","pages":"Article 100515"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001379/pdfft?md5=11137c0d3437f75e98f9f1f9a9a16ad2&pid=1-s2.0-S2347562524001379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning risk prediction model for bloodstream infections related to totally implantable venous access ports in patients with cancer","authors":"Fan Wang ,&nbsp;Yanyi Zhu ,&nbsp;Lijuan Wang ,&nbsp;Caiying Huang ,&nbsp;Ranran Mei ,&nbsp;Li-e Deng ,&nbsp;Xiulan Yang ,&nbsp;Yan Xu ,&nbsp;Lingling Zhang ,&nbsp;Min Xu","doi":"10.1016/j.apjon.2024.100546","DOIUrl":"10.1016/j.apjon.2024.100546","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to develop and validate a machine learning-based risk prediction model for catheter-related bloodstream infection (CRBSI) following implantation of totally implantable venous access ports (TIVAPs) in patients.</p></div><div><h3>Methods</h3><p>A retrospective cohort study design was employed, utilizing the R software package mlr3. Various algorithms including logistic regression, naive Bayes, K nearest neighbor, classification tree, and random forest were applied. Addressing class imbalance, benchmarks were used, and model performance was assessed using the area under the curve (AUC). The final model, chosen for its superior performance, was interpreted using variable importance scores. Additionally, a nomogram was developed to calculate individualized risk probabilities, enhancing clinical utility.</p></div><div><h3>Results</h3><p>The study involved 755 patients across both development and validation cohorts, with a TIVAP-CRBSI rate of 14.17%. The random forest model demonstrated the highest discrimination ability, achieving a validated AUC of 0.94, which was consistent in the validation cohort.</p></div><div><h3>Conclusions</h3><p>This study successfully developed a robust predictive model for TIVAP-CRBSI risk post-implantation. Implementation of this model may aid healthcare providers in making informed decisions, thereby potentially improving patient outcomes.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100546"},"PeriodicalIF":2.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001689/pdfft?md5=2c3c339e4e9e056c9ac7e64ef00603f0&pid=1-s2.0-S2347562524001689-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meditation for the reduction of perioperative anxiety in patients undergoing oncology surgery: A scoping review","authors":"Jennifer R. Majumdar ,&nbsp;Cidalia J. Vital ,&nbsp;Justin M. O'Leary ,&nbsp;Stephen J. Yermal ,&nbsp;John C. Welch","doi":"10.1016/j.apjon.2024.100544","DOIUrl":"10.1016/j.apjon.2024.100544","url":null,"abstract":"<div><h3>Objective</h3><p>Patients undergoing surgery, particularly patients undergoing surgery for oncology diagnoses, experience anxiety. Surgery remains the primary treatment for many common types of cancer. One promising potential intervention to alleviate anxiety in the preoperative and postoperative period is meditation, an integrative medicine intervention. However, there remains a gap in the literature regarding the effectiveness of meditation to alleviate anxiety during the perioperative time period.</p></div><div><h3>Methods</h3><p>The scoping review was conducted using the Arksey and O'Malley framework to synthesize the study findings and was reported with the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). The review included EMBASE, PubMed, Web of Science, CINAHL Plus, Scopus, and Cochrane Review databases from 2013 through 2024. All identified articles were exported to the online systematic review software, Covidence.</p></div><div><h3>Results</h3><p>A total of 538 initial citations were identified, 415 titles and abstracts were screened, and 83 full-text articles reviewed. Six studies were finally included. The data extracted from the literature included: study purpose, study design, sample size, preoperative or postoperative timeframe, instrument to evaluate anxiety, and conclusions.</p></div><div><h3>Conclusions</h3><p>For patients undergoing oncology surgery, the perioperative period can be filled with anxiety. Guided, mindfulness, and loving-kindness meditation may be helpful in reducing anxiety, particularly in patients undergoing surgery for breast cancer during the postoperative period. However, the current literature is extremely limited. Future research should expand on the preliminary effectiveness to broader populations and carefully target the highest-risk populations for the ideal time point for interventions.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100544"},"PeriodicalIF":2.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001665/pdfft?md5=56ceb04eb5c1cb0639d570c8d8611aef&pid=1-s2.0-S2347562524001665-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, barriers and practices concerning cancer therapy–associated oral mucositis amongst oncology nurses: A mixed methods systematic review","authors":"Feifei Zuo ,&nbsp;Tong Li ,&nbsp;Ying Chen,&nbsp;Mianmian Wen,&nbsp;Huijiao Cao","doi":"10.1016/j.apjon.2024.100542","DOIUrl":"10.1016/j.apjon.2024.100542","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate oncology nurses' knowledge, attitudes, barriers and practices regarding the prevention and management of cancer therapy-associated oral mucositis.</p></div><div><h3>Methods</h3><p>A systematic review was conducted by ​mixed-methods; searches were conducted in PubMed, EMBASE, Medline, CINAHL, Cochrane Library and Web of Science databases. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were followed for the systematic review. Searched relevant literature ​published in English between January 2000 and December 2023. The Mixed Methods Appraisal Tool was used to evaluate the quality of the studies.</p></div><div><h3>Results</h3><p>A total of 15 studies were included: 10 cross-sectional studies, 4 non-randomized controlled trials, and one qualitative study. This review provides an overview of the studies: nurses had limited knowledge of cancer therapy-associated oral mucositis; generally positive attitudes towards oral care; there is a slight difference in oral care practices. The main barriers of nurses' prevention and management of cancer therapy-associated oral mucositis were lack of time, lack of knowledge, and lack of staff.</p></div><div><h3>Conclusions</h3><p>Our results highlight the importance of training for oncology nurses regarding the management of cancer therapy-associated oral mucositis. It is suggested that oncology nurses should focus on strengthening and continuing education in oral care, adopting evidence-based practice and evaluation systems, implementing institution-specific written standards for oral care protocols, and promoting multidisciplinary team cooperation.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100542"},"PeriodicalIF":2.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001641/pdfft?md5=000a8a4640781d4f62abe387f2c81ce4&pid=1-s2.0-S2347562524001641-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier)","authors":"David H. Abramson ,&nbsp;Todd Liu ,&nbsp;Edith Guarini ,&nbsp;Jacquelyn Gaccione ,&nbsp;Christina Bracken ,&nbsp;Andrea Bobin ,&nbsp;Angela Foerch ,&nbsp;Melissa A. Robbins ,&nbsp;Ricardo Dodds Rojas ,&nbsp;Jasmine H. Francis","doi":"10.1016/j.apjon.2024.100543","DOIUrl":"https://doi.org/10.1016/j.apjon.2024.100543","url":null,"abstract":"<div><h3>Objective</h3><p>The pupils of children with retinoblastoma are routinely dilated pre-procedure with Tropicamide and Phenylephrine. Despite that, the pupil constricts once general anesthesia begins. The aim of this study is to see if adding Ketorolac to the regular dilating drops given pre-procedure shortens the length of anesthesia.</p></div><div><h3>Methods</h3><p>Retrospective comparison of time under anesthesia for two groups of retinoblastoma children receiving anesthesia for examination under anesthesia: one group (January 1, 2019 to October 1, 2022) had been dilated with Tropicamide 1% and Phenylephrine 2.5% while the second group (October 2, 2022 to July 1, 2023) was dilated with a combination drop using those drugs with topical Ketorolac 0.5% and Proparacaine 0.5%.</p></div><div><h3>Results</h3><p>Average anesthesia time for patients who received the older two-drug combination was 25 minutes vs. 16 minutes (36% reduction in exposure time) for those who received the newer four-drug combination (9 minutes less anesthesia) (<em>P</em> &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>The use of a combined dilating drop that incorporated Tropicamide 1%, Phenylephrine 2.5%, Proparacaine 0.5% and Ketorolac 0.5% significantly shortened the time for exams under anesthesia for children with retinoblastoma because the pupil remained dilated after anesthesia induction with Sevoflurane. Using this combined drop, children will receive 5–10 hours less anesthesia during their treatment for retinoblastoma and staff will have more than 150 hours of fewer exposure to anesthetic gasses. In addition, far fewer drops are necessary pre-anesthesia, minimizing trauma to the children and families.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100543"},"PeriodicalIF":2.4,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001653/pdfft?md5=bb560522586aa9eb111dbc733186e5ad&pid=1-s2.0-S2347562524001653-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of complementary therapy in enhancing quality of life for cancer survivors: A nursing perspective","authors":"Kazuko Onishi","doi":"10.1016/j.apjon.2024.100541","DOIUrl":"10.1016/j.apjon.2024.100541","url":null,"abstract":"","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100541"},"PeriodicalIF":2.4,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S234756252400163X/pdfft?md5=1fe85d8c7fd052bfd41b309cddee15aa&pid=1-s2.0-S234756252400163X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the microbiome and metabolic pathways associated with psychoneurological symptoms in children with cancer","authors":"Caitlin I. Webster ,&nbsp;Janice S. Withycombe ,&nbsp;Jessica Sheth Bhutada ,&nbsp;Jinbing Bai","doi":"10.1016/j.apjon.2024.100535","DOIUrl":"https://doi.org/10.1016/j.apjon.2024.100535","url":null,"abstract":"<div><p>Children with cancer often endure a range of psychoneurological symptoms (PNS), including pain, fatigue, cognitive impairment, anxiety, depressive symptoms, and sleep disturbance. Despite their prevalence, the underlying pathophysiology of PNS remains unclear. Hypotheses suggest an interplay between the gut microbiome and the functional metabolome, given the immune, neurological, and inflammatory influences these processes exert. This mini-review aims to provide a synopsis of the literature that examines the relationship between microbiome–metabolome pathways and PNS in children with cancer, drawing insights from the adult population when applicable. While there is limited microbiome research in the pediatric population, promising results in adult cancer patients include an association between lower microbial diversity and compositional changes, including decreased abundance of the beneficial microbes <em>Fusicatenibacter</em>, <em>Ruminococcus</em>, and <em>Odoribacter</em>, and more PNS. In pediatric patients, associations between peptide, tryptophan, carnitine shuttle, and gut microbial metabolism pathways and PNS outcomes were found. Utilizing multi-omics methods that combine microbiome and metabolome analyses provide insights into the functional capacity of microbiomes and their associated microbial metabolites. In children with cancer receiving chemotherapy, increased abundances of <em>Intestinibacter</em> and <em>Megasphaera</em> correlated with six metabolic pathways, notably carnitine shuttle and tryptophan metabolism. Interventions that target the underlying microbiome–metabolome pathway may be effective in reducing PNS, including the use of pre- and probiotics, fecal microbiome transplantation, dietary modifications, and increased physical activity. Future multi-omics research is needed to corroborate the associations between the microbiome, metabolome, and PNS outcomes in the pediatric oncology population.</p></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 8","pages":"Article 100535"},"PeriodicalIF":2.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2347562524001574/pdfft?md5=7d8d9548249fb2b31e5a4ce943153726&pid=1-s2.0-S2347562524001574-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}