描述年轻成人中化疗诱导的周围神经病变患者报告的结果测量的最小临床重要差异

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing Pub Date : 2025-01-19 DOI:10.1016/j.apjon.2025.100656

Robert Knoerl , Emanuele Mazzola , Lindsay Frazier , Roy L. Freeman , Marilyn Hammer , Ann LaCasce , Jennifer Ligibel , Marlise R. Luskin , Donna Berry

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引用次数: 0

摘要

目的本二次分析的目的是描述欧洲癌症研究与治疗组织生活质量问卷- cipn -20项目（QLQ-CIPN20）在接受紫杉醇或长春新碱治疗的年轻人中随时间变化评分的信度、效度和最小临床重要差异（MCID）。方法50例接受长春新碱或紫杉醇治疗的青年癌症患者，在与累积化疗剂量增加相关的3个时间点完成QLQ-CIPN20。受试者意义问卷于T3完成。采用基于锚定的方法对QLQ-CIPN20感觉和运动分量表进行地板和天花板效应、内部一致性信度、纵向效度、结构效度和MCID的计算分析。结果T3时，50%和52%的参与者分别报告了QLQ-CIPN20感觉和运动分量表在地板上的得分。感觉分量表（α = 0.83）和运动分量表（α = 0.89）的内部一致性信度较高。QLQ-CIPN20感觉亚量表（d = - 0.57）和运动亚量表（d = - 0.47）的Cohen 's d从T1到T3均为小至中等。QLQ-CIPN20感觉亚量表评分（r = 0.45）和运动亚量表评分（r = 0.27）与长春新碱累积剂量之间存在低至中度相关性。QLQ-CIPN20感觉和运动亚量表评分加重的MCID分别为14.37和9.57 (P <；0.01)。研究结果提供了mcd与QLQ-CIPN20评分恶化的初步证据，该锚定基于年轻人CIPN严重程度的感知变化。需要进一步的研究来开发心理测量学上健全的CIPN患者报告的结果测量，以有效地评估CIPN干预对年轻人的影响。

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Describing the minimally clinically important difference of a chemotherapy-induced peripheral neuropathy patient-reported outcome measure in young adults

Objective

The purpose of this secondary analysis was to characterize the reliability, validity, and minimally clinically important difference (MCID) of change scores over time of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN-20 item (QLQ-CIPN20) in young adults receiving paclitaxel or vincristine.

Methods

Fifty young adults receiving vincristine or paclitaxel for the treatment of cancer completed the QLQ-CIPN20 at three time points associated with increasing cumulative chemotherapy dose. The Subject Significance Questionnaire was completed at T3. The analyses were focused on the calculation of floor and ceiling effects, internal consistency reliability, longitudinal validity, construct validity, and the MCID using an anchor-based approach for the QLQ-CIPN20 sensory and motor subscales.

Results

By T3, 50% and 52% of participants reported QLQ-CIPN20 sensory and motor subscale scores at the floor, respectively. The internal consistency reliability of the sensory (α = 0.83) and motor (α = 0.89) subscales was strong. The Cohen’s d from T1 to T3 for the QLQ-CIPN20 sensory (d = −0.57) and motor (d = −0.47) subscales were small to moderate. There were low to moderate correlations between QLQ-CIPN20 sensory (r = 0.45) and motor (r = 0.27) subscale scores and vincristine cumulative dose. The MCID for worsening QLQ-CIPN20 sensory and motor subscale scores was 14.37 and 9.57, respectively (P < 0.01).

Conclusions

Study results provided preliminary evidence surrounding the MCID for worsening of QLQ-CIPN20 scores using an anchor based on young adults' perceived change in CIPN severity. Further research is needed to develop psychometrically sound CIPN patient-reported outcome measures to effectively evaluate the impact of CIPN interventions among young adults.

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