Zhenzhen Su , Liyan Zhang , Xuemin Lian , Yixuan Wang
{"title":"Risk factors associated with immune-related severe adverse events in patients with cancer: A scoping review","authors":"Zhenzhen Su , Liyan Zhang , Xuemin Lian , Yixuan Wang","doi":"10.1016/j.apjon.2025.100661","DOIUrl":"10.1016/j.apjon.2025.100661","url":null,"abstract":"<div><h3>Objective</h3><div>Increasing reports of immune-related severe adverse events (ir-SAEs) among patients with cancer treated with immune checkpoint inhibitors (ICIs) have raised significant concerns regarding patient safety. Although considerable research has addressed immune-related adverse events (irAEs), the risk factors specifically associated with ir-SAEs remain less well defined. This study aims to identify and synthesize the risk factors contributing to ir-SAEs in patients with cancer.</div></div><div><h3>Methods</h3><div>Adhering to the Joanna Briggs Institute scoping review guidelines, we conducted a comprehensive literature search across multiple databases including PubMed, Embase, Web of Science, ProQuest Dissertations and Theses, Clinical Trials, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Studies published from the inception of each database up to 28 January 2024 were considered. Two independent reviewers screened the literature and extracted the relevant data.</div></div><div><h3>Results</h3><div>A total of 41 studies were included, comprising 20 retrospective case-control studies, 9 retrospective cohort studies, 8 prospective cohort studies, and 4 meta-analyses. The analysis identified three primary categories of risk factors: demographic factors, disease-related factors, and laboratory examination-related factors.</div></div><div><h3>Conclusions</h3><div>A diverse range of risk factors is associated with ir-SAEs in patients with cancer. Enhancing the education of clinical oncology nurses regarding these risk factors may facilitate early identification and management of high-risk groups, thereby improving patient safety. Given the observed inconsistencies among studies, further research is warranted to elucidate risk factors with high predictive value for ir-SAEs.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100661"},"PeriodicalIF":2.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New year greetings from the Editor-in-Chief of the Asia–Pacific Journal of Oncology Nursing","authors":"Winnie K.W. So","doi":"10.1016/j.apjon.2025.100660","DOIUrl":"10.1016/j.apjon.2025.100660","url":null,"abstract":"","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100660"},"PeriodicalIF":2.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing research quality through defined and consistent terminology","authors":"Negin Dorri","doi":"10.1016/j.apjon.2025.100659","DOIUrl":"10.1016/j.apjon.2025.100659","url":null,"abstract":"","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100659"},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rika Sato , Tateaki Naito , Haruyasu Murakami , Shota Omori , Haruki Kobayashi , Akira Ono , Nobuaki Mamesaya , Kazushige Wakuda , Ryo Ko , Hirotsugu Kenmotsu , Sakiko Aso , Miho Hasaba , Keita Mori , Toshiaki Takahashi , Naoko Hayashi
{"title":"Correlation between cancer cachexia and psychosocial impact in older patients with advanced lung cancer undergoing chemotherapy","authors":"Rika Sato , Tateaki Naito , Haruyasu Murakami , Shota Omori , Haruki Kobayashi , Akira Ono , Nobuaki Mamesaya , Kazushige Wakuda , Ryo Ko , Hirotsugu Kenmotsu , Sakiko Aso , Miho Hasaba , Keita Mori , Toshiaki Takahashi , Naoko Hayashi","doi":"10.1016/j.apjon.2025.100658","DOIUrl":"10.1016/j.apjon.2025.100658","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the association of cancer cachexia with psychosocial impact, nutrition impact symptoms (NIS), and geriatric assessment in older patients newly diagnosed with advanced lung cancer undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>Older patients with advanced lung cancer scheduled to receive first-line chemotherapy between August 2021 and February 2022 were enrolled. Cachexia was diagnosed according to the International Consensus. NIS and psychosocial impacts were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ) C30, CAX24, and the Eating-Related Distress Questionnaire (ERD). Non-parametric tests evaluated the association between cachexia and its impacts. Patients with cachexia who consented to be interviewed were asked about their experiences with diet and weight changes. Three authors reviewed the interview data to ensure the analysis's veracity.</div></div><div><h3>Results</h3><div>Twenty-one of the 31 participants (68%) had cachexia at baseline. The cachexia group showed significantly greater severity of Food Aversion (<em>P</em> = 0.035), Eating and Weight Loss Worry (<em>P</em> < 0.001), and Loss of Control (<em>P</em> = 0.005) compared to the non-cachexia group. There were no significant differences in the ERD and geriatric assessment (all <em>P</em> > 0.05). The interview revealed that patients with cachexia perceived diet and weight changes early on and tried to manage their symptoms by themselves.</div></div><div><h3>Conclusions</h3><div>Cancer cachexia showed an association with NIS and psychosocial impacts. Older patients with advanced lung cancer scheduled to receive first-line chemotherapy should undergo a comprehensive assessment of cancer cachexia, including its potential physical and psychological impacts.</div></div><div><h3>Trial registration</h3><div>The trial registration number was UMIN 000053843.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100658"},"PeriodicalIF":2.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingtao Meng , Ruitong Gao , Hailing Yang , Fang Zhang , Meimei Shang , Yuping Liu , Lingjuan Li , Lu Chen , Xia Zhong , Hongmei Lu
{"title":"Health-related quality of life and related factors among esophageal cancer survivors after esophagectomy in the 6-month postoperative period: A multicenter cross-sectional study in north China","authors":"Yingtao Meng , Ruitong Gao , Hailing Yang , Fang Zhang , Meimei Shang , Yuping Liu , Lingjuan Li , Lu Chen , Xia Zhong , Hongmei Lu","doi":"10.1016/j.apjon.2025.100655","DOIUrl":"10.1016/j.apjon.2025.100655","url":null,"abstract":"<div><h3>Objective</h3><div>Esophagectomy is a primary curable treatment and a highly challenging procedure for esophageal cancer (EC) survivors. EC survivors experience various unmet needs. This study is aimed to assess unmet needs, health-related quality of life (HRQOL), and psychological distress of postoperative EC survivors.</div></div><div><h3>Methods</h3><div>A multicenter cross-sectional study was conducted between December 2023 and March 2024 across 28 hospitals in northern China. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Hospital Anxiety and Depression Scale, and Supportive Care Need Survey - Short Form 34 were utilized to assess the HRQOL, anxiety, depression, and unmet needs.</div></div><div><h3>Results</h3><div>A total of 357 postoperative EC survivors were recruited, with a mean age of 63.42 years. Approximately 14.6% exhibited borderline anxiety, and 17.9% showed borderline depression. Unmet needs were highest in health information and patient care domains. HRQOL was lower in global health, social, and physical functions post-surgery. Fatigue, appetite loss, insomnia, and financial difficulties were common. Dysphagia, dry mouth, reflux, and choking negatively impacted HRQOL. Multivariable regression analysis indicated that anxiety and depression levels were higher, and HRQOL was lower in those one week to six months post-surgery compared to one-week post-surgery.</div></div><div><h3>Conclusions</h3><div>EC survivors experience significant psychological distress and reduced HRQOL up to six months post-surgery. Dysphagia and unmet needs are prevalent. Compared to immediate post-surgery, EC survivors experienced higher levels of anxiety and depression, and lower level of HRQOL in six months. Future research should focus on developing individualized care strategies to provide optimal support.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100655"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing cancer-related fatigue: Validation of the Korean version of the cancer fatigue scale among cancer survivors","authors":"Haneul Lee , Eun Young Park , Kwang-Hi Park","doi":"10.1016/j.apjon.2025.100657","DOIUrl":"10.1016/j.apjon.2025.100657","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to validate the Korean version of the Cancer Fatigue Scale (CFS-K) as a reliable tool for assessing cancer-related fatigue (CRF) for cancer survivors.</div></div><div><h3>Methods</h3><div>A total of 208 cancer survivors who completed active treatment participated in evaluating the reliability, construct validity, and factor structure of the CFS-K through confirmatory factor analysis (CFA). Correlations with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACT-F) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) scales were analyzed to assess construct validity.</div></div><div><h3>Results</h3><div>The CFS-K demonstrated strong psychometric properties, with high internal consistency (Cronbach’s <em>α</em> = 0.875) and CFA validated a three-factor structure (physical, cognitive, and affective fatigue) with acceptable model fit indices (normed χ<sup>2</sup> = 2.62, CFI = 0.899, TLI = 0.878, RMSEA = 0.088, SRMR = 0.069). The standardized factor loadings for all items exceeded 0.5. Construct validity was confirmed through strong correlations with FACT-F (<em>r</em> = 0.43–0.73) and significant correlations with EORTC QLQ-C30 subscales. Cancer survivors reported significantly higher fatigue levels across all subscales than controls.</div></div><div><h3>Conclusions</h3><div>The CFS-K is a reliable and valid tool for assessing multidimensional CRF in cancer survivors.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100657"},"PeriodicalIF":2.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert Knoerl , Emanuele Mazzola , Lindsay Frazier , Roy L. Freeman , Marilyn Hammer , Ann LaCasce , Jennifer Ligibel , Marlise R. Luskin , Donna Berry
{"title":"Describing the minimally clinically important difference of a chemotherapy-induced peripheral neuropathy patient-reported outcome measure in young adults","authors":"Robert Knoerl , Emanuele Mazzola , Lindsay Frazier , Roy L. Freeman , Marilyn Hammer , Ann LaCasce , Jennifer Ligibel , Marlise R. Luskin , Donna Berry","doi":"10.1016/j.apjon.2025.100656","DOIUrl":"10.1016/j.apjon.2025.100656","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this secondary analysis was to characterize the reliability, validity, and minimally clinically important difference (MCID) of change scores over time of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN-20 item (QLQ-CIPN20) in young adults receiving paclitaxel or vincristine.</div></div><div><h3>Methods</h3><div>Fifty young adults receiving vincristine or paclitaxel for the treatment of cancer completed the QLQ-CIPN20 at three time points associated with increasing cumulative chemotherapy dose. The Subject Significance Questionnaire was completed at T3. The analyses were focused on the calculation of floor and ceiling effects, internal consistency reliability, longitudinal validity, construct validity, and the MCID using an anchor-based approach for the QLQ-CIPN20 sensory and motor subscales.</div></div><div><h3>Results</h3><div>By T3, 50% and 52% of participants reported QLQ-CIPN20 sensory and motor subscale scores at the floor, respectively. The internal consistency reliability of the sensory (<em>α</em> = 0.83) and motor (<em>α</em> = 0.89) subscales was strong. The Cohen’s <em>d</em> from T1 to T3 for the QLQ-CIPN20 sensory (<em>d</em> = −0.57) and motor (<em>d</em> = −0.47) subscales were small to moderate. There were low to moderate correlations between QLQ-CIPN20 sensory (<em>r</em> = 0.45) and motor (<em>r</em> = 0.27) subscale scores and vincristine cumulative dose. The MCID for worsening QLQ-CIPN20 sensory and motor subscale scores was 14.37 and 9.57, respectively (<em>P</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>Study results provided preliminary evidence surrounding the MCID for worsening of QLQ-CIPN20 scores using an anchor based on young adults' perceived change in CIPN severity. Further research is needed to develop psychometrically sound CIPN patient-reported outcome measures to effectively evaluate the impact of CIPN interventions among young adults.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100656"},"PeriodicalIF":2.4,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chengyang Li , Chunfeng Wang , Xueting Zhuang , Ying Wang , Yong Wu , Rong Hu
{"title":"Exploring experiences and needs among children with cancer undergoing peripherally inserted central catheter insertion: A qualitative study","authors":"Chengyang Li , Chunfeng Wang , Xueting Zhuang , Ying Wang , Yong Wu , Rong Hu","doi":"10.1016/j.apjon.2025.100654","DOIUrl":"10.1016/j.apjon.2025.100654","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the experiences of children with cancer undergoing peripherally inserted central catheter (PICC) insertion.</div></div><div><h3>Methods</h3><div>This study employed a descriptive qualitative approach. A total of 20 children undergoing PICC insertion were enrolled through purposive sampling. Semi-structured interviews, supplemented by draw-and-tell techniques, were conducted to collect data. Thematic analysis method was employed to analyze the interview data.</div></div><div><h3>Results</h3><div>Four themes and 11 subthemes were identified regarding the experience of peripherally inserted central catheter insertion in pediatric cancer patients, including (1) uncertainty (unknown procedure and lack of confidence); (2) high sensitivity (vulnerable to environmental influences and care what others think); (3) psychophysical changes (stress response, physical discomfort, disruption of daily routines, and accepted with pleasure); and (4) multidimensional needs (information, comfort, and self-actualization needs).</div></div><div><h3>Conclusions</h3><div>The findings underscore the importance of gaining a deeper understanding of the symptoms and needs of pediatric cancer patients undergoing PICC insertion. By appreciating and honoring children’s voices, we can effectively cater to their distinct worries and guarantee they get the care and consideration they merit.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100654"},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoxue Liu , Haoyun Zhou , Xun Yi , Xinyu Zhang , Yanan Lu , Wei Zhou , Yunzhao Ren , Chuanhua Yu
{"title":"Decomposition analysis of lung cancer and COPD mortality attributable to ambient PM2.5 in China (1990–2021)","authors":"Xiaoxue Liu , Haoyun Zhou , Xun Yi , Xinyu Zhang , Yanan Lu , Wei Zhou , Yunzhao Ren , Chuanhua Yu","doi":"10.1016/j.apjon.2025.100653","DOIUrl":"10.1016/j.apjon.2025.100653","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the long-term trends in lung cancer (LC) and chronic obstructive pulmonary disease (COPD) mortality attributable to particulate matter (PM<sub>2.5</sub>) in China and to identify the contributions of population aging and other risk factors to changes in mortality rates.</div></div><div><h3>Methods</h3><div>Using data from 1991 to 2021, we assessed trends in LC and COPD deaths attributable to PM<sub>2.5</sub> through linear regression. Decomposition analysis was conducted to determine the extent to which changes in mortality rates were driven by demographic and non-demographic factors.</div></div><div><h3>Results</h3><div>The crude mortality rates attributable to PM<sub>2.5</sub> increased significantly for LC (500.40%) and COPD (85.26%). From 1990 to 2021, LC mortality attributable to PM<sub>2.5</sub> increased annually by 4.11% (95% CI: 3.64%, 4.59%), while COPD mortality decreased annually by 1.23% (95% CI: −0.82%, −1.65%). Decomposition analysis revealed that 43.0% of the increase in LC mortality was due to population aging, and 57.0% was attributed to changes in other risk factors. For COPD, population aging contributed to an 18.547/100,000 increase, whereas other risk factors reduced mortality by 10.628/100,000.</div></div><div><h3>Conclusions</h3><div>The findings highlight the critical roles of population aging and risk factor modification in LC and COPD mortality trends. Interventions to address aging-related vulnerabilities and air pollution control are essential to mitigate future health burdens.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100653"},"PeriodicalIF":2.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaofan Bu , Xi Chen , Lu Luo , Rongrong Fan , Ling Jiang , Xiangyu Liu , Doris Y.P. Leung
{"title":"Preliminary testing for affiliate stigma scale: A reliable and valid stigma measure for caregivers of women with breast cancer","authors":"Xiaofan Bu , Xi Chen , Lu Luo , Rongrong Fan , Ling Jiang , Xiangyu Liu , Doris Y.P. Leung","doi":"10.1016/j.apjon.2024.100652","DOIUrl":"10.1016/j.apjon.2024.100652","url":null,"abstract":"<div><h3>Objective</h3><div>Families of breast cancer patients may face discrimination and societal rejection due to prevailing myths, misconceptions and causal beliefs related to breast cancer. This study aims to develop and validate a measurement tool that is sensitive to the affiliate stigma experienced by caregivers of women with breast cancer.</div></div><div><h3>Methods</h3><div>The scale was developed in two phases: (1) item generation based on interviews amongst 18 caregivers of women with breast cancer; (2) psychometric properties of the scale, including content validity, structural validity, and internal consistency reliability. Data were collected from May to June 2023 in 426 caregivers of women with breast cancer from 5 tertiary A hospitals.</div></div><div><h3>Results</h3><div>An exploratory factor analysis produced a 24-item scale across four dimensions, including internal stigma, social isolation, perceived stigma, and reaction. The scale showed good internal consistency and test–retest reliability. The total score of the scale was significantly and positively correlated with scores in caregiving burden and negatively correlated with scores in self-esteem and in social support. The item-level content validity index fell within the range of 0.8–1.0.</div></div><div><h3>Conclusions</h3><div>This is a valid and reliable instrument captured the spectrum of stigma relevant to caregivers of women with breast cancer and may serve as a unique instrument that can be used globally. This study is a step forward for stigma-related studies among caregivers of women with breast cancer and provides a reference for developing effective interventions for those with potentially stigmatized conditions.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"12 ","pages":"Article 100652"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}