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Meditation, its Techniques and its science 冥想，它的技巧和科学
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.82
Sudhir V Shah
{"title":"Meditation, its Techniques and its science","authors":"Sudhir V Shah","doi":"10.15713/ins.bhj.82","DOIUrl":"https://doi.org/10.15713/ins.bhj.82","url":null,"abstract":"Background \u0000For thousands of years, people have been meditating. Meditation is one of the greatest gifts to humanity from ancient sages. It was created to aid in the comprehension of life's sacred and mystical powers and to connect to the higher consciousness. Meditation is widely utilized these days for relaxation and stress reduction and a way to get relief from physical illness and mental agonies as well as to achieve peace and Happiness.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78852655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virus in the throat; Man on the floor Syncopal episodes in a man with Covid-19 喉咙里有病毒;地板上的男子患有Covid-19的晕厥发作
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.85
H. Oza, M. Desai, N. Waghmare, V. Pardasani
{"title":"Virus in the throat; Man on the floor Syncopal episodes in a man with Covid-19","authors":"H. Oza, M. Desai, N. Waghmare, V. Pardasani","doi":"10.15713/ins.bhj.85","DOIUrl":"https://doi.org/10.15713/ins.bhj.85","url":null,"abstract":"Even though infection with SARS-CoV-2 presents primarily with respiratory symptoms, unusual clinical manifestations have also been reported during the current pandemic. In May 2020, a middle-aged man presented to us with three episodes of impaired consciousness, which clinically appeared to be syncopal episodes. Patient had history of a single episode of mild fever 6 days prior to presentation, not accompanied by any respiratory symptoms. As a routine, swab for SARS-CoV-2 was sent and he tested positive. Holter recording was able to record sinus bradycardia followed by junctional escape during one such episode. Patient was managed symptomatically and there was no further recurrence of syncope.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74450187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Myasthenic Syndromes: Early to diagnose, early to rise 先天性肌无力综合征:诊断早，起病早
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.83
Pramod Dhonde, Mayura Dhonde
{"title":"Congenital Myasthenic Syndromes: Early to diagnose, early to rise","authors":"Pramod Dhonde, Mayura Dhonde","doi":"10.15713/ins.bhj.83","DOIUrl":"https://doi.org/10.15713/ins.bhj.83","url":null,"abstract":"Congenital myasthenic syndromes (CMS) are phenotypically heterogeneous disorders with defects at presynaptic, synaptic and postsynaptic level. With the worldwide prevalence of CMS unknown, from India either case reports or hospital based studies 1-3 give insight into the spectrum of CMS. At present more than 20 genes have been associated with CMS, majority are CHRNE (50%, including both autosomal dominant and recessive), RAPSN (15%-20%), DOK7 (10%-15%), COLQ (10%-15%), GFPT1 (2%).4  We are reporting 4 cases of CMS with typical presentation of fatiguable ptosis at early age in all patients and limb girdle weakness in two patients. One presented with history of respiratory arrest after fluoroquinolone use. All of them had positive slow rate repetitive nerve stimulation (RNS). Two patients had pathogenic compound heterozygous and homozygous mutations respectively for CHRNE, one patient had heterozygous mutation for SLC25A1 with uncertain significance with one patient’s report unknown. Two patients (one CHRNE and SLC25A1) responded with pyridostigmine only and two patients responded to pyridostigmine and salbutamol.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83144912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UPDATE ON MYASTHENIA GRAVIS 重症肌无力的最新进展
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.76
R. Singh, V. Aglave
{"title":"UPDATE ON MYASTHENIA GRAVIS","authors":"R. Singh, V. Aglave","doi":"10.15713/ins.bhj.76","DOIUrl":"https://doi.org/10.15713/ins.bhj.76","url":null,"abstract":"Abstract \u0000Myasthenia gravis is an autoimmune disease mediated by autoantibodies against various transmembrane proteins located on the post synaptic membrane. Our understanding of pathophysiology has vastly improved over the last decade, resulting in the development of individualized therapeutic options. Classification into myasthenia subgroups, depending on the antibody profile, helps to better characterize, treat, and prognosticate patients. It is quite evident that MuSK myasthenia needs early Rituximab intervention for a stable remission. Role of thymectomy, although never in doubt, was recently proven in randomized controlled trial. With the advent of monoclonal antibodies and other newer modalities, we should evolve beyond the conventional immunosuppressives, given their toxicities. Better potential options are now available to treat the refractory subgroup. Future of myasthenia treatment clearly has rosy predictions. Present review is an update on myasthenia gravis.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77384535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonconvulsive status epilepticus (NCSE) 非惊厥性癫痫持续状态(NCSE)
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.77
J. Mani
{"title":"Nonconvulsive status epilepticus (NCSE)","authors":"J. Mani","doi":"10.15713/ins.bhj.77","DOIUrl":"https://doi.org/10.15713/ins.bhj.77","url":null,"abstract":"Nonconvulsive seizures (NCS) are seizures that have subtle or no clinical motor phenomena in a patient with impaired consciousness.  Nonconvulsive status epilepticus (NCSE), is a subtype of status epilepticus. NCSE denotes an enduring epileptic condition with reduced or altered consciousness ranging from confusion to coma, behavioral and vegetative abnormalities, or merely subjective symptoms like auras, but without major convulsive movements (1)   NCS occur in 10–25 % of patients with acute brain injury and are associated with worse outcomes  (2). NCSE is also seen a third of patients  presenting with altered mental status to the emergency department ( 3.) Indeed, a diagnosis of NCSE is often missed  both in  the emergency room and in the ICU,  because of its  pleomorphic presentation, often in the  setting of other serious illnesses. ","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73647283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Rare Presentation of Neuralgic Amyotrophy: Hypoglossal Neuropathy 神经痛性肌萎缩的罕见表现:舌下神经病
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.86
H. Oza, Sandeep Borse, Hiral Halani, S. Khadilkar
{"title":"A Rare Presentation of Neuralgic Amyotrophy: Hypoglossal Neuropathy","authors":"H. Oza, Sandeep Borse, Hiral Halani, S. Khadilkar","doi":"10.15713/ins.bhj.86","DOIUrl":"https://doi.org/10.15713/ins.bhj.86","url":null,"abstract":"In this letter, we highlight a rare presentation of neuralgic amyotrophy.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75222755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nodopathies: A distinct pathophysiological and clinical entity 结节病:一种独特的病理生理和临床实体
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.74
Swati H. Shah
{"title":"Nodopathies: A distinct pathophysiological and clinical entity","authors":"Swati H. Shah","doi":"10.15713/ins.bhj.74","DOIUrl":"https://doi.org/10.15713/ins.bhj.74","url":null,"abstract":"Abstract \u0000In recent years, antibodies directed against the proteins located at the node of Ranvier have been identified in patients with immune mediated neuropathies. In this article, we review the structure of node of Ranvier and pathology associated with these antibody mediated neuropathies. We summarize the emerging concept of nodopathy/ paranodopathy, its clinical relevance and treatment implications.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91038188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of evolution of molecular technologies on evaluation of Neuromuscular Disorders in India at a Centre in Mumbai. 分子技术的发展对印度孟买某中心神经肌肉疾病评估的影响。
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.80
Rashna S. Dastur, S. Khadilkar
{"title":"Impact of evolution of molecular technologies on evaluation of Neuromuscular Disorders in India at a Centre in Mumbai.","authors":"Rashna S. Dastur, S. Khadilkar","doi":"10.15713/ins.bhj.80","DOIUrl":"https://doi.org/10.15713/ins.bhj.80","url":null,"abstract":"Abstract: \u0000Advances in molecular methods has made genetic testing as an imperative parameter, to be used in research studies and clinical practice. The present article includes the evolution of Molecular Diagnostic techniques over a period of two decades leading to the corresponding expansion in identification & classification of various Neuromuscular disorders in the population of mainly Western India. \u0000Initially conventional testing was done by mPCR, RFLP-PCR for single gene disorders like DMD/BMD & SMA respectively; followed by MLPA technique, for deletion duplication analysis. Under a research study, immuno-specific Western Blot was used for protein analysis as an initial screening tool for LGMD2B. Sangers sequencing was done for single gene (for a few LGMD2B cases) & known familial variants of LGMD2B & LGMD2A and GNE myopathy. Availability of Next generation sequencing technique involving massive parallel sequencing of multiple genes, improved the possibility of identifying the disease causing/ pathogenic mutations in phenotypically overlapping NMDs like LGMDs and Hereditary Neuropathies. \u0000Since last 12 years, over 2,600 patients from mainly western India have been analysed for various neuromuscular disorders. Carrier status of relatives of the probands was also determined in many of the cases. These molecular technologies have enabled to attained definitive diagnosis of different neuromuscular disorders in India.  The diagnostic and predictive data generated helps in better management of the disease. It also has immense relevance in carrier and prenatal testing for the families at risk, thereby limiting the occurrence of the diseases in the population. \u0000 ","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80360539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare Demyelinating Disease: cause of acute hemiparesis in a young male 一种罕见的脱髓鞘疾病:引起急性偏瘫的年轻男性
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.84
Divij Sharma, Dr Nirmal Surya, Dr. Harsh Oza, Dr. Chandrashekhar
{"title":"A rare Demyelinating Disease: cause of acute hemiparesis in a young male","authors":"Divij Sharma, Dr Nirmal Surya, Dr. Harsh Oza, Dr. Chandrashekhar","doi":"10.15713/ins.bhj.84","DOIUrl":"https://doi.org/10.15713/ins.bhj.84","url":null,"abstract":"Demyelinating diseases of the central nervous system are frequently encountered pathological entities; Multiple Sclerosis (MS) being the most common. Atypical forms of demyelinating diseases such as tumefactive demyelination run an aggressive course, masquerading MS but without classical features of MS. These aggressive entities represent a diagnostic and therapeutic challenge for physicians. The manifestations of a demyelinating disease are protean. This case was fascinating for two reasons: the diagnostic challenge it posed in the face of different etiologies of a demyelinating disease and the rapid response to plasma exchange and rituximab therapy in the acute phase of the disease.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81329783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune encephalitis - Recent Guidelines for Diagnosis and Management 自身免疫性脑炎-诊断和管理的最新指南
The Bombay Hospital journal Pub Date : 2022-02-05 DOI: 10.15713/ins.bhj.79
R. Jain
{"title":"Autoimmune encephalitis - Recent Guidelines for Diagnosis and Management","authors":"R. Jain","doi":"10.15713/ins.bhj.79","DOIUrl":"https://doi.org/10.15713/ins.bhj.79","url":null,"abstract":"Autoimmune encephalitis (AE) is a group of acute to subacute onset, rapidly progressive, non-infectious, immune-mediated, inflammatory disorders of the brain parenchyma often affecting the cortical or deep grey matter with or without involving the white matter, meninges or spinal cord.1-4 An estimated prevalence rate for AE is 13.7/100 000, so possibly as common as infectious encephalitis.5 ‘Autoimmune neurology’ is coming up with the advent of newer antibodies and associated syndromes.6 Identifying these disorders is rewarding in view of favourable response to immunotherapy compared to infectious encephalitis with limited therapeutic options. Clinicians need to suspect AE clinically first to plan investigations and early treatment.1 Long-term management depends on antibody identified. Recent guidelines for diagnosis and management of AE are discussed here.","PeriodicalId":85654,"journal":{"name":"The Bombay Hospital journal","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75340495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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