Nodopathies: A distinct pathophysiological and clinical entity

Abstract

Abstract In recent years, antibodies directed against the proteins located at the node of Ranvier have been identified in patients with immune mediated neuropathies. In this article, we review the structure of node of Ranvier and pathology associated with these antibody mediated neuropathies. We summarize the emerging concept of nodopathy/ paranodopathy, its clinical relevance and treatment implications.