Asian Pacific journal of tropical biomedicine最新文献_第4页

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis 红景天苷通过抑制脱铁性贫血减轻缺氧和缺糖诱导的神经元损伤

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369611

Ying-Zhi Li, Ai-ping Wu, Dan-dan Wang, Pan-Pan Yang, Bin Sheng

{"title":"Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis","authors":"Ying-Zhi Li, Ai-ping Wu, Dan-dan Wang, Pan-Pan Yang, Bin Sheng","doi":"10.4103/2221-1691.369611","DOIUrl":"https://doi.org/10.4103/2221-1691.369611","url":null,"abstract":"Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation (OGD)-treated NT2 cells and its underlying mechanisms of action. Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGD-treated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside. Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside. Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"70 - 79"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49325046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial activities of Acacia genus: A review Acacia属植物的抗菌活性研究进展

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369609

Deeksha Adhikari, N. Rangra

引用次数: 1

Antioxidant, antimicrobial, and α-glucosidase inhibitory activities of saponin extracts from walnut (Juglans regia L.) leaves 核桃叶皂苷提取物抗氧化、抗菌及α-葡萄糖苷酶抑制活性研究

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369610

Youssef Elouafy, Adil El Yadini, Salma Mortada, M. Hnini, H. Harhar, A. Khalid, Ashraf N. Abdalla, A. Bouyahya, K. Goh, L. Ming, M. Faouzi, M. Tabyaoui

{"title":"Antioxidant, antimicrobial, and α-glucosidase inhibitory activities of saponin extracts from walnut (Juglans regia L.) leaves","authors":"Youssef Elouafy, Adil El Yadini, Salma Mortada, M. Hnini, H. Harhar, A. Khalid, Ashraf N. Abdalla, A. Bouyahya, K. Goh, L. Ming, M. Faouzi, M. Tabyaoui","doi":"10.4103/2221-1691.369610","DOIUrl":"https://doi.org/10.4103/2221-1691.369610","url":null,"abstract":"Objective: To investigate the relationship between triterpenoid saponin content and antioxidant, antimicrobial, and α-glucosidase inhibitory activities of 70% ethanolic, butanolic, aqueous, supernate and precipitate extracts of Juglans regia leaves. Methods: Triterpenoid saponins of different Juglans regia leaf extracts were measured by the vanillin method. Antioxidant activity was evaluated against DPPH and ABTS free radicals. We also assessed α-glucosidase inhibitory and antimicrobial activities of the leaf extracts. Pearson′s correlation coefficient was evaluated to determine the correlation between the saponin content and biological activities. Results: The butanolic extract was most effective against DPPH with an IC50 of 6.63 μg/mL, while the aqueous extract showed the highest scavenging activity against ABTS free radical with an IC50 of 42.27 μg/mL. Pearson′s correlation analysis indicated a strong negative correlation (r = -0.956) between DPPH radical scavenging activity (IC50) and the saponin content in the samples examined. In addition, the aqueous extract showed the best α-glucosidase inhibitory activity compared with other extracts. All the extracts had fair antibacterial activity against Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae except for the aqueous extract. Conclusions: Juglans regia extracts show potent antioxidant, antimicrobial, and α-glucosidase inhibitory activities. There is a correlation between saponin levels in Juglans regia leaf extracts and the studied activities. However, additional research is required to establish these relationships by identifying the specific saponin molecules responsible for these activities and elucidating their mechanisms of action.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"60 - 69"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42216261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Kaempferol and its derivatives: Biological activities and therapeutic potential 山奈酚及其衍生物:生物活性和治疗潜力

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.387747

IrshadUl Haq Bhat, Shazia Parveen, Rajeev Bhat

引用次数: 0

Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells 镰状细胞对α-刺激的B16F10小鼠黑色素瘤细胞黑色素生成的抑制作用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385571

Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo

{"title":"Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells","authors":"Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo","doi":"10.4103/2221-1691.385571","DOIUrl":"https://doi.org/10.4103/2221-1691.385571","url":null,"abstract":"Objective: To explore the anti-melanogenic potential of Cyrtomium falcatum. Methods: The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity, melanin content, and the expressions of melanogenesis-related genes and proteins were analyzed in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. Results: α-MSH treatment significantly increased tyrosinase activity, and extracellular and intracellular melanin content, as well as the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2 in B16F10 cells. Treatment with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase, MITF, TRP-1, and TRP-2 in a dose-dependent manner. Conclusions: Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"324 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-derived natural compounds in the treatment of arsenic-induced toxicity 植物源性天然化合物在砷中毒治疗中的应用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385567

Sanjib Bhattacharya

引用次数: 0

Acknowledgment to Reviewers, 2022 对审稿人的感谢，2022

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.372932

引用次数: 0

Erratum to " Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder" “赤藤油改善注意缺陷多动障碍大鼠模型的突触可塑性”的勘误

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.375087

引用次数: 0

Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT₁R axis and attenuates cardiac inflammation and apoptosis β -葡聚糖通过调节ACE-AT1R轴，抑制异丙肾上腺素诱导的心脏重构，减轻心脏炎症和细胞凋亡

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385569

Sengottuvelu Singaravel, Anitha Roy, VasanthaMallenahalli Neelakantappa, Jayashree Ganesan, BalakrishnanRamajayam Asokan, Srinivasan Kulandaivel, V VSathibabu Uddandrao

{"title":"Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT<sub>1</sub>R axis and attenuates cardiac inflammation and apoptosis","authors":"Sengottuvelu Singaravel, Anitha Roy, VasanthaMallenahalli Neelakantappa, Jayashree Ganesan, BalakrishnanRamajayam Asokan, Srinivasan Kulandaivel, V VSathibabu Uddandrao","doi":"10.4103/2221-1691.385569","DOIUrl":"https://doi.org/10.4103/2221-1691.385569","url":null,"abstract":"Objective: To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats, and elucidate the underlying mechanism. Methods: Rats were orally pretreated with beta-glucan (40 mg/kg body weight) for 30 d, and isoproterenol (20 mg/100 g body weight) was administered on days 31 and 32. The effects of beta-glucan on markers of cardiac injury, hemodynamic changes, production of proinflammatory cytokines, and the corresponding mRNA expressions were evaluated. In addition, histological analysis was performed. Results: Pretreatment with beta-glucan prevented isoproterenol-induced cardiac injury by preserving the structural and functional integrity of the plasma membrane and attenuating the production of proinflammatory cytokines (NF-κB, TNF-α, IL-6, IL-Ιβ, and IFN-γ) in the heart. Moreover, beta-glucan significantly downregulated the mRNA expression of ACE, AT1R, TNF-α, IL-6, NF-κB, caspase-3, TLR-4, and Bax, and upregulated Bcl-2 in the heart. At the same time, pretreatment with beta-glucan alleviated myocardial damage as reflected in a reduction in myonecrosis, edema, and erythrocyte extravasation with almost imperceptible inflammation. Conclusions: Beta-glucan can protect against isoproterenol-induced cardiotoxicity by attenuating cardiac inflammation and apoptosis and regulating the ACE-AT1R axis, thereby preventing cardiac remodeling.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity 丝胶通过调节GABA-T酶和线粒体活性减轻戊四唑点燃性癫痫和相关合并症

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.387749

Shamsher Singh, Sania Grover, RajKumar Narang

{"title":"Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity","authors":"Shamsher Singh, Sania Grover, RajKumar Narang","doi":"10.4103/2221-1691.387749","DOIUrl":"https://doi.org/10.4103/2221-1691.387749","url":null,"abstract":"Objective: To assess the effect of sericin against pentylenetetrazole (PTZ) kindling epilepsy and its associated comorbidities. Methods: Epilepsy was induced with PTZ at the dose of 30 mg/kg i.p. on alternative days for 25 days in rats. Sericin was administered orally at the doses of 250, 500, and 1000 mg/kg for 35 days. The behavioral activities were performed using an elevated plus maze, forced swim test, and Morris water maze test. A PTZ challenge test was conducted on day 32. On day 35, rats were sacrificed to perform oxidative stress, mitochondrial dysfunction, neuroinflammation, neurotransmitters, GABA-T activity, and histopathological analyses. Results: Sericin at 500 and 1000 mg/kg significantly reduced behavioral changes and neuroinflammatory cytokines, as well as improved oxidative stress, mitochondrial enzyme complex activity, neurotransmitter level, and GABA-T enzymatic activity (P<0.05). Moreover, sericin improved the neuronal survival altered by PTZ kindling in rat hippocampus. Conclusions: Sericin mitigates epilepsy-associated secondary complications possibly by the modulation of mitochondrial enzyme complexes and GABA-T enzymatic activity.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0