Asian Pacific journal of tropical biomedicine最新文献_第4页

T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity T6SS-5和cGAS-STING通路在假杆菌感染和免疫中的作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-03-01 DOI: 10.4103/2221-1691.372282

N. Semail, N. Zuraina, Y. Ismadi, N. Mohamad, A. Harun, I. Aziah, Z. Deris

{"title":"T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity","authors":"N. Semail, N. Zuraina, Y. Ismadi, N. Mohamad, A. Harun, I. Aziah, Z. Deris","doi":"10.4103/2221-1691.372282","DOIUrl":"https://doi.org/10.4103/2221-1691.372282","url":null,"abstract":"Burkholderia pseudomallei is a causative agent of melioidosis that can infect humans and animals in endemic countries, specifically in Southeast Asia and tropical Australia. A fundamental component for the pathogenesis of Burkholderia pseudomallei is the capability of the bacterium to enter, survive, replicate, and cause disease in a host cell by inducing the host cell fusion. Cell fusion results in multinucleated-giant cell formation, thus enabling the dissemination of Burkholderia pseudomallei intracellularly. cGAS reacts to Burkholderia pseudomallei infection by activating the cGAS-STING pathway and subsequently limiting host’s aberrant cell division and cellular replication by inducing autophagic cell death. In this review, we discuss the host-pathogen interactions between the type Ⅵ secretion system 5 (T6SS-5) of Burkholderia pseudomallei and human cGAS pathway in melioidosis infections. Since T6SS-5 is a main virulent factor in Burkholderia pseudomallei and the cGAS pathway is vital for host immune response, elucidating their functions is important for better understanding the pathogenesis of Burkholderia pseudomallei.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"94 - 103"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47521492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells 双氯芬酸与胡椒碱和D-柠檬烯联合诱导乳腺癌症细胞凋亡和细胞周期阻滞

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369612

Srivarshini Sankar, G. Muthukaliannan

{"title":"Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells","authors":"Srivarshini Sankar, G. Muthukaliannan","doi":"10.4103/2221-1691.369612","DOIUrl":"https://doi.org/10.4103/2221-1691.369612","url":null,"abstract":"Objective: To investigate the potential synergistic activity of diclofenac with piperine and D-limonene in inducing apoptosis and cell cycle arrest in breast cancer MCF-7 cells. Methods: Molecular docking study was conducted to evaluate the binding affinity of diclofenac with piperine and D-limonene against p53, Bax, and Bcl-2. The MTT assay was used to determine IC50, and the Chou-Talay method was used to determine the synergistic concentration of the combination treatment of diclofenac plus piperine and diclofenac plus D-limonene. Apoptosis detection, cell cycle arrest, reactive oxygen species production, and mitochondrial membrane potential were also investigated. Results: Diclofenac, piperine, and D-limonene showed potent binding affinity for p53, Bax, and Bcl-2. Diclofenac plus piperine and diclofenac plus D-limonene enhanced the formation of reactive oxygen species, which also had an effect on the mitochondrial membrane's integrity and caused DNA fragmentation. Diclofenac plus piperine and diclofenac plus D-limonene arrested the cells in the sub-G0 phase while drastically lowering the percentage of cells in the G2/M phase. Furthermore, the elevated apoptosis in the combined therapy was confirmed by annexin V/propidium iodide staining. Conclusions: The combined therapy prominently enhanced the anti-proliferative and apoptotic effects on MCF-7 cells compared with treatment with diclofenac, piperine, and D-limonene alone.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"80 - 92"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47596116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis 红景天苷通过抑制脱铁性贫血减轻缺氧和缺糖诱导的神经元损伤

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369611

Ying-Zhi Li, Ai-ping Wu, Dan-dan Wang, Pan-Pan Yang, Bin Sheng

{"title":"Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis","authors":"Ying-Zhi Li, Ai-ping Wu, Dan-dan Wang, Pan-Pan Yang, Bin Sheng","doi":"10.4103/2221-1691.369611","DOIUrl":"https://doi.org/10.4103/2221-1691.369611","url":null,"abstract":"Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation (OGD)-treated NT2 cells and its underlying mechanisms of action. Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGD-treated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside. Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside. Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"70 - 79"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49325046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial activities of Acacia genus: A review Acacia属植物的抗菌活性研究进展

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369609

Deeksha Adhikari, N. Rangra

引用次数: 1

Antioxidant, antimicrobial, and α-glucosidase inhibitory activities of saponin extracts from walnut (Juglans regia L.) leaves 核桃叶皂苷提取物抗氧化、抗菌及α-葡萄糖苷酶抑制活性研究

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-02-01 DOI: 10.4103/2221-1691.369610

Youssef Elouafy, Adil El Yadini, Salma Mortada, M. Hnini, H. Harhar, A. Khalid, Ashraf N. Abdalla, A. Bouyahya, K. Goh, L. Ming, M. Faouzi, M. Tabyaoui

{"title":"Antioxidant, antimicrobial, and α-glucosidase inhibitory activities of saponin extracts from walnut (Juglans regia L.) leaves","authors":"Youssef Elouafy, Adil El Yadini, Salma Mortada, M. Hnini, H. Harhar, A. Khalid, Ashraf N. Abdalla, A. Bouyahya, K. Goh, L. Ming, M. Faouzi, M. Tabyaoui","doi":"10.4103/2221-1691.369610","DOIUrl":"https://doi.org/10.4103/2221-1691.369610","url":null,"abstract":"Objective: To investigate the relationship between triterpenoid saponin content and antioxidant, antimicrobial, and α-glucosidase inhibitory activities of 70% ethanolic, butanolic, aqueous, supernate and precipitate extracts of Juglans regia leaves. Methods: Triterpenoid saponins of different Juglans regia leaf extracts were measured by the vanillin method. Antioxidant activity was evaluated against DPPH and ABTS free radicals. We also assessed α-glucosidase inhibitory and antimicrobial activities of the leaf extracts. Pearson′s correlation coefficient was evaluated to determine the correlation between the saponin content and biological activities. Results: The butanolic extract was most effective against DPPH with an IC50 of 6.63 μg/mL, while the aqueous extract showed the highest scavenging activity against ABTS free radical with an IC50 of 42.27 μg/mL. Pearson′s correlation analysis indicated a strong negative correlation (r = -0.956) between DPPH radical scavenging activity (IC50) and the saponin content in the samples examined. In addition, the aqueous extract showed the best α-glucosidase inhibitory activity compared with other extracts. All the extracts had fair antibacterial activity against Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae except for the aqueous extract. Conclusions: Juglans regia extracts show potent antioxidant, antimicrobial, and α-glucosidase inhibitory activities. There is a correlation between saponin levels in Juglans regia leaf extracts and the studied activities. However, additional research is required to establish these relationships by identifying the specific saponin molecules responsible for these activities and elucidating their mechanisms of action.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"60 - 69"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42216261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Kaempferol and its derivatives: Biological activities and therapeutic potential 山奈酚及其衍生物:生物活性和治疗潜力

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.387747

IrshadUl Haq Bhat, Shazia Parveen, Rajeev Bhat

引用次数: 0

Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells 镰状细胞对α-刺激的B16F10小鼠黑色素瘤细胞黑色素生成的抑制作用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385571

Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo

{"title":"Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells","authors":"Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo","doi":"10.4103/2221-1691.385571","DOIUrl":"https://doi.org/10.4103/2221-1691.385571","url":null,"abstract":"Objective: To explore the anti-melanogenic potential of Cyrtomium falcatum. Methods: The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity, melanin content, and the expressions of melanogenesis-related genes and proteins were analyzed in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. Results: α-MSH treatment significantly increased tyrosinase activity, and extracellular and intracellular melanin content, as well as the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2 in B16F10 cells. Treatment with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase, MITF, TRP-1, and TRP-2 in a dose-dependent manner. Conclusions: Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"324 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-derived natural compounds in the treatment of arsenic-induced toxicity 植物源性天然化合物在砷中毒治疗中的应用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385567

Sanjib Bhattacharya

引用次数: 0

Acknowledgment to Reviewers, 2022 对审稿人的感谢，2022

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.372932

引用次数: 0

Erratum to " Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder" “赤藤油改善注意缺陷多动障碍大鼠模型的突触可塑性”的勘误

IF 1.7 4区医学