Asian Pacific journal of tropical biomedicine最新文献_第5页

Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells 镰状细胞对α-刺激的B16F10小鼠黑色素瘤细胞黑色素生成的抑制作用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385571

Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo

{"title":"Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells","authors":"Chang-Suk Kong, Xian-Rong Zhou, JungHwan Oh, Fatih Karadeniz, Hyunjung Lee, HyoEun Kim, Migeon Jo, Youngwan Seo","doi":"10.4103/2221-1691.385571","DOIUrl":"https://doi.org/10.4103/2221-1691.385571","url":null,"abstract":"Objective: To explore the anti-melanogenic potential of Cyrtomium falcatum. Methods: The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity, melanin content, and the expressions of melanogenesis-related genes and proteins were analyzed in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. Results: α-MSH treatment significantly increased tyrosinase activity, and extracellular and intracellular melanin content, as well as the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2 in B16F10 cells. Treatment with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase, MITF, TRP-1, and TRP-2 in a dose-dependent manner. Conclusions: Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"324 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-derived natural compounds in the treatment of arsenic-induced toxicity 植物源性天然化合物在砷中毒治疗中的应用

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385567

Sanjib Bhattacharya

引用次数: 0

Acknowledgment to Reviewers, 2022 对审稿人的感谢，2022

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.372932

引用次数: 0

Erratum to " Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder" “赤藤油改善注意缺陷多动障碍大鼠模型的突触可塑性”的勘误

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.375087

引用次数: 0

Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity 丝胶通过调节GABA-T酶和线粒体活性减轻戊四唑点燃性癫痫和相关合并症

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.387749

Shamsher Singh, Sania Grover, RajKumar Narang

{"title":"Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity","authors":"Shamsher Singh, Sania Grover, RajKumar Narang","doi":"10.4103/2221-1691.387749","DOIUrl":"https://doi.org/10.4103/2221-1691.387749","url":null,"abstract":"Objective: To assess the effect of sericin against pentylenetetrazole (PTZ) kindling epilepsy and its associated comorbidities. Methods: Epilepsy was induced with PTZ at the dose of 30 mg/kg i.p. on alternative days for 25 days in rats. Sericin was administered orally at the doses of 250, 500, and 1000 mg/kg for 35 days. The behavioral activities were performed using an elevated plus maze, forced swim test, and Morris water maze test. A PTZ challenge test was conducted on day 32. On day 35, rats were sacrificed to perform oxidative stress, mitochondrial dysfunction, neuroinflammation, neurotransmitters, GABA-T activity, and histopathological analyses. Results: Sericin at 500 and 1000 mg/kg significantly reduced behavioral changes and neuroinflammatory cytokines, as well as improved oxidative stress, mitochondrial enzyme complex activity, neurotransmitter level, and GABA-T enzymatic activity (P<0.05). Moreover, sericin improved the neuronal survival altered by PTZ kindling in rat hippocampus. Conclusions: Sericin mitigates epilepsy-associated secondary complications possibly by the modulation of mitochondrial enzyme complexes and GABA-T enzymatic activity.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT₁R axis and attenuates cardiac inflammation and apoptosis β -葡聚糖通过调节ACE-AT1R轴，抑制异丙肾上腺素诱导的心脏重构，减轻心脏炎症和细胞凋亡

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.385569

Sengottuvelu Singaravel, Anitha Roy, VasanthaMallenahalli Neelakantappa, Jayashree Ganesan, BalakrishnanRamajayam Asokan, Srinivasan Kulandaivel, V VSathibabu Uddandrao

{"title":"Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT<sub>1</sub>R axis and attenuates cardiac inflammation and apoptosis","authors":"Sengottuvelu Singaravel, Anitha Roy, VasanthaMallenahalli Neelakantappa, Jayashree Ganesan, BalakrishnanRamajayam Asokan, Srinivasan Kulandaivel, V VSathibabu Uddandrao","doi":"10.4103/2221-1691.385569","DOIUrl":"https://doi.org/10.4103/2221-1691.385569","url":null,"abstract":"Objective: To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats, and elucidate the underlying mechanism. Methods: Rats were orally pretreated with beta-glucan (40 mg/kg body weight) for 30 d, and isoproterenol (20 mg/100 g body weight) was administered on days 31 and 32. The effects of beta-glucan on markers of cardiac injury, hemodynamic changes, production of proinflammatory cytokines, and the corresponding mRNA expressions were evaluated. In addition, histological analysis was performed. Results: Pretreatment with beta-glucan prevented isoproterenol-induced cardiac injury by preserving the structural and functional integrity of the plasma membrane and attenuating the production of proinflammatory cytokines (NF-κB, TNF-α, IL-6, IL-Ιβ, and IFN-γ) in the heart. Moreover, beta-glucan significantly downregulated the mRNA expression of ACE, AT1R, TNF-α, IL-6, NF-κB, caspase-3, TLR-4, and Bax, and upregulated Bcl-2 in the heart. At the same time, pretreatment with beta-glucan alleviated myocardial damage as reflected in a reduction in myonecrosis, edema, and erythrocyte extravasation with almost imperceptible inflammation. Conclusions: Beta-glucan can protect against isoproterenol-induced cardiotoxicity by attenuating cardiac inflammation and apoptosis and regulating the ACE-AT1R axis, thereby preventing cardiac remodeling.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scopoletin: Anticancer potential and mechanism of action 东莨菪碱:抗癌潜能及作用机制

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.367685

Lia Meilawati, R. Dewi, A. Tasfiyati, A. Septama, L. Antika

引用次数: 2

Molluscicidal effect of green synthesized silver nanoparticles using Azadirachta indica on Biomphalaria alexandrina snails and Schistosoma mansoni cercariae 印楝绿色合成纳米银对山绿螺和曼氏血吸虫尾蚴的杀螺效果

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.367688

Salwa S Younis, I. Abou-El-Naga, K. Radwan

{"title":"Molluscicidal effect of green synthesized silver nanoparticles using Azadirachta indica on Biomphalaria alexandrina snails and Schistosoma mansoni cercariae","authors":"Salwa S Younis, I. Abou-El-Naga, K. Radwan","doi":"10.4103/2221-1691.367688","DOIUrl":"https://doi.org/10.4103/2221-1691.367688","url":null,"abstract":"Objective: To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles (neem-Ag NPs) against Biomphalaria alexandrina, the snail intermediate host for Schistosoma mansoni, and their cercaricidal potential. Methods: Methanol extracts from neem fruits were used for green synthesis of neem-Ag NPs. The neem-Ag NPs were characterized using UV-visible absorption spectra, dynamic laser light scattering technique, and transmission electron microscopy. The potential molluscicidal effect against adult and juvenile Biomphalaria alexandrina and the effect of the sub-lethal concentration on hatching of snail eggs and Schistosoma mansoni cercariae were evaluated. Results: The surface plasmon resonance of neem-Ag NPs showed a sharp absorption peak at λmax = 518 nm together with multiple peaks. The hydrodynamic diameter was (77.15±34.53) nm, the polydispersity index (0.338±0.000) and the zeta-potential −14.07 mV. Moreover, transmission electron microscopy showed that the average size of the nanoparticles was (27±2) nm. Agglomeration was evident and a light-colored capping layer could be seen coating the nanoparticles. Juvenile snails (LC50: 0.83 ppm) were more susceptible to neem-Ag NPs than adults (LC50: 1.07 ppm). In addition, neem-Ag NPs and neem at LC50 concentrations inhibited the egg-hatching of snails and showed cercaricidal activity in a time-dependent manner. Conclusions: Neem-Ag NPs have lethal activities against Biomphalaria alexandrina snails and their eggs, as well as Schistosoma mansoni cercariae. Hence, neem-Ag NPs could be a potential agent to control schistosomiasis.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"35 - 44"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43273293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major 槲皮素对主要利什曼原虫引起的皮肤利什曼病的抗利什曼炎、免疫调节和抗氧化活性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.367689

A. Oryan, E. Bemani, S. Bahrami

{"title":"Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major","authors":"A. Oryan, E. Bemani, S. Bahrami","doi":"10.4103/2221-1691.367689","DOIUrl":"https://doi.org/10.4103/2221-1691.367689","url":null,"abstract":"Objective: To evaluate the in vitro and in vivo efficacy of quercetin and its immunomodulatory and anti-oxidative activity against Leishmania major (L. major). Methods: L. major promastigotes and amastigotes were incubated with different concentrations of quercetin to estimate EC50. For in vivo study, the base of tails of mice was infected with L. major. After developing ulcers in the inoculation site, mice were treated with 50 mg/kg quercetin orally for 28 consecutive days. The wound-healing potential of quercetin was evaluated by histopathological analysis of tissue sections stained by hematoxylin and eosin as well as Masson′s trichrome. In addition, the levels of tumor necrosis factor-α, interleukin-6, malondialdehyde, and adiponectin, the ferric reducing ability of plasma, as well as superoxide dismutase and glutathione peroxidase activities were measured. Results: The EC50 values of quercetin against L. major promastigotes and intracellular amastigotes were 0.27 and 0.85 μM, respectively. Histopathological analysis showed that fewer inflammatory cells, more fibroblasts, and more collagen deposition were observed in tissue sections of quercetin-treated mice. In addition, treatment with quercetin markedly increased glutathione peroxidase activity, the ferric reducing ability of plasma and adiponectin levels while decreasing malondialdehyde, interleukin-6, and tumor necrosis factor-α levels. Conclusions: Quercetin shows anti-leishmanial activity, immunomodulatory, anti-oxidative, and anti-inflammatory effects. Therefore, it may be further explored as an effective drug in treating leishmaniasis.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"26 - 34"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48128448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Calorie restriction potentiates epigallocatechin-3-gallate-mediated Nrf2 activation in hepatocytes of aged rats 卡路里限制增强了衰老大鼠肝细胞中表没食子儿茶素-3-没食子酸介导的Nrf2激活

4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-01-01 DOI: 10.4103/2221-1691.387748

Kalaiselvi Periandavan, Rajeswari Ravindran, Malathi Manuel, Thangarajeswari Mohan, Ravindran Jaganathan

{"title":"Calorie restriction potentiates epigallocatechin-3-gallate-mediated Nrf2 activation in hepatocytes of aged rats","authors":"Kalaiselvi Periandavan, Rajeswari Ravindran, Malathi Manuel, Thangarajeswari Mohan, Ravindran Jaganathan","doi":"10.4103/2221-1691.387748","DOIUrl":"https://doi.org/10.4103/2221-1691.387748","url":null,"abstract":"Objective: To explore the combinatorial effect of epigallocatechin-3-gallate (EGCG) and calorie restriction on activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor involved in the antioxidant defense system of aged rats. Methods: Aged male Wistar rats were calorie-restricted and treated with EGCG orally for 45 days. The initial body weight of aged rats was recorded, and the final body weight was measured at the end of the experimental period. Serum lipid and lipoprotein status, oxidative stress markers such as free radicals and malondialdehyde levels, and reduced glutathione were assessed. In addition, RT-PCR and Western blotting analyses were performed. Results: Calorie restriction potentiated the effect of EGCG on enhancing antioxidant status, improving the levels of serum lipid and lipoproteins, upregulating Nrf2 and Bcl2, and downregulating Keap1, cullin3, Bax and cytochrome c in aged rats. Conclusions: Calorie restriction can promote EGCG-mediated Nrf2 activation in aged rats. This preliminary finding paves the way for a combinatory approach to replenishing the antioxidant status during aging, thereby reducing the risk for age-associated degenerative diseases.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135210808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0