Asian Pacific journal of tropical biomedicine最新文献_第3页

Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model Solanum procumbens对低剂量完全弗氏佐剂诱导的关节炎大鼠模型的抗炎作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377408

Xuan-Hai Do, Trong Nguyen, Thanh Dang, Thi Nguyen, Trung Nguyen, Van Do, Huu Le, X. Nguyen, Hai-Anh H. Dang, Giang-Linh Nguyen, Dinh-Khanh Hoang, Van-Quan Le, V. Cấn

{"title":"Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model","authors":"Xuan-Hai Do, Trong Nguyen, Thanh Dang, Thi Nguyen, Trung Nguyen, Van Do, Huu Le, X. Nguyen, Hai-Anh H. Dang, Giang-Linh Nguyen, Dinh-Khanh Hoang, Van-Quan Le, V. Cấn","doi":"10.4103/2221-1691.377408","DOIUrl":"https://doi.org/10.4103/2221-1691.377408","url":null,"abstract":"Objective: To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund's adjuvant-induced arthritis rat models. Methods: We isolated and identified five compounds in the ethanol-soluble Solanum procumbens extract (SP) with anti-inflammatory effects, including ursolic acid, β-sitosterol, hexadecanoic acid, cis-vaccenic acid, and vanillic acid. Additionally, we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms, including paw volumes, local temperatures, withdrawal latency, and mechanical withdrawal threshold at the hind paw and white blood cell (WBC) number from complete Freund's adjuvant-induced arthritis rat models. Results: We have successfully established a complete Freund's adjuvant-induced arthritis rat model at a low dose (1 mg/mL). SP extract significantly reduced paw volumes (P<0.05), prolonged withdrawal latencies (P<0.05), decreased local temperature, and increased the mechanical withdrawal threshold (P<0.05), but only SP extract at the dose of 300 mg/kg significantly decreased WBC numbers. Conclusions: SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis, but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"214 - 221"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45833487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of hydroalcoholic leaf extract of Cassia fistula L. on type II collagen-induced arthritis in rats 决明子水醇叶提取物对Ⅱ型胶原诱导的大鼠关节炎的影响

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377406

Vineet Mehta, P. Nagu, Arun Parashar, Manjusha Chaudhary

{"title":"Effect of hydroalcoholic leaf extract of Cassia fistula L. on type II collagen-induced arthritis in rats","authors":"Vineet Mehta, P. Nagu, Arun Parashar, Manjusha Chaudhary","doi":"10.4103/2221-1691.377406","DOIUrl":"https://doi.org/10.4103/2221-1691.377406","url":null,"abstract":"Objective: To explore the effect of Cassia fistula on collagen II-induced arthritis in rats. Methods: The effect of 250 and 500 mg/kg chloroform and hydroalcoholic extract of Cassia fistula leaf on collagen II-induced arthritis was investigated by evaluating paw volume, arthritis index, spleen index, and biochemical parameters. Histopathological analysis and docking study were also performed. Results: A dose-dependent reduction in paw volume, arthritic index, and spleen index was observed following oral administration of the chloroform and hydroalcoholic extracts. Treatment with Cassia fistula extracts reduced tumor necrosis factor-α, interleukin (IL)-1β, IL-6, prostaglandin E2, aspartate aminotransferase, alanine aminotransferase, total leucocyte count, and erythrocyte sedimentation rate while increasing IL-10 level. In addition, Cassia fistula extracts improved joint architecture, and prevented cartilage and bone destruction. Docking analysis demonstrated that the physcion, 1-octacosanol, 5,3',4'-trihydroxy-6-methoxy-7-O-α-L-rhamnopyranosyl-(1,2)-O-β-D-galactopyranoside and scopoletin may be responsible for the anti-arthritic effect of Cassia fistula. Conclusions: Cassia fistula suppresses the progression of collagen II-induced arthritis by lowering the inflammatory factors, decreasing paw volume and arthritic index, and alleviating joint architecture. However, further studies are required to confirm the bioactive molecule responsible for the anti-arthritic potential of Cassia fistula.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"195 - 204"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48023625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro antioxidant and wound healing activity of Sargassum polycystum hydroethanolic extract in fibroblasts and keratinocytes 马尾藻水乙醇提取物对成纤维细胞和角质形成细胞的体外抗氧化和伤口愈合活性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377409

Wanwipha Woonnoi, Furoida Moolsap, Supita Tanasawet, Nattakanwadee Khumpirapang, Chakkapat Aenglong, Wanida Sukketsiri

{"title":"In vitro antioxidant and wound healing activity of Sargassum polycystum hydroethanolic extract in fibroblasts and keratinocytes","authors":"Wanwipha Woonnoi, Furoida Moolsap, Supita Tanasawet, Nattakanwadee Khumpirapang, Chakkapat Aenglong, Wanida Sukketsiri","doi":"10.4103/2221-1691.377409","DOIUrl":"https://doi.org/10.4103/2221-1691.377409","url":null,"abstract":"Objective: To investigate the in vitro antioxidant and wound healing properties of the hydroethanolic extract of Sargassum polycystum, and elucidate the mechanism of its wound healing activity. Methods: Human dermal fibroblast and HaCaT cells were used to evaluate the proliferation by sulforhodamine B and dsDNA assay after treatment with Sargassum polycystum extracts. Scratch wound healing and phalloidin-rhodamine staining were employed to observe migratory activity and filopodia formation, respectively. Western blot and real-time RT-PCR assays were performed to determine the protein and gene expressions related to wound healing activities. Results: The phytochemical analysis found a higher level of flavonoid than phenolic compound in Sargassum polycystumextracts. In human dermal fibroblast cells, Sargassum polycystum extracts at 50 and 100 µg/mL significantly increased fibroblast proliferation and the gene expressions of hyaluronic acid synthase 1 (HAS1), HAS2, HAS3, collagen type 1 alpha 1 chain (COL1A1), collagen type 3 alpha 1 chain (COL3A1), and elastin. The phosphorylation of Akt, ERK1/2, and p38 MAPK was also significantly upregulated after treatment with Sargassum polycystumextracts. Additionally, 50 and 100 µg/mL of the extracts prominently enhanced the proliferation, migration, and filopodia formation of HaCaT cells, as well as the protein levels of pFAK/FAK, pSrc/Src, pAkt/Akt, pERK1/2/ERK1/2, Rac1 and Cdc42. Conclusions: Sargassum polycystum extracts show promising wound healing activities in human dermal fibroblasts and keratinocytes.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"222 - 232"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48931772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural polysaccharides for ulcerative colitis: A general overview 天然多糖治疗溃疡性结肠炎：综述

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377405

Nikhil Sharma, Akshita Arora, Dipti Kakkar

{"title":"Natural polysaccharides for ulcerative colitis: A general overview","authors":"Nikhil Sharma, Akshita Arora, Dipti Kakkar","doi":"10.4103/2221-1691.377405","DOIUrl":"https://doi.org/10.4103/2221-1691.377405","url":null,"abstract":"Ulcerative colitis is a colonic disease characterized by the disruption of the mucosal epithelial layer and inflammation. For the treatment of this disease, various chemotherapeutic agents are available. However, the toxicities associated with chemotherapeutics greatly hamper treatment. Polysaccharide from natural resources is emerging as a potentially therapeutic substance with comparative minimum adverse effects. In this article, we are discussing polysaccharide from diverse sources (plants, edible mushrooms, and algae) which are being used in the treatment of ulcerative colitis. These polysaccharides exert their therapeutic action on ulcerative colitis through several mechanisms, including suppression of inflammatory cascades NF-ĸB, MAPK, IL-6/JAK2/STAT3, preventing the release of certain inflammatory mediators, modulating the intestinal microbiome, maintaining the integrity of intestinal barriers, and regulating the certain inflammatory markers. The present review compiles the role of different polysaccharides being used successfully in the management/treatment of ulcerative colitis. Special emphasis was given to explaining the biomolecular pathway.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"185 - 194"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46246421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats d -蒎醇对博莱霉素诱导大鼠肺纤维化的调节作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377407

Yuzhou Duan, Zhi-Hua Wang, Yanfei Huo, Yang Zhang, Xiao-Ran Wu, Cuike Gong, Lin-lin Bai

{"title":"Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats","authors":"Yuzhou Duan, Zhi-Hua Wang, Yanfei Huo, Yang Zhang, Xiao-Ran Wu, Cuike Gong, Lin-lin Bai","doi":"10.4103/2221-1691.377407","DOIUrl":"https://doi.org/10.4103/2221-1691.377407","url":null,"abstract":"Objective: To assess the effect of D-pinitol on pulmonary fibrosis induced by bleomycin. Methods: Sprague-Dawley rats received intratracheal bleomycin (6 IU/kg) to induce pulmonary fibrosis, followed by administration of either D-pinitol (5, 10, or 20 mg/kg) or vehicle or methylprednisolone (10 mg/kg) over 28 days after bleomycin administration. Lung function, biochemical parameters, serum biochemistry, mRNA expressions, and histological features were observed. Results: D-pinitol at 10 and 20 mg/kg significantly (P<0.05) attenuated bleomycin-induced bronchoalveolar lavage fluid, decreased myeloperoxidase, nitric oxide, malondialdehyde levels, and increased glutathione and superoxide dismutase level. D-pinitol also improved lung function (enhanced pause, frequency of breathing, expired volume, and tidal volume). Besides, D-pinitol significantly (P<0.05) upregulated Nrf2 and downregulated mRNA expressions of TGF-β, collagen-1, and Smad-3. Furthermore, considerably less inflammation (peribronchial, perivascular, and total), Ashcroft, and interstitial fibrosis scores were observed in the D-pinitol group. Conclusions: D-pinitol exerts its effect against bleomycin-induced pulmonary fibrosis via antioxidative and anti-fibrotic pathways.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"205 - 213"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardio-protective effects of Pinus eldarica bark extract on adrenaline-induced myocardial infarction in rats 接骨木皮提取物对肾上腺素诱发大鼠心肌梗死的保护作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374231

L. Safaeian, Zahra Haghighatian, B. Zolfaghari, Mahdi Amindeldar

引用次数: 0

Phytochemical composition and toxicity assessment of Ammi majus L. 麻米的植物化学成分及毒性评价。

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374233

A. Bouyahya, ToongHai Sam, LongChiau Ming, O. El-Guourrami, N. Salhi, F. Benkhouili, G. Zengin, MustafaAbdullah Yilmaz, Mouna Ameggouz, Ahmed Zahidi, L. Rouas, KhangWen Goh, A. Doukkali, H. Benzeid

引用次数: 0

Hesperidin attenuates arsenic trioxide-induced cardiac toxicity 橙皮苷减轻三氧化二砷引起的心脏毒性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374232

JeevanRanjan Dash, G. Khuntia, B. Jena, Umakanta Mishra, S. Parija

引用次数: 2

Natural sources, biosynthesis, biological functions, and related mechanism of shikimic acid and its derivatives: A mini-review 莽草酸及其衍生物的天然来源、生物合成、生物学功能及相关机制综述

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374230

G. Gandhi, AlanBruno Silva Vasconcelos, P. Antony, M. Montalvao, Mariana Nobre Farias de Franca, VargheseEdwin Hillary, S. Ceasar, Dan Liu

引用次数: 0

Molluscicidal activities of green-synthesized Alstonia congensis silver nanoparticles 绿色合成的银粉纳米颗粒的杀螺活性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374234

Oyetunde T. Oyeyemi, B. Babalola, TaiwoC Akinmulero, PreciousA Adesida, I. Oyeyemi

引用次数: 1