Asian Pacific journal of tropical biomedicine最新文献_第3页

Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats d -蒎醇对博莱霉素诱导大鼠肺纤维化的调节作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI: 10.4103/2221-1691.377407

Yuzhou Duan, Zhi-Hua Wang, Yanfei Huo, Yang Zhang, Xiao-Ran Wu, Cuike Gong, Lin-lin Bai

{"title":"Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats","authors":"Yuzhou Duan, Zhi-Hua Wang, Yanfei Huo, Yang Zhang, Xiao-Ran Wu, Cuike Gong, Lin-lin Bai","doi":"10.4103/2221-1691.377407","DOIUrl":"https://doi.org/10.4103/2221-1691.377407","url":null,"abstract":"Objective: To assess the effect of D-pinitol on pulmonary fibrosis induced by bleomycin. Methods: Sprague-Dawley rats received intratracheal bleomycin (6 IU/kg) to induce pulmonary fibrosis, followed by administration of either D-pinitol (5, 10, or 20 mg/kg) or vehicle or methylprednisolone (10 mg/kg) over 28 days after bleomycin administration. Lung function, biochemical parameters, serum biochemistry, mRNA expressions, and histological features were observed. Results: D-pinitol at 10 and 20 mg/kg significantly (P<0.05) attenuated bleomycin-induced bronchoalveolar lavage fluid, decreased myeloperoxidase, nitric oxide, malondialdehyde levels, and increased glutathione and superoxide dismutase level. D-pinitol also improved lung function (enhanced pause, frequency of breathing, expired volume, and tidal volume). Besides, D-pinitol significantly (P<0.05) upregulated Nrf2 and downregulated mRNA expressions of TGF-β, collagen-1, and Smad-3. Furthermore, considerably less inflammation (peribronchial, perivascular, and total), Ashcroft, and interstitial fibrosis scores were observed in the D-pinitol group. Conclusions: D-pinitol exerts its effect against bleomycin-induced pulmonary fibrosis via antioxidative and anti-fibrotic pathways.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"205 - 213"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardio-protective effects of Pinus eldarica bark extract on adrenaline-induced myocardial infarction in rats 接骨木皮提取物对肾上腺素诱发大鼠心肌梗死的保护作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374231

L. Safaeian, Zahra Haghighatian, B. Zolfaghari, Mahdi Amindeldar

引用次数: 0

Phytochemical composition and toxicity assessment of Ammi majus L. 麻米的植物化学成分及毒性评价。

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374233

A. Bouyahya, ToongHai Sam, LongChiau Ming, O. El-Guourrami, N. Salhi, F. Benkhouili, G. Zengin, MustafaAbdullah Yilmaz, Mouna Ameggouz, Ahmed Zahidi, L. Rouas, KhangWen Goh, A. Doukkali, H. Benzeid

引用次数: 0

Hesperidin attenuates arsenic trioxide-induced cardiac toxicity 橙皮苷减轻三氧化二砷引起的心脏毒性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374232

JeevanRanjan Dash, G. Khuntia, B. Jena, Umakanta Mishra, S. Parija

引用次数: 2

Natural sources, biosynthesis, biological functions, and related mechanism of shikimic acid and its derivatives: A mini-review 莽草酸及其衍生物的天然来源、生物合成、生物学功能及相关机制综述

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374230

G. Gandhi, AlanBruno Silva Vasconcelos, P. Antony, M. Montalvao, Mariana Nobre Farias de Franca, VargheseEdwin Hillary, S. Ceasar, Dan Liu

引用次数: 0

Molluscicidal activities of green-synthesized Alstonia congensis silver nanoparticles 绿色合成的银粉纳米颗粒的杀螺活性

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-04-01 DOI: 10.4103/2221-1691.374234

Oyetunde T. Oyeyemi, B. Babalola, TaiwoC Akinmulero, PreciousA Adesida, I. Oyeyemi

引用次数: 1

Ponatinib and gossypol act in synergy to suppress colorectal cancer cells by modulating apoptosis/autophagy crosstalk and inhibiting the FGF19/FGFR4 axis Ponatinib和棉酚协同作用，通过调节凋亡/自噬串扰和抑制FGF19/FGFR4轴抑制结直肠癌细胞

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-03-01 DOI: 10.4103/2221-1691.372286

N. El-Lakkany, Hadeel H Elkattan, A. Elsisi

{"title":"Ponatinib and gossypol act in synergy to suppress colorectal cancer cells by modulating apoptosis/autophagy crosstalk and inhibiting the FGF19/FGFR4 axis","authors":"N. El-Lakkany, Hadeel H Elkattan, A. Elsisi","doi":"10.4103/2221-1691.372286","DOIUrl":"https://doi.org/10.4103/2221-1691.372286","url":null,"abstract":"Objective: To evaluate the efficacy of ponatinib plus gossypol against colorectal cancer HCT-116 and Caco-2 cells. Methods: Cells were treated with ponatinib and/or gossypol at increasing concentrations to evaluate synergistic drug interactions by combination index. Cell viability, FGF19/FGFR4, and apoptotic and autophagic cell death were studied. Results: Ponatinib (1.25-40 μM) and gossypol (2.5-80 μM) monotherapy inhibited HCT-116 and Caco-2 cell viability in a dose- and time-dependent manner. The combination of ponatinib and gossypol at a ratio of 1 to 2 significantly decreased cell viability (P<0.05), with a > 2- and > 4-fold reduction in IC50, respectively, after 24 h and 48 h, as compared to the IC50 of ponatinib. Lower combined concentrations showed greater synergism (combination index<1) with a higher ponatinib dose reduction index. Moreover, ponatinib plus gossypol induced morphological changes in HCT-116 and Caco-2 cells, increased beclin-1 and caspase-3, and decreased FGF19, FGFR4, Bcl-2 and p-Akt as compared to treatment with drugs alone. Conclusions: Gossypol enhances ponatinib's anticancer effects against colorectal cancer cells through antiproliferative, apoptotic, and autophagic mechanisms. This may open the way for the future use of ponatinib at lower doses with gossypol as a potentially safer targeted strategy for colorectal cancer treatment.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"131 - 138"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44280330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin alleviates oxidative stress, inflammation, apoptosis, and DNA damage in acrylamide–induced nephrotoxicity in rats 褪黑素可减轻丙烯酰胺肾毒性大鼠的氧化应激、炎症、细胞凋亡和DNA损伤

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-03-01 DOI: 10.4103/2221-1691.372285

F. Ibaokurgil, H. Aydın, S. Yıldırım, E. Sengul

{"title":"Melatonin alleviates oxidative stress, inflammation, apoptosis, and DNA damage in acrylamide–induced nephrotoxicity in rats","authors":"F. Ibaokurgil, H. Aydın, S. Yıldırım, E. Sengul","doi":"10.4103/2221-1691.372285","DOIUrl":"https://doi.org/10.4103/2221-1691.372285","url":null,"abstract":"Objective: To investigate the effects of melatonin on renal inflammation, oxidative stress, apoptosis, as well as DNA and tissue damage in acrylamide-induced nephrotoxicity in rats. Methods: Fifty male rats were randomly divided into five groups. The control group received distilled water by gastric lavage for 11 days and the acrylamide group was administered acrylamide (50 mg/kg, i.g.) for 11 days. The MEL10+ACR and MEL20+ACR groups received intraperitoneal melatonin 10 and 20 mg/kg, respectively, for 11 days, and acrylamide (50 mg/kg, i.g.) was administered 1 h after melatonin injection. The MEL20 group was injected with melatonin (20 mg/kg) for 11 days. Kidney function tests were performed and biochemical and inflammatory parameters were determined. In addition, histopathological, immunohistochemical, and immunofluorescence examinationswerecarried out. Results: Melatonin significantly abated acrylamide-induced rise in serum urea and creatinine levels. Acrylamide caused oxidative stress, inflammation, apoptosis, as well as DNA and tissue damage in the kidneys. Melatonin treatment alleviated acrylamide-induced renal damage by exhibiting antioxidant, anti-inflammatory, and anti- apoptotic effects. Moreover, melatonin significantly ameliorated acrylamide-caused histopathological changes in kidney tissue. Conclusions: Melatonin attenuates acrylamide-induced renal oxidative stress, inflammation, apoptosis, and DNA damage in rats.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"121 - 130"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46165435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral activity of mangiferin from the rhizome of Anemarrhena asphodeloides against herpes simplex virus type 1 山参根茎芒果苷对1型单纯疱疹病毒的抗病毒作用

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-03-01 DOI: 10.4103/2221-1691.372284

Wen‐Da Wang, Gang Chen

{"title":"Antiviral activity of mangiferin from the rhizome of Anemarrhena asphodeloides against herpes simplex virus type 1","authors":"Wen‐Da Wang, Gang Chen","doi":"10.4103/2221-1691.372284","DOIUrl":"https://doi.org/10.4103/2221-1691.372284","url":null,"abstract":"Objective: To evaluate the antiviral activity of pure compounds against herpes simplex virus type 1 (HSV-1) from the rhizome of Anemarrhena asphodeloides. Methods: Bioassay-guided isolation was conducted to separate the active compound and its chemical structure was elucidated by spectral analysis. In vitro antiviral efficacy of active compound was detected by Cell Counting Kit-8 assay, plaque reduction assay, and fluorescence observation. RT-PCR was used to determine the viral load and the cytokine-related gene expression after HSV-1 infection. In vivo study was also conducted to further determine antiviral efficacy of an active compound against HSV-1. Results: An active compound was isolated and elucidated as mangiferin. Mangiferin significantly inhibited the replication of HSV-1 in Vero cells with a half maximal inhibitory concentration (IC50) of 64.0 mg/L. Time-of-addition and time-of-removal assays demonstrated that mangiferin could effectively inhibit the replication of HSV-1 in the early stage (8 h). UL12, UL42, and UL54 gene expression levels of HSV-1 in the 64 mg/L mangiferin-treated group were markedly reduced as compared with the HSV-1 group (P<0.01). Fluorescence observation showed that mangiferin attenuated the mitochondrial damage maintaining ΔΨm induced by HSV-1 in Vero cells. The expression of inflammatory factors TNF-α, IL- 1β, and IL-6 was remarkably increased in the virus-infected group as compared with that in the normal group (P<0.05), the levels of these inflammatory factors dropped after treatment with mangiferin. Mangiferin significantly decreased the viral load and attenuated the HSV-1-induced up-regulation of TNF-α, IL1β, and IL-6. The relative protection rate of HSV-1-infected mice could reach up to 55.5% when the concentration of mangiferin was 4 g/kg. Conclusions: Mangiferin exhibits promising antiviral activity against HSV-1 in vitro and in vivo and could be a potential antiviral agent for HSV-1.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"112 - 120"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colon cancer and their targeting approaches through nanocarriers: A review 癌症及其纳米载体靶向研究进展

IF 1.7 4区医学

Asian Pacific journal of tropical biomedicine Pub Date : 2023-03-01 DOI: 10.4103/2221-1691.372283

R. Kumari, Nikhil Sharma, R. Karwasra, Kushagra Khanna

引用次数: 0