Asian Journal of Research in Chemistry最新文献_第5页

Extraction of Silica from Different Sources of Agricultural Waste 从不同来源的农业废弃物中提取二氧化硅

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00016

I. Kouadri, Bachir BEN SEGHİR, H. Hemmami, S. Zeghoud, N. Allag, A. Rebiai, Ilham Ben Amor, A. Chala, H. Belkhalfa

引用次数: 2

Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets 盐酸维洛嗪双层基质片的制备及评价

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00015

K. Nagasree, Uppalanchi Prashanthi, R. Sri. S

{"title":"Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets","authors":"K. Nagasree, Uppalanchi Prashanthi, R. Sri. S","doi":"10.52711/0974-4150.2023.00015","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00015","url":null,"abstract":"Aim of study was to develop bilayer drug delivery for treatment of attention deficit hyperactivity disorder (ADHD) by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepared drug loaded bilayer tablets were evaluated for pre and post compression parameters. The tablets were prepared by direct compression and wet granulation method. The loading dose was delivered in the form of immediate release layer prepared by different super-disintegrations and maintenance dose was delivered through sustained release layer prepared by using polymers like Ethyl cellulose and Carbopol. Both the immediate release layer and sustained release layers were separately optimized and then combined to optimize the bilayer tablets. No interactions were found between drug and excipients. Formulation containing Cross Carmellose shows immediate drug release. Formulation Containing Carbopol shows sustained release action and bilayer formulations F5 shows releases up to 12 hours. Bilayer tablets with release characteristics offer critical advantages such as, site specificity with improved absorption and efficacy.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86232438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Zirconium Oxide Nanoparticles using Sapindus mukorossi (Soapnut) as natural surfactant, A green synthetic approach 以皂子为天然表面活性剂的氧化锆纳米颗粒的合成与表征，绿色合成方法

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00013

Avnish Kumar Arora, Lalit Chauhan, Pankaj Kumar

引用次数: 0

Silico Methodologies Modelling of Aquatic Toxicity in Tetrahymena Pyriformis Via Aromatic Amines 通过芳香胺对梨形四膜虫水生毒性的硅方法模拟

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00001

N. Ziani, Khadidja Amirat, Souhaila Meneceur, Fatiha Mebarki, Abderrhmane Bouafia

{"title":"Silico Methodologies Modelling of Aquatic Toxicity in Tetrahymena Pyriformis Via Aromatic Amines","authors":"N. Ziani, Khadidja Amirat, Souhaila Meneceur, Fatiha Mebarki, Abderrhmane Bouafia","doi":"10.52711/0974-4150.2023.00001","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00001","url":null,"abstract":"EU Directive for the Protection of Laboratory Animals mandates and encourages the use of alternative methods that could substitute, cut down on, and generally improve animal testing. Quantitative structure-activity relationship models (QSAR) as well as in vitro toxicity testing are among the most notable of such. QSARs are defined as computerized mathematical models that can utilize a compound’s (aromatic amine) biological activity—aquatic toxicity—to calculate or provide the experimental descriptors of the chemical structure of this compound. Multiple Linear Regression (MLR) and Artificial Neural Networks (ANN) are the approaches we use for the aim of predicting aquatic toxicity. The best models for two descriptors are the electrotopological descriptors derived from E-calc, and the partition coefficient derived by the Hyperchem software, applying a genetic algorithm—variable subset selection procedure. The important values of the statistical parameters obtained by the two approaches were as follows: By MLR: R2= 92.18, Q2 = 90.51, Q2ext= 95.26, F=188.5466, S = 0.1995. By ANN were: Q2 = 94.79, RMSE= 0.16, Q2ext= 91.71, RMSEext=0.18.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83865467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of reactive dyes in Validation of favipiravir from pharmaceutical dosages 活性染料在法匹拉韦药量验证中的应用

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00005

R. V. Rele, Prathamesh P. Tiwatane

引用次数: 0

Use of Artificial Intelligence in Drug Discovery and its Application in Drug Development 人工智能在药物发现中的应用及其在药物开发中的应用

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00014

Shaikh Habeeba

{"title":"Use of Artificial Intelligence in Drug Discovery and its Application in Drug Development","authors":"Shaikh Habeeba","doi":"10.52711/0974-4150.2023.00014","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00014","url":null,"abstract":"Artificial intelligence is an area of computer science that deals with the ability to solve problems using symbolic programming. Artificial intelligence can help solve health-care issues with large-scale applications. Expert system development is a significant and effective application of artificial intelligence. Artificial intelligence (AI) is a technology-based system that uses a variety of advanced tools and networks to simulate human intelligence. AI makes use of systems and software that can read and learn from data and to make independent judgments in order to achieve certain goals. Its applications in the pharmaceutical area are constantly being expanded, as discussed in this chapter. Recently, healthcare sector is facing some complex challenges, such as the increased cost of drugs and therapies, and society needs specific significant changes in this area. Personalized medications with the necessary dose, release parameters, and other required aspects can be manufactured according to individual patient need with the use of AI in pharmaceutical product manufacturing. Using the latest AI-based technologies will not only reduce the time it takes for products to reach the market, but it will also improve product quality and overall safety of the manufacturing process, as well as provide better resource utilization and cost-effectiveness, emphasize the importance of automation. This chapter emphasizes the importance of artificial intelligence (AI) in the pharmaceutical sector, including drug research and development, medication repurposing, enhancing pharmaceutical productivity, and clinical trials And its current and future applications in drug discovery development.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87235162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads 植物基异喹啉生物碱:一些重要线索的化学和药理学概况

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00008

Arjun Singh

{"title":"Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads","authors":"Arjun Singh","doi":"10.52711/0974-4150.2023.00008","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00008","url":null,"abstract":"Plant-based products are a one-of-a-kind source of favoured molecules with a wide scaffold variety and broad multi-target potential for the treatment of complicated disorders. Among multi-target NPs, alkaloids have showed anti-inflammatory, anticancer, cardioprotective, and neuroprotective effects, supporting their promise in the treatment of chronic multifactorial disorders. Several recent investigations have revealed that isoquinoline alkaloids (IAs) have multimodal potential, sparking growing interest in the polypharmacological research of these small molecules, particularly in the field of neurological illnesses and cancer. IAs are a broad and diversified category of nitrogenous compounds that are extensively dispersed in living organisms, mostly in plants family. Isoquinolines are known as highly conserved metabolites in early vascular plants at the chemotaxonomic level; moreover, biochemical and molecular phylogenetic investigations have revealed that these alkaloids play an evolutionarily monophyletic role in basal angiosperms.As a result, medicinal chemistry has been experimenting with various ways in order to overcome the constraints of existing paradigms and increase the effectiveness of novel therapeutic molecules. In this context, the search or design of multi-target medications has shown an accelerated breakthrough; in fact, this strategy has sparked the interest of both the scientific community and the pharmaceutical business, allowing several multimodal agents already on the market to be positioned.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80607596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico molecular docking against C-KIT Tyrosine Kinase and ADME studies of 3-Ethyl-2-(2,3,4-trifluoro-phenylimino)-thiazolidin-4-one derivatives 针对C-KIT酪氨酸激酶和ADME的3-乙基-2-(2,3,4-三氟苯基)-噻唑烷-4- 1衍生物的硅分子对接研究

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00010

Shreyash D. Kadam, D. Mammen, Deepak S. Kadam, Sudhakar G. Patil

{"title":"In silico molecular docking against C-KIT Tyrosine Kinase and ADME studies of 3-Ethyl-2-(2,3,4-trifluoro-phenylimino)-thiazolidin-4-one derivatives","authors":"Shreyash D. Kadam, D. Mammen, Deepak S. Kadam, Sudhakar G. Patil","doi":"10.52711/0974-4150.2023.00010","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00010","url":null,"abstract":"Thiazolidin-4-one derivatives have been hailed as “wonder nucleus” due to their profound biological activities. A number of derivatives with variable functional groups attached to the five-membered heterocyclic ring which have been synthesized and further subjected to molecular docking studies, against C-KIT Tyrosine kinase target protein (1T46). The interactions, binding and affinity variations due to differences in functional groups have been studied using ChemDraw Ultra 7.0, RCSB – Protein Data Bank, BIOVIA Discovery Studio Visualizer 2021, MGL AutoDock Tools, AutoDock Vina and Vina Split software. The docking studies showed good interaction of the synthesized molecules with the 1T46 target protein. The ADME studies of these molecules have also been studied to identify which of the synthesized molecules have the potential to cross the Human Intestinal lining (HIA), as well as the BBB barrier. Out of the 18 molecules studied, 12 of them showed good potential to be absorbed by the intestine out of which only one molecule was able to show potential to cross the BBB barrier. There were 4 molecules that could not cross both the barrier. These studies could reveal which functionalities present attached to the thiazolidin-4-one could assist in human intestinal absorption and the crossing of the BBB barrier.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77616352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Evaluation of Mentha longifolia Plant for Domestic Waste water Treatment under arid climate conditions (Tamanrasset region, Algeria) 干旱气候条件下长叶薄荷厂处理生活污水的性能评价(阿尔及利亚Tamanrasset地区)

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00006

Abdelaziz Bouhoreira, Benzahi Khedidja, B. Labed, Zorai Ameur, Serraoui Mabrouk, Sabrina Batoul Benachoura, Benzahi Rabia

{"title":"Performance Evaluation of Mentha longifolia Plant for Domestic Waste water Treatment under arid climate conditions (Tamanrasset region, Algeria)","authors":"Abdelaziz Bouhoreira, Benzahi Khedidja, B. Labed, Zorai Ameur, Serraoui Mabrouk, Sabrina Batoul Benachoura, Benzahi Rabia","doi":"10.52711/0974-4150.2023.00006","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00006","url":null,"abstract":"The objective of this work is to highlight the purification performance of the Mentha longifolia plant for wastewater under a horizontal flow regime and a hot and dry (arid) climate. In this research, we made a comparison between a planted bed of Mentha longifolia and a non-planted bed (control) as well as the study of the performance of the Mentha longifolia to purify the wastewater. The study is carried out according to an experimental pilot in the urban wastewater treatment zone within the National Sanitation Office (NSO) in Tamanghasset. The experimental pilot consists of pots of capacity 130 liters filled from bottom to top on a thickness of 45 cm of gravel (15 / 25mm) of 10 cm of sand. The pot is planted with young stems of Mentha longifolia (36 stems / m2) and the other non-planted pot is taken as a control. The pots are fed by urban wastewater (18 liters / day), once a week. The water obtained after 5 days is collected in a container located under the pot. The performance information shown is for the periods from the month of January - April 2021.After four months of follow –up, we obtained the pollutant removal results with the following percentages: COD (77.74%), BOD5 (72.47%), MES (87.78%), NO3-(63.40%), NO2- (62.03%), PO43- (62.77%), E. coli (99.43%). The existence of the plant Mentha longifolia in planted beds maintains a sufficient porosity that prevents clogging. The significant reduction of pollutants and pathogenic microorganisms allows us to consider the reuse of treated water in agriculture and industry.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89015211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validated RP-HPLC Method for Simultaneous Estimation of Perphenazine and Amitriptyline in Bulk and Tablet Dosage form 反相高效液相色谱法同时测定安非那嗪和阿米替林散装和片剂的含量

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00009

P. A. Reddy, Vommidarapu Srujana, R. Sri. S

{"title":"Validated RP-HPLC Method for Simultaneous Estimation of Perphenazine and Amitriptyline in Bulk and Tablet Dosage form","authors":"P. A. Reddy, Vommidarapu Srujana, R. Sri. S","doi":"10.52711/0974-4150.2023.00009","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00009","url":null,"abstract":"A new, simple, precise, rapid, selective and stability reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous quantification of Perphenazine and Amitriptyline in pure form and its pharmaceutical dosage form. The method is based on Phenomenex Gemini C18 (4.6×250mm) 5µ column. The separation is achieved using isocratic elution by Methanol: TEA Buffer in the ratio of 65:35% v/v, pumped at flow rate 1.0mL/min and UV detection at 230nm. The column is maintained at 40°C throughout the analysis. The total run time is about 6min. The method is validated for specificity, accuracy, precision and linearity, robustness and ruggedness, system suitability, limit of detection and limit of quantitation as per International conference of harmonization (ICH) Guidelines. The method is accurate and linear for quantification of Perphenazine, Amitriptyline between 10 - 50µg/mL and 20 - 100µg/mL respectively. Further, satisfactory results are also established in terms of mean percent- age recovery (100.37% for Perphenazine and 100.34% for Amitriptyline, intra-day and inter-day precision (<2%) and robustness. The advantages of this method are good resolution with sharper peaks and sufficient precision. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75034278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0