Asian Journal of Research in Chemistry最新文献

Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of Andrographis paniculata (King of bitters): An Overview 穿心莲（苦味之王）的民族药理学、植物化学、药理和临床意义：概述

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00011

Arjun Singh

{"title":"Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of Andrographis paniculata (King of bitters): An Overview","authors":"Arjun Singh","doi":"10.52711/0974-4150.2024.00011","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00011","url":null,"abstract":"Traditional medicine is a set of knowledge, abilities, and procedures based on assumptions, beliefs, and experiences of traditional societies to preserve their health. Many rural or indigenous people in many undeveloped nations place a high importance on traditional herbal remedies. Andrographis paniculata Wall (family Acanthaceae) is a common medicinal plant that has been used for millennia in Asia, America, and Africa to treat a variety of maladies including cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia, and malaria. It contains several photochemical compounds that have distinct and intriguing biological effects. To bridge the gap for future research prospects, this study discusses the past and present state of research on Andrographis paniculata in terms of medicinal usage, phytochemistry, pharmacological activities, toxicity profile, and therapeutic usage. This assessment is based on a review of the literature in scientific journals and books obtained from libraries and electronic sources. Natural therapeutic properties are just one benefit of medicinal plants; they also provide disease prevention. In this concise overview study research, we are trying to summarize, aggregate the number of plants, and identify their ethnopharmacological properties.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological screening to identify hits the Therapeutic Targets of Alzheimer's disease and their role in the pathogenesis 通过生物筛选确定阿尔茨海默病的治疗靶点及其在发病机制中的作用

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00009

Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh

{"title":"Biological screening to identify hits the Therapeutic Targets of Alzheimer's disease and their role in the pathogenesis","authors":"Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh","doi":"10.52711/0974-4150.2024.00009","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00009","url":null,"abstract":"Alzheimer's disease (AD) is a major problem in today's societies. More than five million Americans are living with Alzheimer's disease in the United States, with the majority being 65 and older. According to the Alzheimer's Association Report, the number of persons affected by Alzheimer's disease in the United States would rise to fourteen million by 2060. The disease, which is the most prevalent form of dementia, is a progressive and irreversible brain disorder that gradually deteriorates an individual's cognitive function. It advances from preclinical to early- to moderate- to late-stage disease. Early symptoms primarily include cognitive impairment, particularly memory loss. Current Alzheimer's disease treatment can be divided into two categories based on the disease's stage. Galantamine, rivastigmine, and donepezil as acetylcholinesterase inhibitors are suitable for mild to moderate cases to provide transient symptomatic relief among patients. Memantine, an N-methyl D-aspartate (NMDA) antagonist, is used as monotherapy to treat symptoms of moderate to severe Alzheimer's disease. These medications are typically selective molecules that target certain proteins (\"one compound-one target\" method), and their main goal is to restore physiological acetylcholine levels. Nonetheless, multiple pathways of Alzheimer's disease pathogenesis have been hypothesized to far, and they have been proven to overlap and influence one another.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"18 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Cadmium Oxide NPs using Sapindus mukorossi (Soapnut) as natural surfactant 使用无患子（皂荚）作为天然表面活性剂合成氧化镉 NPs 并确定其特性

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00008

Avnish Kumar Arora

引用次数: 0

In-vivo Studies conducted following the success In-vitro and Dissemination of Anticancer Clinical Trials 在体外抗癌临床试验取得成功后进行的体内研究和抗癌临床试验的传播

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00010

Priyanka Kumari, Divya Sharma, Arjun Singh

{"title":"In-vivo Studies conducted following the success In-vitro and Dissemination of Anticancer Clinical Trials","authors":"Priyanka Kumari, Divya Sharma, Arjun Singh","doi":"10.52711/0974-4150.2024.00010","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00010","url":null,"abstract":"Since the beginnings of cancer research, phytochemicals have been a focal point because they were some of the first antineoplastic drugs found (e.g., leucovorin in 1950, carzinophilin in 1954, vincristine in 1963, actinomycin D in 1964, etc.). Additionally, their research is still ongoing today. It is crucial to note that natural substances are used both as adjuvants and chemotherapeutic agents in the treatment of cancer. By summarizing the three aspects of natural compounds' anticancer activity, this review offers a fresh perspective on their use in the field of oncology. Chemotherapeutic drugs because of their inherent antitumor effects, chemopreventive drugs, and sensitizers for multi-drug resistance are the first three categories. Numerous active agents are undergoing preclinical and clinical trials right now. It is crucial to draw attention to the important advancements that have been made in this field of study, with some secondary plant metabolites already in use in medicine and others being tested in human clinical trials as anticancer agents. Phytochemicals have numerous positive effects on human health and are crucial in preventing the development and spread of cancer. Through a diet high in fruits and vegetables, as well as with the aid of highly-standardized supplements containing the active compounds, one may achieve the ideal intake of natural chemopreventive agents.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace level Determination of 2-(3-(trifluoromethyl)phenyl)propanal in Calcium Sensing Receptor drug by GCMS 用气相色谱法痕量测定钙传感受体药物中的 2-(3-(三氟甲基)苯基)丙醛

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00005

Perla Ganesh, CH. B. V. Narasimha Raju, N. Jagadeesh, Hemant M. Gandhi, BM. Rao, Dharamasoth Rama Devi, K. Basavaiah

{"title":"Trace level Determination of 2-(3-(trifluoromethyl)phenyl)propanal in Calcium Sensing Receptor drug by GCMS","authors":"Perla Ganesh, CH. B. V. Narasimha Raju, N. Jagadeesh, Hemant M. Gandhi, BM. Rao, Dharamasoth Rama Devi, K. Basavaiah","doi":"10.52711/0974-4150.2024.00005","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00005","url":null,"abstract":"The study aimed to develop and validate the method for trace level analysis of 2-(3-(trifluoromethyl)phenyl)propanal (2-TFL) impurity in calcium sensing receptor drugs by gas chromatographic method using mass spectrometry (GC-MS). The method utilizes a capillary column with 6% cyanopropyl phenyl and 94% dimethylpolysiloxane stationary phase with EI source in Selective Ion Monitoring (SIM) mode under programming temperature was used. After successful development, the method was validated according to our in-house validation guidelines for trace level analysis. The method proved to be selective for 2-(3-(trifluoromethyl) phenyl)propanal impurity in drug substance. A dissolve and injection approach was adopted for sample introduction in a split mode. Methanol was used as a diluent. The calibration curves showed good linearity over the concentration range from 1.85 (LOQ to 5.56ppm (150%)) of the target concentration of 3 ppm. The correlation coefficient obtained was >0.999. A limit of detection (LOD) of about 0.56ppm was achieved and limit of quantitation (LOQ) of 1.85ppm was achieved for 2-(3-(trifluoromethyl)phenyl)propanal impurity, when the samples were prepared at 20mg/mL. While recovery proved to be 101.0% at Limit of quantification (LOQ) level, 102.1% at Target analytical level (TAL) and 98.1% at 150% of the TAL, demonstrate the absence of matrix effect.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"101 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes 硫代氨基脲衍生席夫碱-金属复合物的生物活性研究

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00002

Tariqul Islam, Nur Amin Bitu, F. Hossen, A. Asraf, Kudrat E-Zahan

{"title":"Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes","authors":"Tariqul Islam, Nur Amin Bitu, F. Hossen, A. Asraf, Kudrat E-Zahan","doi":"10.52711/0974-4150.2024.00002","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00002","url":null,"abstract":"A Schiff base ligand was synthesized via the condensation reaction of thiosemicarbazide and salicylaldehyde. A series of transition metal complexes of VO(IV), Ni(II), Cu(II), and Zn(II) were obtained by the complexation reaction with the synthesized Schiff base ligand. The Schiff base ligand and its metal complexes were characterized by UV-Vis and FTIR spectroscopy, TGA-DTA, and some physical measurements. FTIR spectral studies showed that the NOS donor ligand coordinated to the metal ions through the N of azomethine group, S of thiolate, and O of deprotonated hydroxyl group. Molar conductance values indicated non electrolytic nature of the complexes. Magnetic moment values coupled with electronic spectral data exhibited the geometrical structure of the complexes. The Schiff base and its complexes were exposed to disinfectant studies tested by using the disc diffusion method. All the synthesized compounds exhibited moderate to strong antibacterial activity. The copper complexes showed more antibacterial activity than other complexes and Schiff bases. All the Synthesized complexes showed a good cytotoxic activity.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Screening and Pharmacophore Modeling for discovery of Biologically Active Natural Products as Inhibitors of Odorant-binding Proteins 利用虚拟筛选和药效学建模发现具有生物活性的天然产品作为气味结合蛋白的抑制剂

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00004

Sathish Kumar Mittapalli, J. N. N. Sharath Chandra, Jay Prakash Soni, Ram Babu Tripathi, I. Rizwana

{"title":"Virtual Screening and Pharmacophore Modeling for discovery of Biologically Active Natural Products as Inhibitors of Odorant-binding Proteins","authors":"Sathish Kumar Mittapalli, J. N. N. Sharath Chandra, Jay Prakash Soni, Ram Babu Tripathi, I. Rizwana","doi":"10.52711/0974-4150.2024.00004","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00004","url":null,"abstract":"More than 100 nations in Africa, the Americas and the Eastern Mediterranean have endemic dengue and malaria, and these bites have the potential to have inflammatory or infectious local or systemic effects. The mosquito repellents from various sources were examined and plant repellents, researchers frequently exaggerate toxicity of the mentioned compound, alleging that it poses a threat to human health or even the environment and reported by recent studies. The aim of the research article, the historical developmental strategies of synthetics and natural and those acts on certain targets as repellent property, target discovery aims to identify and validate appropriate pharmacological targets for therapeutic interventions and establishment of correlations between the molecule and its potency as repellent using various physicochemical parameters and in silico studies. From this study proved that some of the natural compounds were potent in comparison with the some of the standard insect repellents and the paradigm offers a wide variety of prospects that will fasten the lead molecular modifications influences the novel targets and ultimately result in the optimization of the molecular properties by considering the all the methodologies leads to design novel molecules.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"16 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction and Standardisation of Acid Phosphatase from the seeds of Abelmoschus esculentus (Okra) 从秋葵种子中提取酸性磷酸酶并将其标准化

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00003

Padmashree D, Srinivas M, Pooja D, Hema S, Karigar C S, Krupa S

引用次数: 0

Quantitative Determination of Sulphur in Manikaran’s Water 马尼卡兰水中硫含量的定量测定

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00007

Pramod Kumar, Aman Kapoor, Abhishek Kumar, V. K. Gupta

引用次数: 0

Total Alkaloid content and In vitro Antiplasmodial activity of Grangea maderaspatana collected from Burkina Faso 布基纳法索采集的 Grangea maderaspatana 的总生物碱含量和体外抗疟活性

Asian Journal of Research in Chemistry Pub Date : 2024-02-22 DOI: 10.52711/0974-4150.2024.00006

Yougoubo Abdoulaye, D. Constantin M., Soré Harouna, Bationo K. Rémy, Ganame Arouna, Sawadogo Assétou, Roamba Noëlle Edwige, Bazié Benjamin, Kabore S. Dominique, Koala Moumouni, Palé Eloi, Nebie C. H. Roger, N. Mouhoussine

{"title":"Total Alkaloid content and In vitro Antiplasmodial activity of Grangea maderaspatana collected from Burkina Faso","authors":"Yougoubo Abdoulaye, D. Constantin M., Soré Harouna, Bationo K. Rémy, Ganame Arouna, Sawadogo Assétou, Roamba Noëlle Edwige, Bazié Benjamin, Kabore S. Dominique, Koala Moumouni, Palé Eloi, Nebie C. H. Roger, N. Mouhoussine","doi":"10.52711/0974-4150.2024.00006","DOIUrl":"https://doi.org/10.52711/0974-4150.2024.00006","url":null,"abstract":"Effective management of malaria remains a major concern for the scientific community mainly due to the resistance of Plasmodium falciparum to the common antimalarials. Many studies are conducted to identify plants that can fight against this disease. This work aimed to contribute to a better knowledge of antiplasmodial activity of different parts of Grangea maderaspatana (Asteracea). Thus, roots, flowers, leafy branches and whole plant of Grangea maderaspatana were extracted with hexane, dichloromethane, ethyl acetate and methanol. Alkaloid contents and antiplasmodial activity of extracts were respectively determined by bromocresol green method and enzyme-linked immunosorbent assay based on pLDH quantification. Total alkaloid contents ranged from 21.036 in methanolic extract of leafy branches to 1074.752µg qE/g in dichloromethane extract of whole plant. Extracts showed moderate to very active antiplasmodial effects. Antiplasmodial activity evaluated on chloroquino (CQ)-sensitive D10 and CQ-resistant Dd2 strains of Plasmodium falciparum showed that hexane and dichloromethane leafy branches extracts had a better activity. Alkaloid could be potentially responsible for antiplasmodial activity observed. None extract found to be toxic for cells at 50 and 100µg/ml. Dichloromethane extract of leafy branches could be a potential source of antiplasmodial molecules.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0