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Medicinal herbs in the management of Common Skin disease – Ethno Botanical Approach 常见皮肤病的草药治疗——民族植物学方法
Asian Journal of Research in Chemistry Pub Date : 2022-10-01 DOI: 10.52711/0974-4150.2022.00065
R. Raja, Y. Haribabu, C. Sajeeth
{"title":"Medicinal herbs in the management of Common Skin disease – Ethno Botanical Approach","authors":"R. Raja, Y. Haribabu, C. Sajeeth","doi":"10.52711/0974-4150.2022.00065","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00065","url":null,"abstract":"The acceptance and appreciation of herbal medicine is rising day by day. One of the significant reasons in growing this significance is the alertness of normal remedies being additional efficient and less dangerous than synthetic drugs. Skin health is imperative aspect of primary health care among many communities, because of the enhance challenge of HIV-AIDS, skin conditions being among the common opportunistic diseases in immune-compromised individuals. India has a rich myths of therapeutic plant on healthcare. A huge number of formulations have been used in India for management of cuts, wounds, burns and various skin disorders. The present review attempts to investigate the ethno botanical information foundation for dealing of various skin diseases. The medicinal plants used in this review are arranged alphabetically followed by family name; parts used and explained the Siddha herbs completely used in the skin disease with references.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74882468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Estimation of Ibrutinib in Dosage Form and in Bulk Drug by UV Spectrophotometric and Colorimetry Methods 紫外分光光度法和比色法测定伊鲁替尼剂型和原料药的含量
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00044
Sheema Sultana, Nirmal. T. Havannavar, Husnain Fathima
{"title":"Estimation of Ibrutinib in Dosage Form and in Bulk Drug by UV Spectrophotometric and Colorimetry Methods","authors":"Sheema Sultana, Nirmal. T. Havannavar, Husnain Fathima","doi":"10.52711/0974-4150.2022.00044","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00044","url":null,"abstract":"A simple, sensitive, accurate, rapid and economical Spectrophotometric and colorimetric methods was developed for estimation of Ibrutinib in pure drug and tablet dosage form. The absorbance was measured at 248nm and 552nm using ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml and 1-5µg/ml with coefficient of correlation (r2) of 0.998 and 0.996. Limit of detection (LOD) was found to be 1.226µg/ml and1.000µg/ml Limit of quantitation (LOQ) was found to be 5.226µg/ml and 2.760µg/ml. The proposed analytical methods were validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73992689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Electroorganic Synthesis of Copper and Zinc Complexes with Novel Ligand Oxalic Acid 新型草酸配体铜锌配合物的电有机合成
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00048
Shreya Gorai, M. Alam, B. Gorai
{"title":"Electroorganic Synthesis of Copper and Zinc Complexes with Novel Ligand Oxalic Acid","authors":"Shreya Gorai, M. Alam, B. Gorai","doi":"10.52711/0974-4150.2022.00048","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00048","url":null,"abstract":"A convenient electroorganic synthesis of divalent metal complexes of empirical formulation [ML2] (M (II) = Cu and Zn; L= oxalic acid) were synthesized at sacrificial metal electrode anode. The metal, as the anode in an undivided cell, is oxidized in the presence of the parent compound of the ligand (HL) in an organic solvent mixture. Gram quantities of complex can be produced in a few hours. Complexes were characterized by elemental analysis, Infrared spectral data, Atomic Absorption spectroscopy and thermal spectral data. The geometrical structure of the synthesized complexes has been identified.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91470417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrophotometric Determination of Alprazolam in Pure and Pharmaceutical Forms using Triphenyl Methane Dyes 三苯甲烷染料分光光度法测定阿普唑仑的纯度和药物含量
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00047
V. Nandu, T. Veeraiah
{"title":"Spectrophotometric Determination of Alprazolam in Pure and Pharmaceutical Forms using Triphenyl Methane Dyes","authors":"V. Nandu, T. Veeraiah","doi":"10.52711/0974-4150.2022.00047","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00047","url":null,"abstract":"Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Alprazolam either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 410, 408 and 405nm with use of the cited reagents, respectively. The stoichiometry of the complex is found to be 1:1 in each case. Beer’s law is obeyed in the concentration ranges 3.0-25, 4.0-30, and 4.5-40μg/ml with BTB, BPB and BCG respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82528195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ab initio Calculations of Structural and Electronic Properties of Pt3 and Cu3 clusters adsorbed on ZnO(000 ̅1) ZnO(000)上吸附Pt3和Cu3团簇结构和电子性质的从头计算
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00049
Y. Benkrima, A. Souigat, Y. Chaouche, Z. Korichi, Mohammed Elbar Soudani, A. Belfar
{"title":"Ab initio Calculations of Structural and Electronic Properties of Pt3 and Cu3 clusters adsorbed on ZnO(000 ̅1)","authors":"Y. Benkrima, A. Souigat, Y. Chaouche, Z. Korichi, Mohammed Elbar Soudani, A. Belfar","doi":"10.52711/0974-4150.2022.00049","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00049","url":null,"abstract":"This search paper is focus on the investigation of the most stability structures of Pt3 and Cu3 clusters adsorbed on ZnO (000 ̅1) surfaces in the Wurtzite stable structure. The results are obtained by using the Density Function Theory (DFT). All the calculations are performed using the Gradient Generalized Approximation to describe the exchange correlation term in SIESTA code. From this work we found new structures of Pt3 and Cu3 clusters with lowest energy. Also we have calculated the binding energy, relaxation interlayer for each cluster, bond lengths, vertical ionization potential PIv and the density of states DOS. Through the results we found that the Pt3 cluster is more stable than Cu3 cluster and confirmed by the DOS, in the other hand the ZnO-O surface is more stable than ZnO-Zn surface. The computed electron structure and DOS illustrate that the Pt3/ZnO and Cu3/ZnO clusters adsorbed on ZnO-O surfaces display metallic characteristics.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91306942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Simple Extractive Spectrophotometric Method for Determination of Favipiravir from Pharmaceutical Formulation 简单萃取分光光度法测定制剂中法匹拉韦的含量
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00053
R. V. Rele, Prathamesh P. Tiwatane
{"title":"Simple Extractive Spectrophotometric Method for Determination of Favipiravir from Pharmaceutical Formulation","authors":"R. V. Rele, Prathamesh P. Tiwatane","doi":"10.52711/0974-4150.2022.00053","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00053","url":null,"abstract":"Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of favipiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0μg/ml, 2-20μg/ml, 1-16μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of favipiravir in tablets.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85972466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Quality by Design (QbD) concept Review in Pharmaceuticals 药品设计质量(QbD)概念回顾
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00054
Kaustubh Jagtap, B. Chaudhari, V. Redasani
{"title":"Quality by Design (QbD) concept Review in Pharmaceuticals","authors":"Kaustubh Jagtap, B. Chaudhari, V. Redasani","doi":"10.52711/0974-4150.2022.00054","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00054","url":null,"abstract":"Quality by Design (QbD) refers to a holistic approach towards drug development. Quality by design is a vital part of the modern approach to pharmaceutical quality. The purpose of this practice school topic is to discuss the pharmaceutical Quality by Design (QbD) and illustrate how it can be used to ensure pharmaceutical quality. The QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include: Defining Quality target product profile, identifying critical quality attributes, link the drug excipients attributes, establishing design space, control strategy, critical process parameters and product life cycle management. Using QbD, pharmaceutical quality is assured by understanding and controlling formulation and manufacturing variables. A new approach to drug development could increase efficiencies, provide regulatory support and flexibility, and offer important business benefits throughout the product’s life cycle. This PS topic explores the processes used in developing a market formulation and required supportive data, particularly in light of the industry’s current movement toward submissions based on QbD. The work also facilitates the adoption and implementation of QbD. Principles in the development of pharmaceutical industries. Successful implementation of QbD concepts requires cooperation across a multitude of company teams, from R&D to manufacturing to quality control and regulatory affairs. This is necessary to ensure that QbD concepts are incorporated not only when the first activities are initiated around a product’s design but also during the design of the process used to make the product and other activities associated with a product’s life cycle. The application of the concept of quality by design (QbD) presented in this paper aligns with the principles of ICH Q8, Q9 and Q10 guidelines.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85944350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First Principle Calculation: Effect of Doped Gold Clusters with Platinum Atom on Chemical Catalysis 第一性原理计算:掺杂铂原子的金团簇对化学催化的影响
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00045
Y. Benkrima, A. Souigat, Mohammed Elbar Soudani, Mohammed Seyf Eddine Bougoffa, Z. Korichi
{"title":"First Principle Calculation: Effect of Doped Gold Clusters with Platinum Atom on Chemical Catalysis","authors":"Y. Benkrima, A. Souigat, Mohammed Elbar Soudani, Mohammed Seyf Eddine Bougoffa, Z. Korichi","doi":"10.52711/0974-4150.2022.00045","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00045","url":null,"abstract":"In this paper, we present a systematic computational study based on the density function theory (DFT), Which aims to shed light on the potential effects of doped gold Au clusters with a platinum Pt atom,and finding the new structural and electronic properties that will be enjoyed by gold doped with platinum PtAun (n = 1-9) clusters, So that the most stable clusters are selected from the rest of the isomers for each cluster size. We doped Aun clusters with Pt atom, we obtained very interesting results, Stable and most stable structures reveal three-dimensional structures starting from (n=6), Also, the results of the fragmentation energy and the second difference in binding energy of these clusters in relation to their size have been studied in depth. The electronic properties, such as the Homo-Lumo gap energy, Vertical ionization potential (VIP) and adiabatic ionization potential (AIP) as a function of cluster size are also studied and discussed. All properties calculated by the generalized gradient approximation (GGA) were compared with the results of the local density approximation (LDA). Whereas, the results showed that the Aun clusters doped with Pt atom changed significantly.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74370695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Determination of Molnupiravir by Extractive Colorimetric Method from Pharmaceutical Dosage Form 萃取比色法测定药物剂型中莫诺匹拉韦的含量
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00046
R. V. Rele, Prathamesh P. Tiwatane
{"title":"Determination of Molnupiravir by Extractive Colorimetric Method from Pharmaceutical Dosage Form","authors":"R. V. Rele, Prathamesh P. Tiwatane","doi":"10.52711/0974-4150.2022.00046","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00046","url":null,"abstract":"Simple and accurate extractive colorimetric method was developed for the estimation of molnupiravir in Pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in organic solvent like chloroform. The absorbance values were measured at 620 respectively. The proposed method was validated statistically. A recovery of method was carried out by standard addition methods. The Beer’s law ranges were found to be 1-14 μg/ml, respectively. The low values of standard deviation and percentage RSD indicate high precision of method. Hence the method is useful for routine estimation of molnupiravir in tablets respectively.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81755904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Estimation and Validation of Bilastine in Pharmaceutical Dosage Form and in Bulk Drug by Spectrophotometric Method 分光光度法测定制剂和原料药中胆碱的含量及验证
Asian Journal of Research in Chemistry Pub Date : 2022-08-06 DOI: 10.52711/0974-4150.2022.00050
Afnaz Jahan, Mohamed Khaleel, Husnain Fathima
{"title":"Estimation and Validation of Bilastine in Pharmaceutical Dosage Form and in Bulk Drug by Spectrophotometric Method","authors":"Afnaz Jahan, Mohamed Khaleel, Husnain Fathima","doi":"10.52711/0974-4150.2022.00050","DOIUrl":"https://doi.org/10.52711/0974-4150.2022.00050","url":null,"abstract":"A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Bilastine in pure drug and tablet dosage form. The absorbance was measured at 226.2nm using Methanol as solvent system. It obeyed Beer’s law at the concentration range of 2-12µg/ml with coefficient of correlation (r2) of 0.9993. Limit of detection (LOD) was found to be 1.224µg/ml and Limit of quantitation (LOQ) was found to be 4.088µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89392349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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