Determination of Molnupiravir by Extractive Colorimetric Method from Pharmaceutical Dosage Form

Abstract

Simple and accurate extractive colorimetric method was developed for the estimation of molnupiravir in Pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in organic solvent like chloroform. The absorbance values were measured at 620 respectively. The proposed method was validated statistically. A recovery of method was carried out by standard addition methods. The Beer’s law ranges were found to be 1-14 μg/ml, respectively. The low values of standard deviation and percentage RSD indicate high precision of method. Hence the method is useful for routine estimation of molnupiravir in tablets respectively.