Asian Journal of Research in Chemistry最新文献_第6页

An Overview of Imidazole, Derivatives Ofimidazole and its Pharmacological Applications 咪唑、咪唑衍生物及其药理应用综述

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00012

R. Godge, Amol S Dighe, Piyusha Kolhe

{"title":"An Overview of Imidazole, Derivatives Ofimidazole and its Pharmacological Applications","authors":"R. Godge, Amol S Dighe, Piyusha Kolhe","doi":"10.52711/0974-4150.2023.00012","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00012","url":null,"abstract":"In recent decades, many studies have been carried out on heterocycles, especially imidazole rings. The pharmacological properties such as antibacterial, antifungal, anticancer, antiviral and antidiabetic properties Apart from that, there are few side effects. The search for new biologically active imidazoles remains an area of interest An overview of medicinal chemistry. This white paper aims to collect and explain a wealth of information. Antibacterial profile of imidazole. Therefore, it can be used for future development to obtain new effective drug molecules. These heterocycles are important building blocks of functional molecules used in various fields. Used on a daily basis. Emphasis was placed on the bonds that form during the formation of imidazole. The usefulness of these methods is based on functional group compatibility. Processes around the ring and the resulting permutation patterns are described, including domain descriptions. Limitations, Reaction Mechanisms, and Future Challenges. The imidazole ring is part of several important natural products Products containing purines, histamine, histidine, nucleic acids. as polar and ionic Aromatic compounds that improve the pharmacokinetic properties of lead molecules Used as a remedy to optimize poorly proposed solubility and bioavailability parameters soluble lead molecule. Imidazole derivatives occupy a unique position in the art medicinal chemistry. Imidazole drugs have expanded the scope of eliminating various dispositions in clinics dose.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81704483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harmful Effects of Different Classes of Heavy Metals in Our Beautiful Environment 不同种类的重金属对我们美丽环境的有害影响

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00003

A. Saha, Sanjay Dhar Roy

引用次数: 0

To Assess Causality, Severity and Preventability of Adverse drug reactions of Amlodipine in the treatment of hypertension 评价氨氯地平治疗高血压不良反应的因果关系、严重程度及可预防性

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00007

Akanksha K. Mane, V. Chaware

{"title":"To Assess Causality, Severity and Preventability of Adverse drug reactions of Amlodipine in the treatment of hypertension","authors":"Akanksha K. Mane, V. Chaware","doi":"10.52711/0974-4150.2023.00007","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00007","url":null,"abstract":"Background: Every drug has the potentiality to cause an adverse drug reaction (ADR). ADRs are a major problem in drug therapy. The aim of this study was to assess the incidence and causality, severity and Preventability of ADRs Amlodipine (antihypertensive agents) used for the essential hypertensive patients during the time period of April 2022 to Jun 2022. Methods: This prospective-observational study was carried out in general medicine outpatient department in 15 Patients. Results: Out of 15 patients, 10 (66.66%) patients were developed ADRs to antihypertensive drugs. 8 (85.72%) were male and 2 (14.28%) were female. Calcium channel blockers were the commonest therapeutic class of antihypertensive drugs associated with ADRS (n = 50, 64.10%). According to WHO causality assessment scale most of the ADRs of Amlodipine were \"probable\" 8(57.14%) followed by \"possible\" 2 (14.28%), certain 4 (28.57%)). According to Hartwig and Siegel scale of severity assessment, the most of the adrs were mild 10(71.42%) and moderate 4 (28.57%). According to Schumock and Thornton scale of preventability assessment all ADR are definitely preventable. \u0000Conclusions: The results of this study concluded that antihypertensive drugs able to induce the development of adverse drug reactions, which were significant cause of increase burden on health care system and decrease the quality of life, the health care professionals should take care about the rational use of antihypertensive agents. Thus, to minimize the incidence of adverse drug reaction and to increase the quality of life.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79701875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of Aquatic Toxicity of a Set of Phenols in Silico 一组苯酚在硅中的水生毒性模拟

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00011

Khadidja Amirat, N. Ziani, Souhaila Meneceur, Fatiha Mebarki, Abderrhmane Bouafia

引用次数: 0

Variation in Phenolic Composition, Antioxidant Activity and Cyclic Voltammetry Study of Juncus rigidus Desf. (Juncaceae) Root Extracts according Flowering and Ripening Period 刚枝花酚类成分、抗氧化活性及循环伏安法研究。(榕树科)按开花和成熟时间分类的根提取物

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00004

Mimouna Hani, C. Boubekri, T. Lanez

{"title":"Variation in Phenolic Composition, Antioxidant Activity and Cyclic Voltammetry Study of Juncus rigidus Desf. (Juncaceae) Root Extracts according Flowering and Ripening Period","authors":"Mimouna Hani, C. Boubekri, T. Lanez","doi":"10.52711/0974-4150.2023.00004","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00004","url":null,"abstract":"In this study, two solvents with different polarity were used in the extraction of the dried powdered roots of the plant Juncus rigidus; ethanol, acetone, during two different growth stages : ripening period (November) and flowering period (April). Total phenolics, total flavonoids, and total flavanols contents were evaluated using the colorimetric assays. The obtained results were very significant and showed that polarity of solvents and growth stage affects the composition of the plant. The highest content in total phenolic (87,249 ± 0.005 mg GAE/g), total flavonoid (28,109 ± 0.041 mg QE/g) and total flavonol (33,195 ± 0,013 mg GAE/g) contents was obtained in acetone extract during flowering period witch decrease during ripening period. The best result for the evaluation of the antioxidant activity indicated that highest value in DPPH free radical scavenging activity (0,014 ± 0,0003 mg/mL-1), phosphomolybdenum assay (425,168 ± 0,006 mL/mg), ferric reducing antioxidant power (1217,914 ± 0,022 mgFeSO4/g) and cyclic voltammetry (47,07 ± 0,04 mg/g) was unregistered during ripening stage using acetone solvent.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83344789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols 膳食多酚的民族药理学、植物化学和临床意义综述

Asian Journal of Research in Chemistry Pub Date : 2023-02-24 DOI: 10.52711/0974-4150.2023.00002

Arjun Singh, Rupendra Kumar

引用次数: 0

Synthesis, characterization and DFT studies of Schiff base (E)-4-(((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino)-benzenesulfonamide and its MoO2 (II) complex 席夫碱(E)-4-((5-羟基-3-甲基-1-苯基- 1h -吡唑-4-基)亚甲基)氨基)-苯磺酰胺及其MoO2 (II)配合物的合成、表征和DFT研究

Asian Journal of Research in Chemistry Pub Date : 2023-01-01 DOI: 10.22271/reschem.2023.v4.i1a.81

PK Vishwakarma, RC Maurya

{"title":"Synthesis, characterization and DFT studies of Schiff base (E)-4-(((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino)-benzenesulfonamide and its MoO2 (II) complex","authors":"PK Vishwakarma, RC Maurya","doi":"10.22271/reschem.2023.v4.i1a.81","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.81","url":null,"abstract":"This research article reports the experimental and theoretical model of the synthesised ligand (E)-4- (((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino) benzenesulfonamide (HL) and their complex cis-[MoO 2 (L) 2 )] {1}. The physicochemical, spectral, and theoretical results proposed the molecular formula of the complex as cis-[MoO 2 (L) 2 ] (where L = monobasic bidentate ligand of 4 - formyl-3-methyl-1-phenyl-2-pyrazoline-5-one with sulfanilamide . The colored solid mass was grown, washed with ethanol, and dried in air. The complex is soluble in inorganic solvent like DMF and DMSO and organic solvents like methanol, ethanol, and acetonitrile. The computed results like geometry, molecular orbital analysis and NLO properties done via DFT approach. The computed geometrical results have determined the molecular structure of the compound. It has been shaped that the ligand coordinates via azomethine nitrogen and enolic oxygen of Schiff base moiety, by a 1:2 metal-ligand ratio. Furthermore, the title compounds were also showing Insilco bioactivity score and drug-likeness by molinspiration software and ADME properties resulted pharmacological action of the compounds.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72756225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and theoretical studies of MoO2(II) complexes based on pyrazoline and hydrazone derived Schiff base 吡唑啉-腙基席夫碱MoO2(II)配合物的实验与理论研究

Asian Journal of Research in Chemistry Pub Date : 2023-01-01 DOI: 10.22271/reschem.2023.v4.i1a.82

P. Vishwakarma, R. Maurya

引用次数: 0

Assessment of some hematological and biochemical parameters in patients with renal failure in Al-najaf province Al-najaf省肾功能衰竭患者血液学和生化指标的评估

Asian Journal of Research in Chemistry Pub Date : 2023-01-01 DOI: 10.22271/reschem.2023.v4.i1a.77

D. Aziz, Ruqaya Ali Mahdi, Mustafa Ammar Mahdi, Zainab Muwafaq Talib, Ahmed Hussein Mohsin, Esraa Zeman Dayea

{"title":"Assessment of some hematological and biochemical parameters in patients with renal failure in Al-najaf province","authors":"D. Aziz, Ruqaya Ali Mahdi, Mustafa Ammar Mahdi, Zainab Muwafaq Talib, Ahmed Hussein Mohsin, Esraa Zeman Dayea","doi":"10.22271/reschem.2023.v4.i1a.77","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.77","url":null,"abstract":"Chronic renal failure is a condition in which the kidneys gradually lose their ability to function because of the gradual loss of their parenchyma. This study aimed to detect some hematological and biochemical parameters in patients with chronic kidney disease (CKD) attending a hemodialysis center. A cross-sectional study included a review of (89) cases of chronic kidney disease at Al-Hakeem Hospital's dialysis center in Najaf from September 7th to October 16th, 2021. The collected data were analyzed using Office Excel and SPSS-23. Variables were analyzed by frequencies, proportions, and percentages. The current study discovered that males had longer sequences than females, and that patients in rural areas had longer sequences than those in urban areas. In the current study, blood Sug, B. Urea, S. Crea, K, Na, Cl, Ca+2, Alb, and Tpro levels did not differ significantly between males and females with renal failure, whereas HB and TCA levels did. At last, we recommend people conduct an early medical examination for kidney disease, especially those who suffer from symptoms such as low urine output, swelling of the legs, fatigue, tachycardia, and others, to obtain early treatment.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75304867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of superabsorbent hydrogels based on carboxymethyl cellulose and agar: Agar for smart swelling and controllable delivery 羧甲基纤维素和琼脂高吸水性凝胶的合成与表征:琼脂智能膨胀和可控输送

Asian Journal of Research in Chemistry Pub Date : 2023-01-01 DOI: 10.22271/reschem.2023.v4.i1a.69

M. Soni, D. Gautam, Dr. Pawan Raj Shakya

{"title":"Synthesis and characterization of superabsorbent hydrogels based on carboxymethyl cellulose and agar: Agar for smart swelling and controllable delivery","authors":"M. Soni, D. Gautam, Dr. Pawan Raj Shakya","doi":"10.22271/reschem.2023.v4.i1a.69","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.69","url":null,"abstract":"The current study described a thorough analysis of the adsorption characteristics of a hydrogel that was chemically connected and built on agar and carboxymethyl cellulose (CMC). With regard to swelling %, the Agar-Agar/ECH/CMC hydrogel was created under ideal conditions. In order to achieve the highest percentage of swelling, different response parameters were changed. The structure and morphology of the hydrogels were characterized by FT-IR spectroscope, thermogravimetric analysis and scanning electron microscope. The results revealed that the CMC contributed to the enhanced size of pore, whereas Agar-Agar as a strong backbone in the hydrogel to support it for keeping its appearance. Their equilibrium swelling ratio in distilled water and different physiological fluids were evaluated, indicating the maximum swelling ratio in water reached an exciting level of 1000 as the hydrogels still keeping a steady appearance. Moreover, the hydrogels exhibited smart swelling and shrinking in NaCl or CaCl2 aqueous solution, as well as the release behavior of bovine serum albumin (BSA) that could be controlled by changing CMC content. The Agar-Agar -based hydrogels are promising for the applications","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77548135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0