Arkhiv patologii最新文献_第6页

[Pathological changes in the muscular tissue of the colon in diverticular disease]. [憩室疾病中结肠肌肉组织的病理变化]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248604113

A K Konyukova, L M Mikhaleva, M A Kozlova, D A Areshidze, V V Pechnikova, S G Shapovaliants, A I Mikhalev, K V Bolikhov, A V Shulaev

{"title":"[Pathological changes in the muscular tissue of the colon in diverticular disease].","authors":"A K Konyukova, L M Mikhaleva, M A Kozlova, D A Areshidze, V V Pechnikova, S G Shapovaliants, A I Mikhalev, K V Bolikhov, A V Shulaev","doi":"10.17116/patol20248604113","DOIUrl":"https://doi.org/10.17116/patol20248604113","url":null,"abstract":"The high incidence of colonic diverticular disease (DD) in the general population is a serious public health problem. According to statistics, DD is among the top five most common colorectal diseases. Complicated course of DD is observed in 12-15% of patients, and in 10.7% of cases can lead to death. Algorithms and recommendations for predicting the complicated course of DD for further prevention have not been developed.Objective: Comparative analysis of clinical data and structural characteristics of the colonic muscular tissue in patients with different course of DD and without colonic diverticula to identify morphological predictors of a complicated DD.Material and methods: A comparative analysis of clinical data, pathomorphological and ultrastructural changes of the colonic musculature in the surgical material from 68 patients undergoing left-sided hemicolectomy was carried out.Results: The operative material of 37 patients with complicated course of DD, 19 with uncomplicated course of DD and 12 without diverticula was analyzed. In men, this disease occurs at a younger age than in women (Median age of men 49 (39.5; 61) years, women 66.5 (58; 81) years; U=178, p<0.001). It was shown that the area occupied by connective tissue fibres in the colonic musculature in patients with a complicated DD was 5 times greater (15%) than in observations with an uncomplicated DD (3%) and 50 times greater than in cases without colonic diverticula (0.3%; p<0.001).Conclusion: The present study demonstrates age- and sex-specific features of DD, as well as significant differences in the prevalence of fibrosis of the colonic musculature, which can be considered as a potential predictor of a complicated course of DD.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 4","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Fatal case of rhinocerebral mucormycosis on the background of type II diabetes mellitus]. [Ⅱ型糖尿病背景下的犀脑粘液瘤病死亡病例]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248603152

A V Smirnov, V V Ermilov, A N Sasin, N V Grigor'eva, A E Poplavskiy, O A Chernetsky, S V Blokhina, V S Grableva, O N Barkanova, D Yu Gurov, I V Ermilova, A A Poplavskaya

{"title":"[Fatal case of rhinocerebral mucormycosis on the background of type II diabetes mellitus].","authors":"A V Smirnov, V V Ermilov, A N Sasin, N V Grigor'eva, A E Poplavskiy, O A Chernetsky, S V Blokhina, V S Grableva, O N Barkanova, D Yu Gurov, I V Ermilova, A A Poplavskaya","doi":"10.17116/patol20248603152","DOIUrl":"10.17116/patol20248603152","url":null,"abstract":"Mucormycosis is a disease caused by fungi of the Mucorales family, widespread in the environment, with pronounced angiotropism and the ability to angioinvasion, leading to thrombosis with surrounding necrosis. The main triggers for the development of mucormycosis are: immunodeficiency states, use of glucocorticosteroid drugs, decompensation of diabetes mellitus, concomitant diseases, age > 65 years. We present a clinical case of rhinocerebral mucormycosis in a 79-year-old patient against the background of uncontrolled type 2 diabetes mellitus with ketoacidosis, a condition after previous glucocorticosteroid therapy for COVID-19 (according to the severity of the disease). After suffering a new coronavirus infection caused by the SARS-CoV-2 virus, she was admitted to the hospital with complaints characteristic of mucormycosis. On the 5th day of hospital stay, the patient's condition worsened significantly, despite the correction of the therapy, and on the 12th day the patient died. According to the results of the autopsy, it was established that the rhinocerebral mucormycosis was complicated by thrombosis of the anterior and posterior left cerebral arteries with subsequent infarctions in the frontal lobe and parieto-occipital region of the brain left hemisphere, cerebral edema, which was the immediate cause of death.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 3","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Oral squamous cell carcinoma in the background of oral submucous fibrosis - a systematic review]. [口腔黏膜下纤维化背景下的口腔鳞状细胞癌--系统回顾]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248601157

S Kizhakkoottu, P Ramani

{"title":"[Oral squamous cell carcinoma in the background of oral submucous fibrosis - a systematic review].","authors":"S Kizhakkoottu, P Ramani","doi":"10.17116/patol20248601157","DOIUrl":"10.17116/patol20248601157","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) in the background of oral submucous fibrosis (OSMF) is one of the most common presentations of oral cancer among Asian population. OSCC arising in the background of OSMF (OSCC with OSMF) has been a topic of interest among researchers recently and a few studies have considered this to be a distinct clinicopathological entity. This systematic review analyses the demographic and clinicopathological variations of OSCC with OSMF from conventional OSCC to evaluate the distinctiveness of OSCC with OSMF. A comprehensive search from PubMed, Google scholar and manual search were carried out and 4 articles were retrieved and analysed systematically. Out of the total 377 OSCC with OSMF cases and 542 conventional OSCC, males were found to be predominantly affected (82.7% and 73.6%). 47% of the OSCC with OSMF cases were well differentiated squamous cell carcinomas as against 33.4% in conventional OSCC. Lymph node metastases were seen predominantly in conventional OSCC (49.1%) than OSCC with OSMF cases (40.7%). OSCC with OSMF were more prevalent in males and showed better tumour differentiation and lesser lymph node metastasis. Even though the present results inculpate OSCC with OSMF as a distinct clinicopathological entity, there is a dire need for thorough investigation.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[IgD expression in various immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma in children]. [儿童结节性淋巴细胞占优势的霍奇金淋巴瘤各种免疫结构模式中的 IgD 表达]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248601121

M A Senchenko, D M Konovalov

{"title":"[IgD expression in various immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma in children].","authors":"M A Senchenko, D M Konovalov","doi":"10.17116/patol20248601121","DOIUrl":"10.17116/patol20248601121","url":null,"abstract":"Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) consist of lymphocyte predominant cell or LP-cell. Despite their origin from active germinal centers, in some cases LP-cells express IgD, which is characteristic of naive B-lymphocytes of the mantle zone. Due to the rarity of NLPHL, assessing the frequency of IgD-positive cases is difficult. This marker can serve not only for differential diagnosis with other diseases, but also indicate the possible heterogeneity of NLPHL, which is currently represented by six immunoarchitectural patterns.Objective: To determine the frequency of IgD-positive cases of NLPHL in children with subsequent assessment of the association with types of immunoarchitectural patterns.Material and methods: The study included 52 cases of NLPHL, which were divided to typical and atypical patterns. Differences between two groups were compared using Fisher's exact tests.Results: IgD expression was found in LP-cells in 26 of 52 cases (50%) and was positively correlated with atypical types (typical - 5/23, 21.7% vs atypical - 21/29, 72.4%, p=0.0003), among which pattern C was most common.Conclusion: Due to the high incidence of IgD-positive cases in NLPHL, this marker may be useful in differential diagnosis with histologic mimics. At the same time, positive IgD status was associated with atypical patterns, which may likely determine the different biology of neoplastic cells within the same form.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Exosomes' role in intercellular interactions in different variants of lung injury in fatal cases of COVID-19]. [外泌体在 COVID-19 死亡病例肺损伤不同变体中的细胞间相互作用中的作用]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248602122

E A Zarubin, E A Kogan, N V Zharkov, A M Avdalyan, D N Procenko

{"title":"[Exosomes' role in intercellular interactions in different variants of lung injury in fatal cases of COVID-19].","authors":"E A Zarubin, E A Kogan, N V Zharkov, A M Avdalyan, D N Procenko","doi":"10.17116/patol20248602122","DOIUrl":"https://doi.org/10.17116/patol20248602122","url":null,"abstract":"Background: Extracellular vesicles are surrounded by a phospholipid bilayer, carrying various active biomolecules and participating in many physiological and pathological processes, including infectious ones.Objective: To research the role of exosomes in intercellular interactions in the pathogenesis of various types of lung damage in fatal cases of COVID-19.Material and methods: We conducted a clinical and morphological analysis of 118 fatal cases caused by coronavirus infection in Moscow. We selected 32 cases with morphological signs of various types of lung lesions for immunohistochemical reaction (IHC) with antibodies against tetraspanin proteins (CD63, CD81), which are involved in the assembly of exosomes, as well as with antibodies against viral proteins: nucleocapsid and spike protein. We determined the main producing cells of extracellular vesicles and cells containing viral proteins, carried out their comparison and quantitative analysis.Results: IHC reaction with antibodies against CD63 showed cytoplasmic granular uniform and subapical staining of cells, as well as granular extracellular staining. We determined similar staining using antibodies against viral proteins. Extracellular vesicles were found in the same cells as viral proteins. The main producing cells of vesicles and cells containing viral proteins were found to be macrophages, type II pneumocytes, and endothelial cells.Conclusion: Taking into account the results of the literature, the localization of viral proteins and extracellular vesicles in the same cells indicates the key role of vesicles in the pathogenesis of various forms of lung damage by the SARS-CoV-2 virus, in the dissemination of the pathogen in the organism, which leads to interaction with the adaptive immune system and the formation of immunity.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 2","pages":"22-29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The algorithm for morphological assessment of malignant potential of adrenocortical tumors using mathematical modeling method]. [利用数学建模方法对肾上腺皮质肿瘤恶性潜能进行形态学评估的算法]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248603121

L S Urusova, N V Pachuashvili, E E Porubayeva, A R Elfimova, D G Beltsevich, A Chevais, T A Demura, N G Mokrysheva

{"title":"[The algorithm for morphological assessment of malignant potential of adrenocortical tumors using mathematical modeling method].","authors":"L S Urusova, N V Pachuashvili, E E Porubayeva, A R Elfimova, D G Beltsevich, A Chevais, T A Demura, N G Mokrysheva","doi":"10.17116/patol20248603121","DOIUrl":"https://doi.org/10.17116/patol20248603121","url":null,"abstract":"Objective: To develop the mathematical model with high sensitivity and specificity to assess the malignant potential of adrenal cortical tumors, which can be used to diagnose adrenocortical carcinoma (ACC) in adults.Material and methods: Pathomorphological examination of surgical and consultative material of adrenocortical neoplasms was carried out. All cases were verified according to the WHO Classification of adrenal gland tumors (5th ed., 2022), the tumor's histogenesis was confirmed by immunohistochemical examination. Statistical analysis of the histological and immunohistochemical factors in terms of their value in relation to the diagnosis of ACC was carried out on Python 3.1 in the Google Colab environment. ROC analysis was used to identify critical values of predictors. The cut-off point was selected according to the Youden`s index. Logistic regression analysis using l1-regularisation was performed. To validate the model, the initial sample was divided into training and test groups in the ratio of 9:1, respectively.Results: The study included 143 patients divided into training (128 patients) and test (15 patients) samples. A prognostic algorithm was developed, which represent a diagnostically significant set of indicators of the currently used Weiss scale. The diagnosis is carried out in 3 stages. This mathematical model showed 100% accuracy (95% CI: 96-100%) on the training and test samples.Conclusion: The developed algorithm could solve the problem of subjectivity and complexity in the interpretation of some of the criteria of current diagnostic algorithms. The new model is unique in that, unlike others, it allows verification of all morphological variants of ACC.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 3","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The role of immunohistochemical examination in the differential diagnosis of atypical tumors and carcinomas of parathyroid glands]. [免疫组化检查在甲状旁腺非典型肿瘤和癌的鉴别诊断中的作用]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol2024860415

E I Kim, A A Lavreniuk, L S Urusova, A K Eremkina, A R Elfimova, N G Mokrysheva

{"title":"[The role of immunohistochemical examination in the differential diagnosis of atypical tumors and carcinomas of parathyroid glands].","authors":"E I Kim, A A Lavreniuk, L S Urusova, A K Eremkina, A R Elfimova, N G Mokrysheva","doi":"10.17116/patol2024860415","DOIUrl":"https://doi.org/10.17116/patol2024860415","url":null,"abstract":"Differential diagnosis of atypical parathyroid tumors (APT) and parathyroid carcinomas (PC) is important in determining further management and prognosis. Morphologic diagnosis is sometimes difficult, in which case it is supplemented by immunohistochemical (IHC) examination.Objective: Studying the role of IHC analysis in the differential diagnosis of APT and PC.Material and methods: The study included 44 patients with morphologic diagnosis of the APT established after surgical treatment for primary hyperparathyroidism on the basis of Endocrinology Research Centre during 2018-2023. All cases underwent IHC examination with evaluation of CD31/CD34 and parathormone (PTH) expression for identification of vascular invasion, Ki-67, parafibromin.Results: According to the results of IHC analysis in 8/44 patients (18.2%) the diagnosis of APT was revised in favor of the PC: in 7 of them vascular invasion was detected; in 1 patient the additional series of slices in the surrounding fatty tissue revealed foci of tumor growth, confirmed by positive reaction with antibodies to PTH. According to IHC results, the material was divided into 2 groups: APT and PC. There were no differences in clinical and morphological characteristics, Ki-67% level and parafibromin expression between the groups.Conclusion: Assessment of clinical and laboratory-instrumental data at the preoperative stage does not allow differentiating APT from PC. In case of APT diagnosis and detection of suspicious morphological features, it is necessary to perform IHC examination to exclude PC.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 4","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical and laboratory parameters and pathomorphological features of the lungs in patients who have had COVID-19 viral pneumonia]. [COVID-19病毒性肺炎患者肺部的临床和实验室参数及病理形态特征]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248601127

A S Kontorshchikov, L M Mikhaleva, M A Sharafetdinova, O A Vasyukova, I S Kozlov, R A Vandysheva, L V Kakturskiy

引用次数: 0

[Papillary renal neoplasm with reverse polarity]. [极性相反的乳头状肾肿瘤]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248601144

E A Dubova, V N Vysotskaya

引用次数: 0

[Patterns of CAF expression in tumors of the genitourinary system]. [泌尿生殖系统肿瘤中 CAF 的表达模式]。

Arkhiv patologii Pub Date : 2024-01-01 DOI: 10.17116/patol20248606128

N A Oleynikova, I N Sycheva, I A Mikhailov, I A Zhestkov, M G Varenzov, P G Malkov

{"title":"[Patterns of CAF expression in tumors of the genitourinary system].","authors":"N A Oleynikova, I N Sycheva, I A Mikhailov, I A Zhestkov, M G Varenzov, P G Malkov","doi":"10.17116/patol20248606128","DOIUrl":"https://doi.org/10.17116/patol20248606128","url":null,"abstract":"Cancer-associated fibroblasts (CAF), as the most important component of the tumor microenvironment, have been the subject of targeted study in recent years. There is increasing evidence of CAF heterogeneity and their different roles in tumor progression. However, there is no single marker identifying CAF, and there is also no understanding of the similarity of CAF markers in various tumors of the genitourinary system.Objective: To evaluate the response of CAF markers - FAP and PDGFRα+β in bladder cancer and prostate cancer.Material and methods: An immunohistochemical study with antibodies to FAP and PDGFRα+β was conducted on material from 34 patients with prostate cancer and 44 patients with bladder cancer in order to identify statistical relationships with stage, morphological characteristics and survival, as well as to understand the applicability of the same markers for cancer of different localizations.Results: An increased FAP reaction was shown in prostate cancer with metastases (p=0.0239), a significantly higher number of recurrences in the group with a high PDGFRa+β (3+) reaction (p=0.0018); the presence of FAP reaction only in invasive bladder cancers (p=0.0094) and bladder cancers with high grade dysplasia (p=0.0000234), the absence of a relationship between the level of PDGFRa+β and clinical and morphological characteristics in bladder cancer.Conclusion: Our results confirm the heterogeneity of CAF in both bladder and prostate tumors and indicate that FAP is one of CAF subpopulation marker.Considering that FAP is expressed in a population of CAFs that lead to resistance to treatment with immune checkpoint inhibitors in melanoma, the FAP marker may also be diagnostically significant for tumors of the genitourinary system, especially given the fact that bladder tumors are treated with the BCG vaccine.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"86 6","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0