Arkhiv patologii最新文献

{"title":"[Pathogenesis of fibrosis development in ovarian endometriosis].","authors":"O I Patsap, O V Bratchikova, A V Babkina, M B Khabarova, S A Mikhalev, L M Mikhaleva","doi":"10.17116/patol20258702173","DOIUrl":"https://doi.org/10.17116/patol20258702173","url":null,"abstract":"<p><p>Endometriosis-associated fibrosis is a complex phenomenon, and the underlying mechanisms are still not fully understood. Fibrosis is invariably present in all forms of the disease and contributes to the classic endometriosis-associated symptoms such as chronic pelvic pain and infertility. The purpose of this literature review was to study the role of various cell populations, biological mechanisms and signaling pathways in inducing fibrogenesis of endometriosis lesions. PubMed and MEDLINE searched for studies published in English over the past 5 years that studied fibrosis in ovarian endometriosis.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 2","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathomorphological quality assessment of complete mesocolonectomy in right colon cancer].","authors":"I P Reznik, V A Avdeenko, A A Nevolskikh, R F Zibirov, V N Grinevich, S A Ivanov, A D Kaprin","doi":"10.17116/patol20258703162","DOIUrl":"https://doi.org/10.17116/patol20258703162","url":null,"abstract":"<p><p>Complete mesocolonectomy (CME) is the current standard of treatment for colon cancer patients. At the same time, there are currently no clear standards for the pathomorphological assessment of CME quality, allowing for a comprehensive and independent assessment of the quality of surgical treatment.</p><p><strong>Objective: </strong>Creation of a standardized system of pathomorphological assessment of the quality of TMCE based on the developed set of universal criteria.</p><p><strong>Material and methods: </strong>The prospective study included the results of treatment of patients with adenocarcinomas of the right half of the colon, who underwent surgical interventions in the volume of right-sided hemicolectomy (RSHE) in the period from 2022 to 2024. The method of pathomorphological examination included mandatory photo documentation, as well as mesocolonectomy quality assessment using the classification of N. West et al., visual assessment of CME quality using the classification of S. Benz et al., standard microscopic examination to determine the presence of metastatic lymph nodes (LN) lesions, dividing them into groups according to the Japanese classification.</p><p><strong>Results: </strong>The study included 142 patients, 116 (81.7%) of whom underwent laparoscopic interventions, while 105 (73.9%) had D3 lymphodissection. According to the pathomorphological study, the most common (65 cases - 45.8%) tumors were located in the ascending section of the transverse colon, multicentric tumor growth within the colon was detected in 3 (2.1%) cases. The overwhelming majority of patients had stage III (92 patients - 64.9%) and IV (25 patients - 17.6%) clinical stages of the disease.</p><p><p>The median of the studied LN was 48 (12-225), affected - 3 (1-51) LN. LN lesion was detected in 79 patients (55.6%). Damage to the apical LN was found in 9 (6.3%) cases. Unfavorable prognosis factors (perineural growth, lympho- and angiovascular invasion, the presence of tumor deposits and metastases in the lung) were identified in 92 (64.7%) patients.</p><p><p>Good quality of mesocolic fascia isolation (Grade 3) according to West was found in 101 cases (71.1%), true CME (Type 0 according to Benz) was performed in 74 cases (52.1%).</p><p><strong>Conclusion: </strong>The quality assessment of the removed specimen after RSHE should be based on a detailed examination of all removed lymph nodes with division into groups in accordance with the Japanese Clinical Classification, assessment of the plane of intestinal resection according to N. West and the quality of CME according to S. Benz.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 3","pages":"62-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation of tumor budding with DNA mismatch repair system and PD-L1-status in gastric cancer].","authors":"T V Polushkina, D V Kalinin, N V Danilova","doi":"10.17116/patol2025870415","DOIUrl":"10.17116/patol2025870415","url":null,"abstract":"<p><strong>Objective: </strong>To detect the presence or absence of correlations between the degree of tumor budding (TB) and pMMR/dMMR (proficient Mismatch Repair System/deficient Mismatch Repair System) and PD-L1 status in gastric cancer (GC).</p><p><strong>Material and methods: </strong>Surgical material from 173 patients with verified gastric cancer of the tubular histological subtype, where the invasive edge of the carcinoma was examined, tumor budding were identified and counted by three methods: H. Ueno, L. Wang and, E. Karamitopolou. Patients with GC were divided into two groups - with low and high degree of tumor budding (LG-TB and HG-TB). dMMR and PD-L1 status were identified by immunohistochemical staining.</p><p><strong>Results: </strong>Using the H. Ueno method, a predominance of low-grade TB was found in the group of dMMR carcinomas (90.5% of dMMR cases were associated with LG-TB, <i>p</i>=0.035). According to the L. Wang method, 85.7% of dMMR cases were identified that were associated with LG-TB, <i>p</i>=0.028. According to the E. Karamitopolou method, it was found that 76.2% of dMMR cases were associated with LG-TB, <i>p</i>=0.106. When analyzing the relationship between tumor budding and PD-L1 expression, no statistically significant differences were found (<i>p</i>>0.05).</p><p><strong>Conclusion: </strong>The low degree of tumor budding, estimated by the methods of H. Ueno and L. Wang, correlates with the dMMR status of tumor tissue. No statistically significant association was found when counting tumor budding using the E. Karamitopolou method. The degree of tumor budding determined by any of the methods does not correlate with the PD-L1 status of GC.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 4","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endometrial vascularisation in hyperplasia without atypia].","authors":"I V Maiborodin, M A Goncharov, B V Sheplev, A O Shumeikina, S E Krasil'nikov, E S Chernomortseva","doi":"10.17116/patol20258706128","DOIUrl":"https://doi.org/10.17116/patol20258706128","url":null,"abstract":"<p><p>Various benign processes in the endometrium are the cause of vascular changes. Endometrial cancer is also accompanied by changes in the density of microvessels. The detection of vascularization of the hyperplastic endometrium without signs of atypia, expressed significantly more than described in the literature, served as the basis for this work.</p><p><strong>Objective: </strong>To assess the state of the vascularization of the simple endometrial hyperplasia without atypia and to compare the obtained results with literary data.</p><p><strong>Material and methods: </strong>Vascularization of the endometrium in its simple hyperplasia without atypia was studied in 31 women by light microscopy using an immunohistochemical reaction with antibodies to the CD34 antigen and morphometry.</p><p><strong>Results: </strong>Different patients had different degrees of expression, but always large, vascularization of the endometrium with simple endometrial hyperplasia without atypia. The vessels accounted 5.97±4.18% of the section area, while their number per 1 mm² was 391±180. These data significantly exceed most of the results of other studies presented in the literature, which differ several times even from each other.</p><p><strong>Conclusion: </strong>Endometrium with simple endometrial hyperplasia without atypia is characterized by different, often very high levels of vascularization, the real average values much exceed most of the literary data, which are also very contradictory. A very critical attention to the results describing the features of angiogenesis and vascularization of hyperplastic endometrium without atypia is necessary.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 6","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dysplastic nevi: difficulties in diagnosis].","authors":"A A Borzova, K I Ampleenkova, M A Krot, M A Nefedova, V A Smolyannikova, A V Filatov","doi":"10.17116/patol20258706112","DOIUrl":"https://doi.org/10.17116/patol20258706112","url":null,"abstract":"<p><p>Dysplastic nevus is one of the most common tumors in the practice of a dermatologist and pathologist. However, despite this and the presence of a large number of published studies, since the late 1970s and to this day, the diagnosis and treatment of dysplastic nevi have been controversial.</p><p><strong>Objective: </strong>To determine the accuracy and reproducibility of morphological findings in the group of dysplastic nevi.</p><p><strong>Material and methods: </strong>A total of 178 skin resection specimens for 2023 were used in our study, which can be conditionally divided into three groups according to the correct clinical diagnosis: (1) with suspected dysplastic nevus/melanoma - 56% (99/178), (2) dysplastic nevus - 35% (62/178), (3) without dysplastic nevus/melanoma - 9% (7/178). Of the 178 observations, 31 cases were selected for further review. The selection criteria were the following morphological findings: (1) DN with moderate/severe atypia, (2) DN with any degree of atypia without clinical suspicion for it, (3) melanoma without clinical suspicion for it. Agreement between pathology reports and the original diagnosis was measured by the proportion of the same reports in the same educational category, using Wilson 95% confidence interval.</p><p><strong>Results: </strong>There were 72 dysplastic nevi after first pathology report: 77.8% (56/72) with mild atypia, 18.1% (13/72) with moderate atypia, 4.2% (3/72) with severe atypia. The agreement between the clinical and primary morphological diagnoses was 58.4% (104/178), and in the dysplastic nevus group - 40.3% (25/62). When reviewing the 31 cases, the percentage of agreement for a simple nevus was 100%, for dysplastic with mild atypia - 70.8%, for dysplastic nevus with severe atypia - 33.3%, for melanoma - 48.4%. The coincidence of the initial and repeated diagnoses was 54.8% (14/31), 51.6% (16/31) and 29.0% (9/31) for each of the doctors.</p><p><strong>Conclusion: </strong>Our study revealed low accuracy and reproducibility of morphological conclusions in the group of dysplastic nevi. The determination of similar lesions by different pathologists and deviations from the initial diagnoses can primarily be explained by insufficiently reproducible diagnostic criteria.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 6","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Heterogeneity of ALDH1, CD133 and CD34 expression in cancer stem cells of lung adenocarcinoma].","authors":"E A Kogan, E E Shchelokova, T A Demura, N V Zharkov, S T Avraamova, N V Kovyazina, G A Meerovich, I G Meerovich, E A Ermakova, A E Kholschenkova, I V Reshetov","doi":"10.17116/patol20258705136","DOIUrl":"https://doi.org/10.17116/patol20258705136","url":null,"abstract":"<p><p>Lung adenocarcinoma (LAC) is one of the leading causes of cancer mortality, which is most likely due to the presence of cancer stem cells (CSC) in the tumor, which form a heterogeneous hierarchy and are responsible for the occurrence and progression of carcinoma, as well as its unfavorable prognosis. The ability of CSC to form heterogeneous tumor populations in lung cancer has not been sufficiently studied.</p><p><strong>Objective: </strong>Detection of cancer cells with signs of stemness in LAC and establishment of their heterogeneity by expression of ALDH1, CD133 and CD34 markers in surgical material depending on the histological type, degree of malignancy and stage of the tumor process, as well as in the A549 cell culture.</p><p><strong>Material and methods: </strong>Clinical and morphological analysis of surgical material of LAC from 32 patients was performed, and the culture of lung adenocarcinoma cells A549 was studied. Stem cell markers ALDH1, CD133 and CD34 were detected in the analyzed material by immunohistochemistry. The percentage of positively stained cells was calculated in the preparations.</p><p><strong>Results: </strong>In all cases of ALCL, CSCs containing ALDH1, CD133 and CD34 were found both in the surgical material and in the A549 cell culture. Heterogeneity of CSCs for the studied markers was established. In patients with early stages of cancer without metastases in the lymph nodes, the number of ALDH1+ CSCs predominated in the primary tumor tissue. With the appearance of metastases in the regional lymph nodes, a significant increase in the number of cells with positive staining in reactions with antibodies to CD34 was found in the ALCL tissue. In patients with metastatic cancer, staining of the overwhelming majority of tumor cells was detected in reactions with all markers - ALDH1, CD133 and CD34.</p><p><strong>Conclusion: </strong>In ACL, both in the surgical material and in the A549 culture, CSCs expressing the stemness markers ALDH1, CD133 and CD34 were detected. An increase in the number of CSCs expressing the stemness markers ALDH1, CD34 and CD133 in the tumor tissue occurs with carcinoma progression. In ACL, heterogeneity of CSCs by the studied markers is noted: at early stages in patients without metastases in the lymph nodes, ALDH1+ CSCs predominate in the tumor tissue, while with the appearance of metastatic lesions of the lymph nodes, CD34+ CSC populations dominate. Quantitative heterogeneity is also observed in the A549 cell culture: the largest number was CD34+ CSCs, slightly less ALDH1+ CSCs and a minimum number of cells with CD133+ CSCs.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 5","pages":"36-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Aseptic osteitis of the tibia after intraarticular injection of hyaluronic acid in a patient with knee osteoarthritis].","authors":"G K Eshmotova, A A Semina, A V Korshunov, D A Kobzarev, A I Semenov, A P Bonartsev, A Yu Zarov, L V Kaktursky, A V Volkov","doi":"10.17116/patol20258702169","DOIUrl":"https://doi.org/10.17116/patol20258702169","url":null,"abstract":"<p><p>Knee osteoarthritis is a widespread disease with an insufficiently studied pathogenesis that affects various age groups and leads to progressive disappearance of hyaline cartilage with a severe impairment of function. In some cases, it requires a radical treatment - endoprotestics. Among conservative methods of osteoarthritis treatment intra-articular injections of hyaluronic acid preparations are often used alongside with drug therapy. We present a case of granulomatous osteitis of the proximal tibial epiphysis caused by the injection of hyaluronic acid in a patient with severe osteoarthritis. X-ray examination revealed apparent dystrophic-degenerative changes in the left knee joint and the cancellous bone of the proximal tibial epiphysis in the patient. Macro- and microscopic examination showed absence of articular cartilage on a large area of the joint surface and its partial replacement by fibrous cartilage. Microscopic examination and scanning electron microscopy of the cancellous bone of the left proximal tibial epiphysis revealed fields of homogeneous gel-like, electron-transparent substance with a giant cell reaction to it. We present the first case in Russia of osteitis of the proximal tibial epiphysis due to intra-articular injection of hyaluronic acid in a patient with severe osteoarthritis.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 2","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ultrastructural changes of skeletal muscle tissue of patients with dysferlinopathy].","authors":"I A Chekmareva, S N Bardakov, I S Limaev, A M Emelin, R V Deev","doi":"10.17116/patol20258701128","DOIUrl":"10.17116/patol20258701128","url":null,"abstract":"<p><p>Dysferlinopathy represents an orphan disease within the spectrum of progressive muscular dystrophies, occurring at a frequency of 1 to 9 cases per 1.000.000 individuals (Orphanet, 2024). It arises from mutations in the <i>DYSF</i> gene (OMIM 603009, 2p13, NM_003494.4), which is responsible for coding the transmembrane protein dysferlin. Dysferlin plays a critical role in the repair of muscle fiber membranes and the cellular processes of skeletal muscle regeneration. Although the molecular mechanisms of dysferlin-mediated repair are under active investigation, reports on the ultrastructural alterations in human skeletal muscles due to dysferlin deficiency are sparse.</p><p><strong>Objective: </strong>To identify the ultrastructural pathomorphological features of skeletal muscles in 6 patients with dysferlinopathy.</p><p><strong>Material and methods: </strong>This study presents pathomorphological, immunohistochemical, and ultrastructural data from skeletal muscle biopsies of 6 patients with molecularly confirmed dysferlinopathy.</p><p><strong>Results: </strong>Examination of paraffin-embedded sections of the anterior tibialis and vastus lateralis muscles, stained with hematoxylin and eosin, identified a primarily myopathic pattern of skeletal muscle injury. Immunohistochemical staining with dysferlin antibodies revealed the absence of the protein in muscle tissue compared to the positive control. Transmission electron microscopy has revealed ultrastructural alterations characteristic of dysferlinopathy, although not specific, including thickening and fragmentation of the basal membrane, thinning and lysis of myofibrils, folding and disruptions of the sarcolemma, destruction of mitochondria, and, newly described in this disease, necrosis of myosatellite cells and telocytes in skeletal muscles.</p><p><strong>Conclusion: </strong>Despite the non-specificity of the identified ultrastructural alterations, electron microscopy of skeletal muscle biopsies in dysferlinopathy can provide additional information about the mechanisms underlying the disease development. The finding of myosatellite cell and telocyte necrosis indicates the impairment of skeletal muscle regenerative capacity, which may be a novel link in the pathogenesis of dysferlinopathy.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 1","pages":"28-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia].","authors":"Z P Asaulenko, Yu A Krivolapov","doi":"10.17116/patol20258701122","DOIUrl":"10.17116/patol20258701122","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare morphometric and histotopographic characteristics of megakaryocytic lineage in preparations stained with H&E or antibodies to CD42b in diagnostic trepanobioptates of bone marrow of patients with primary myelofibrosis and essential thrombocythemia with <i>JAK2</i> or <i>CALR</i> mutation. Analyze the dimensions and quantity of CD42b-positive megakaryocytes in 1 mm² area of section and assess suitability of these parameters as an additional differential pathomorphological criterion.</p><p><strong>Material and methods: </strong>108 trephine biopsies of the bone marrow from patients with primary myelofibrosis (N=53) and essential thrombocythemia (N=55) with <i>JAK2</i> or <i>CALR</i> mutation were selected. Digitized bone marrow slides stained with H&E or antibodies to CD42b (clone EP409) were the object of study. In every sample the average values of perimeter and area of megakaryocytes were analyzed, as well as the average number of megakaryocytes in 1 mm² area of myeloid tissue section. Logistic regression analysis was used to describe the relationship between CD42b-positive megakaryocyte characteristics and disease (primary myelofibrosis or essential thrombocythemia).</p><p><strong>Results: </strong>Immunohistochemical examination of bone marrow biopsy specimens using antibodies to CD42b in comparison with H&E staining allows to multiply the number of identifiable megakaryocytes in myeloid tissue by 3.5-4 times (<i>p</i><0.0001). Statistically significant differences in the mean values of the number of megakaryocytes in 1 mm² of the section area and megakaryocyte perimeter in patients with primary myelofibrosis and essential thrombocythemia have been demonstrated. ROC analysis (AUC=0.84, 95% CI 0.7782-0.9199) justifies the inclusion of the average perimeter size of CD42b-positive megakaryocytes and their number in 1 mm² of the section area in the differential diagnostic panel as an additional pathomorphological criterion.</p><p><strong>Conclusion: </strong>The revealed statistically significant differences in quantitative and geometric characteristics of megakaryocytes allowed to calculate differential threshold values of characteristics of megakaryocytic lineage of myeloid tissue in diagnostic trepanobioptates of bone marrow from patients with primary myelofibrosis and essential thrombocythemia. Counting the number of CD42b-positive megakaryocytes in one field of view at a magnification of 400 times was proposed as an additional pathomorphological differential-diagnostic sign.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 1","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review].","authors":"I V Sidorov, A S Sharlai, D M Konovalov","doi":"10.17116/patol20258701137","DOIUrl":"10.17116/patol20258701137","url":null,"abstract":"<p><p>Plexiform fibromyxoma (PFM) and gastroblastoma (GB) are rare gastric tumors with a specific <i>MALAT1::GLI1</i> rearrangement, included in the conditional spectrum of neoplasms with alterations of the <i>GLI1</i> gene. The article presents a clinical case of PFM in a 6-year-old girl and a literature review highlighting current data on the morphology, immunophenotype and molecular genetic characteristics of PFM and GB. Despite the common genetic anomaly, differences in the morphology and clinical course of these tumors indicate the need for further research to clarify their relationship and potential reclassification in the light of new data on tumors with <i>GLI1</i> gene abnormalities. Integrating the accumulated knowledge about tumors with <i>GLI1</i> gene alterations into diagnostic algorithms and therapeutic approaches will help improve the treatment outcomes of patients with these rare neoplasms.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}