Arkhiv patologii最新文献_第10页

[Morphological aspects of diaphragm dysfunction in COVID-19-associated pneumonia]. [covid -19相关性肺炎膈膜功能障碍的形态学方面]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238503119

A Yu Yakovlev, A A Pevnev, V O Nikolskiy, A Yu Smorkalov, V N Maksimychev

{"title":"[Morphological aspects of diaphragm dysfunction in COVID-19-associated pneumonia].","authors":"A Yu Yakovlev, A A Pevnev, V O Nikolskiy, A Yu Smorkalov, V N Maksimychev","doi":"10.17116/patol20238503119","DOIUrl":"https://doi.org/10.17116/patol20238503119","url":null,"abstract":"Objective: To assess morphological changes in the diaphragm and phrenic nerve in patients who died from COVID-19.Material and methods: In a case-control study, an analysis was made of autopsy material of the diaphragm and phrenic nerve of those who died from COVID-19 infection complicated by SARS-CoV-2-associated pneumonia, confirmed in vivo by the presence of SARS-CoV-2 RNA (Group 1, n=12), and those who died with a diagnosis of acute cerebrovascular accident of the ischemic type without parenchymal respiratory failure (Group 2, n=3).Results: The main histopathological features in the diaphragm of the 1st group were the edema of the pericellular spaces of muscle fibers, edema of perivascular spaces, diapedese hemorrhages, plethora in arteriolas, in most veins and capillaries, red blood clots were revealed; in the diaphragmatic nerve - swelling of the perineral space, severe edema around the nerve fibers inside the nerve trunk. In the diaphragm of group 2, edema of pericellular spaces of muscle fibers and edema of perivascular spaces were less pronounced (p<0.001), hemorrhages were not determined; in the diaphragmatic nerve, moderate edema of the perineral space, mild swelling inside the nerve trunk around the nerve fibers was revealed (p<0.001). The glycogen content in the muscle cells of group 1 is significantly lower compared to group 2 (p<0.001).Conclusion: The study confirms the characteristic pathological picture of organ damage in COVID-19. However, the leading pathological mechanism of organ damage requires further investigation.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"85 3","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Microglandular adenosis of the breast]. [乳腺微腺性腺病]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238502140

V I Nikitina, V A Khorzhevskii, I V Vershinin, S V Gappoev, E V Alymova, L G Levkovich

引用次数: 0

[Adrenocortical carcinoma: modern concepts of morphological diagnosis and classification]. 肾上腺皮质癌:形态学诊断和分类的现代概念。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238504132

L S Urusova, I S Kletskaya, E E Porubayeva, D G Beltsevich

引用次数: 0

[Vaginal leiomyosarcoma in pregnancy]. 【妊娠期阴道平滑肌肉瘤】

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238504154

I V Barinova, S N Buyanova, T A Glebov, N V Yudina, A A Aksyonova, O V Girya

引用次数: 0

[Undifferentiated pancreatic carcinoma with osteoclast-like giant cells]. [带有破骨细胞样巨细胞的未分化胰腺癌]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238501162

A Yu Shamanova, D M Rostovtsev, A V Privalov, L V Yarina, K S Aristarkhova, G V Sychugov, I V Vasil'kova, A S Artem'eva, V V Saevets, E A Alymov

引用次数: 0

[Small cell neuroendocrine carcinoma of the endometrium]. [子宫内膜小细胞神经内分泌癌]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238504159

G A Demyashkin, R F Zibirov, A A Lugovskoi, A A Sigorskaia, I A Stoliarov

引用次数: 0

[Verification of the diagnosis of supratentorial ependymomas by real-time PCR]. [实时荧光定量PCR诊断幕上室管膜瘤的验证]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol2023850315

S A Galstyan, E N Telysheva, A O Lavrinovich, E G Shaikhaev, G P Snigireva, E I Petrova, S K Gorelyshev, O G Zheludkova, Y V Kushel, E V Kumirova, M V Ryzhova

{"title":"[Verification of the diagnosis of supratentorial ependymomas by real-time PCR].","authors":"S A Galstyan, E N Telysheva, A O Lavrinovich, E G Shaikhaev, G P Snigireva, E I Petrova, S K Gorelyshev, O G Zheludkova, Y V Kushel, E V Kumirova, M V Ryzhova","doi":"10.17116/patol2023850315","DOIUrl":"https://doi.org/10.17116/patol2023850315","url":null,"abstract":"Background: Differential diagnosis of supratentorial ependymomas is of particular difficulty in neurooncology due to nonspecific clinical and radiographic findings, a rare seen «classic» morphological picture, and a nonspecific immunophenotype. Thanks to molecular genetic methods, in particular real-time PCR, it has become possible to verify supratentorial ependymomas and identify their molecular group, on which further prognosis depends.Objective: To develop a set of molecular genetic tests based on real-time PCR to verify supratentorial ependymomas.Material and methods: 56 tissue samples were collected from patients with supratentorial ependymomas, WHO Grade II, and anaplastic ependymomas, WHO Grade III. We developed primers and fluorescent TaqMan probes for real-time PCR analysis to detect the ZFTA::RELA, ZFTA::MAML2, ZFTA::NCOA2, ZFTA::MAML3, YAP1::MAMLD1, and YAP1::FAM118B gene fusions. For immunohistochemical analysis, monoclonal rabbit anti-NF-kb p65 antibodies (HUABIO, China) were used, the study was carried out on AutostainerLink 48 immunostainer (DAKO, Denmark).Results: Real-time PCR was able to verify the diagnosis for 69.9% (n=39) of samples and classify them into molecular groups of ZFTA- or YAP1-positive supratentorial ependymomas. Immunohistochemically it was possible to verify 58% (n=29) ependymomas.Conclusion: Diagnosis by real-time PCR is a relatively fast, accessible and easily interpreted method that allows verification of the molecular group in 70% of cases of supratentorial ependymomas without the use of additional methods.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"85 3","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Angiomyolipoma of the liver]. [肝脏血管平滑肌脂肪瘤]

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238501170

G A Demyashkin, R F Zibirov, O A Anurova, S R Kozaeva, M I Yeronova

引用次数: 1

[Alveolar rhabdomyosarcoma: novel surrogate markers associated with oncogenic translocation]. [肺泡横纹肌肉瘤:与致癌易位相关的新替代标志物]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238501110

A V Tarakanova, A S Sharlay, D M Konovalov

{"title":"[Alveolar rhabdomyosarcoma: novel surrogate markers associated with oncogenic translocation].","authors":"A V Tarakanova, A S Sharlay, D M Konovalov","doi":"10.17116/patol20238501110","DOIUrl":"https://doi.org/10.17116/patol20238501110","url":null,"abstract":"Background: Anomalies of the FOXO1 gene in alveolar rhabdomyosarcoma are associated with a worse clinical prognosis, which determines the high value of studying the status of this gene when choosing a therapy strategy. The «gold standard» for determining FOXO1 gene rearrangements is currently the fluorescent in situ hybridization (FISH) technique.Objective: Study of the relationship between canonical FOXO1 translocation and immunohistochemical expression of new surrogate markers in alveolar rhabdomyosarcoma to determine their predictive value.Material and methods: 139 cases of rhabdomyosarcoma were retrospectively studied. The study used tissue matrix technology (TMA). On sections obtained from TMA blocks, the FISH technique was implemented using the locus-specific probe MetaSystems XL FOXO1 Break Apart (Metasystems, Germany). Immunohistochemical studies were performed on similar sections from TMA blocks with OLIG2 (Cell Marque Antibodies, clone 211F1.1) and MUC4 (Cell Marque Antibodies, clone 8G7) antibodies.Results: The final expression analysis and statistical processing using a 2x2 contingency table and Fisher's exact test passed 111 cases (76 without FOXO1 rearrangement and 35 with rearrangement). The specificity of OLIG2 and MUC4 expression for FOXO1-rearranged alveolar rhabdomyosarcoma was 85.53% and 80.26%, respectively (p<0.01).Conclusion: The present study confirms the high predictive value of the expression of surrogate markers OLIG2 and MUC4 in determining the genetic status of alveolar rhabdomyosarcoma, which makes it possible to predict with high specificity the detection of the FOXO1 gene rearrangement.","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"85 1","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10721786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[WHO classification of tumors of hematopoietic and lymphoid tissues, 2022 (5th edition): lymphoid tumors]. [WHO造血和淋巴组织肿瘤分类，2022(第5版):淋巴肿瘤]。

Arkhiv patologii Pub Date : 2023-01-01 DOI: 10.17116/patol20238504124

D V Baram, Z P Asaulenko, I N Spiridonov, Yu A Krivolapov

引用次数: 0