Arkhiv patologii最新文献

{"title":"[Breast implant-associated anaplastic large cell lymphoma: a case report and literature review].","authors":"M E Fedchenko, Z P Asaulenko, Yu A Krivolapov","doi":"10.17116/patol20268804165","DOIUrl":"https://doi.org/10.17116/patol20268804165","url":null,"abstract":"<p><p>Breast implant-associated anaplastic large cell lymphoma is a mature CD30-positive T-cell lymphoma that develops around the implant as a peri-implant fluid collection confined by a fibrous capsule, and less commonly as a tumor with infiltrative growth. The disease was recognized as a distinct clinico-pathological entity in 2022 in the 5^th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This work analyzed current understanding of the disease: epidemiological data, etiopathogenetic aspects, and diagnostic algorithms. The article discusses the association of the disease with textured implants, predominantly manufactured by Allergan Biocell (USA). The main pathogenetic mechanisms are reviewed: chronic inflammation, the role of bacterial biofilms, and JAK/STAT signaling pathway activation. Current approaches to diagnosis and staging are described. The necessity of establishing a national registry of BIA-ALCL cases in the Russian Federation and developing domestic clinical guidelines for optimizing patient management is emphasized. A description of a clinical case of BIA-ALCL is presented, one of the few registered cases in the Russian Federation.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of subpopulations of lymphocytes and cells of the liver mononuclear phagocyte system in the acute period and in the long term after COVID-19 disease].","authors":"S F Krasnenkova, O V Zayratyants, A S Kontorshchikov, K Yu Midiber, V V Pechnikova, L M Mikhaleva","doi":"10.17116/patol2026880415","DOIUrl":"10.17116/patol2026880415","url":null,"abstract":"<p><strong>Objective: </strong>Comparative analysis of liver subpopulations of lymphocytes and cells of the system of mononuclear phagocytes on the material of autopsies in deaths from acute period of COVID-19, without its previous diseases and bacterial/mycotic superinfection, as well as from noninfection diseases in the distant future after the new coronavirus infection.</p><p><strong>Material and methods: </strong>Study of morphological changes of the liver in 47 deaths from COVID-19, confirmed by a PCR test, and noninfection diseases within 40 to 300 days after a new coronavirus infection. The study did not include those who died with previous liver diseases and comorbid diseases accompanied by liver damage, and in the first two groups of observations - also with bacterial/mycotic superinfection, and after hepatotoxic therapy. 1 group consisted of 10 observations (average age - 75.2 years) with the exudative phase of diffuse alveolar damage (DAD), 2^nd group - 27 observations (average age - 71.7 years) with the proliferative or exudative-proliferative phases of DAD, 3d group - 10 observations (average age - 84.7 years), died from cardiovascular diseases in the period from 40 to 300 days after the transfer COVID-19. Imunohistochemical (IHC) reactions with antibodies to CD3, CD4, CD8, CD20, CD56 and CD68 were used with statistical analysis.</p><p><strong>Results: </strong>In portal tracts and perisinusoid spaces, the total number of CD3+, CD4+, CD8+, CD56+ and CD20+ lymphocytes and CD68+ cells are not higher in the acute period COVID-19, and in perisinusoid spaces are even less than in observations after a new coronavirus infection in patients died from cardiovascular diseases. The number of intraepithelial CD3+, CD4+, CD8+, CD56+ lymphocytes of the bile ducts of portal tracts was increased, which also infiltrate the walls of small vessels. Number of CD4+ lymphocytes in the stroma and liver parenchyma, ratio CD4+/CD8+ lymphocytes and proliferation of Kupfer cells are most increased in the exudative phase of DAD in COVID-19.</p><p><strong>Conclusion: </strong>The study confirms that the morphological substrate COVID-19-associated liver damage may be ischemic hepatitis and COVID-19-associated cholangiopathy and microangiopathy give it a certain specificity. The revealed changes do not allow to exclude that the pathogenesis of liver damage can be also associated, including with other factors the direct action of SARS-CoV2 or immune disorders associated with COVID-19.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experience in validating equipment and reagents for immunohistochemical studies in the context of changing consumables market].","authors":"O A Kuznetsova, E M Olyushina, L V Moskvina, L E Zavalishina","doi":"10.17116/patol20268805156","DOIUrl":"https://doi.org/10.17116/patol20268805156","url":null,"abstract":"<p><p>The practical implementation of new immunohistochemical reagents and equipment requires validation in the each pathology department of a medical institution performing intravital diagnostics. This article presents the validation results for reagents and an immunostainer, which required optimizing certain parameters. This enabled reproducible results to those performed using conventional instrument platforms and routine reagents.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 5","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Persistent inflammation, immunosuppression, and catabolism syndrome].","authors":"I K Slepov, R V Deev, O V Zayratyants, O D Mishnev","doi":"10.17116/patol2026880515","DOIUrl":"https://doi.org/10.17116/patol2026880515","url":null,"abstract":"<p><p>Reduced early mortality in sepsis and severe injuries led to the formation of a cohort of patients with chronic critical conditions (diseases). One of the mechanisms of chronization of acute critical conditions is the development of persistent inflammation, immunosuppression and catabolism syndrome (PICS). Diagnosis of PICS is currently based on clinical and laboratory markers, whereas morphological changes insufficiently studied. Lack of pathogenesis and morphogenesis understanding makes it difficult to stratify patients with prolonged critical conditions and develop new treatment approaches, and also leads to the absence of PICS in clinical and anatomical diagnoses. The article systematized current understanding of PICS mechanisms of development and morphological manifestations. Examples of clinical cases are presented.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 5","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Low-grade urothelial carcinoma of the bladder with osteoclast-like differentiation as part of primary multiple malignancies. Case report and literature review].","authors":"D A Mudrak, V A Ankudavichus, A M Mylnikov, E E Vrabie, E V Deeva, K E Gorshkova, G N Maslyakova","doi":"10.17116/patol20268803147","DOIUrl":"10.17116/patol20268803147","url":null,"abstract":"<p><p>Low-grade urothelial carcinoma of the bladder with an atypical stromal reaction and accumulation of osteoclast-like giant cells is a rare form of urothelial cancer. A meta-analysis of literature data over the past 53 years revealed 30 publications containing a total of 50 cases of this form of urothelial cancer. In ²/₃ of the cases, the primary tumor was located in the bladder, while the remaining cases were located in the renal pelvis. The disease is extremely aggressive: the median survival time is 12 months, and distant metastases are detected in 65% of cases. The article describes a clinical case of a patient with primary multiple synchronous cancers, including poorly differentiated urothelial carcinoma with osteoclast-like differentiation of the bladder, papillary renal carcinoma, and acinar adenocarcinoma of the prostate.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 3","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and morphological study of the prognostic value of tumor deposits in colorectal cancer].","authors":"N V Kretova, T A Demura, A Yu Suvorov, A E Kasel","doi":"10.17116/patol20268804114","DOIUrl":"https://doi.org/10.17116/patol20268804114","url":null,"abstract":"<p><p>Currently, the presence of tumor deposits in colorectal cancer does not significantly affect the staging and their role in the prognosis of the disease is controversial.</p><p><strong>Objective: </strong>To study the clinical and morphological features and disease-free survival in patients with colorectal cancer (CRC) with tumor deposits (TD).</p><p><strong>Material and methods: </strong>The medical histories and histological material of 60 patients with CRC who were treated at the Sechenov University Clinical Center were retrospectively analyzed. The first group included 29 patients with stage III-IV of the disease, in whom, during morphological examination of the surgical material, TD were found in the paracolic/pararectal tissue. The second group consisted of 31 patients with stage III-IV disease without TD. The groups were compared by gender, age, stages (TNM), localization and degree of malignancy of the tumor, presence/absence of lymphatic, vascular and perineural invasion. Recurrence-free survival was studied for 36 months, both locoregional recurrences and distant metastases were taken into account. A statistical analysis of the data obtained was carried out.</p><p><strong>Results: </strong>It was found that in the group with TD in CRC, the chance of recurrence was 4.4 times (<i>p</i>=0.031) higher than in the group without deposits, and the average time to recurrence decreased, which was 26.1±13.2 months in group 1 (CRC with TD); 32.8±8.4 months in group 2 (CRC without TD) (<i>p</i>=0.013). It was found that tumors with TD are more often localized in the left half of the colon and rectum, have a large stage at the time of diagnosis, and perineural invasion is significantly more common (<i>p</i>=0.016).</p><p><strong>Conclusion: </strong>The study found that the presence of tumor deposits in the paracolic and pararectal tissue is an important prognostic factor and is associated with a decrease in disease-free survival in stage III-IV colorectal cancer.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intraductal oncocytic papillary neoplasm of the pancreas].","authors":"E A Dubova, I A Martinkevich, K A Pavlov","doi":"10.17116/patol20268804150","DOIUrl":"https://doi.org/10.17116/patol20268804150","url":null,"abstract":"<p><p>Intraductal oncocytic papillary neoplasm is a rare tumor of pancreatic duct epithelia with a good prognosis. The tumor has unique morphologic and genetic properties that distinguish it from intraductal papillary mucinous neoplasm. Here we present a case report and a literature review of intraductal oncocytic papillary neoplasm of the pancreas in a 56-year-old women. Histologic and immunohistochemical diagnostic criteria of the tumor are given, as well as the similarity with fibrolamellar hepatocellular carcinoma. The rarity of the tumor and the absence of described cases in the domestic literature make this case report of interest to pathologists and physicians.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Morphology of the kidneys in the antenatal period].","authors":"A G Talalaev, P A Akhsanova, I S Davydov, I A Shiripenko","doi":"10.17116/patol20268805187","DOIUrl":"10.17116/patol20268805187","url":null,"abstract":"<p><p>The article is devoted to the morphological characteristics of fetal kidney structures according to the literature data. As illustrations, own histological preparations of fetal kidneys at different stages of intrauterine development are demonstrated.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 5","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[IgG4-related lesion of the retroperitoneum, ureter, and kidney, mimicking infiltrating endometriosis].","authors":"I V Barinova, S G Radenska-Lopovok, D V Suslikova, O V Girya, T A Glebov, Yu I Sopova, E A Mamedov, A A Popov","doi":"10.17116/patol20268805174","DOIUrl":"10.17116/patol20268805174","url":null,"abstract":"<p><p>Urinary tract endometriosis is rare, and ureteral involvement is particularly insidious due to its asymptomatic nature. The absence of symptoms can lead to ureteral stricture, hydronephrosis, chronic kidney disease up to end-stage renal failure, and irreversible loss of kidney function. Diagnosis requires imaging methods to assess the degree of obstruction, while treatment involves surgical release of the ureter from endometriotic infiltrates to preserve organ function. Our observation illustrates the difficulty of establishing the etiology of a retroperitoneal tumor-like infiltrate leading to ureteral obstruction and hydronephrosis, as well as the need for differential diagnosis of endometriosis with other infiltrative processes.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 5","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[TRPS1 as a novel immunohistochemical marker in breast cancer diagnosis].","authors":"S V Vtorushin, N V Krakhmal, S S Naumov","doi":"10.17116/patol20268801180","DOIUrl":"10.17116/patol20268801180","url":null,"abstract":"<p><p>TRPS1 (Tricho-rhino-phalangeal syndrome type 1) - a transcription factor of the GATA family, has recently emerged as a promising immunohistochemical marker for breast cancer. This review summarizes current data on the diagnostic, prognostic, and potential therapeutic relevance of TRPS1, as well as its molecular functions and expression patterns across different breast cancer subtypes. TRPS1 demonstrates high sensitivity, including in diagnostically challenging cases such as triple-negative and poorly differentiated carcinomas, where traditional markers (GATA3, mammaglobin) may be absent or weakly expressed. The advantages of TRPS1 in the differential diagnosis of metastatic lesions and its possible role in prognostic panels are highlighted. Methodological limitations of the using marker, standardization needs and future perspectives for clinical implementation are also discussed in article.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}