Arkhiv patologii最新文献

{"title":"[Distinguishing relapse from sustained remission in acute myeloid leukemia. Lineage-specific developmental stage distributions].","authors":"S E Esipov, Yu A Krivolapov","doi":"10.17116/patol20268805129","DOIUrl":"10.17116/patol20268805129","url":null,"abstract":"<p><p>We characterize bone marrow cell populations at minimal residual disease (MRD) by their distribution across hematopoietic developmental stages within each major lineage. Using the BoneMarrowMap atlas (263.159 reference cells, 24 broad cell types) as a coordinate system, we assign each cell in a patient's MRD sample to a developmental stage along one of five lineages (myeloid, erythroid, B-cell, T/natural killer, dendritic). Each patient is then represented by stage histograms compared to four reference populations (healthy control, diagnosis, relapsed MRD, sustained-remission MRD) via uncertainty-normalized distances and adjacent-stage concordance <i>τ</i>_NN. Applied to 47 patients from four independent cohorts (Ennis et al. 2023, Lambo et al. 2023, Naldini et al. 2023, Beneyto-Calabuig et al. 2023; accessed through the Zeng et al. 2025 compendium), 28 of whom relapsed and 19 of whom remained in sustained remission, the combined feature set achieves area under the receiver operating characteristic curve (AUC) 0.95 by leave-one-out cross-validation, 0.93 by leave-two-out, and 0.92 by repeated 70/30 stratified splits. The dominant signal is developmental maturity at MRD: relapsing patients show a higher fraction of terminally differentiated cells across all lineages-particularly plasmacytoid dendritic cells and monocytes-while sustained-remission MRD retains more primitive cells and resembles healthy marrow. These signatures are measurable from standard single-cell RNA sequencing and a public reference atlas.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 5","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative analysis of endometrial receptivity in young women with endometrial and ovarian infertility factors].","authors":"D N Masalimova, L M Mikhaleva, M R Orazov, S A Mikhalev, V V Pechnikova, O A Parfyonova, A V Ilyichev, E V Kavteladze","doi":"10.17116/patol20268801126","DOIUrl":"10.17116/patol20268801126","url":null,"abstract":"<p><p>Infertility is a significant medical problem associated with morphological and functional changes in the endometrium and ovarian diseases that can lead to endometrial dysfunction. In this regard, it remains extremely important to study the role of endometrial and ovarian pathology in the development of infertility.</p><p><strong>Objective: </strong>Comparative analysis of endometrial receptivity in young women with endometrial and ovarian factors of infertility.</p><p><strong>Material and methods: </strong>We conducted a retrospective study that included 195 patients of reproductive age. Group 1 included patients with endometrial infertility factor (<i>n</i>=97), Group 2 included patients with ovarian infertility factor (<i>n</i>=38), Group 3 included women with a combination of both infertility factors (<i>n</i>=35). The comparison group consisted of women with infertility associated with male factor who were examined before IVF procedure (<i>n</i>=25). For pathomorphologic and immunohistochemical studies, the endometrium was sampled by pipelle biopsy on the 19^th-22^nd day of the menstrual cycle during the expected implantation window period.</p><p><strong>Results: </strong>Analysis of the results of the pathomorphologic study revealed different degrees of impaired development of pinopodes and delayed secretory transformation of the endometrium in patients of the three groups. Immunohistochemical study revealed a significant decrease in the expression level of estrogen receptors (ER) and increase in the expression of progesterone receptors (PR) in the glandular compartment in all studied groups compared to the comparison group, as well as a decrease in the expression level of ER in the stromal compartment of the endometrium in patients of groups 1 and 3.</p><p><strong>Conclusion: </strong>One of the leading causes of implantation disorders in patients with endometrial and ovarian infertility factors is impaired maturation of pinopodes, delayed secretory transformation of the endometrium and displacement of the implantation window, as well as decreased expression of ER and increased expression of PR in glandular compartments in patients of the studied groups compared to the morphological control group, decreased expression of ER in the stromal compartment, in patients of groups 1 and 3.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Molecular genetic characteristics of epithelial neoplasia of extrahepatic bile ducts].","authors":"D E Suraev, A A Barinov, I A Demidova, D Yu Kanner, O V Paklina, D V Kalinin, L A Marinova","doi":"10.17116/patol20268804128","DOIUrl":"https://doi.org/10.17116/patol20268804128","url":null,"abstract":"<p><strong>Objective: </strong>To determine the molecular genetic characteristics of the epithelial neoplasia of extrahepatic bile ducts (EHD) depending on the degree of epithelial dysplasia in order to identify mutations that facilitate their differential diagnosis.</p><p><strong>Material and methods: </strong>The study included 44 EHD biopsies containing epithelial neoplasms and cholangiocarcinoma. All samples underwent massive parallel sequencing of DNA isolated from 10-<i>μ</i>m-thick histological sections. Mutations of categories I-III of clinical significance were considered. Statistical analysis of the obtained data utilized a two-tailed Pearson <i>χ</i>² test with Holm's correction for multiple comparisons (<i>p</i><0.045).</p><p><strong>Results: </strong>The most frequent mutations in epithelial neoplasia of the EHD were identified: <i>MYC, KRAS, PIK3CA, CDKN2A, ERBB2, KIT 6, TP53 6, FBXW7, POLE</i> and <i>TERT.</i> The highest proportion of mutations was in biliary intraepithelial neoplasia and cholangiocarcinoma. Among epithelial neoplasia and cholangiocarcinoma, mutations in <i>KRAS, POLE</i> and <i>TERT</i> differed significantly. <i>KRAS</i> (<i>p</i><0.045) - BilIN LG and BilIN HG, IPNB HG and cholangiocarcinoma; <i>POLE</i> (<i>p</i><0.045) - BilIN LG and cholangiocarcinoma; <i>TERT</i> (<i>p</i><0.045) - BilIN LG and cholangiocarcinoma. Specificity and sensitivity indicators for <i>KRAS</i> were 28 and 50%; <i>POLE</i> - 35 and 100%; <i>TERT</i> - 100 and 100%.</p><p><strong>Conclusion: </strong>Mutations have been identified that should be considered in the differential diagnosis of the degree of epithelial dysplasia and the types of epithelial neoplasia of the extrahepatic bile ducts.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Errors and difficulties in diagnosing bronchiolar adenoma].","authors":"I V Dvorakovskaya, G A Raskin, S N Bugrov, Yu V Perminov, A O Nefedov, M M Mortada","doi":"10.17116/patol20268803154","DOIUrl":"10.17116/patol20268803154","url":null,"abstract":"<p><p>This article presents a rare clinical case of a 65-year-old female patient with bilateral lung lesions who underwent surgery for a ciliated muconodular papillary tumor/bronchiolar adenoma. The article highlights the challenges of differential diagnosis with adenocarcinoma during the preliminary examination stage during surgical planning, as well as the issues that arise during intraoperative examination. Multislice computed tomography data and the results of histological and immunohistochemical studies are presented. The histological features of proximal and distal types of bronchiolar adenoma are discussed. The differential diagnosis of bronchiolar adenoma from mucinous adenocarcinoma is discussed, along with a list of immunohistochemical markers used. Using this case as an example, the author presents the results of molecular genetic studies on bronchiolar adenoma, as well as published data.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 3","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Morphological and immunohistochemical characteristics of the heart of patients with COVID-19].","authors":"G A Lapii, M A Bakarev, E L Lushnikova","doi":"10.17116/patol20268801144","DOIUrl":"10.17116/patol20268801144","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the pathomorphological and immunohistochemical characteristics of the hearts of patients who died from COVID-19.</p><p><strong>Material and methods: </strong>A comprehensive pathomorphologic study of the heart in 88 autopsies of patients who died from severe COVID-19 was performed. The presence of SARS-CoV-2 infection was confirmed by positive PCR tests in all cases. Immunohistochemical study was used to analyze the expression of viral nucleocapsid protein (NP), CD3, CD68, CD31, CD34, Willebrand factor (vWF) in cell populations and myocardial structures.</p><p><strong>Results: </strong>In most cases, polymorphism of structural changes was observed, which was expressed in a combination of signs of chronic and acute myocardial damage. Numerous foci of interstitial and perivascular fibrosis and lipomatosis, irregular hypertrophy of cardiomyocytes, amyloid deposits were indicative of previous cardiovascular diseases. Acute and subacute pathological changes in myocardium included circulatory disorders (hyperemia, intraluminal megakaryocytes, microvascular thrombosis, interstitial edema), vascular damage, and alterative changes in cardiomyocytes. Lymphomacrophage infiltration was present in 45% of cases and was associated with immunohistochemical detection of NP in cardiomyocytes and vascular cells. Weak expression of CD31 and high expression of vWF in microvascular endothelium was found.</p><p><strong>Conclusion: </strong>NP expression in cardiomyocytes, macrophages and endothelial cells of cardiac vessels indicates their direct infection with SARS-CoV-2 virus and possible long-term persistence of viral infection. It was found that in severe COVID-19 CD3- and CD68-positive cells are detected in the heart; endothelial dysfunction is observed, which is indicated by decreased expression of CD31 and high expression of vWF. The identified myocardial changes may influence the development of post-COVID cardiovascular complications.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 1","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Differential diagnostics of inflammatory changes and epithelial neoplasia of extrahepatic bile ducts].","authors":"D E Suraev, D V Kalinin, L A Marinova, O V Paklina, D Yu Kanner","doi":"10.17116/patol20268802172","DOIUrl":"10.17116/patol20268802172","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the histological and immunohistochemical characteristics of epithelial neoplasia of the extrahepatic bile ducts (EHBD) and to develop a diagnostic algorithm.</p><p><strong>Material and methods: </strong>The study included 104 patients. All patients underwent biliary tract biopsy. Morphological and immunohistochemical parameters were compared in biopsies with inflammation, low- and high-grade biliary intraepithelial neoplasia (BilIN), low- and high-grade intraductal papillary neoplasia (IPNB), and cholangiocarcinoma (CC). The main parameters in the study of the histological characteristics of epithelial neoplasia of the EHBD were: cellular atypia, nuclear polymorphism, nuclear polarity, the state of the brush border, inflammatory infiltration, and histological architecture. Immunohistochemical studies were performed using antibodies to MUC1, MUC2, MUC5AC, MUC6, and CD10. When studying the IHC characteristics of epithelial neoplasms of the EHBD, the localization of the reaction in epithelial cells, its intensity, and prevalence were assessed, and specificity and sensitivity were evaluated. Statistical analysis of the data used the two-sided Pearson <i>χ</i>² criterion (<i>p</i><0.05).</p><p><strong>Results: </strong>Based on the results of the morphological stage of the study, a scale for assessing the degree of dysplasia in biopsy specimens was developed; a certain number of points were assigned to each type of epithelial neoplasia of the EHBD. Based on the results of the IHC study, taking into account statistically significant changes, an immunophenotype was established for each type of epithelial neoplasia of the EHBD: inflammation and BilIN LG - MUC1, MUC2, MUC6, CD10; BilIN HG - MUC1, MUC2, MUC5AC, MUC6; IPNB LG - MUC1, MUC2, MUC5AC, MUC6, CD10; IPNB HG - MUC1, MUC2, MUC5AC, MUC6; CC - MUC1, MUC5AC, MUC6. For differential diagnosis of the degree of dysplasia in epithelial neoplasia of the EHBD, it is recommended to use an IHC panel with the presence of antibodies to MUC1, MUC2, CD10. It is proposed to use antibodies to MUC2, MUC5AC and MUC6 as an IHC panel for differential diagnosis of IPNB subtypes.</p><p><strong>Conclusion: </strong>Clear morphological and immunohistochemical criteria for the differential diagnosis of non-invasive lesions of the EHBD, inflammation and cholangiocarcinoma have been identified, and an algorithm for the comprehensive differential diagnosis of epithelial neoplasia of the EHBD has been developed.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 2","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathomorphological features of various etiological forms of aortic aneurysm].","authors":"B A Magrupov, D A Alimov, A A Abdurakhmanov, O S Sultanov","doi":"10.17116/patol20268802143","DOIUrl":"10.17116/patol20268802143","url":null,"abstract":"<p><strong>Objective: </strong>To identify differential diagnostic pathomorphological features of the aortic wall structure in various forms of aortic aneurysm.</p><p><strong>Material and methods: </strong>The study was conducted in the Pathology Department of the Republican Research Center of Emergency Medicine (Tashkent, Uzbekistan) from January 2024 to September 2025. A total of 19 biological samples of aorta from patients with aortic aneurysms, from whom biological material was obtained intraoperatively, were studied. These included atherosclerotic lesions (<i>n</i>=9), Marfan syndrome (<i>n</i>=5), sinus of Valsalva rupture (<i>n</i>=3), and Takayasu syndrome (<i>n</i>=2). Histological preparations were examined using a Carl ZEISS Axiostar Plus microscope. Quantitative analysis was performed using Fiji by ImageJ software, and statistical analysis was conducted in SPSS 23.0.</p><p><strong>Results: </strong>In atherosclerosis, typical plaques with lipid cores, pronounced medial layer calcification, and cholesterol crystals were identified. In Marfan syndrome, focal destruction of elastic fibers in the tunica media and mucoid degeneration of the media with uneven accumulation of mucopolysaccharides were found. In sinus of Valsalva aneurysms, uneven thickness of collagen and reticulin fibers with pronounced edema of the middle layer was present. In Takayasu syndrome, inflammatory infiltration of the middle layer and marked reduction in smooth muscle fiber quantity were detected.</p><p><strong>Conclusion: </strong>Morphological examination of the aortic wall revealed significant differences in the structure and composition of wall components, confirming the heterogeneity of aortic aneurysm pathogenesis. Quantitative morphometric criteria for diagnosis verification were determined: elastic fiber density (<20% characteristic of Marfan syndrome), inflammatory cell count (>250/mm² specific for Takayasu arteritis), medial calcification (>40% indicates atherosclerotic origin).</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 2","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Morphological features of immune-related cutaneous adverse events associated with anti-PD-1/PD-L1 cancer immunotherapy].","authors":"A Yu Syryseva, E A Shatokhina, I A Pokataev, A A Bobyreva, N V Danilova","doi":"10.17116/patol20268804120","DOIUrl":"https://doi.org/10.17116/patol20268804120","url":null,"abstract":"<p><strong>Objective: </strong>To study the morphological patterns of immune-related cutaneous lesions (irCLs) that occur during antitumor immunotherapy in cancer patients.</p><p><strong>Material and methods: </strong>The study included 48 patients with the following nosology: malignant neoplasms of the skin and soft tissues - 20 patients (41.7%), malignant neoplasms of the genitourinary system - 13 (27%), malignant neoplasms of the lungs and bronchi - 9 (18.8%), malignant neoplasms of the upper respiratory tract - 5 (10.4%), malignant neoplasms of the gastrointestinal tract - 1 (2.1%), with immune-mediated skin lesions during treatment with pembrolizumab - 25 (52.1%), nivolumab - 18 (37.5%), prolgolimab - 4 (8.3%), avelumab - 1 (2.1%).</p><p><strong>Results: </strong>Among the irCLs in the study cohort, lichenoid - 14 (29.2%) cases and psoriasiform - 11 cases (22.9%) were predominant, while other morphological variants were significantly less common. IrCL morphologically mimic classic dermatoses, but have distinctive features indicating their drug-induced, immune-related nature.</p><p><strong>Conclusion: </strong>The study demonstrated that irCLs are clinically significant complications of PD-1/PD-L1 inhibitor therapy. Histological analysis confirmed their immunoinflammatory nature and revealed characteristic morphological changes, emphasizing the importance of routine skin biopsies for optimal patient management.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 4","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Identification of the entosis stages in situ in lung cancer tissue and their changes after neoadjuvant chemotherapy].","authors":"K A Gaptulbarova, M V Zavyalova, S S Naumov, S V Vtorushin, N V Litviakov","doi":"10.17116/patol20268803120","DOIUrl":"https://doi.org/10.17116/patol20268803120","url":null,"abstract":"<p><strong>Objective: </strong>To identify in situ stages of entosis in non-small cell lung cancer (NSCLC) tissue and to assess the impact of neoadjuvant chemotherapy (NACT) on their frequency.</p><p><strong>Material and methods: </strong>The study included 9 patients with morphologically verified NSCLC (stage T1-2N0-1M0-1) classified according to the WHO classification (2021). Four patients received NACT (vinorelbine + carboplatin), while five underwent surgery without prior therapy. Histological specimens were examined using Whole Slide Imaging (Pannoramic Mirax Midi, Carl Zeiss, Germany) and analyzed with Panoramic Viewer software. Entotic events were identified according to Mackay's criteria. Statistical analysis was performed using the Mann-Whitney U test.</p><p><strong>Results: </strong>All five lysosomal stages of entosis were successfully identified in situ. Stage II was the most frequently observed. In patients treated with NACT, Stage III was more common, suggesting a slowing of this phase, while the frequency of Stage V was significantly lower (<i>p</i>=0.01). A trend toward an overall increase in entotic events after NACT was noted; however, when normalized to tumor section area, no significant differences between groups were detected. For the first time in situ, variants of entomammoptosis were identified, including binucleated \"loser\" cells and mitosis of the internalized cell.</p><p><strong>Conclusion: </strong>Neoadjuvant chemotherapy does not increase the overall frequency of entosis in NSCLC tissue but alters the distribution of stages, prolonging Stage III and reducing the completion of the process at Stage V. The results expand current understanding of the role of entosis in tumor cell adaptation and the development of drug resistance in NSCLC.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 3","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Wolffian adnexal tumors (FATWO)].","authors":"O P Matylevich, I A Tarasau, S V Taranenka, M V Galka","doi":"10.17116/patol20268802180","DOIUrl":"10.17116/patol20268802180","url":null,"abstract":"<p><p>Tumors originating from the remnants of the mesonephral (Wolf's) duct, known as FATWO (Female Adnexal Tumor of Probable Wolffian Origin), belong to the category of rare neoplasms of the female reproductive system. The tumor was first described in 1973 by doctors Kariminijad and Scully from the University of Texas M.D. Anderson Cancer Center. Since then, about 100 cases of FATWO have been recorded worldwide. The localization of the tumor is associated with the threefold laying of the Wolf duct in embryogenesis: from the ovarian gate, along the mesosalpinx, in the wide ligament of the uterus along its lateral wall to the outer third of the vagina. This publication presents the case of a 57-year-old patient whose abdominal ultrasound revealed a bulky tumor of the right ovary. During intraoperative revision of the abdominal cavity and pelvic cavity, tumor masses were also found on the parietal peritoneum, mesentery of the sigmoid colon, in the large omentum, and fatty tissue of the anterior abdominal wall. A radical surgical intervention was performed with the removal of all metastatic foci. Upon histological examination, the structure and cytological signs of the formation were not characteristic of a tumor with a high degree of malignancy. Taking into account the results of the immunohistochemical study and the data of the clinical course, the diagnosis of FATWO was made. The rarity of this nosological form and its genetic heterogeneity create difficulties in the pathohistological diagnosis of neoplasms due to the presence of only relatively specific immunohistochemical markers, which make it possible to exclude more common tumors with a similar morphological pattern.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"88 2","pages":"80-86"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}