Guo-Bin Zhang , Hao-Yi Li , Wei-Jie Yu , Yu-Zhe Ying , Dao Zheng , Xiao-Kang Zhang , Yong-Gang Wang , Guang-Zhi Shi , Hua-Wei Huang
{"title":"Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis","authors":"Guo-Bin Zhang , Hao-Yi Li , Wei-Jie Yu , Yu-Zhe Ying , Dao Zheng , Xiao-Kang Zhang , Yong-Gang Wang , Guang-Zhi Shi , Hua-Wei Huang","doi":"10.1016/j.ajp.2024.104132","DOIUrl":"10.1016/j.ajp.2024.104132","url":null,"abstract":"<div><h3>Objectives</h3><p>Delirium is a significant health concern in acute stroke patients. We aim to systematically summarize existing evidence to conduct a meta-analysis to quantify the occurrence and risk factors for delirium after acute stroke.</p></div><div><h3>Method</h3><p>PubMed, EMBASE and MEDLINE were searched from inception to Feb. 2023 for prospective observational studies that reported the incidence or prevalence of post-stroke delirium and/or evaluated potential risk factors. The search strategy was created using controlled vocabulary terms and text words for stroke and delirium. We performed a meta-analysis of the estimates for occurrence and risk factors using random-effects models. Meta-regression and subgroup meta-analyses were conducted to explore the sources of heterogeneity. Study quality and quality of evidence were assessed using the customized Newcastle-Ottawa Scale and GRADE, respectively.</p></div><div><h3>Results</h3><p>Forty-nine studies that enrolled 12383 patients were included. The pooled occurrence rate of post-stroke delirium was 24.4 % (95 %CI, 20.4 %-28.9 %, I<sup>2</sup>=96.2 %). The pooled occurrence of hyperactive, hypoactive, and mixed delirium was 8.5 %, 5.7 % and 5.0 %, respectively. Study location, delirium assessment method and stroke type independently affected the heterogeneity of the pooled estimate of delirium. Statistically significant risk factors were older age, low education level, cigarette smoking, alcohol drinking, atrial fibrillation, lower ADL level, higher pre-stroke mRS score, premorbid cognitive impairment or dementia, aphasia, total anterior circulation impairment, higher National Institute of Health Stroke Scale score and infection.</p></div><div><h3>Conclusions</h3><p>Delirium affected 1 in 4 acute stroke patients, although reported rates may depend on assessment method and stroke type. Timely prevention, recognition and intervention require prioritizing patients with dominant risk factors.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876201824002259/pdfft?md5=4a1ccee08a6741d5190b3a7a0d9695c6&pid=1-s2.0-S1876201824002259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of the Malay version of the Patient Health Questionnaire-4 (PHQ-4) among Malaysian undergraduates","authors":"","doi":"10.1016/j.ajp.2024.104134","DOIUrl":"10.1016/j.ajp.2024.104134","url":null,"abstract":"<div><p>The study’s objective is to validate the Malay version of the Patient Health Questionnaire-4 (PHQ-4) among Malaysian undergraduates. A cross-sectional survey was distributed at three universities in Malaysia (<em>N</em> = 500; mean age = 21.66 ± 1.57). The internal consistency of the Malay PHQ-4 was acceptable (α = .78, 95 % <em>CI</em> [.74, .81]), while the test-retest reliability was good (ICC = .77, 95 % <em>CI</em> [.34, .91], <em>p</em> < .001). The one-factor structure showed the best fit in confirmatory factor analysis and was similar across sexes. The Malay PHQ-4 has acceptable psychometric properties and can be used for pre-clinical screening purposes among Malaysian undergraduate students.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Supporting suicide prevention among college students” [Asian J. Psychiatry (2023) 103324]","authors":"Dani Fadillah","doi":"10.1016/j.ajp.2024.104127","DOIUrl":"10.1016/j.ajp.2024.104127","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187620182400220X/pdfft?md5=a1ec5f70bfa50b9d8a7f8d234de20d2f&pid=1-s2.0-S187620182400220X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiseung Kang , Hyeri Lee , Soeun Kim , Hyeon Jin Kim , Hayeon Lee , Rosie Kwon , Yejun Son , Sunyoung Kim , Ho Geol Woo , Min Seo Kim , Ai Koyanagi , Lee Smith , Guillaume Fond , Laurent Boyer , Masoud Rahmati , Guillermo F. López Sánchez , Elena Dragioti , Marco Solmi , Jae Il Shin , Tae Kim , Samuele Cortese
{"title":"Comorbid health conditions in people with attention-deficit/hyperactivity disorders: An umbrella review of systematic reviews and meta-analyses","authors":"Jiseung Kang , Hyeri Lee , Soeun Kim , Hyeon Jin Kim , Hayeon Lee , Rosie Kwon , Yejun Son , Sunyoung Kim , Ho Geol Woo , Min Seo Kim , Ai Koyanagi , Lee Smith , Guillaume Fond , Laurent Boyer , Masoud Rahmati , Guillermo F. López Sánchez , Elena Dragioti , Marco Solmi , Jae Il Shin , Tae Kim , Samuele Cortese","doi":"10.1016/j.ajp.2024.104135","DOIUrl":"https://doi.org/10.1016/j.ajp.2024.104135","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to systematically review meta-analyses on the link between attention-deficit/hyperactivity disorder (ADHD) and a broad range of psychiatric, physical, and behavioral health conditions (PROSPERO; no.CRD42023448907).</p></div><div><h3>Results</h3><p>We identified 22 meta-analyses that included 544 primary studies, covering 76 unique conditions in over 234 million participants across 36 countries and six continents. We found high-certainty evidence for the associations between ADHD and neuropsychiatric conditions (bipolar disorders, personality disorders, schizophrenia, and pragmatic language skills), night awakenings, obesity, decayed incipient surfaces, asthma, astigmatism, hyperopia and hypermetropia, strabismus, and suicide ideation. Moderate-certainty evidence suggested that ADHD was associated with headache, mood/affective disorders, depression, bruxism, bone fractures, atopic rhinitis, vision problems, suicide attempts, completed suicide, and all-cause mortality. Low-certainty evidence indicated associations with eating disorders, sleep efficiency, type 2 diabetes, dental trauma prevalence, atopic diseases, and atopic dermatitis. Very low-certainty evidence showed associations between ADHD and several sleep parameters.</p></div><div><h3>Conclusion</h3><p>We found varied levels of evidence for the associations of ADHD with multiple health conditions. Therefore, clinicians should consider a wide range of neurological, psychiatric, sleep and suicide-related, metabolic, musculoskeletal, oral, allergic, and visual conditions, as well as the increased risk of mortality when assessing individuals with ADHD.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Clozapine in persons with a history of seizures: A retrospective study","authors":"Sandeep Grover, Arshia Sood, Subho Chakrabarti","doi":"10.1016/j.ajp.2024.104144","DOIUrl":"https://doi.org/10.1016/j.ajp.2024.104144","url":null,"abstract":"<div><h3>Background</h3><p>Seizures are considered to be one of the dreaded side effects of clozapine, and due to this, the use of clozapine is avoided in patients with treatment-resistant schizophrenia. Resultantly, there is little information about the use of clozapine among patients with seizure disorder.</p></div><div><h3>Aim</h3><p>To assess the safety of clozapine in patients with history of seizures in their lifetime before starting clozapine and receiving clozapine for the management of psychotic disorders.</p></div><div><h3>Results</h3><p>Out of the 958 patients, 35 (3.65 %) had a history of at least one seizure episode before starting clozapine, with a mean of 5.06 (SD: 7.23; Median: 3.00) seizures before starting clozapine. The mean duration between the last seizure and the starting of clozapine was 123.75 (SD: 124.99; Median: 84) months, with nine patients having an episode of seizure in the previous 12 months and 15 patients being seizure-free for more than ten years. About one-fourth (25.7 %; nine out of 35) of the patients had recurrence of seizure while receiving clozapine for a mean duration of about five years. When the recurrence of seizure after starting clozapine was evaluated in patients receiving antiepileptics along with clozapine, the incidence of at least one seizure was 26.67 % (4 out of 15), and among those not receiving antiepileptics, the incidence of at least one seizure was 25 % (5 out of 20). The dose of clozapine at which seizure was noted ranged from 12.5 mg to 600 mg/day with a mean of 236.25 (SD: 169.04; Median: 162.5) mg/day. In none of the patients, clozapine had to be stopped due to the continuation of seizures.</p></div><div><h3>Conclusion</h3><p>About one-fourth of the patients with history of an episode of seizure have recurrence of seizure while receiving clozapine. The demographic and clinical variables do not differ between those who develop and who do not develop seizures after starting clozapine, including concomitant use of antiepileptics.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoyun Guo , Xinqun Luo , Yong Zhang , Zongyang Yu , Zewen Tan , Liping Cao , Jiawu Ji , Xiaoping Wang , Kesheng Wang , Zhiren Wang , Chiang-shan R. Li , Yunlong Tan , Xingguang Luo
{"title":"Phenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder","authors":"Xiaoyun Guo , Xinqun Luo , Yong Zhang , Zongyang Yu , Zewen Tan , Liping Cao , Jiawu Ji , Xiaoping Wang , Kesheng Wang , Zhiren Wang , Chiang-shan R. Li , Yunlong Tan , Xingguang Luo","doi":"10.1016/j.ajp.2024.104145","DOIUrl":"10.1016/j.ajp.2024.104145","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fayaz Ahmad Paul , Arif Ali , Aasim Ur Rehman Ganie
{"title":"Dignity therapy: An emerging therapeutic approach for restoring meaning and purpose of patients in mental health care","authors":"Fayaz Ahmad Paul , Arif Ali , Aasim Ur Rehman Ganie","doi":"10.1016/j.ajp.2024.104129","DOIUrl":"https://doi.org/10.1016/j.ajp.2024.104129","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An experience of using Clozapine in elderly patients with mental disorders","authors":"Sandeep Grover, Pranshu Sharma, Subho Chakrabarti","doi":"10.1016/j.ajp.2024.104143","DOIUrl":"10.1016/j.ajp.2024.104143","url":null,"abstract":"<div><h3>Background</h3><p>There is little information on using clozapine in elderly patients with mental disorders from India.</p></div><div><h3>Aim</h3><p>To evaluate the sociodemographic and clinical profile of elderly (age ≥ 60 years) patients started on clozapine.</p></div><div><h3>Methodology</h3><p>The clozapine registry in the department was screened to identify elderly patients who were started on clozapine. Treatment records of these patients were reviewed to extract sociodemographic and clinical details.</p></div><div><h3>Results</h3><p>Out of the available information of 1058 patients in the registry, 42 (3.96 %) were elderly (≥ 60 years) patients. About two-thirds of the patients had treatment resistance, i.e., their psychotic illness had not responded to two adequate trials of antipsychotics, and the second most common indication for starting clozapine was tardive dystonia or tardive dyskinesia (23.8 %). The mean dose of clozapine was 135.89 (SD: 109.6; Range: 37.5–500; median: 87.5) mg/day. The mean duration of clozapine use at the time of data extraction for the study sample was 3.55 (SD: 2.15; Range 0.3–9; median: 3) years. At the last follow-up, about three-fourths of patients were experiencing at least one side effect, with constipation being the most common side effect, followed by sedation, weight gain, and hypersalivation. In only four patients, clozapine was stopped during the follow-up. In terms of effectiveness, majority of the patients were rated as much improved or very much improved on Clinical Global Impression-Improvement subscale.</p></div><div><h3>Conclusion</h3><p>Clozapine can be safely used in elderly patients with mental disorders. Hence, clozapine should not be withheld in elderly patients with mental disorders whenever indicated.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mental health among school children and adolescents in China: A comparison of one-child and multiple-children families from a nationwide survey","authors":"","doi":"10.1016/j.ajp.2024.104130","DOIUrl":"10.1016/j.ajp.2024.104130","url":null,"abstract":"<div><p>The influence of China’s “one-child” policy on the mental health of children and adolescents is still unclear. This study examined the associations between number of children and children’s mental health using data from the national school children and adolescents survey of China. Mental health was measured using the Achenbach’s Child Behavior Checklist (CBCL). Linear regression models were used to explore the relationship between number of children per family and children’s mental health. A total of 64,017 students were enrolled, with 68.60 % from one-child families. Compared with children from one-child families, those from multiple-children families had significantly higher scores on the total CBLC and each of its subscales (all <em>P</em><0.001). Analyses suggested children from multiple-child families have a higher risk of mental health problems (total problems on the CBCL: adjusted B=2.217, 95 %CI=1.883–2.550, <em>P</em><0.001). Regular mental health assessments should be implemented and effective interventions should be developed for those in need.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}