Tingting Li , Yiding Han , Haohao Yan , Dongsheng Lv , Ping Yao , Lixia Chen , Yonggui Yuan , Jingping Zhao , Wenbin Guo , Zhiguo Guo , Bing Lang
{"title":"Prediction of treatment efficacy in the suanzaoren decoction and estazolam for chronic insomnia disorder, along with brain function and cognitive changes before and after treatment, and potential gene expression profiles","authors":"Tingting Li , Yiding Han , Haohao Yan , Dongsheng Lv , Ping Yao , Lixia Chen , Yonggui Yuan , Jingping Zhao , Wenbin Guo , Zhiguo Guo , Bing Lang","doi":"10.1016/j.ajp.2025.104563","DOIUrl":"10.1016/j.ajp.2025.104563","url":null,"abstract":"<div><h3>Objective</h3><div>This study compared the brain function changes in chronic insomnia disorder (CID) before and after treatment by suanzaoren decoction (SZRD) and estazolam, to reveal their effects in cognition improvement, and to explore the potential genetic basis underpinning the ReHo changes in CID.</div></div><div><h3>Methods</h3><div>We recruited 54 healthy controls (HCs) and 82 patients diagnosed with CID. All patients conducted clinical evaluation and fMRI scanning at baseline and after SZRD or estazolam treatment for six weeks. We used the mixed-effects model analysis to assess the pharmacological treatment response. Machine learning and transcriptome-neuroimaging spatial correlation analysis based on ReHo were presented to forecast therapeutic response and gene profiles.</div></div><div><h3>Results</h3><div>Compared to HCs, CID patients exhibited altered ReHo values in the right inferior parietal gyrus, left posterior cingulate cortex, left superior parietal gyrus, and left precuneus. Both the SZRD and estazolam groups demonstrated improvement in sleep duration and efficiency. Compared to the baseline, the SZRD group presented decreased ReHo value in the left supramarginal gyrus, increased ReHo value in the right middle occipital gyrus (MOG) and increased CoHe-ReHo value in the left MOG. The estazolam group showed no changes. The machine learning model fit the samples well, with predicted changes in PSQI and ISI scores positively correlated with actual changes. Additionally, genes associated with the imaging results were identified.</div></div><div><h3>Conclusions</h3><div>SZRD can improve CID symptoms and present advantages to cognitive function. Abnormal ReHo changes may serve as imaging markers for CID and predict drug efficacy and gene expression profiles related to CID.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104563"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oshini Sri Jayasinghe (also known as ‘V P K Krishani Jayasinghe’) , Asiri Hewamalage , Athula Sumathipala , Siham Sikander , Atif Rahman
{"title":"“Nothing about us, without us”: Translation and cultural adaptation of the Thinking Healthy Programme for perinatal depression to Sri Lankan context using a co-designing approach","authors":"Oshini Sri Jayasinghe (also known as ‘V P K Krishani Jayasinghe’) , Asiri Hewamalage , Athula Sumathipala , Siham Sikander , Atif Rahman","doi":"10.1016/j.ajp.2025.104564","DOIUrl":"10.1016/j.ajp.2025.104564","url":null,"abstract":"<div><h3>Introduction</h3><div>‘Thinking Healthy Program’ (THP) is an evidence-based psychosocial intervention endorsed by the World Health Organization as the first line of treatment for perinatal depression (PND), especially in low & middle-income countries. Sri Lanka, a low & middle-income country in Southeast Asia, is yet to introduce an intervention to the existing national maternal and child health programme to address PND. The THP is required to be adapted to the Sri Lankan context before implementation.</div></div><div><h3>Objectives</h3><div>We adapted the THP to the Sri Lankan context. In this article, the process and outcomes of the adaptation of THP is reported.</div></div><div><h3>Methods</h3><div>The THP materials were adapted using a co-designing approach. Adaptation was carried out in steps including translation & back translation and cultural adaptation of the manual, checking the manual for its face validity, and pre-testing the documents. The adaptation was guided by the Bernal Framework of Translation and Adaptation of Interventions.</div></div><div><h3>Results</h3><div>Key adaptations were made in the THP in the areas of language, concepts, contexts, individuals, and delivery methods. No significant changes were made to the structure and the content. A supplementary document including metaphors that can be used to describe mental health-related concepts in the local context was prepared. It was identified that the translation and the adaptations were relevant, understandable, and acceptable to stakeholders.</div></div><div><h3>Conclusions</h3><div>The adapted version of the THP is relevant within the Sri Lankan cultural and healthcare context and might be suitable to be introduced to the existing Sri Lankan maternal and child health programme.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104564"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crisis help line and suicide prevention in Bangladesh: Challenges and ways ahead","authors":"S.M. Yasir Arafat , Chandrima Mourin, Rubina Jahan","doi":"10.1016/j.ajp.2025.104565","DOIUrl":"10.1016/j.ajp.2025.104565","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104565"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Minor physical anomalies in patients with bipolar disorder – A cross-sectional study done in a tertiary psychiatric institute","authors":"S. D’silva, P. Jayaprakash","doi":"10.1016/j.ajp.2025.104562","DOIUrl":"10.1016/j.ajp.2025.104562","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104562"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sri Padma Sari , Halimah Wenny Yulina Astuti, Haipeng Liu, Andy Turner, Faith Martin
{"title":"Gender differences in resilience among patients with schizophrenia","authors":"Sri Padma Sari , Halimah Wenny Yulina Astuti, Haipeng Liu, Andy Turner, Faith Martin","doi":"10.1016/j.ajp.2025.104557","DOIUrl":"10.1016/j.ajp.2025.104557","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104557"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yajing Sun , Quan Zhang , Weijian Wu , Junkang Lin , Shufang Sun , Jing An , Diyang Qu , Runsen Chen
{"title":"Efficacy of a localized caregiver gatekeeper training program for suicide prevention among Chinese adolescents: A pilot study","authors":"Yajing Sun , Quan Zhang , Weijian Wu , Junkang Lin , Shufang Sun , Jing An , Diyang Qu , Runsen Chen","doi":"10.1016/j.ajp.2025.104555","DOIUrl":"10.1016/j.ajp.2025.104555","url":null,"abstract":"<div><div>Gatekeeper programmes seldom focus on caregivers, even though they are on the frontline of adolescent suicide prevention. In this pilot, caregivers completed the Chinese Life Gatekeeper Training Programme, which covered risk recognition, suicide communication, safety planning and referral skills. Suicide literacy (LOSS), stigma (SOSS), perceived competence and willingness to intervene (WIS) were assessed at baseline, immediately after training and at one month follow-up. Linear mixed-effects models adjusted for sex, socioeconomic status and marital status showed significant post-training gains in suicide literacy (β = 2.833, p <.001) and reductions in stigma (β = −4.50, p <.001); literacy remained higher at follow‑up (β = 2.199, p <.001). Caregivers also successfully identified and referred at‑risk adolescents, and overall training satisfaction was high. These results indicate that a culturally adapted, gatekeeper programme is feasible, acceptable and effective for enhancing key caregiver competencies in suicide prevention among Chinese adolescents. Larger controlled studies with extended follow-up are needed to confirm and extend these findings.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104555"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thinking bipolar disorder as a symptom rather than a disease","authors":"Ming Zheng","doi":"10.1016/j.ajp.2025.104540","DOIUrl":"10.1016/j.ajp.2025.104540","url":null,"abstract":"<div><div>Bipolar affective disorder (BAD), a major global health challenge, has traditionally been classified as a distinct psychiatric condition characterized by episodes of mania and depression. Recent findings suggest that BAD may not represent a singular disease but rather a manifestation of broader, interconnected pathophysiological processes underlying mood dysregulation. This study proposes a paradigm shift, conceptualizing BAD as a shared symptom reflecting common pathophysiological mechanisms rather than a discrete disorder. Through a systematic disease-wide association study (DWAS) of over 7,000 BAD patients and 337,000 controls, this study identified a wide range of comorbid conditions across multiple organ systems—neurological, metabolic, gastrointestinal, cardiovascular, and immune-related disorders. These comorbidities indicate a deeper etiological connection rather than coincidental associations. This study suggests that BAD is part of a larger, transdiagnostic continuum, supporting the growing emphasis on dimensional models of psychopathology. This reconceptualization offers important clinical advantages, including enhanced diagnostic accuracy, integrated interventions targeting common pathophysiological pathways, and more effective patient management. By transcending traditional diagnostic boundaries, this approach fosters precision psychiatry and lays the groundwork for future research focused on shared biomarkers and therapeutic targets, ultimately improving the clinical care and outcomes for individuals with mood disorders.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104540"},"PeriodicalIF":3.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhamad Idris, Rahmad Fauzi, Hermansyah, Aldora Pratama, Dina Sri Nindiati, Erfan Ramadhani, Ramtia Darma Putri, Afdhal Ilahi
{"title":"Enhancing well-being in juvenile justice: Insights from a low-intensity mental health intervention","authors":"Muhamad Idris, Rahmad Fauzi, Hermansyah, Aldora Pratama, Dina Sri Nindiati, Erfan Ramadhani, Ramtia Darma Putri, Afdhal Ilahi","doi":"10.1016/j.ajp.2025.104545","DOIUrl":"10.1016/j.ajp.2025.104545","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104545"},"PeriodicalIF":3.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exposure therapy for capgras syndrome in schizophrenia: A novel case report","authors":"Ron Walfisch , Dor Hadida Barzilai","doi":"10.1016/j.ajp.2025.104547","DOIUrl":"10.1016/j.ajp.2025.104547","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104547"},"PeriodicalIF":3.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayed M. Ismail, Mohamad Ahmad Saleem Khasawneh, Ashish Kakkad, H. Malathi, Aniruddh Dash, Ashish Singh Chauhan
{"title":"Cognitive-Environmental Coherence Theory (CECT): A novel framework for culturally-embedded mental health","authors":"Sayed M. Ismail, Mohamad Ahmad Saleem Khasawneh, Ashish Kakkad, H. Malathi, Aniruddh Dash, Ashish Singh Chauhan","doi":"10.1016/j.ajp.2025.104536","DOIUrl":"10.1016/j.ajp.2025.104536","url":null,"abstract":"<div><div>This study introduces the Cognitive-Environmental Coherence Theory (CECT), a novel theoretical framework redefining mental health as an emergent outcome of dynamic alignment between internal cognitive schemas and external environmental structures. Grounded in cultural psychology and systems theory, CECT challenges biomedical individualism by emphasizing culturally embedded mental processes and ecological congruence. Cross-national evidence from six Asian countries supports the model, demonstrating that schema-environment coherence predicts resilience and psychological well-being, while misalignment exacerbates distress. CECT offers a scientifically grounded, culturally responsive paradigm with transformative implications for global mental health research, policy, and practice.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104536"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}