Jiahong Su, Jingfeng Su, Weidong Tang, Hengzi Chen, Jiaming Su, Quliang Chen, Handi Zhang
{"title":"Longitudinal analysis of peripheral C3, C4 and CRP in patients with schizophrenia and their association with antipsychotic treatment efficacy","authors":"Jiahong Su, Jingfeng Su, Weidong Tang, Hengzi Chen, Jiaming Su, Quliang Chen, Handi Zhang","doi":"10.1016/j.ajp.2025.104621","DOIUrl":"10.1016/j.ajp.2025.104621","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104621"},"PeriodicalIF":3.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The clozapine package inserts need to reflect lower doses for Asians","authors":"Jose de Leon , Rajiv Tandon","doi":"10.1016/j.ajp.2025.104622","DOIUrl":"10.1016/j.ajp.2025.104622","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104622"},"PeriodicalIF":3.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindsey Bertin , Jeffrey S. Katz , Gopikrishna Deshpande , Frank Krueger
{"title":"Beyond the human touch: A critical review of the promise and challenges of animal- and robot-assisted therapy in loneliness and mental healthcare","authors":"Lindsey Bertin , Jeffrey S. Katz , Gopikrishna Deshpande , Frank Krueger","doi":"10.1016/j.ajp.2025.104615","DOIUrl":"10.1016/j.ajp.2025.104615","url":null,"abstract":"<div><div>Mental health disorders, including depression, anxiety, post-traumatic stress disorder, and dementia, are increasingly recognized as exacerbated by social isolation and loneliness, prompting growing interest in Artificial Intelligence (AI) driven and robotic interventions for social support. Traditional interventions such as animal-assisted therapy (AAT) have demonstrated effectiveness by leveraging the human-animal bond to reduce stress, enhance social engagement, and improve emotional well-being. However, AAT faces logistical challenges, including availability, cost, and animal welfare concerns. In response, robot-assisted therapy (RAT) has emerged as a scalable alternative, offering consistent social interaction and emotional support without the limitations of live animals. Advances in AI have enhanced RAT’s potential by enabling more adaptive, engaging interactions, yet questions remain regarding these connections' emotional significance and depth. This review critically evaluates the efficacy of AAT and RAT in addressing mental health disorders, comparing their impact on loneliness, stress, and mental health outcomes. While AAT has demonstrated moderate yet significant benefits across various populations, its accessibility remains limited. Early RAT studies suggest potential in mitigating loneliness and improving mood, particularly in older adults and individuals with neurodevelopmental disorders. However, methodological limitations and uncertainties about emotional depth persist. Future research should enhance robotic interventions through greater emotional responsiveness, personalization, and long-term engagement. Ethical concerns surrounding data privacy and user attachment must be addressed to ensure responsible implementation. By examining the strengths and limitations of both approaches, this review discusses the evolving role of social robotics in mental healthcare, highlighting the need for further investigation to optimize therapeutic potential.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104615"},"PeriodicalIF":3.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huang-Li Lin, Yueh-Pin Lin, Tian-Mei Si, Roy Abraham Kalliyalil, Andi J. Tanra, Amir Hossein Jalali Nadoushan, Toshiya Inada, Seon-Cheol Park, Kok Yoon Chee, Afzal Javed, Kang Sim, Kuan-Lun Huang, Pornjira Pariwatcharakul, Norman Sartorius, Mian-Yoon Chong, Naotaka Shinfuku, Takahiro A. Kato, Shih-Ku Lin
{"title":"Diagnostic distribution of antidepressant users: Findings from the REAP-AD3 study","authors":"Huang-Li Lin, Yueh-Pin Lin, Tian-Mei Si, Roy Abraham Kalliyalil, Andi J. Tanra, Amir Hossein Jalali Nadoushan, Toshiya Inada, Seon-Cheol Park, Kok Yoon Chee, Afzal Javed, Kang Sim, Kuan-Lun Huang, Pornjira Pariwatcharakul, Norman Sartorius, Mian-Yoon Chong, Naotaka Shinfuku, Takahiro A. Kato, Shih-Ku Lin","doi":"10.1016/j.ajp.2025.104617","DOIUrl":"10.1016/j.ajp.2025.104617","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104617"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bridging the silent crisis: Strengthening mental health support for university students in the Philippines","authors":"Danilo V. Rogayan Jr.","doi":"10.1016/j.ajp.2025.104616","DOIUrl":"10.1016/j.ajp.2025.104616","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104616"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuni Nur Rohman, Berlima Pasaribu, Anne Hafina Adiwinata, Ipah Saripah, Eka Sakti Yudha
{"title":"Adolescent mental health policy: A reflection on policy gaps and urgent needs in Indonesia","authors":"Yuni Nur Rohman, Berlima Pasaribu, Anne Hafina Adiwinata, Ipah Saripah, Eka Sakti Yudha","doi":"10.1016/j.ajp.2025.104619","DOIUrl":"10.1016/j.ajp.2025.104619","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104619"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonmoy Alam Shuvo, Sorif Hossain, Riyadh Hossain, Nelufa Aktar
{"title":"Suicide attempts among female adolescents: A study of risk factors in the Philippines","authors":"Tonmoy Alam Shuvo, Sorif Hossain, Riyadh Hossain, Nelufa Aktar","doi":"10.1016/j.ajp.2025.104618","DOIUrl":"10.1016/j.ajp.2025.104618","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104618"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of an automated digital neuropsychological assessment system (DNAS)","authors":"Li Liang , Chetwyn C.H. Chan , Tatia M.C. Lee","doi":"10.1016/j.ajp.2025.104612","DOIUrl":"10.1016/j.ajp.2025.104612","url":null,"abstract":"<div><h3>Introduction</h3><div>Diagnosing neurocognitive disorders, mild or major, requires a comprehensive assessment of domains of cognitive functions according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Conventional neuropsychological assessments, usually conducted on a one-to-one assessment format, are under constant challenge of the demand on manpower and time resources, let alone its limited scalability to serve a larger population. Entering the era of digital healthcare emphasizing scalability, accessibility, and cost-effectiveness in delivering healthcare services, we have developed an automated digital neuropsychological assessment system - the Digital Neuropsychological Assessment System (DNAS), administered in individual or group format with minimal supervision.</div></div><div><h3>Methods</h3><div>We conducted a validation study of the DNAS, which encompasses 13 subtests assessing a spectrum of cognitive domains delineated in the DSM-5-TR for diagnosing neurocognitive disorders. These 13 tests fall in the domains of processing speed, attention, working memory, visual and verbal memory, spatial judgment, higher-order cognition, and social cognition tests.</div></div><div><h3>Results</h3><div>On a sample of 60 Chinese-speaking younger adults (mean age = 25.4 years old, SD = 3.6 years), we demonstrated the criterion validity (<em>r</em>s or <em>ρ</em>s = .30 to .62) substantiated by the significant correlations between the DNAS and conventional assessment results.</div></div><div><h3>Conclusions</h3><div>Our findings confirmed that the DNAS is a promising alternative to conventional neuropsychological assessments in the era of digital healthcare. The DNAS contributes to improving the cost-effectiveness of delivering neuropsychological services and research. Its automated design enhances the scalability of neuropsychological services to people whose access to healthcare settings is limited.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104612"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating LMICs challenges through educational and legal reforms to strengthen adolescent mental health in Indonesia","authors":"Zalik Nuryana, Atqo Darmawan Aji, Herdian Herdian","doi":"10.1016/j.ajp.2025.104614","DOIUrl":"10.1016/j.ajp.2025.104614","url":null,"abstract":"<div><div>Adolescent mental health represents a critical yet underserved public health issue, particularly in low- and middle-income countries (LMICs) such as Indonesia. Responding positively to Ramaswamy et al. call for a paradigm shift towards adolescent-centered policy frameworks, this editorial explores the integration of educational strategies and legal frameworks to enhance adolescent mental health interventions. Despite Indonesia's progressive legislation, including the Mental Health Law (No.18/2014) and Juvenile Justice System Law (No.11/2012), substantial gaps remain in youth participation and comprehensive preventive measures. This letter proposes strengthening education-based mental health interventions and restorative justice mechanisms. It further advocates for meaningful adolescent engagement in research and policymaking, positioning education and law as key sectors for navigating LMIC-specific challenges in building resilient adolescent populations.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104614"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Wang Fung , Antonia Leousi , Anson Kai Chun Chau , Ka Yan Sit , Cheuk Chi Lam , Celine Mylx Li , Chak Hei Ocean Huang , Cherry Tin Yan Cheung , Stanley Kam Ki Lam , Edward K.S. Wang , Grace Wing Ka Ho
{"title":"Prevalence of ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD in the general populations: A systematic review and meta-analysis","authors":"Hong Wang Fung , Antonia Leousi , Anson Kai Chun Chau , Ka Yan Sit , Cheuk Chi Lam , Celine Mylx Li , Chak Hei Ocean Huang , Cherry Tin Yan Cheung , Stanley Kam Ki Lam , Edward K.S. Wang , Grace Wing Ka Ho","doi":"10.1016/j.ajp.2025.104610","DOIUrl":"10.1016/j.ajp.2025.104610","url":null,"abstract":"<div><div>The ICD-11 has revised the diagnostic criteria for post-traumatic stress disorder (PTSD) and introduced complex PTSD (CPTSD) as a new diagnosis. This study presents the first systematic review and meta-analysis of ICD-11 PTSD and CPTSD prevalence in general population samples. In this pre-registered review (CRD42024579951), we searched the Web of Science, Scopus, and PubMed databases to identify potentially relevant articles. Meta-analyses were conducted among (1) samples from non-war exposed/economically developed countries/regions and (2) samples from war-exposed/less economically developed countries/regions. Out of 835 unique records, 10 eligible studies examining ICD-11 PTSD and CPTSD in representative adult general population samples were included. Most studies were assessed as having a “low risk” of bias across all quality domains. The studies were conducted in Ukraine (3), Germany (2), Republic of Ireland (2), Hong Kong, Israel, Kenya, Nigeria, and Ghana. All studies used the International Trauma Questionnaire (ITQ) to assess ICD-11 PTSD and CPTSD. In the five samples from non-war-exposed/economicallydeveloped countries/regions, the pooled prevalence rates for PTSD and CPTSD were 2 % and 4 %, respectively, based on a total of 7718 participants. In the five samples from war-exposed/less economically developed countries/regions, the pooled prevalence rates for PTSD and CPTSD were 16 % and 15 %, respectively, based on a total of 9870 participants. Given the high prevalence of PTSD and CPTSD, especially in war-exposed/less economically developed countries, there is a pressing need for more effective and scalable interventions to support affected populations. Pooled prevalence rates should be cautiously interpreted due to a limited number of studies.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104610"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}