Asian journal of psychiatry最新文献

{"title":"Crisis help line and suicide prevention in Bangladesh: Challenges and ways ahead","authors":"S.M. Yasir Arafat , Chandrima Mourin, Rubina Jahan","doi":"10.1016/j.ajp.2025.104565","DOIUrl":"10.1016/j.ajp.2025.104565","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104565"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a localized caregiver gatekeeper training program for suicide prevention among Chinese adolescents: A pilot study","authors":"Yajing Sun ,&nbsp;Quan Zhang ,&nbsp;Weijian Wu ,&nbsp;Junkang Lin ,&nbsp;Shufang Sun ,&nbsp;Jing An ,&nbsp;Diyang Qu ,&nbsp;Runsen Chen","doi":"10.1016/j.ajp.2025.104555","DOIUrl":"10.1016/j.ajp.2025.104555","url":null,"abstract":"<div><div>Gatekeeper programmes seldom focus on caregivers, even though they are on the frontline of adolescent suicide prevention. In this pilot, caregivers completed the Chinese Life Gatekeeper Training Programme, which covered risk recognition, suicide communication, safety planning and referral skills. Suicide literacy (LOSS), stigma (SOSS), perceived competence and willingness to intervene (WIS) were assessed at baseline, immediately after training and at one month follow-up. Linear mixed-effects models adjusted for sex, socioeconomic status and marital status showed significant post-training gains in suicide literacy (β = 2.833, p &lt;.001) and reductions in stigma (β = −4.50, p &lt;.001); literacy remained higher at follow‑up (β = 2.199, p &lt;.001). Caregivers also successfully identified and referred at‑risk adolescents, and overall training satisfaction was high. These results indicate that a culturally adapted, gatekeeper programme is feasible, acceptable and effective for enhancing key caregiver competencies in suicide prevention among Chinese adolescents. Larger controlled studies with extended follow-up are needed to confirm and extend these findings.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104555"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking bipolar disorder as a symptom rather than a disease","authors":"Ming Zheng","doi":"10.1016/j.ajp.2025.104540","DOIUrl":"10.1016/j.ajp.2025.104540","url":null,"abstract":"<div><div>Bipolar affective disorder (BAD), a major global health challenge, has traditionally been classified as a distinct psychiatric condition characterized by episodes of mania and depression. Recent findings suggest that BAD may not represent a singular disease but rather a manifestation of broader, interconnected pathophysiological processes underlying mood dysregulation. This study proposes a paradigm shift, conceptualizing BAD as a shared symptom reflecting common pathophysiological mechanisms rather than a discrete disorder. Through a systematic disease-wide association study (DWAS) of over 7,000 BAD patients and 337,000 controls, this study identified a wide range of comorbid conditions across multiple organ systems—neurological, metabolic, gastrointestinal, cardiovascular, and immune-related disorders. These comorbidities indicate a deeper etiological connection rather than coincidental associations. This study suggests that BAD is part of a larger, transdiagnostic continuum, supporting the growing emphasis on dimensional models of psychopathology. This reconceptualization offers important clinical advantages, including enhanced diagnostic accuracy, integrated interventions targeting common pathophysiological pathways, and more effective patient management. By transcending traditional diagnostic boundaries, this approach fosters precision psychiatry and lays the groundwork for future research focused on shared biomarkers and therapeutic targets, ultimately improving the clinical care and outcomes for individuals with mood disorders.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104540"},"PeriodicalIF":3.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing well-being in juvenile justice: Insights from a low-intensity mental health intervention","authors":"Muhamad Idris,&nbsp;Rahmad Fauzi,&nbsp;Hermansyah,&nbsp;Aldora Pratama,&nbsp;Dina Sri Nindiati,&nbsp;Erfan Ramadhani,&nbsp;Ramtia Darma Putri,&nbsp;Afdhal Ilahi","doi":"10.1016/j.ajp.2025.104545","DOIUrl":"10.1016/j.ajp.2025.104545","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104545"},"PeriodicalIF":3.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure therapy for capgras syndrome in schizophrenia: A novel case report","authors":"Ron Walfisch ,&nbsp;Dor Hadida Barzilai","doi":"10.1016/j.ajp.2025.104547","DOIUrl":"10.1016/j.ajp.2025.104547","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104547"},"PeriodicalIF":3.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-Environmental Coherence Theory (CECT): A novel framework for culturally-embedded mental health","authors":"Sayed M. Ismail,&nbsp;Mohamad Ahmad Saleem Khasawneh,&nbsp;Ashish Kakkad,&nbsp;H. Malathi,&nbsp;Aniruddh Dash,&nbsp;Ashish Singh Chauhan","doi":"10.1016/j.ajp.2025.104536","DOIUrl":"10.1016/j.ajp.2025.104536","url":null,"abstract":"<div><div>This study introduces the Cognitive-Environmental Coherence Theory (CECT), a novel theoretical framework redefining mental health as an emergent outcome of dynamic alignment between internal cognitive schemas and external environmental structures. Grounded in cultural psychology and systems theory, CECT challenges biomedical individualism by emphasizing culturally embedded mental processes and ecological congruence. Cross-national evidence from six Asian countries supports the model, demonstrating that schema-environment coherence predicts resilience and psychological well-being, while misalignment exacerbates distress. CECT offers a scientifically grounded, culturally responsive paradigm with transformative implications for global mental health research, policy, and practice.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104536"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning in neuroimaging and computational pathophysiology of Parkinson’s disease: A comprehensive review and meta-analysis","authors":"Khushi Sharma,&nbsp;Manjula Shanbhog,&nbsp;Kuljeet Singh","doi":"10.1016/j.ajp.2025.104537","DOIUrl":"10.1016/j.ajp.2025.104537","url":null,"abstract":"<div><div>In recent years, machine learning and deep learning have shown potential for improving Parkinson's disease (PD) diagnosis, one of the most common neurodegenerative diseases. This comprehensive analysis examines machine learning and deep learning-based Parkinson's disease diagnosis using MRI, speech, and handwriting datasets. To thoroughly analyze PD, this study collected data from scientific literature, experimental investigations, publicly accessible datasets, and global health reports. This study examines the worldwide historical setting of Parkinson's disease, focusing on its increasing prevalence and inequities in treatment access across various regions. A comprehensive summary consolidates essential findings from clinical investigations and pertinent datasets related to Parkinson's disease management. The worldwide context, prospective treatments, therapies, and drugs for Parkinson's disease have been thoroughly examined. This analysis identifies significant research deficiencies and suggests future methods, emphasizing the necessity for more extensive and diverse datasets and improved model accessibility. The current study proposes the Meta-Park model for diagnosing Parkinson’s disease, achieving training, testing, and validation accuracy of 97.67 %, 95 %, and 94.04 %. This method provides a dependable and scalable way to improve clinical decision-making in managing Parkinson's disease. This research seeks to provide innovative, data-driven decisions for early diagnosis and effective treatment by merging the proposed method with a thorough examination of existing interventions, providing renewed hope to patients and the medical community.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104537"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study of risk factors and new prediction model for inpatient aggression in a Turkish forensic psychiatric cohort with psychotic illness","authors":"Yasin Hasan Balcioglu ,&nbsp;Melih Avci ,&nbsp;Fatih Oncu ,&nbsp;Mehmet Sinan Iyisoy ,&nbsp;Sakir Gica ,&nbsp;Jonas Forsman ,&nbsp;Howard Ryland","doi":"10.1016/j.ajp.2025.104538","DOIUrl":"10.1016/j.ajp.2025.104538","url":null,"abstract":"<div><h3>Background</h3><div>Aggression among psychiatric inpatients causes harm and disrupts care. While often linked to modifiable risk factors, their role remains unclear, and many prediction tools overlook them. This study aimed to assess the relationship between risk factors and inpatient aggression among forensic patients with psychotic disorders in Turkiye and to develop a population-specific prediction model.</div></div><div><h3>Methods</h3><div>Eight static and ten dynamic risk factors were assessed. Dynamic factors were collected fortnightly, with the outcome defined as any physical or verbal aggression between assessment rounds. Multilevel logistic regression analyses assessed the association between dynamic risk factors and outcomes. A new population-specific prediction model was developed by refitting the previously developed elsewhere (FOxWeb). Models incorporating fixed effects were used to assess predictive performance.</div></div><div><h3>Results</h3><div>Over four months, 102 forensic psychiatric inpatients underwent 811 dynamic risk assessments, with 603 aggressive incidents recorded. Forty-two patients were involved in at least one incident. Many dynamic factors were significantly associated with outcomes in both univariable and multivariable analyses. The total dynamic score was a significant predictor, improving the discrimination of the fixed-effects model (AUC = 0.84, 95 % CI: 0.81–0.87) compared to the model using static factors alone (AUC=0.73, 95 % CI: 0.69–0.77).</div></div><div><h3>Conclusion</h3><div>Combining dynamic and static factors in the prediction model showed strong performance for assessing aggression risk. Refitting existing prediction models to specific populations may offer enhanced performance, but this requires external validation in independent samples as development models may be overfitted. Highly quality predicative models could enhance interventions, optimize resource use, and improve clinical decision-making.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104538"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased left brain specialization in bipolar disorder patients and its association with neurotransmitter and genetic profiles: A longitudinal study","authors":"Leyi Zhang ,&nbsp;Yiding Han ,&nbsp;Haohao Yan ,&nbsp;Chunguo Zhang ,&nbsp;Xiaoling Li ,&nbsp;Jiaquan Liang ,&nbsp;Chaohua Tang ,&nbsp;Weibin Wu ,&nbsp;Wen Deng ,&nbsp;Guojun Xie ,&nbsp;Wenbin Guo","doi":"10.1016/j.ajp.2025.104539","DOIUrl":"10.1016/j.ajp.2025.104539","url":null,"abstract":"<div><div>Brain specialization plays a crucial role in human behavior and cognition. Previous studies have suggested abnormal specialization in psychiatric disorders; however, the specialization patterns of bipolar disorder (BD) and the effects of medication on these changes remain unclear. According to Crow’s hypothesis regarding the key role of language in the origin of psychoses, BD patients (BDPs) may exhibit abnormal language-related specialization. Here, we aimed to explore brain specialization alterations of BDPs before and after pharmacological treatment. The autonomy index, based on resting-state images, was used to assess brain specialization in 82 BDPs and 88 healthy controls (HCs). Among patients, 43 BDPs who underwent 3 months of pharmacological treatment completed the follow-up. Using autonomy index as input, support vector regression (SVR) analysis was conducted to predict treatment response. Additionally, we conducted cross-sample correlation analyses between autonomy index and genetic profiles or the densities of neurotransmitter receptors/transporters. At baseline, BDPs exhibited reduced autonomy index in the left middle temporal gyrus (MTG) relative to HCs. However, no significant alterations were observed following pharmacological treatment. Using autonomy index, the SVR model could predict treatment response for BDPs with a correlation coefficient of 0.705. Brain specialization patterns were correlated with six genes and neurotransmitters including dopaminergic (D1R, D2R, and DAT) and serotonergic (5-HT2A) transmission. In line with Crow’s hypothesis, we found reduced brain specialization in a key node of the language network (LN) in BDPs. We also provided potential genetic and biological mechanisms underlying BD.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104539"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the policy gap between adolescent mental health and school systems in indonesia","authors":"Zalik Nuryana,&nbsp;Herdian","doi":"10.1016/j.ajp.2025.104543","DOIUrl":"10.1016/j.ajp.2025.104543","url":null,"abstract":"<div><div>Adolescent mental health remains an under-addressed priority in national policies across Southeast Asia, including Indonesia. Although mental health legislation and adolescent health programs exist, integration within the school system is limited and inconsistent with international standards. This commentary builds on Mudunna et al.’s regional policy review by highlighting the critical gap in Indonesia’s cross-sectoral coordination between health and education. Drawing on recent national data, we underscore the urgency of school-based mental health interventions in Indonesia, where prevalence rates of anxiety, depression, and suicidal ideation among adolescents are high, yet treatment access remains alarmingly low. We argue that adolescence must be understood not only as a period of psychological vulnerability but also as a transformative stage shaped by biological, social, and legal factors. In the context of LMICs like Indonesia, policy development must consider rights-based, participatory, and culturally appropriate approaches. We call for context-specific frameworks to embed mental health within the national education system as an essential investment in Indonesia’s youth and national development.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"109 ","pages":"Article 104543"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}