Asian journal of psychiatry最新文献

筛选
英文 中文
The effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with catatonia associated with another mental disorder: A systematic review. 重复经颅磁刺激(rTMS)对伴有其他精神障碍的紧张症患者的疗效:系统综述。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-11-19 DOI: 10.1016/j.ajp.2024.104311
Sarvenaz Esmaeelzadeh, Razi Mahmood, Altaf Masood
{"title":"The effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with catatonia associated with another mental disorder: A systematic review.","authors":"Sarvenaz Esmaeelzadeh, Razi Mahmood, Altaf Masood","doi":"10.1016/j.ajp.2024.104311","DOIUrl":"https://doi.org/10.1016/j.ajp.2024.104311","url":null,"abstract":"<p><strong>Background: </strong>Catatonia is a rare but life-threatening condition characterized by a constellation of psychomotor disturbances. The most widely used treatments of catatonia include benzodiazepines and electroconvulsive therapy. Despite the widespread use of benzodiazepines and the high response rate of catatonia to ECT, there are instances where catatonia does not respond to first-line treatments. This study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in managing catatonia.</p><p><strong>Methods: </strong>A systematic literature search was conducted on the following databases: Medline, PubMed, Cochrane Library, Embase, PsycINFO and ClinicalTrials.gov for registered but not yet published studies.</p><p><strong>Results: </strong>Out of 244 initially identified articles, there remained eight case reports and 1 case series eligible after screening. Of the twelve total cases, nine showed clinical improvement. However, there was significant heterogeneity in the complexity of the clinical situation, the severity of clinical features of catatonia, underlying causes, and rTMS treatment protocols between studies.</p><p><strong>Conclusion: </strong>The results of this study are inconclusive. However, rTMS might be trialed for the management of catatonia when first-line treatment options fail, are unavailable, or need to be used with caution. Our review incorporating the most up to date evidence highlights the need for more extensive, standardized, randomized clinical trials to investigate the efficacy of rTMS for treating catatonia.</p>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"103 ","pages":"104311"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enduring conflict: The effects of war trauma on the well-being of Palestinian children. 持久的冲突:战争创伤对巴勒斯坦儿童福祉的影响。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-11-08 DOI: 10.1016/j.ajp.2024.104304
Amani N Alansari
{"title":"Enduring conflict: The effects of war trauma on the well-being of Palestinian children.","authors":"Amani N Alansari","doi":"10.1016/j.ajp.2024.104304","DOIUrl":"https://doi.org/10.1016/j.ajp.2024.104304","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"103 ","pages":"104304"},"PeriodicalIF":3.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered resting-state brain activity of the superior parietal cortex and striatum in major depressive disorder and schizophrenia 重度抑郁障碍和精神分裂症患者的上顶叶皮层和纹状体静息态大脑活动改变。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104303
Cheng Chen , Baoli Zhang , Xucong Qin , Huan Huang , Bei Rong , Huiling Wang , Liang Zhang , Wei Yuan
{"title":"Altered resting-state brain activity of the superior parietal cortex and striatum in major depressive disorder and schizophrenia","authors":"Cheng Chen ,&nbsp;Baoli Zhang ,&nbsp;Xucong Qin ,&nbsp;Huan Huang ,&nbsp;Bei Rong ,&nbsp;Huiling Wang ,&nbsp;Liang Zhang ,&nbsp;Wei Yuan","doi":"10.1016/j.ajp.2024.104303","DOIUrl":"10.1016/j.ajp.2024.104303","url":null,"abstract":"<div><h3>Background</h3><div>Resting-state functional magnetic resonance imaging (fMRI) studies have shown altered brain activity in major depressive disorder (MDD) and schizophrenia (SZ). Despite differing diagnoses, SZ and MDD share similar features. However, functional brain activity similarities and differences between SZ and MDD remain unclear.</div></div><div><h3>Methods</h3><div>Participants with MDD, SZ, and normal controls (n=36 each) underwent resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFF) was used to analyze the preprocessed rs-fMRI data. One-way ANOVAs and post hoc analyses compared ALFF values in different brain regions. Pearson correlation analysis examined associations with clinical symptoms.</div></div><div><h3>Results</h3><div>Comparison among the three groups revealed significant differences in ALFF values within the left superior parietal cortex (L-SPC) and bilateral striatum. Through pairwise comparisons, patients with SZ but not patients with MDD were found to exhibit increased striatum ALFF values relative to NC individuals, but decreased in MDD. Meanwhile, L-SPC ALFF values were significantly increased in patients with SZ relative to both normal control individuals and patients with MDD, while no differences in these values were observed between the normal control and MDD groups. The Pearson correlation analyses showed significant positive correlations between ALFF in the striatum and PANSS positive score, but no significant correlation with other symptom severity in SZ and MDD.</div></div><div><h3>Conclusion</h3><div>These findings support the hypothesis of alterations in brain functional activity as a fundamental component of the pathogenesis of MDD and SZ. The observed differences in functional brain activity in the superior parietal cortex and striatum between MDD and SZ provide a neuroimaging basis that can contribute to the differential diagnosis of these debilitating conditions.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104303"},"PeriodicalIF":3.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulating neuroplasticity through synergistic ketamine and accelerated sequential theta burst stimulation (TBS) for treatment-resistant depression (TRD) – A case report 通过氯胺酮和加速序列θ爆发刺激(TBS)的协同作用调节神经可塑性,治疗耐药抑郁症(TRD)--病例报告
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104302
Veena Ramesh, Varsha Shamanna, Harsh Pathak, Swarna Buddha Nayok, Anushree Bose, Vanteemar S. Sreeraj, Ganesan Venkatasubramanian
{"title":"Modulating neuroplasticity through synergistic ketamine and accelerated sequential theta burst stimulation (TBS) for treatment-resistant depression (TRD) – A case report","authors":"Veena Ramesh,&nbsp;Varsha Shamanna,&nbsp;Harsh Pathak,&nbsp;Swarna Buddha Nayok,&nbsp;Anushree Bose,&nbsp;Vanteemar S. Sreeraj,&nbsp;Ganesan Venkatasubramanian","doi":"10.1016/j.ajp.2024.104302","DOIUrl":"10.1016/j.ajp.2024.104302","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104302"},"PeriodicalIF":3.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe suicide attempts, day of the week, and holidays in South Korea: A nationwide case time series study 韩国的严重自杀企图、星期和节假日:全国病例时间序列研究。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104299
Harin Min , Jiwoo Park , Hyewon Yoon, Jieun Oh, Sojin Ahn, Cinoo Kang, Whanhee Lee
{"title":"Severe suicide attempts, day of the week, and holidays in South Korea: A nationwide case time series study","authors":"Harin Min ,&nbsp;Jiwoo Park ,&nbsp;Hyewon Yoon,&nbsp;Jieun Oh,&nbsp;Sojin Ahn,&nbsp;Cinoo Kang,&nbsp;Whanhee Lee","doi":"10.1016/j.ajp.2024.104299","DOIUrl":"10.1016/j.ajp.2024.104299","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104299"},"PeriodicalIF":3.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability and validity study of the Turkish version of the Schizophrenia Cognition Rating Scale (SCoRS-TR) 土耳其版精神分裂症认知评定量表(SCoRS-TR)的可靠性和有效性研究。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104301
Nedim Özak , Emine Ilgın Hoşgelen , Berna Binnur Akdede , Köksal Alptekin
{"title":"Reliability and validity study of the Turkish version of the Schizophrenia Cognition Rating Scale (SCoRS-TR)","authors":"Nedim Özak ,&nbsp;Emine Ilgın Hoşgelen ,&nbsp;Berna Binnur Akdede ,&nbsp;Köksal Alptekin","doi":"10.1016/j.ajp.2024.104301","DOIUrl":"10.1016/j.ajp.2024.104301","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is characterized by significant dysfunction in cognitive domains. Despite its crucial role in prognosis, evaluating neurocognitive impairments is challenging in outpatient settings because of the time-consuming nature of neurocognitive assessments. SCoRS “Schizophrenia Cognition Rating Scale” is a scale that provides brief cognitive evaluation. This study aimed to establish the validity and reliability of the Turkish version of the “Schizophrenia Cognition Rating Scale” (SCoRS-TR) in patients with schizophrenia and examine the correlation between SCoRS and cognitive tests.</div></div><div><h3>Methods</h3><div>Data were collected from 130 patients with schizophrenia who met the DSM-5 criteria and 40 healthy controls. SCoRS rating, Positive and Negative Syndrome Scale (PANSS), and a neurocognitive test battery were administered.</div></div><div><h3>Results</h3><div>Findings indicated that SCoRS-TR is a reliable and valid scale for the Turkish population. The scale demonstrated strong internal consistency, with Cronbach's alpha values ranging from 0.937 to 0.940. High interrater reliability (ranging from 0.90 to 0.98) and test-retest reliability (ranging from 0.976 to 0.990) were observed. SCoRS-TR significantly discriminated patients from healthy controls (p&lt;0.001). SCoRS-TR exhibited significant correlations to neurocognitive tests.</div></div><div><h3>Discussion</h3><div>Results indicated that SCoRS-TR had significant reliability and validity scores that may be useful for evaluating daily life functioning related to cognitive dysfunction in patients with schizophrenia. This approach may be useful for neurocognitive evaluation and monitoring in clinical follow-up and outpatient settings.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104301"},"PeriodicalIF":3.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closure risk of general hospital psychiatric units: Impact of financial pressures and psychiatrist staffing challenges 综合医院精神科关闭的风险:财务压力和精神科医生人员配备挑战的影响
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-29 DOI: 10.1016/j.ajp.2024.104300
Michitaka Funayama, Shigeki Sato, Hiraki Koishikawa, Naoko Satake, On Kato, Masayuki Noguchi, Tomoji Takata, Yusuke Hasegawa, Hisashi Wada, Takaki Akahane, Naohisa Tsujino, Katsuji Nishimura
{"title":"Closure risk of general hospital psychiatric units: Impact of financial pressures and psychiatrist staffing challenges","authors":"Michitaka Funayama,&nbsp;Shigeki Sato,&nbsp;Hiraki Koishikawa,&nbsp;Naoko Satake,&nbsp;On Kato,&nbsp;Masayuki Noguchi,&nbsp;Tomoji Takata,&nbsp;Yusuke Hasegawa,&nbsp;Hisashi Wada,&nbsp;Takaki Akahane,&nbsp;Naohisa Tsujino,&nbsp;Katsuji Nishimura","doi":"10.1016/j.ajp.2024.104300","DOIUrl":"10.1016/j.ajp.2024.104300","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104300"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a package of community-based mental healthcare services to address perinatal mental disorders in Bangladesh: A cluster-randomized controlled trial 以社区为基础的一揽子精神保健服务对解决孟加拉国围产期精神障碍的有效性:分组随机对照试验
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-25 DOI: 10.1016/j.ajp.2024.104290
Goutam Kumar Dutta , Helal Uddin Ahmed , Md. Quiume Talukder , Dipika Shankar Bhattacharyya , M. Shamim Reza , Md. Musfikur Rahman , Ratna Majumdar , Fahmida Tofail , Henry B. Perry , Taposh Kumar Biswas
{"title":"Effectiveness of a package of community-based mental healthcare services to address perinatal mental disorders in Bangladesh: A cluster-randomized controlled trial","authors":"Goutam Kumar Dutta ,&nbsp;Helal Uddin Ahmed ,&nbsp;Md. Quiume Talukder ,&nbsp;Dipika Shankar Bhattacharyya ,&nbsp;M. Shamim Reza ,&nbsp;Md. Musfikur Rahman ,&nbsp;Ratna Majumdar ,&nbsp;Fahmida Tofail ,&nbsp;Henry B. Perry ,&nbsp;Taposh Kumar Biswas","doi":"10.1016/j.ajp.2024.104290","DOIUrl":"10.1016/j.ajp.2024.104290","url":null,"abstract":"<div><h3>Background</h3><div>Perinatal mental disorders of women have an impact on their pregnancy and their child’s brain development across low and middle-income countries. However, to address this issue, there are no specific guidelines for community-level service providers in Bangladesh. Therefore, we aimed to develop a community-based mental healthcare (CBMHC) service package and test its effectiveness in reducing depression, anxiety, and stress among mothers during the perinatal period.</div></div><div><h3>Methods</h3><div>A cluster-randomized controlled trial (cRCT) was applied to test the CBMHC package in 2017 and 2018. It was provided to one group of mothers along with routine maternal care while another group received only routine maternal care. Paired sample t-test was applied to assess mean changes at baseline and endline in the Depression, Anxiety, and Stress Scales-21 (DASS-21) and EuroQol-5 Dimension and 3 Level (EQ5D3L) scales. A linear mixed-effects model was used to assess the relationship between the DASS-21 score and EQ5D3L.</div></div><div><h3>Results</h3><div>1215 participants were enrolled, including 605 in the intervention group and 610 in the control group. Measures of depression, anxiety, and stress were significantly decreased in both groups. Reduction in the levels of stress, as measured by changes in the stress score, were significantly greater in the intervention than in the control group (diff: 1.2, 95 % CI: 0.1, 2.2). The EQ5D3L index improved significantly, 0.02 units more at endline in the intervention group than in the control group (diff: 0.02, 95 % CI: 0.007, 0.03). The levels of mobility, usual activities, pain or discomfort, depression, and anxiety improved by 1.4 %, 7.6 %, 4.4 %, 2.6 %, and 0.4 % more, respectively, in the intervention group compared to the control groups. These improvements were statistically significant. The DASS-21 score was negatively and significantly correlated with both the EQ-5D3L index and the Visual Analogue Scale (VAS) score for the intervention group as well as for the usual care group, indicating that EQ5D3L improved when common mental disorders decreased.</div></div><div><h3>Conclusion</h3><div>Although the improvements were modest, a CBMHC service package was effective in reducing perinatal levels of stress among Bangladeshi rural women.</div></div><div><h3>Trial Registration</h3><div>ClinicalTrials.gov ID: NCT03678415</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104290"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review 人类粪便微生物群移植与精神分裂症动物模型中肠道微生物群特征的关系:范围综述
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-24 DOI: 10.1016/j.ajp.2024.104285
Raghunath Singh , Kristoffer Panganiban , Emily Au , Rekha Ravikumar , Sandra Pereira , Thomas D. Prevot , Daniel J. Mueller , Gary Remington , Sri Mahavir Agarwal , Elena F. Verdu , Premysl Bercik , Giada De Palma , Margaret K. Hahn
{"title":"Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review","authors":"Raghunath Singh ,&nbsp;Kristoffer Panganiban ,&nbsp;Emily Au ,&nbsp;Rekha Ravikumar ,&nbsp;Sandra Pereira ,&nbsp;Thomas D. Prevot ,&nbsp;Daniel J. Mueller ,&nbsp;Gary Remington ,&nbsp;Sri Mahavir Agarwal ,&nbsp;Elena F. Verdu ,&nbsp;Premysl Bercik ,&nbsp;Giada De Palma ,&nbsp;Margaret K. Hahn","doi":"10.1016/j.ajp.2024.104285","DOIUrl":"10.1016/j.ajp.2024.104285","url":null,"abstract":"<div><div>More recently, attention has turned to the putative role of gut microbiome (GMB) in pathogenesis, symptomatology, treatment response and/or resistance in schizophrenia (SCZ). It is foreseeable that fecal microbiota transplantation (FMT) from SCZ patients (SCZ-FMT) to germ-free mice could represent a suitable experimental framework for a better understanding of the relationship between GMB and SCZ. Thus, we set out to identify literature (i) characterizing the GMB in animal models of SCZ, and (ii) employing SCZ-FMT into rodents to model SCZ in relation to behavioral and molecular phenotypes. Five studies examining animal models of SCZ suggest distinct GMB composition compared to respective control groups, which was correlated with SCZ-like behavioral phenotypes. Four additional studies investigated SCZ-FMT into rodents in relation to behavioral phenotypes, including spontaneous hyperlocomotion, social deficits, exaggerated startle response, and cognitive impairments, resembling those observed in SCZ patients. Mice receiving SCZ-FMT showed altered neurochemical and metabolic pathways in the brain. Animal models of SCZ have shown altered GMB composition, whereas reported behavioral and neurochemical alterations following FMT from patients into rodents suggest early face and construct validity for SCZ-FMT animal models. However, the predictive validity of these models remains to be validated.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104285"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Default at fault? Exploring neural correlates of default mode network in children with ADHD, their unaffected siblings versus neurotypical controls: A quantitative EEG study 默认模式有问题?探索多动症儿童及其未受影响的兄弟姐妹与神经典型对照组默认模式网络的神经相关性:脑电图定量研究。
IF 3.8 4区 医学
Asian journal of psychiatry Pub Date : 2024-10-24 DOI: 10.1016/j.ajp.2024.104291
Chaithanya Leon , Simran Kaur , Rajesh Sagar , Prashant Tayade , Ratna Sharma
{"title":"Default at fault? Exploring neural correlates of default mode network in children with ADHD, their unaffected siblings versus neurotypical controls: A quantitative EEG study","authors":"Chaithanya Leon ,&nbsp;Simran Kaur ,&nbsp;Rajesh Sagar ,&nbsp;Prashant Tayade ,&nbsp;Ratna Sharma","doi":"10.1016/j.ajp.2024.104291","DOIUrl":"10.1016/j.ajp.2024.104291","url":null,"abstract":"<div><h3>Background</h3><div>Sustained activation of default mode network has been implicated for momentary lapses of attention and higher errors during performance of cognitive tasks in attention deficit hyperactive disorder (ADHD) children. Despite emerging evidence indicating the genetic basis of ADHD, there is paucity of literature investigating the alteration of DMN in children with ADHD and their unaffected siblings.</div></div><div><h3>Aim</h3><div>To study the cortical sources of DMN in children with ADHD compared to their siblings and neurotypical controls.</div></div><div><h3>Methods</h3><div>Eighty-six participants (35 ADHD (12.4(±2.7) years), 16 unaffected siblings (11.8(±4.3) years) and 35 matched neurotypical controls (12.6 (±3.6) years) participated in the study. 128 channel EEG data was acquired during rest and Stroop cognitive task and analyzed for cortical source estimation using LORETA software.</div></div><div><h3>Results</h3><div>Higher activation of DMN and DMN associated areas were observed during encoding of the color-word stimuli in children with ADHD. Sustained activation of core DMN areas namely medial frontal gyrus, posterior cingulate gyrus, parahippocampal gyrus and inferior parietal lobule was observed across all groups. Among the three groups, distinct cortical source activation differences were identified solely in the DMN and its associated areas among children with ADHD during the task encoding phase compared to baseline. In contrast, both siblings and neurotypical controls displayed activation in fronto-parieto-temporal areas subserving executive function were also observed.</div></div><div><h3>Conclusion</h3><div>Sustained activity of DMN areas with minimal activity in executive network in ADHD children and unaffected siblings during encoding of stimulus implies potential endophenotypic marker in children with ADHD compared to neurotypical controls.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104291"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信