Asian journal of psychiatry最新文献

{"title":"Resting-state functional connectivity of the default mode network subsystems as a potential biomarker for delusions in patients with first-episode drug-naïve schizophrenia","authors":"Qihui Guo ,&nbsp;Rongrong Zhu ,&nbsp;Jianliang Gao ,&nbsp;Anzhen Wang ,&nbsp;Ruomei Fan ,&nbsp;Liusu Wang ,&nbsp;Dongmei Wang ,&nbsp;Xiangyang Zhang","doi":"10.1016/j.ajp.2025.104733","DOIUrl":"10.1016/j.ajp.2025.104733","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous studies have indicated a close association between delusions and the default mode network (DMN). This study aimed to explore the relationship between delusions and resting-state functional connectivity (rsFC) of subsystem-specific DMN in patients with first-episode drug-naïve schizophrenia (FESCZ).</div></div><div><h3>Methods</h3><div>This study recruited 79 FESCZ patients. The severity of delusions was assessed using the PANSS P1 item, with a score of ≥ 4 defining the clear presence of delusions. Seed-to-seed rsFC matrices were calculated between 11 DMN seed regions, which belong to three subsystems: the core, the dorsomedial prefrontal cortex (dMPFC), and the medial temporal lobe (MTL).</div></div><div><h3>Results</h3><div>Compared with patients without clear delusions, patients with clear delusions exhibited hyperconnectivity between the core and the MTL subsystems. The severity of delusions was positively correlated with the core-MTL rsFC strength. Post-hoc analyses revealed that specific rsFC edges (rsFC between posterior cingulate cortex and retrosplenial cortex, as well as between posterior cingulate cortex and posterior inferior parietal lobule) were significantly correlated with the severity of delusions.</div></div><div><h3>Conclusions</h3><div>The DMN core-MTL rsFC strength is associated with delusions in FESCZ patients, which may serve as a potential biomarker for the severity of delusions and offer novel neurobiological insights for delusions treatment.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104733"},"PeriodicalIF":4.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of maximal handgrip strength and handgrip strength asymmetry with suicidal behaviors: Evidence from a nationally representative sample of Korean adults","authors":"Seong-Uk Baek,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.ajp.2025.104731","DOIUrl":"10.1016/j.ajp.2025.104731","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104731"},"PeriodicalIF":4.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decriminalization of suicide in Asia: The progress","authors":"S. M. Yasir Arafat","doi":"10.1016/j.ajp.2025.104728","DOIUrl":"10.1016/j.ajp.2025.104728","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104728"},"PeriodicalIF":4.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot and AI applications in obsessive-compulsive disorder and related disorders: A bibliometric analysis of publications from 2010 to 2025","authors":"Ming Chen ,&nbsp;Haozhang Huang ,&nbsp;Shiqun Chen ,&nbsp;Cailan Hou","doi":"10.1016/j.ajp.2025.104730","DOIUrl":"10.1016/j.ajp.2025.104730","url":null,"abstract":"<div><h3>Objective</h3><div>Recent advancements in robot and artificial intelligence (AI) applications show promise in mental health, particularly in treating obsessive-compulsive disorder (OCD) and related disorders. This study aims to analyze the landscape of publications regarding robot and AI applications in OCD and related disorders.</div></div><div><h3>Methods</h3><div>Data were sourced from the PubMed database, with bibliometric and visualization analyses conducted to evaluate sources, institutions, countries, high-impact literature, and keywords relevant to the field.</div></div><div><h3>Results</h3><div>A total of 179 articles were retrieved, authored by 1403 contributors. The overall number of published articles has shown a consistent upward trend, with “FRONTIERS IN PSYCHIATRY” emerging as the leading journal by publication volume. The top three contributing countries were China, the United States, and the Netherlands. Notably, China's multi-country publication (MCP) rate was only around 6 %. Additionally, Chinese authors had limited representation in high-impact literature, with only 2 out of the top 10 high-impact articles and just 1 out of the top 10 most cited articles. High-frequency keywords identified included \"OCD\", \"Machine Learning\" and “Artificial Intelligence” with robot references notably absent.</div></div><div><h3>Conclusions</h3><div>Regardless of the increased publication output from China, there is a critical need to enhance research quality and promote greater international collaboration to fully leverage the potential benefits of robot and AI applications for treating OCD and related disorders.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104730"},"PeriodicalIF":4.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does AI speak your language? Large language models and psychometric development in Indian languages","authors":"Vyoma Shah,&nbsp;Sourabh Sundaresh,&nbsp;Swarna Buddha Nayok,&nbsp;Harsh Pathak,&nbsp;Vanteemar S. Sreeraj,&nbsp;Venkataram Shivakumar,&nbsp;Vijay Kumar,&nbsp;Ganesan Venkatasubramanian","doi":"10.1016/j.ajp.2025.104729","DOIUrl":"10.1016/j.ajp.2025.104729","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104729"},"PeriodicalIF":4.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for promoting resilience among adolescents in South Asia: A scoping review","authors":"Ravi Sadhu ,&nbsp;Priyanka Suneja ,&nbsp;Brinda Singh Raikwar ,&nbsp;Adarsh Ratnakaran ,&nbsp;Kimberley Monteiro ,&nbsp;Pattie Gonsalves ,&nbsp;Vikram Patel ,&nbsp;Ravindra Agrawal","doi":"10.1016/j.ajp.2025.104727","DOIUrl":"10.1016/j.ajp.2025.104727","url":null,"abstract":"<div><div>Resilience has emerged as a crucial factor in healthy coping, navigating adversity, and protection against mental health problems, including suicidal ideation, among adolescents. The literature on programs and initiatives promoting adolescent resilience in South Asia, home to 350 million adolescents, is sparse and has not been systematically studied. This scoping review synthesises the evidence on resilience-promoting interventions targeting South Asian adolescents. Drawing on scoping review methodology, we searched 10 databases, including PubMed, CINAHL, and PsycINFO, to identify peer-reviewed studies published between January 1, 2000, and March 23, 2024. With no language barriers, we included studies targeting adolescents aged 10–19 with resilience identified as a primary or secondary outcome of interest. From 3987 searches, we identified 13 interventions from India, Pakistan, and Nepal targeting diverse subpopulations. Common active intervention components included mindfulness, art-based expression, and life skills training. Most interventions were delivered face-to-face through group lessons and activities, particularly in a classroom setting. Outside of the school setting, there is a need to adapt and scale multilevel community-led resilience-promoting interventions that enhance social scaffolding for adolescents in the region.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104727"},"PeriodicalIF":4.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When an individual with schizophrenia has co-witnessed a crime: Exploring memory conformity for crime event in schizophrenia","authors":"Aishwarya Shinde ,&nbsp;Devvarta Kumar","doi":"10.1016/j.ajp.2025.104726","DOIUrl":"10.1016/j.ajp.2025.104726","url":null,"abstract":"<div><div>When multiple witnesses discuss a crime, they can influence each other’s memory of the event. This phenomenon is known as the ‘co-witness effect.’ Empirical evidence indicates that factors such as an individual’s cognitive capacities, memory confidence, personality traits, and interpersonal dynamics with a co-witness may moderate the co-witness effect. However, there is a dearth of research on whether psychosis increases vulnerability to co-witness influences. Given the cognitive impairments and susceptibility to memory distortions often associated with psychosis, it is crucial to determine whether individuals with psychosis are likely to succumb to misinformation given by their co-witnesses. Using the Manipulation of Overlapping Rivalrous Images (MORI) technique, we assessed co-witness memory conformity in schizophrenia. Results show individuals with schizophrenia are no more susceptible to co-witness misinformation than those without psychiatric illness.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104726"},"PeriodicalIF":4.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychosis continuum: Systematic review on prodromal markers, symptom progression, and early intervention strategies","authors":"Valerio Ricci ,&nbsp;Alessandro Sarni ,&nbsp;Giovanni Martinotti ,&nbsp;Giuseppe Maina","doi":"10.1016/j.ajp.2025.104725","DOIUrl":"10.1016/j.ajp.2025.104725","url":null,"abstract":"<div><div>This systematic review synthesizes evidence from 60 studies (2000–2025) examining prodromal symptoms and psychotic onsets, following PRISMA guidelines. The review included 35 prospective cohort studies (58.3 %), 9 cross-sectional studies (15.0 %), 9 randomized controlled trials (15.0 %), 5 case-control studies (8.3 %), and 2 qualitative studies (3.3 %).</div><div>Prodromal presentations show marked heterogeneity, with initial manifestations predominantly non-specific (depression 52 %, worry 41 %, anxiety 38 %) before attenuated psychotic symptoms emerge. Negative symptoms typically precede positive symptoms by 12 months, with three distinct trajectories: persistent (35 %), fluctuating (42 %), and improving (23 %). Neurobiological markers demonstrate stepwise brain alterations, with machine learning approaches achieving clinically meaningful prediction accuracy (77.6 % for eye-tracking; AUC=0.84 for multimodal assessment). Environmental factors significantly influence transition risk: childhood trauma affects 61 % of UHR individuals, while cannabis use confers 4-fold increased risk (10-fold with genetic vulnerability). Notably, premorbid deterioration may reflect environmental factors (particularly high-potency cannabis) rather than elevated genetic liability.</div><div>Psychological interventions, particularly cognitive-behavioral approaches, show favorable risk-benefit profiles (NNT=5), with evidence suggesting shared anti-inflammatory mechanisms with biological treatments. Omega-3 supplementation demonstrates promise with reduced transition rates (4.9 % vs. 27.5 % controls) and favorable safety profile. Emerging interventions including low-dose lithium show potential neuroprotective effects warranting further investigation. The evidence supports expanding from transition-focused approaches to broader recovery-oriented frameworks that prioritize psychosis prevention while also addressing functioning, distress, and quality of life in all individuals at risk. We recommend personalized, stage-specific interventions integrating phenomenological, neurobiological, and intervention insights, emphasizing layered assessment, developmentally-contextualized interpretation, trauma-informed care, and accessible neurophysiological markers combined with machine learning for enhanced risk prediction.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104725"},"PeriodicalIF":4.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem comorbidity architecture and pre-existing risk profiles of post-traumatic stress disorder","authors":"Ming Zheng","doi":"10.1016/j.ajp.2025.104722","DOIUrl":"10.1016/j.ajp.2025.104722","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104722"},"PeriodicalIF":4.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sadness-specific speech-in-noise impairments and subregional left insular volume reduction in schizophrenia with auditory verbal hallucinations","authors":"Bingyan Gong ,&nbsp;Qiuhong Li ,&nbsp;Shenglin She ,&nbsp;Yingjun Zheng ,&nbsp;Chao Wu","doi":"10.1016/j.ajp.2025.104721","DOIUrl":"10.1016/j.ajp.2025.104721","url":null,"abstract":"<div><div>This study investigated the association between regional volumes of the left insula, emotional speech-in-noise recognition (ESR), and auditory verbal hallucinations (AVHs) in individuals with schizophrenia. Fifty‑eight patients were categorized into two groups according to the PANSS P3 score: AVHs (n = 19) and non‑AVHs (n = 39). All participants completed ESR tasks and underwent structural MRI for volumetric analysis. Compared to the non-AVH group, patients with AVHs exhibited impaired ESR of sadness and reduced gray matter volumes in five left insular subregions. However, group differences in ESR performance became non-significant after controlling for PANSS cognitive symptoms, and volumetric differences were attenuated after adjusting for sex, negative symptoms, and cognitive symptoms. Following normalization to total intracranial volume, patients with AVHs still exhibited smaller volumes in the left insula, specifically in two subregions of the left ventral and dorsal agranular insula. Moreover, volumes in the dorsal agranular and dysgranular insula were significantly correlated with both AVH severity and ESR performance. These findings suggest that structural abnormalities in specific left insular subregions may underlie to emotional speech processing deficits in schizophrenia, highlighting potential neuroanatomical biomarkers and intervention targets in patients with AVHs. Given that AVH grouping was based on current symptoms (past week) rather than lifetime history, this limitation should be considered in future studies when interpreting the present findings.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"113 ","pages":"Article 104721"},"PeriodicalIF":4.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}