Huang-Li Lin, Yueh-Pin Lin, Tian-Mei Si, Roy Abraham Kalliyalil, Andi J. Tanra, Amir Hossein Jalali Nadoushan, Toshiya Inada, Seon-Cheol Park, Kok Yoon Chee, Afzal Javed, Kang Sim, Kuan-Lun Huang, Pornjira Pariwatcharakul, Norman Sartorius, Mian-Yoon Chong, Naotaka Shinfuku, Takahiro A. Kato, Shih-Ku Lin
{"title":"Diagnostic distribution of antidepressant users: Findings from the REAP-AD3 study","authors":"Huang-Li Lin, Yueh-Pin Lin, Tian-Mei Si, Roy Abraham Kalliyalil, Andi J. Tanra, Amir Hossein Jalali Nadoushan, Toshiya Inada, Seon-Cheol Park, Kok Yoon Chee, Afzal Javed, Kang Sim, Kuan-Lun Huang, Pornjira Pariwatcharakul, Norman Sartorius, Mian-Yoon Chong, Naotaka Shinfuku, Takahiro A. Kato, Shih-Ku Lin","doi":"10.1016/j.ajp.2025.104617","DOIUrl":"10.1016/j.ajp.2025.104617","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104617"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bridging the silent crisis: Strengthening mental health support for university students in the Philippines","authors":"Danilo V. Rogayan Jr.","doi":"10.1016/j.ajp.2025.104616","DOIUrl":"10.1016/j.ajp.2025.104616","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104616"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuni Nur Rohman, Berlima Pasaribu, Anne Hafina Adiwinata, Ipah Saripah, Eka Sakti Yudha
{"title":"Adolescent mental health policy: A reflection on policy gaps and urgent needs in Indonesia","authors":"Yuni Nur Rohman, Berlima Pasaribu, Anne Hafina Adiwinata, Ipah Saripah, Eka Sakti Yudha","doi":"10.1016/j.ajp.2025.104619","DOIUrl":"10.1016/j.ajp.2025.104619","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104619"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonmoy Alam Shuvo, Sorif Hossain, Riyadh Hossain, Nelufa Aktar
{"title":"Suicide attempts among female adolescents: A study of risk factors in the Philippines","authors":"Tonmoy Alam Shuvo, Sorif Hossain, Riyadh Hossain, Nelufa Aktar","doi":"10.1016/j.ajp.2025.104618","DOIUrl":"10.1016/j.ajp.2025.104618","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104618"},"PeriodicalIF":3.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of an automated digital neuropsychological assessment system (DNAS)","authors":"Li Liang , Chetwyn C.H. Chan , Tatia M.C. Lee","doi":"10.1016/j.ajp.2025.104612","DOIUrl":"10.1016/j.ajp.2025.104612","url":null,"abstract":"<div><h3>Introduction</h3><div>Diagnosing neurocognitive disorders, mild or major, requires a comprehensive assessment of domains of cognitive functions according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Conventional neuropsychological assessments, usually conducted on a one-to-one assessment format, are under constant challenge of the demand on manpower and time resources, let alone its limited scalability to serve a larger population. Entering the era of digital healthcare emphasizing scalability, accessibility, and cost-effectiveness in delivering healthcare services, we have developed an automated digital neuropsychological assessment system - the Digital Neuropsychological Assessment System (DNAS), administered in individual or group format with minimal supervision.</div></div><div><h3>Methods</h3><div>We conducted a validation study of the DNAS, which encompasses 13 subtests assessing a spectrum of cognitive domains delineated in the DSM-5-TR for diagnosing neurocognitive disorders. These 13 tests fall in the domains of processing speed, attention, working memory, visual and verbal memory, spatial judgment, higher-order cognition, and social cognition tests.</div></div><div><h3>Results</h3><div>On a sample of 60 Chinese-speaking younger adults (mean age = 25.4 years old, SD = 3.6 years), we demonstrated the criterion validity (<em>r</em>s or <em>ρ</em>s = .30 to .62) substantiated by the significant correlations between the DNAS and conventional assessment results.</div></div><div><h3>Conclusions</h3><div>Our findings confirmed that the DNAS is a promising alternative to conventional neuropsychological assessments in the era of digital healthcare. The DNAS contributes to improving the cost-effectiveness of delivering neuropsychological services and research. Its automated design enhances the scalability of neuropsychological services to people whose access to healthcare settings is limited.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104612"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating LMICs challenges through educational and legal reforms to strengthen adolescent mental health in Indonesia","authors":"Zalik Nuryana, Atqo Darmawan Aji, Herdian Herdian","doi":"10.1016/j.ajp.2025.104614","DOIUrl":"10.1016/j.ajp.2025.104614","url":null,"abstract":"<div><div>Adolescent mental health represents a critical yet underserved public health issue, particularly in low- and middle-income countries (LMICs) such as Indonesia. Responding positively to Ramaswamy et al. call for a paradigm shift towards adolescent-centered policy frameworks, this editorial explores the integration of educational strategies and legal frameworks to enhance adolescent mental health interventions. Despite Indonesia's progressive legislation, including the Mental Health Law (No.18/2014) and Juvenile Justice System Law (No.11/2012), substantial gaps remain in youth participation and comprehensive preventive measures. This letter proposes strengthening education-based mental health interventions and restorative justice mechanisms. It further advocates for meaningful adolescent engagement in research and policymaking, positioning education and law as key sectors for navigating LMIC-specific challenges in building resilient adolescent populations.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104614"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Wang Fung , Antonia Leousi , Anson Kai Chun Chau , Ka Yan Sit , Cheuk Chi Lam , Celine Mylx Li , Chak Hei Ocean Huang , Cherry Tin Yan Cheung , Stanley Kam Ki Lam , Edward K.S. Wang , Grace Wing Ka Ho
{"title":"Prevalence of ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD in the general populations: A systematic review and meta-analysis","authors":"Hong Wang Fung , Antonia Leousi , Anson Kai Chun Chau , Ka Yan Sit , Cheuk Chi Lam , Celine Mylx Li , Chak Hei Ocean Huang , Cherry Tin Yan Cheung , Stanley Kam Ki Lam , Edward K.S. Wang , Grace Wing Ka Ho","doi":"10.1016/j.ajp.2025.104610","DOIUrl":"10.1016/j.ajp.2025.104610","url":null,"abstract":"<div><div>The ICD-11 has revised the diagnostic criteria for post-traumatic stress disorder (PTSD) and introduced complex PTSD (CPTSD) as a new diagnosis. This study presents the first systematic review and meta-analysis of ICD-11 PTSD and CPTSD prevalence in general population samples. In this pre-registered review (CRD42024579951), we searched the Web of Science, Scopus, and PubMed databases to identify potentially relevant articles. Meta-analyses were conducted among (1) samples from non-war exposed/economically developed countries/regions and (2) samples from war-exposed/less economically developed countries/regions. Out of 835 unique records, 10 eligible studies examining ICD-11 PTSD and CPTSD in representative adult general population samples were included. Most studies were assessed as having a “low risk” of bias across all quality domains. The studies were conducted in Ukraine (3), Germany (2), Republic of Ireland (2), Hong Kong, Israel, Kenya, Nigeria, and Ghana. All studies used the International Trauma Questionnaire (ITQ) to assess ICD-11 PTSD and CPTSD. In the five samples from non-war-exposed/economicallydeveloped countries/regions, the pooled prevalence rates for PTSD and CPTSD were 2 % and 4 %, respectively, based on a total of 7718 participants. In the five samples from war-exposed/less economically developed countries/regions, the pooled prevalence rates for PTSD and CPTSD were 16 % and 15 %, respectively, based on a total of 9870 participants. Given the high prevalence of PTSD and CPTSD, especially in war-exposed/less economically developed countries, there is a pressing need for more effective and scalable interventions to support affected populations. Pooled prevalence rates should be cautiously interpreted due to a limited number of studies.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104610"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Nardostachys Jatamansi DC as an adjuvant to escitalopram in the treatment of major depressive disorder – A randomized double-blind placebo-controlled study","authors":"VS Jismi, Kishore Kumar Ramakrishna, Urvakhsh Meherwan Mehta , Shivarama Varambally , Venkataram Shivakumar , Talakad N. Sathyaprabha , Kaviraja Udupa","doi":"10.1016/j.ajp.2025.104611","DOIUrl":"10.1016/j.ajp.2025.104611","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104611"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of economic crisis on the mental health of children and adolescents: A systematic review","authors":"Rita Feghali , Charline El-Hachem , Georges Bakhos , Myriam Zarzour , Rami Bou Khalil","doi":"10.1016/j.ajp.2025.104613","DOIUrl":"10.1016/j.ajp.2025.104613","url":null,"abstract":"<div><h3>Introduction</h3><div>Economic crises significantly affect mental health across individuals, families, and communities, with children and adolescents being especially vulnerable. Financial stress, parental distress, and family conflict can disrupt development and increase emotional, behavioural, and cognitive difficulties. This review uses Bronfenbrenner’s ecological systems theory to examine how economic hardship influences youth mental health through interconnected individual, familial, and societal systems.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a systematic search was conducted on PubMed and Google Scholar for studies (2015–2025) addressing economic hardship and mental health in children, adolescents, and parents. Inclusion required original research in English or French, with low or moderate risk of bias assessed using the Newcastle–Ottawa Scale (NOS) and its cross-sectional adaptation (NOS-CSS). Of 7104 records, 66 studies met criteria. Findings were grouped into three domains: mental health outcomes, child development, and the parent–child relationship.</div></div><div><h3>Results</h3><div>Financial hardship was consistently linked to increased rates of depression, anxiety, and substance use, often in a dose-response pattern. Socioeconomic disadvantage worsened access to care and outcomes, especially among the unemployed, less educated, women, and minorities. Youth exposed to economic strain showed higher rates of self-harm and suicide risk. Developmental impact, cognitive, emotional, and physical, was mediated by maternal mental health, parenting, nutrition, and environmental stress. Parental warmth and developmental knowledge emerged as protective factors.</div></div><div><h3>Conclusion</h3><div>Bronfenbrenner’s framework illustrates how economic crises affect child mental health across ecological layers. Coordinated responses addressing parenting, healthcare access, policy, and early-life support are essential to mitigate long-term harm in vulnerable populations.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104613"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bing Li , Sheng Guo , Lin Liu , Hao Xu , Haitao Chen , Jiaqi Song , Yan Chen , Xia Du , Shuping Tan
{"title":"Can circadian rhythms of heart rate variability identify major depressive disorder? — A study based on support vector machine analysis","authors":"Bing Li , Sheng Guo , Lin Liu , Hao Xu , Haitao Chen , Jiaqi Song , Yan Chen , Xia Du , Shuping Tan","doi":"10.1016/j.ajp.2025.104609","DOIUrl":"10.1016/j.ajp.2025.104609","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a prevalent and severe psychiatric condition for which objective diagnostic tools are lacking. Heart rate variability (HRV), an index of autonomic nervous system (ANS) function, has shown potential for distinguishing patients with MDD. This study aimed to improve classification performance by leveraging circadian rhythm features derived from multiple HRV indices using a support vector machine (SVM) approach.</div></div><div><h3>Methods</h3><div>Twenty-four-hour electrocardiographic recordings were collected from 116 patients with MDD and 63 healthy controls (HCs). Thirteen HRV indices, spanning the time domain, frequency domain, and nonlinear measures, were extracted, along with five corresponding circadian rhythm features (CRFs) for each index. To reduce feature dimensionality, a recursive feature elimination strategy based on the SVM was applied. The selected CRFs were then used to train the SVM classifier. Separate SVM models were constructed using CRFs derived from linear indices, nonlinear indices, and their combinations. Furthermore, their performance was compared across multiple metrics.</div></div><div><h3>Results</h3><div>The SVM model constructed using CRFs from all HRV indices achieved an accuracy of 97.80 %, sensitivity of 98.01 %, and specificity of 97.60 %. The models based on the CRFs from linear HRV indices outperformed those based on nonlinear indices, whereas the combination of all HRV indices yielded the best overall performance.</div></div><div><h3>Conclusions</h3><div>The results highlight the potential utility of HRV CRFs for objective MDD classification. Moreover, with an equal number of features, the CRFs derived from linear HRV indices proved to be more effective than those derived from nonlinear indices in discriminating patients with MDD.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104609"},"PeriodicalIF":3.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}