Asian journal of psychiatry最新文献

{"title":"Altered resting-state brain activity of the superior parietal cortex and striatum in major depressive disorder and schizophrenia","authors":"Cheng Chen ,&nbsp;Baoli Zhang ,&nbsp;Xucong Qin ,&nbsp;Huan Huang ,&nbsp;Bei Rong ,&nbsp;Huiling Wang ,&nbsp;Liang Zhang ,&nbsp;Wei Yuan","doi":"10.1016/j.ajp.2024.104303","DOIUrl":"10.1016/j.ajp.2024.104303","url":null,"abstract":"<div><h3>Background</h3><div>Resting-state functional magnetic resonance imaging (fMRI) studies have shown altered brain activity in major depressive disorder (MDD) and schizophrenia (SZ). Despite differing diagnoses, SZ and MDD share similar features. However, functional brain activity similarities and differences between SZ and MDD remain unclear.</div></div><div><h3>Methods</h3><div>Participants with MDD, SZ, and normal controls (n=36 each) underwent resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFF) was used to analyze the preprocessed rs-fMRI data. One-way ANOVAs and post hoc analyses compared ALFF values in different brain regions. Pearson correlation analysis examined associations with clinical symptoms.</div></div><div><h3>Results</h3><div>Comparison among the three groups revealed significant differences in ALFF values within the left superior parietal cortex (L-SPC) and bilateral striatum. Through pairwise comparisons, patients with SZ but not patients with MDD were found to exhibit increased striatum ALFF values relative to NC individuals, but decreased in MDD. Meanwhile, L-SPC ALFF values were significantly increased in patients with SZ relative to both normal control individuals and patients with MDD, while no differences in these values were observed between the normal control and MDD groups. The Pearson correlation analyses showed significant positive correlations between ALFF in the striatum and PANSS positive score, but no significant correlation with other symptom severity in SZ and MDD.</div></div><div><h3>Conclusion</h3><div>These findings support the hypothesis of alterations in brain functional activity as a fundamental component of the pathogenesis of MDD and SZ. The observed differences in functional brain activity in the superior parietal cortex and striatum between MDD and SZ provide a neuroimaging basis that can contribute to the differential diagnosis of these debilitating conditions.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104303"},"PeriodicalIF":3.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating neuroplasticity through synergistic ketamine and accelerated sequential theta burst stimulation (TBS) for treatment-resistant depression (TRD) – A case report","authors":"Veena Ramesh,&nbsp;Varsha Shamanna,&nbsp;Harsh Pathak,&nbsp;Swarna Buddha Nayok,&nbsp;Anushree Bose,&nbsp;Vanteemar S. Sreeraj,&nbsp;Ganesan Venkatasubramanian","doi":"10.1016/j.ajp.2024.104302","DOIUrl":"10.1016/j.ajp.2024.104302","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104302"},"PeriodicalIF":3.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe suicide attempts, day of the week, and holidays in South Korea: A nationwide case time series study","authors":"Harin Min ,&nbsp;Jiwoo Park ,&nbsp;Hyewon Yoon,&nbsp;Jieun Oh,&nbsp;Sojin Ahn,&nbsp;Cinoo Kang,&nbsp;Whanhee Lee","doi":"10.1016/j.ajp.2024.104299","DOIUrl":"10.1016/j.ajp.2024.104299","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104299"},"PeriodicalIF":3.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity study of the Turkish version of the Schizophrenia Cognition Rating Scale (SCoRS-TR)","authors":"Nedim Özak ,&nbsp;Emine Ilgın Hoşgelen ,&nbsp;Berna Binnur Akdede ,&nbsp;Köksal Alptekin","doi":"10.1016/j.ajp.2024.104301","DOIUrl":"10.1016/j.ajp.2024.104301","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is characterized by significant dysfunction in cognitive domains. Despite its crucial role in prognosis, evaluating neurocognitive impairments is challenging in outpatient settings because of the time-consuming nature of neurocognitive assessments. SCoRS “Schizophrenia Cognition Rating Scale” is a scale that provides brief cognitive evaluation. This study aimed to establish the validity and reliability of the Turkish version of the “Schizophrenia Cognition Rating Scale” (SCoRS-TR) in patients with schizophrenia and examine the correlation between SCoRS and cognitive tests.</div></div><div><h3>Methods</h3><div>Data were collected from 130 patients with schizophrenia who met the DSM-5 criteria and 40 healthy controls. SCoRS rating, Positive and Negative Syndrome Scale (PANSS), and a neurocognitive test battery were administered.</div></div><div><h3>Results</h3><div>Findings indicated that SCoRS-TR is a reliable and valid scale for the Turkish population. The scale demonstrated strong internal consistency, with Cronbach's alpha values ranging from 0.937 to 0.940. High interrater reliability (ranging from 0.90 to 0.98) and test-retest reliability (ranging from 0.976 to 0.990) were observed. SCoRS-TR significantly discriminated patients from healthy controls (p&lt;0.001). SCoRS-TR exhibited significant correlations to neurocognitive tests.</div></div><div><h3>Discussion</h3><div>Results indicated that SCoRS-TR had significant reliability and validity scores that may be useful for evaluating daily life functioning related to cognitive dysfunction in patients with schizophrenia. This approach may be useful for neurocognitive evaluation and monitoring in clinical follow-up and outpatient settings.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104301"},"PeriodicalIF":3.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closure risk of general hospital psychiatric units: Impact of financial pressures and psychiatrist staffing challenges","authors":"Michitaka Funayama,&nbsp;Shigeki Sato,&nbsp;Hiraki Koishikawa,&nbsp;Naoko Satake,&nbsp;On Kato,&nbsp;Masayuki Noguchi,&nbsp;Tomoji Takata,&nbsp;Yusuke Hasegawa,&nbsp;Hisashi Wada,&nbsp;Takaki Akahane,&nbsp;Naohisa Tsujino,&nbsp;Katsuji Nishimura","doi":"10.1016/j.ajp.2024.104300","DOIUrl":"10.1016/j.ajp.2024.104300","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104300"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcortical and insula functional connectivity aberrations and clinical implications in first-episode schizophrenia","authors":"Bixin Wang,&nbsp;Meng Zhang,&nbsp;Fengmei Fan,&nbsp;Chunyu Yuan,&nbsp;Zhiren Wang,&nbsp;Yunlong Tan,&nbsp;Shuping Tan","doi":"10.1016/j.ajp.2024.104298","DOIUrl":"10.1016/j.ajp.2024.104298","url":null,"abstract":"<div><h3>Introduction</h3><div>Schizophrenia is a complex mental disorder whose pathophysiology remains elusive, particularly in the roles of subcortex. This study aims to explore the role of subcortex and insula and their relationship with symptom changes in first-episode schizophrenia (FES) patients by utilizing machine learning algorithms and functional connectivity (FC).</div></div><div><h3>Methods</h3><div>The study encompasses 261 participants, sourced from two independent samples of FES patients and their matched healthy controls (HC). The discovery dataset includes 77 FES patients at baseline (FES0W) and 77 matched HCs, with the patients undergoing a follow-up scan after eight weeks of antipsychotic treatment (FES8W, N = 34). A validation dataset from another region comprises 47 FES patients and 47 matched HCs.</div></div><div><h3>Results</h3><div>Significant differences in subcortical FCs were observed between FES and controls, correlating with symptom severity and symptom changes. Machine learning models were developed to diagnose schizophrenia on an individual basis, achieving a balanced accuracy of 79.55 % across diverse centers.</div></div><div><h3>Conclusions</h3><div>These findings suggest that subcortical connectivity patterns offer potential as biomarkers for schizophrenia, enabling personalized treatment strategies and improving prognosis by facilitating early diagnosis.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"103 ","pages":"Article 104298"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a package of community-based mental healthcare services to address perinatal mental disorders in Bangladesh: A cluster-randomized controlled trial","authors":"Goutam Kumar Dutta ,&nbsp;Helal Uddin Ahmed ,&nbsp;Md. Quiume Talukder ,&nbsp;Dipika Shankar Bhattacharyya ,&nbsp;M. Shamim Reza ,&nbsp;Md. Musfikur Rahman ,&nbsp;Ratna Majumdar ,&nbsp;Fahmida Tofail ,&nbsp;Henry B. Perry ,&nbsp;Taposh Kumar Biswas","doi":"10.1016/j.ajp.2024.104290","DOIUrl":"10.1016/j.ajp.2024.104290","url":null,"abstract":"<div><h3>Background</h3><div>Perinatal mental disorders of women have an impact on their pregnancy and their child’s brain development across low and middle-income countries. However, to address this issue, there are no specific guidelines for community-level service providers in Bangladesh. Therefore, we aimed to develop a community-based mental healthcare (CBMHC) service package and test its effectiveness in reducing depression, anxiety, and stress among mothers during the perinatal period.</div></div><div><h3>Methods</h3><div>A cluster-randomized controlled trial (cRCT) was applied to test the CBMHC package in 2017 and 2018. It was provided to one group of mothers along with routine maternal care while another group received only routine maternal care. Paired sample t-test was applied to assess mean changes at baseline and endline in the Depression, Anxiety, and Stress Scales-21 (DASS-21) and EuroQol-5 Dimension and 3 Level (EQ5D3L) scales. A linear mixed-effects model was used to assess the relationship between the DASS-21 score and EQ5D3L.</div></div><div><h3>Results</h3><div>1215 participants were enrolled, including 605 in the intervention group and 610 in the control group. Measures of depression, anxiety, and stress were significantly decreased in both groups. Reduction in the levels of stress, as measured by changes in the stress score, were significantly greater in the intervention than in the control group (diff: 1.2, 95 % CI: 0.1, 2.2). The EQ5D3L index improved significantly, 0.02 units more at endline in the intervention group than in the control group (diff: 0.02, 95 % CI: 0.007, 0.03). The levels of mobility, usual activities, pain or discomfort, depression, and anxiety improved by 1.4 %, 7.6 %, 4.4 %, 2.6 %, and 0.4 % more, respectively, in the intervention group compared to the control groups. These improvements were statistically significant. The DASS-21 score was negatively and significantly correlated with both the EQ-5D3L index and the Visual Analogue Scale (VAS) score for the intervention group as well as for the usual care group, indicating that EQ5D3L improved when common mental disorders decreased.</div></div><div><h3>Conclusion</h3><div>Although the improvements were modest, a CBMHC service package was effective in reducing perinatal levels of stress among Bangladeshi rural women.</div></div><div><h3>Trial Registration</h3><div>ClinicalTrials.gov ID: NCT03678415</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104290"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review","authors":"Raghunath Singh ,&nbsp;Kristoffer Panganiban ,&nbsp;Emily Au ,&nbsp;Rekha Ravikumar ,&nbsp;Sandra Pereira ,&nbsp;Thomas D. Prevot ,&nbsp;Daniel J. Mueller ,&nbsp;Gary Remington ,&nbsp;Sri Mahavir Agarwal ,&nbsp;Elena F. Verdu ,&nbsp;Premysl Bercik ,&nbsp;Giada De Palma ,&nbsp;Margaret K. Hahn","doi":"10.1016/j.ajp.2024.104285","DOIUrl":"10.1016/j.ajp.2024.104285","url":null,"abstract":"<div><div>More recently, attention has turned to the putative role of gut microbiome (GMB) in pathogenesis, symptomatology, treatment response and/or resistance in schizophrenia (SCZ). It is foreseeable that fecal microbiota transplantation (FMT) from SCZ patients (SCZ-FMT) to germ-free mice could represent a suitable experimental framework for a better understanding of the relationship between GMB and SCZ. Thus, we set out to identify literature (i) characterizing the GMB in animal models of SCZ, and (ii) employing SCZ-FMT into rodents to model SCZ in relation to behavioral and molecular phenotypes. Five studies examining animal models of SCZ suggest distinct GMB composition compared to respective control groups, which was correlated with SCZ-like behavioral phenotypes. Four additional studies investigated SCZ-FMT into rodents in relation to behavioral phenotypes, including spontaneous hyperlocomotion, social deficits, exaggerated startle response, and cognitive impairments, resembling those observed in SCZ patients. Mice receiving SCZ-FMT showed altered neurochemical and metabolic pathways in the brain. Animal models of SCZ have shown altered GMB composition, whereas reported behavioral and neurochemical alterations following FMT from patients into rodents suggest early face and construct validity for SCZ-FMT animal models. However, the predictive validity of these models remains to be validated.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104285"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Default at fault? Exploring neural correlates of default mode network in children with ADHD, their unaffected siblings versus neurotypical controls: A quantitative EEG study","authors":"Chaithanya Leon ,&nbsp;Simran Kaur ,&nbsp;Rajesh Sagar ,&nbsp;Prashant Tayade ,&nbsp;Ratna Sharma","doi":"10.1016/j.ajp.2024.104291","DOIUrl":"10.1016/j.ajp.2024.104291","url":null,"abstract":"<div><h3>Background</h3><div>Sustained activation of default mode network has been implicated for momentary lapses of attention and higher errors during performance of cognitive tasks in attention deficit hyperactive disorder (ADHD) children. Despite emerging evidence indicating the genetic basis of ADHD, there is paucity of literature investigating the alteration of DMN in children with ADHD and their unaffected siblings.</div></div><div><h3>Aim</h3><div>To study the cortical sources of DMN in children with ADHD compared to their siblings and neurotypical controls.</div></div><div><h3>Methods</h3><div>Eighty-six participants (35 ADHD (12.4(±2.7) years), 16 unaffected siblings (11.8(±4.3) years) and 35 matched neurotypical controls (12.6 (±3.6) years) participated in the study. 128 channel EEG data was acquired during rest and Stroop cognitive task and analyzed for cortical source estimation using LORETA software.</div></div><div><h3>Results</h3><div>Higher activation of DMN and DMN associated areas were observed during encoding of the color-word stimuli in children with ADHD. Sustained activation of core DMN areas namely medial frontal gyrus, posterior cingulate gyrus, parahippocampal gyrus and inferior parietal lobule was observed across all groups. Among the three groups, distinct cortical source activation differences were identified solely in the DMN and its associated areas among children with ADHD during the task encoding phase compared to baseline. In contrast, both siblings and neurotypical controls displayed activation in fronto-parieto-temporal areas subserving executive function were also observed.</div></div><div><h3>Conclusion</h3><div>Sustained activity of DMN areas with minimal activity in executive network in ADHD children and unaffected siblings during encoding of stimulus implies potential endophenotypic marker in children with ADHD compared to neurotypical controls.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104291"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ban on alcohol consumption and the tragedy of death by alcohol poisoning in Iran","authors":"Bijan Pirnia,&nbsp;Alireza Ellieen","doi":"10.1016/j.ajp.2024.104286","DOIUrl":"10.1016/j.ajp.2024.104286","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104286"},"PeriodicalIF":3.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}