Asian journal of psychiatry最新文献

{"title":"A systematic review of clozapine in the Arab world: Patterns of use, barriers and facilitators in clinical practice","authors":"Salim AL-Huseini ,&nbsp;Mohammed Qutishat ,&nbsp;Osamah Khan ,&nbsp;Ikhlaq Ahmed","doi":"10.1016/j.ajp.2025.104698","DOIUrl":"10.1016/j.ajp.2025.104698","url":null,"abstract":"<div><h3>Background</h3><div>Clozapine is the only drug licensed for treatment-resistant schizophrenia (TRS) but is grossly underutilised. It is essential to understand the use of Clozapine in clinical practice in the Arab world, where mental health services face numerous challenges, including stigma and resource limitations. This systematic review aims to evaluate existing evidence on clozapine usage, focusing on patterns, barriers, and future directions.</div></div><div><h3>Method</h3><div>We conducted a search using electronic databases (PubMed, Scopus, Embase, PsycINFO to identify studies published since 1982. The review adhered to the PRISMA guidelines and included studies on the use of clozapine in Arab countries. Two independent reviewers screened titles, abstracts, and full texts. They evaluated methodological quality using an adapted version of the Newcastle–Ottawa Scale, tailored for cross-sectional designs, and the JBI Critical Appraisal Checklist for Qualitative Research. Researchers extracted and synthesised data using an integrative approach, allowing for convergence across different study types.</div></div><div><h3>Results</h3><div>Eighteen studies from nine Arab countries were analyzed, involving a total of 6079 participants. Sample sizes varied significantly, ranging from 13 to 1246. Only 10 studies (55.6 %) provided sex-disaggregated data, all of which showed a male majority. The majority of studies were single-site retrospective or cross-sectional investigations, highlighting a regionally focused evidence base in the Middle East and North Africa. Four main themes were identified: implementation barriers, facilitators, adverse effects, and sociocultural influences. However, standardised outcome measures and patient perspectives were largely missing.</div></div><div><h3>Conclusion</h3><div>Despite its widespread use, clozapine is still underutilized in the Arab world due to systemic, clinical, and patient-level barriers. To improve outcomes in treatment-resistant schizophrenia, it is essential to address issues such as polypharmacy, inadequate training, limited access to monitoring, and non-adherence through targeted reforms and service integration.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104698"},"PeriodicalIF":4.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data alone is not enough: Improvement initiatives and recommendations for PEERS intervention measures: Impact of social knowledge and skills training based on UCLA PEERS® on social communication and interaction skills of adolescents or young adults with autism: A systematic review and meta-analysis","authors":"Andika Ari Saputra ,&nbsp;Arizona Arizona ,&nbsp;Rio Saputra ,&nbsp;Triana Asih ,&nbsp;Jati Rinakri Atmaja ,&nbsp;Wahyu Kusumaningtyas","doi":"10.1016/j.ajp.2025.104696","DOIUrl":"10.1016/j.ajp.2025.104696","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104696"},"PeriodicalIF":4.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant hippocampal subregional network associated with episodic memory decline in amnestic mild cognitive impairment","authors":"Shengxiang Liang ,&nbsp;Li Huang ,&nbsp;Jingfang Zhu ,&nbsp;Miaoran Lin ,&nbsp;Minguang Yang ,&nbsp;Jiahui Gao ,&nbsp;Chuyi Ma ,&nbsp;Xiaolong Yin ,&nbsp;Junchao Yang ,&nbsp;Lei Yang ,&nbsp;Weilin Liu ,&nbsp;Jing Tao ,&nbsp;Lidian Chen","doi":"10.1016/j.ajp.2025.104683","DOIUrl":"10.1016/j.ajp.2025.104683","url":null,"abstract":"<div><h3>Background</h3><div>Amnestic mild cognitive impairment (aMCI) is characterized by marked episodic memory decline. The hippocampus is essential for episodic memory, and integration of information within its subregions is central to this process. This study examined how alterations in hippocampal subregional network relate to episodic memory impairment in aMCI.</div></div><div><h3>Methods</h3><div>Participants with aMCI (n = 32) were recruited between March 2021 and May 2022, with cognitively normal controls (n = 32) matched for age, sex, and years of education. Episodic memory was evaluated using the Logical Memory subtest of the Wechsler Memory Scale–Revised. Resting-state functional MRI data were acquired. Hippocampal subregional networks were constructed to characterize functional connectivity and topological alterations in aMCI. Pearson correlation analyses were used to assess the relationships between network metrics and episodic memory function.</div></div><div><h3>Results</h3><div>We found impaired integration of the hippocampal subregion network in aMCI, as reflected by increased path length and decreased global efficiency (p &lt; 0.05). Longer path length correlated with lower Logical Memory scores. Functional connectivity decreased between the bilateral parasubiculum and the left granule and molecular layer of the dentate gyrus and between the right parasubiculum and left CA1 (connection-level threshold p &lt; 0.001, network-level threshold pFDR &lt; 0.05). Nodal analyses revealed reduced degree centrality and nodal efficiency in the bilateral parasubiculum and presubiculum (pFDR &lt; 0.05), both positively associated with episodic memory in aMCI (pFDR &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>These findings suggest that episodic memory impairment in aMCI is linked to altered hippocampal subregional integration, with the parasubiculum and presubiculum as potential key regions.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104683"},"PeriodicalIF":4.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction in depression: Mechanisms and targeted therapy strategies","authors":"Xue Xia ,&nbsp;Kaiqing Li ,&nbsp;Baiyi Jiang ,&nbsp;Wei Zou ,&nbsp;Long Wang","doi":"10.1016/j.ajp.2025.104694","DOIUrl":"10.1016/j.ajp.2025.104694","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a severe mental illness with complex pathophysiology. Growing evidence highlights mitochondrial dysfunction as a key player in MDD, influencing neuroinflammation, synaptic plasticity, and energy metabolism. This review summarizes recent advances in understanding how mitochondrial defects—including mtDNA mutations, impaired mitophagy, disrupted dynamics, altered biogenesis, and metabolic dysregulation—contribute to depressive pathogenesis. We also evaluate mitochondria-targeted therapeutic strategies, encompassing both pharmacological agents (e.g., antioxidants, CoQ10, NAD+ precursors, SSRIs, and natural compounds) and non-pharmacological interventions (e.g., exercise, ketogenic diet, photobiomodulation, and electroacupuncture). Importantly, we emphasize the interplay between mitochondrial processes and the need to balance anabolic and catabolic functions. While preclinical results are promising, further clinical translation is essential. This review underscores mitochondrial health as a central theme in MDD research and therapy development.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104694"},"PeriodicalIF":4.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring ICD-11 dissociative identity disorder: Cross-cultural validation of the international dissociative identity disorder questionnaire","authors":"Hong Wang Fung ,&nbsp;Anson Kai Chun Chau ,&nbsp;Colin A. Ross ,&nbsp;Vedat Şar ,&nbsp;Görkem Derin ,&nbsp;Aslı Dila Akiş ,&nbsp;Henry Tak Shing Chiu ,&nbsp;Audrey Zatopek ,&nbsp;Grace Wing Ka Ho","doi":"10.1016/j.ajp.2025.104685","DOIUrl":"10.1016/j.ajp.2025.104685","url":null,"abstract":"<div><div>Recently, the ICD-11 has updated the diagnostic requirements for dissociative identity disorder (DID) and introduced partial DID as a new diagnosis. This study validated the first measure of DID and partial DID as defined in ICD-11. Two convenience samples of mental health service users (118 Chinese speakers and 115 English speakers) completed the International Dissociative Identity Disorder Questionnaire (IDIDQ), the Dissociative Experiences Scale-Taxon (DES-T), and the Multiscale Dissociation Inventory (MDI) in their respective language. The IDIDQ had good to excellent internal consistency (α =.861 to.892) and test-retest reliability (ICC =.682 to.854, p &lt; .001) in both samples. The 3-factor structure of DID (i.e., amnesia, dissociative identities, and switching), as proposed in ICD-11, was supported by our cross-cultural data, with configural, metric and scalar invariance established across the Chinese- and English-speaking samples. The IDIDQ reliably detected probable ICD-11 DID and partial DID (κ =.517 to.781, p &lt; .001) during a one-week test-retest period. The IDIDQ subscales were strongly correlated with the respective MDI subscales and the DES-T scores. The IDIDQ results had moderate to substantial agreement with the MDI Identity Dissociation subscale and the DES-T in both samples (κ =.514 to.741, p &lt; .001). This study provides first evidence showing the ICD-11 DID and partial DID can be reliably and validly measured using the IDIDQ.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104685"},"PeriodicalIF":4.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and transition accuracy of natural language processing in high risk for psychosis individuals: A systematic review","authors":"José Tomás García-Molina ,&nbsp;Maximiliano Downey ,&nbsp;Emmanuel Méndez ,&nbsp;Alicia Figueroa-Barra","doi":"10.1016/j.ajp.2025.104695","DOIUrl":"10.1016/j.ajp.2025.104695","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia spectrum disorders often emerge in adolescence or early adulthood and are a leading cause of global disability. Early identification of clinical high‑risk for psychosis (CHR‑P) can reduce comorbidity and shorten untreated psychosis duration, yet clinician‑administered tools (e.g., SIPS/SOPS, CAARMS, PSYCHS) are time‑consuming and only moderately predictive.</div></div><div><h3>Objective</h3><div>To systematically review the diagnostic and prognostic accuracy of natural language processing (NLP) applied to speech in CHR‑P populations, and to map methodological trends and gaps.</div></div><div><h3>Methods</h3><div>We searched PubMed, Scopus, and Embase through May 2025 for English or Spanish studies enrolling CHR‑P individuals by validated criteria, applying NLP to speech transcripts, and reporting quantitative metrics (accuracy, sensitivity, specificity, AUC‑ROC). Two reviewers independently screened studies, extracted data, and assessed bias with QUADAS‑2; disagreements were resolved by a third reviewer.</div></div><div><h3>Results</h3><div>Results: From 356 records, nine studies (eight unique cohorts; N = 353 CHR-P, 197 controls) met inclusion. Four case–control studies and one prospective cohort assessed cross-sectional discrimination of CHR-P from healthy controls, reporting accuracies of 56–95 % (AUC-ROC 0.86–0.99). Four prospective studies examined transition prediction, with accuracies ranging from 83 % to 100 %. Studies covered five languages and employed diverse NLP pipelines (e.g., LSA, Word2Vec, USE, SBERT, graph metrics, sentiment analysis). However, feature heterogeneity, small samples (≤ 50 CHR-P), varied speech tasks, and inconsistent validation limited comparability.</div></div><div><h3>Conclusions</h3><div>NLP‑based speech analysis shows promise as an objective biomarker for early psychosis detection and risk stratification. To advance clinical utility, future research should adopt standardized protocols, recruit larger and more diverse cohorts, and implement multicenter validation.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104695"},"PeriodicalIF":4.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of compulsive sexual behavior disorder (CSBD) with a naltrexone implant: A case report","authors":"Liu Liu ,&nbsp;Xiwen Tian ,&nbsp;Xuhui Zhou","doi":"10.1016/j.ajp.2025.104686","DOIUrl":"10.1016/j.ajp.2025.104686","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104686"},"PeriodicalIF":4.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of vestibular dysfunctions in schizophrenia and bipolar disorder – A comprehensive systematic review","authors":"Rahina Abubacker ,&nbsp;Pradeep Yuvaraj ,&nbsp;Aravind Kumar Rajasekaran ,&nbsp;Aravinda Hanumathapura Ramalingaiah ,&nbsp;Binukumar Bhaskarapillai ,&nbsp;Suresh Sukumar ,&nbsp;Hari Prakash ,&nbsp;Muralidharan Kesavan","doi":"10.1016/j.ajp.2025.104679","DOIUrl":"10.1016/j.ajp.2025.104679","url":null,"abstract":"<div><h3>Background</h3><div>The vestibular system is closely linked to brain regions such as hippocampus, thalamus, and prefrontal cortex involved in self-perception, spatial orientation, and emotional regulation. Disruptions in these pathways may underlie symptoms such as hallucinations or mood instability, with emerging evidence suggesting a role of vestibular dysfunction in the clinical features and comorbidities of schizophrenia and bipolar disorder.</div></div><div><h3>Objective</h3><div>The aim of this systematic review was to critically examine the available data on vestibular dysfunction in individuals with schizophrenia and BD, explore possible mechanisms, and evaluate the clinical implications, including therapeutic relevance.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we searched PubMed, Scopus, Web of Science, Cochrane Library, and HTA Database (Jan 2000–Apr 2025) for peer-reviewed studies assessing vestibular function in adults with BD and/or schizophrenia using quantitative methods. Study quality was appraised with the Cochrane Risk of Bias Tool and Newcastle-Ottawa Scale. The review is registered on PROSPERO (CRD42024124991).</div></div><div><h3>Results</h3><div>Of 854 records, five studies (four cross-sectional, one RCT) met inclusion criteria, using posturography and electrovestibulography to assess vestibular function. Both BD and schizophrenia showed vestibular abnormalities: BD exhibited state-dependent changes during mood episodes, while schizophrenia showed illness-related visual dependence. Vestibular dysfunctions were also linked to cognitive deficits and anxiety. Limitations included small samples, medication effects, and heterogeneous methods.</div></div><div><h3>Conclusion</h3><div>This review highlights preliminary evidence that vestibular dysfunction is an underrecognized feature of schizophrenia and BD. Integrating vestibular assessments may improve diagnosis and guide rehabilitation, while longitudinal studies are needed to clarify causal links and therapeutic potential.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104679"},"PeriodicalIF":4.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatrist-digital integration in LMIC primary care","authors":"Komang Ariyanto","doi":"10.1016/j.ajp.2025.104680","DOIUrl":"10.1016/j.ajp.2025.104680","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104680"},"PeriodicalIF":4.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordinated mental health and psychosocial support in Iran following acute cross-border hostilities (Jun 13, 2025 – Jun 24, 2025): A rapid response from Iran’s Ministry of Health and Medical Education","authors":"Alireza Raeisi,&nbsp;Hadi Zarafshan,&nbsp;Ali Bahramnejad,&nbsp;Mohammadreza Ghaffarzadeh Razzaghi,&nbsp;Ali Asadi,&nbsp;Hamid Reza Fathi,&nbsp;Zeinab Nasirimahini,&nbsp;Seyed Ebrahim Ghoddousi,&nbsp;Mohammadreza Shalbafan","doi":"10.1016/j.ajp.2025.104684","DOIUrl":"10.1016/j.ajp.2025.104684","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104684"},"PeriodicalIF":4.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}