Asian journal of psychiatry最新文献

{"title":"Can circadian rhythms of heart rate variability identify major depressive disorder? — A study based on support vector machine analysis","authors":"Bing Li ,&nbsp;Sheng Guo ,&nbsp;Lin Liu ,&nbsp;Hao Xu ,&nbsp;Haitao Chen ,&nbsp;Jiaqi Song ,&nbsp;Yan Chen ,&nbsp;Xia Du ,&nbsp;Shuping Tan","doi":"10.1016/j.ajp.2025.104609","DOIUrl":"10.1016/j.ajp.2025.104609","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a prevalent and severe psychiatric condition for which objective diagnostic tools are lacking. Heart rate variability (HRV), an index of autonomic nervous system (ANS) function, has shown potential for distinguishing patients with MDD. This study aimed to improve classification performance by leveraging circadian rhythm features derived from multiple HRV indices using a support vector machine (SVM) approach.</div></div><div><h3>Methods</h3><div>Twenty-four-hour electrocardiographic recordings were collected from 116 patients with MDD and 63 healthy controls (HCs). Thirteen HRV indices, spanning the time domain, frequency domain, and nonlinear measures, were extracted, along with five corresponding circadian rhythm features (CRFs) for each index. To reduce feature dimensionality, a recursive feature elimination strategy based on the SVM was applied. The selected CRFs were then used to train the SVM classifier. Separate SVM models were constructed using CRFs derived from linear indices, nonlinear indices, and their combinations. Furthermore, their performance was compared across multiple metrics.</div></div><div><h3>Results</h3><div>The SVM model constructed using CRFs from all HRV indices achieved an accuracy of 97.80 %, sensitivity of 98.01 %, and specificity of 97.60 %. The models based on the CRFs from linear HRV indices outperformed those based on nonlinear indices, whereas the combination of all HRV indices yielded the best overall performance.</div></div><div><h3>Conclusions</h3><div>The results highlight the potential utility of HRV CRFs for objective MDD classification. Moreover, with an equal number of features, the CRFs derived from linear HRV indices proved to be more effective than those derived from nonlinear indices in discriminating patients with MDD.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104609"},"PeriodicalIF":3.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Thailand’s mental health services to enhance quality of life and recovery outcomes through integrated patient-reported outcome measure","authors":"Peanchanan Leah ,&nbsp;Wachara Riewpaiboon","doi":"10.1016/j.ajp.2025.104608","DOIUrl":"10.1016/j.ajp.2025.104608","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104608"},"PeriodicalIF":3.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations between anxiety, depressive symptoms and suicidal ideation in older adults: Undirected and Bayesian network analyses","authors":"Min Li ,&nbsp;Lu Zhang ,&nbsp;Chuchu Li,&nbsp;Haoran Chen,&nbsp;Hailong Shu,&nbsp;Wentao Fang,&nbsp;Fangfang Liu,&nbsp;Linsheng Yang,&nbsp;Gengfu Wang,&nbsp;Puyu Su","doi":"10.1016/j.ajp.2025.104607","DOIUrl":"10.1016/j.ajp.2025.104607","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104607"},"PeriodicalIF":3.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellum and obsessive-compulsive disorder: A narrative review of neuroimaging evidence from MRI studies","authors":"Yuanyuan Yang ,&nbsp;Yu Xia ,&nbsp;Zimo Zhou ,&nbsp;Zhenru Guo ,&nbsp;Lin Tian","doi":"10.1016/j.ajp.2025.104606","DOIUrl":"10.1016/j.ajp.2025.104606","url":null,"abstract":"<div><div>Obsessive-Compulsive Disorder (OCD) is a psychiatric condition characterized by recurrent obsessions (intrusive thoughts) and compulsions (repetitive behaviors), with its neurobiological mechanisms remaining a central focus of research. Since the 1980s, neuroimaging studies have revealed significant structural and functional brain differences between OCD patients and healthy controls. Early research primarily relied on the cortico-striato-thalamo-cortical (CSTC) circuit model to explain OCD pathophysiology. However, magnetic resonance imaging (MRI) studies over the past two decades have identified substantial cerebellar abnormalities closely associated with OCD pathogenesis. This review synthesizes evidence from structural MRI (sMRI), diffusion tensor imaging (DTI), functional MRI (fMRI), and meta-analyses to elucidate the cerebellum's role in OCD. Current findings demonstrate that cerebellar abnormalities in OCD patients not only exist independently but also interact with the basal ganglia and CSTC circuits, thereby refining the traditional CSTC model. These findings point to the cerebellum as a potentially critical node in the broader network underlying OCD symptoms. Future directions include exploration of cerebellar-cortical interactions, particularly at the level of symptom-dimensions and subregional specificity, as well as the development of cerebellum-targeted interventions guided by advanced neuroimaging and computational techniques.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104606"},"PeriodicalIF":3.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GenAI and psychiatry: Between multimodal promise and ethical perils","authors":"Rio Saputra ,&nbsp;Moh Ramdhan Arif Kaluku ,&nbsp;Hartoto ,&nbsp;Edi Setiawan ,&nbsp;Arizona ,&nbsp;Triana Asih ,&nbsp;Andika Ari Saputra","doi":"10.1016/j.ajp.2025.104605","DOIUrl":"10.1016/j.ajp.2025.104605","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104605"},"PeriodicalIF":3.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the cycle of oxidative stress for better behavioral health in autism spectrum disorder: A scoping review","authors":"Rinvil Renaldi ,&nbsp;Antonio M. Persico ,&nbsp;Tjhin Wiguna ,&nbsp;Andi Jayalangkara Tanra","doi":"10.1016/j.ajp.2025.104575","DOIUrl":"10.1016/j.ajp.2025.104575","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by socio-communicative and behavioral challenges. ASD is increasingly linked to oxidative stress, which stems from a destructive imbalance state whereby excessive reactive oxygen species (ROS) overwhelm antioxidant defenses. This redox imbalance triggers a cascade of cellular dysfunctions, which in neurons include synaptic inefficiency, altered receptor function, excitotoxicity, and chronic neuroinflammation. All these dysfunctions add an additional burden to the genetic and epigenetic contributions underlying autism pathophysiology in each single individual, ultimately exacerbating ASD core symptoms. Strikingly, children with ASD exhibit diminished antioxidant capacity, correlated with heightened behavioral severity and impaired quality of life. This scoping review explores the intricate relationship between oxidative stress and ASD, evaluating current therapeutic strategies aimed at restoring redox balance while identifying critical research gaps. Interventions such as N-acetylcysteine (NAC), vitamin and mineral supplementation, and dietary antioxidants have shown promise in mitigating oxidative damage and improving social responsiveness. Other strategies, in particular hyperbaric oxygen therapy (HBOT) and cleanroom environments, are highly controversial. Well-designed randomized placebo-controlled trials (RCTs) integrating clinical and psychodiagnostic measures with precision medicine frameworks, are crucial for developing targeted therapies that, restoring redox homeostasis, may optimize neurodevelopmental outcomes. By summarizing current evidence and addressing these gaps, this review underscores the therapeutic potential of oxidative stress correction in improving the quality of life of individuals with ASD.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104575"},"PeriodicalIF":3.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment approaches and efficacy in psychedelic-induced psychosis: A systematic review","authors":"Adi Sulstarova ,&nbsp;Luise Scheuerlein ,&nbsp;Silvia Monari ,&nbsp;Federico Seragnoli ,&nbsp;Thorens Gabriel ,&nbsp;Katrin Preller ,&nbsp;Kerem Böge ,&nbsp;Othman Sentissi ,&nbsp;Stefan Kaiser ,&nbsp;Marco Solmi ,&nbsp;Matthias Kirschner ,&nbsp;Michel Sabé","doi":"10.1016/j.ajp.2025.104604","DOIUrl":"10.1016/j.ajp.2025.104604","url":null,"abstract":"<div><div>Psychedelics are increasingly used in the general population, yet they are associated with increased risk of psychosis in a minority of users that can experience psychedelic-induced psychosis (&lt;1 % in controlled trial settings). In contrast, the evidence regarding the treatment of psychedelics-induced psychosis remains to date scarce. We conducted a PRISMA 2020-compliant systematic review (CRD42023399591), searching electronic databases (inception–August 2024) for interventional, observational studies, case series, or case reports on the treatment of psychedelic-induced psychosis. Frequencies of population, treatment, and outcome characteristics were analyzed. We included 14 case series, 20 case reports, and one prospective study, reporting on 93 cases of psychedelic-induced psychosis, between 1955 and 2024. The primary substances implicated were LSD (47.3 %) and MDMA (38.7 %), and the average patient age of 23.7 ± 6.3 years, with a predominance of male subjects (88 %). Psychosis lasted an average of 1.8 weeks. We identified two main treatment categories: first-generation antipsychotics (n = 37) and second-generation antipsychotics (n = 57). Electroconvulsive therapy was used in a minor subset of cases (n = 9). The response rate for first-generation antipsychotics (27 %) was significantly lower than that for second-generation agents (91.3 %) and electroconvulsive therapy (91 %). Follow-up data indicated 34 % of patients later developed schizophrenia spectrum disorders, and 20.4 % were diagnosed with bipolar disorder. However, the lack of comprehensive follow-up limits the interpretation of findings In conclusion, the evidence supporting treatment options remains limited, primarily based on case reports. Our findings suggest that second-generation antipsychotics seem to be more beneficial in managing psychedelic-induced psychosis, warranting further investigation into optimized treatment protocols.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104604"},"PeriodicalIF":3.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal psychometric validation and measurement invariance of the PTSD checklist for DSM-5 (PCL-5)","authors":"Celine Mylx Li ,&nbsp;Grace Wing Ka Ho ,&nbsp;Stanley Kam Ki Lam ,&nbsp;Hong Wang Fung","doi":"10.1016/j.ajp.2025.104599","DOIUrl":"10.1016/j.ajp.2025.104599","url":null,"abstract":"<div><div>Despite the adoption of the four-factor model of posttraumatic stress disorder (PTSD) in the DSM-5, very few studies have provided longitudinal examinations of the temporal stability of the PTSD Checklist for DSM-5 (PCL-5), particularly in East Asian contexts. In addition, its factorial structure and validity have been a subject of considerable debate, with accumulating evidence suggesting that alternative models may better capture the heterogeneity of PTSD symptoms. To address these gaps, the present study evaluated the psychometric properties of the Traditional Chinese version of the PCL-5 (TC-PCL-5) across three timepoints (N = 412 at Time 1, 232 at Time 2, and 132 at Time 3) in a community sample of Hong Kong adults, testing both the four- and six-factor structures of the PCL-5. Internal consistency of the scale remained stable across all three waves of the study <span><math><mrow><mo>(</mo><mi>T</mi><mn>1</mn><mo>:</mo><mspace></mspace><mi>ω</mi><mo>=</mo><mn>0.97</mn></mrow></math></span>; <span><math><mrow><mi>T</mi><mn>2</mn><mo>:</mo><mspace></mspace><mi>ω</mi><mo>=</mo><mn>0.98</mn></mrow></math></span>; <span><math><mrow><mi>T</mi><mn>3</mn><mo>:</mo><mspace></mspace><mi>ω</mi><mo>=</mo><mn>0.98</mn><mo>)</mo></mrow></math></span>. Intraclass correlation analyses revealed good test–retest reliability. Confirmatory factor analyses supported both factorial structures at each timepoint. Results demonstrated configural, metric, and scalar invariance across all three waves and indicated that the underlying factor structure, item loadings, and intercepts remained stable over time, with the six-factor structure showing a slightly better fit.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104599"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A missing piece in inconsistent suicidality reporting: Suicide plans without suicidal ideation","authors":"Romain Brisson","doi":"10.1016/j.ajp.2025.104602","DOIUrl":"10.1016/j.ajp.2025.104602","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104602"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide rates in China: What will be the next?","authors":"Jie Zhang","doi":"10.1016/j.ajp.2025.104603","DOIUrl":"10.1016/j.ajp.2025.104603","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"110 ","pages":"Article 104603"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}