Asian journal of psychiatry最新文献

{"title":"Sense-of-agency as clinically accessible features for schizophrenia prediction: Interpretable ensemble machine learning research and webserver development","authors":"Chaochao Pan ,&nbsp;Caimei Yang ,&nbsp;Jun Mao","doi":"10.1016/j.ajp.2025.104674","DOIUrl":"10.1016/j.ajp.2025.104674","url":null,"abstract":"<div><div>Schizophrenia is a high-risk, high-burden psychiatric disorder characterized by a prolonged course and severe disability. Accurate identification and early intervention can mitigate socioeconomic adversities, including illness-induced poverty and public safety risks. Traditional diagnosis relies predominantly on structured clinical interviews, with clinicians using positive symptoms as key diagnostic indicators for schizophrenia and related disorders. Recent advances in machine learning-driven computer-aided diagnostic systems have emerged as a transformative frontier. These systems can effectively capture correlations between quantifiable features and schizophrenia, enabling not only auxiliary diagnostic predictions but also providing potential directions for clinical treatment. Notably, deficits in sense of agency (SoA) represent a core feature of schizophrenia; however, directly predicting schizophrenia based on SoA deficits and quantifying their diagnostic significance remain critical unresolved challenges. In this work, one hundred and fifty-five participants were recruited, and interpretable ensemble machine learning models were developed to investigate the SoA features for schizophrenia prediction and interpretability analysis. First, agency rating, time interval estimation and intentional binding methods were used for SoA features generation. Then, six baseline machine learning algorithms were trained, with RF and TabPFN demonstrating optimal performance. To further enhance reliability, an ensemble modeling strategy with RF and TabPFN was implemented, yielding a high-performance classifier SchNet (Accuracy of 0.90, F1-Score of 0.91). To bridge theory and practice, we also deployed SchNet webserver (<span><span>https://github.com/jourmore/SchNet-webserver</span><svg><path></path></svg></span>), offering SoA test online, schizophrenia risk prediction and interpretability analysis. This tool serves as a translational bridge between computer research and clinical application, supporting data-informed therapeutic strategies for schizophrenia.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104674"},"PeriodicalIF":4.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019 pandemic and suicide rates in South Korea: A time-series analysis of its onset and end","authors":"Jeong Hun Yang ,&nbsp;Gahui Yoon ,&nbsp;Sang Jin Rhee ,&nbsp;Sooyeon Min ,&nbsp;Han-Sung Lee ,&nbsp;Yong Min Ahn","doi":"10.1016/j.ajp.2025.104664","DOIUrl":"10.1016/j.ajp.2025.104664","url":null,"abstract":"<div><div>This study examined the impact of the coronavirus disease 2019 pandemic on suicide rates in South Korea by age and sex using an interrupted time series (ITS) analysis. We analyzed the monthly suicide mortality data from 2012 to 2023, covering 144 months across 16 sex- and age-specific groups. The study period was divided into three stages: pre-pandemic, pandemic, and post-pandemic. Regression models were constructed to assess changes in suicide rates at the onset and end of the pandemic while controlling for seasonality using sine and cosine terms. The results showed that overall suicide rates decreased during the pandemic compared with the pre- and post-pandemic periods. In men, there was no significant difference in the suicide rate or its slope before and after the pandemic. However, in women, the suicide rate increased at the beginning of the pandemic. Certain subgroups—including men in their 20 s and 70 s and women across several age groups—showed significant increases at the onset of the pandemic or rising trends during and after. Suicide rates steadily declined before the pandemic, while younger female groups showed rising trends even before their onset. Seasonal analysis revealed that suicide rates were lower in winter and higher during the rest of the year, with distinct seasonal patterns across age groups. This study highlights the differential impact of the pandemic on suicide trends across demographic groups.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104664"},"PeriodicalIF":4.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine dose for Asians: An account from India","authors":"Vijay Kumar,&nbsp;Gautam Sudhakar N ,&nbsp;Monalisha Sharma,&nbsp;Bhanu Dahiya,&nbsp;Veena Ramesh,&nbsp;Satish Suhas,&nbsp;Priyamvada Sharma,&nbsp;Vanteemar S. Sreeraj,&nbsp;Shivarama Varambally,&nbsp;Ganesan Venkatasubramanian,&nbsp;Pratima Murthy","doi":"10.1016/j.ajp.2025.104673","DOIUrl":"10.1016/j.ajp.2025.104673","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104673"},"PeriodicalIF":4.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social contact support for patients with schizophrenia using a computer graphics avatar in a real city street environment","authors":"Hirokazu Kumazaki,&nbsp;Nobukazu Kanchi,&nbsp;Megumi Kawata,&nbsp;Akira Utsumi,&nbsp;Takahiro Miyashita,&nbsp;Taichi Sono,&nbsp;Akinobu Lee,&nbsp;Daisuke Taniguchi,&nbsp;Minoru Tsukazaki,&nbsp;Yuichiro Yoshikawa,&nbsp;Hiroshi Ishiguro","doi":"10.1016/j.ajp.2025.104668","DOIUrl":"10.1016/j.ajp.2025.104668","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104668"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The revised Suicide Crisis Inventory-2 (SCI-2) in Chinese college students: Examining factor structure and validity","authors":"Luming Liu ,&nbsp;Wenchao Wang ,&nbsp;Yang Li ,&nbsp;Huimin Chen ,&nbsp;Liying Zhang ,&nbsp;Chao Song","doi":"10.1016/j.ajp.2025.104672","DOIUrl":"10.1016/j.ajp.2025.104672","url":null,"abstract":"<div><h3>Background</h3><div>The situation of suicidal thoughts and behaviors (STB) among Chinese college students is concerning. The Suicide Crisis Inventory-2 (SCI-2), an assessment tool for suicide crisis syndrome (an imminent warning sign of STB), can effectively contribute to screening and preventing STB. However, the psychometric properties of the SCI-2 and its key items associated with STB have not been explored in Chinese college students.</div></div><div><h3>Methods</h3><div>We conducted two studies with a total of 11,620 Chinese college students included. In study 1 (<em>N</em> = 1480), we investigated the psychometric properties of the SCI-2 using confirmatory factor analyses (CFA) and other methods. In Study 2, we explored key SCI-2 items associated with STB with machine-learning approaches. In sample 1 (<em>N</em> = 5296), we selected features based on the CFA results in study 1 and built four tree-based models. In sample 2 (<em>N</em> = 4844), we externally tested the models. Shapley Additive exPlanations (SHAP) values were used for model interpretation.</div></div><div><h3>Results</h3><div>The one-factor and five-factor models of the SCI-2 are both acceptable among Chinese college students, and SCI-2 showed good internal consistency as well as convergent validity with STB and other criteria. Meanwhile, the core symptoms within the entrapment and social withdrawal clusters of the SCI-2 showed higher SHAP values to STB.</div></div><div><h3>Conclusion</h3><div>The SCI-2 is suitable for assessing the imminent suicide risk among Chinese college students. Symptoms of entrapment and social withdrawal need additional attention.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104672"},"PeriodicalIF":4.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community prevalence of at-risk state for bipolar disorder: Validation of the Korean version of Bipolar Prodrome Symptom Interview and Scale-Abbreviated Screen for Patients (BPSS-AS-P)","authors":"Junhee Lee ,&nbsp;Taeyoung Lee ,&nbsp;Christoph U. Correll","doi":"10.1016/j.ajp.2025.104669","DOIUrl":"10.1016/j.ajp.2025.104669","url":null,"abstract":"<div><h3>Introduction</h3><div>The progression towards early identification and intervention of bipolar disorder (BD) has been dampened by a scarcity of reliable early screening instruments for BD risk. The Bipolar Prodrome Symptom Interview and Scale–Abbreviated Screen for Patients (BPSS-AS-P) is a self-rated questionnaire devised to screen individuals at risk of developing BD but has not been validated in a community-dwelling individuals. The current study aimed to validate its psychometric properties and determine the optimal cut-off in a community sample.</div></div><div><h3>Methods</h3><div>The study included community-dwelling residents, aged 14–34, who underwent two-phased, semi-structured interviews. Among those, 138 individuals who screened positive on the Mood Disorder Questionnaire (MDQ) participated in the second stage interview by a psychiatrist and completed the BPSS-AS-P. The psychometric properties of the BPSS-AS-P were evaluated, including internal consistency, convergent validity, and optimal cut-offs.</div></div><div><h3>Results</h3><div>Fifty-eight individuals (42.0 % of the second stage interviewees or 4.2 % of the total participants) were identified as being at risk of developing BD (BDRisk+). The median (IQR) age was 25 (20–30) and 24 (18–29) years, for the BDRisk+ and BDRisk– individuals. The BPSS-AS-P showed very good internal consistency (Cronbach’s α=.89). The BPSS-AS-P raw summed total score was significantly positively correlated with BDRisk+ (P = .044), discriminating BDRisk+ from BDRisk– individuals (AUC=.800, P &lt; .001) at a cut-off score= 25.</div></div><div><h3>Conclusions</h3><div>Among community-dwelling participants, prevalence of BDRisk+ individuals was 4.2 %. The BPSS-AS-P, a self-report questionnaire version of the semi-structured interview for identifying BDRisk+ individuals had satisfactory psychometric properties in a community sample. Future studies on the predictive validity of the BPSS-AS-P to predict full-blown BD are needed.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104669"},"PeriodicalIF":4.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journalistic freedom, trust, and the Asian Journal of Psychiatry","authors":"Rajiv Tandon","doi":"10.1016/j.ajp.2025.104671","DOIUrl":"10.1016/j.ajp.2025.104671","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104671"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depressive symptoms and incident type 2 diabetes in a prospective multi-ethnic semirural Malaysian population","authors":"Hamimatunnisa Johar,&nbsp;Seryan Atasoy,&nbsp;Norlaili Halim,&nbsp;Badariah Ahmad,&nbsp;Tin Tin Su","doi":"10.1016/j.ajp.2025.104670","DOIUrl":"10.1016/j.ajp.2025.104670","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104670"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of MRI parameters of brain waste clearance function with cortisol and inflammatory markers in middle-aged and older adults with major depressive disorder","authors":"Chun Yang ,&nbsp;Shiyun Tian ,&nbsp;Meichen Liu ,&nbsp;Fan Tan ,&nbsp;Weiwei Wang ,&nbsp;Wei Du ,&nbsp;Bingbing Gao ,&nbsp;Qingwei Song ,&nbsp;Tieli Liu ,&nbsp;Huimin Zhang ,&nbsp;Yanwei Miao","doi":"10.1016/j.ajp.2025.104667","DOIUrl":"10.1016/j.ajp.2025.104667","url":null,"abstract":"<div><h3>Background</h3><div>Suicide risk remains high in middle-aged and older adults with major depressive disorder (MDD). Dysregulation of cortisol (CORT) and neuroinflammation may impair glymphatic clearance, but their effects in this population are unclear.</div></div><div><h3>Methods</h3><div>Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), free water (FW) in white matter, and enlarged perivascular space (EPVS) grading of 20 MDD patients with elevated CORT (high-CORT), 39 MDD with normal CORT levels (normal-CORT), and 29 healthy controls (HCs) were compared. Inflammatory indices included the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). MRI parameters were also correlated with inflammatory indices and neuropsychological scales.</div></div><div><h3>Results</h3><div>After controlling for age, gender, ACTH and HAMD-sleep disturbance, high-CORT group exhibited the lowest DTI-ALPS index (<em>p</em> &lt; 0.01), significantly higher CPV (<em>p</em> = 0.04) compared to HCs, and tended to be higher BG EPVS grading compared to normal-CORT (<em>p</em> = 0.02). The DTI-ALPS index was negatively correlated with depression severity and HAMD-cognitive impairment (<em>r</em> ranging from −0.437 to −0.300; <em>p</em> ranging from 0.001 to 0.031). Moreover, the DTI-ALPS index was negatively associated with NLR (<em>r</em> = −0.277, <em>p</em> = 0.047). Additionally, CPV was positively correlated with multiple inflammatory indices (<em>r</em> ranging f<em>r</em>om 0.380 to 0.595, all <em>p</em> ≤ 0.01).</div></div><div><h3>Conclusion</h3><div>Significant differences in MRI-based markers of brain metabolic waste clearance were observed among middle-aged and older MDD patients with varying cortisol levels and HCs. These alterations were linked to depressive symptoms, cognitive impairment, and inflammation markers.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104667"},"PeriodicalIF":4.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive correlation between left hippocampal dentate gyrus volume and 18F-fluorodeoxyglucose uptake in the left hippocampus after bright light exposure","authors":"Hirofumi Hirakawa,&nbsp;Takeshi Terao,&nbsp;Masaaki Muronaga,&nbsp;Toshihiko Izumi,&nbsp;Kentaro Kohno","doi":"10.1016/j.ajp.2025.104665","DOIUrl":"10.1016/j.ajp.2025.104665","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"112 ","pages":"Article 104665"},"PeriodicalIF":4.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}