Asian journal of psychiatry最新文献_第5页

Aberrant predictive learning along the positive schizotypy - autistic traits continuum: evidence from ambiguous social information processing 积极分裂型-自闭症特征连续体的异常预测学习：来自模糊社会信息加工的证据

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-15 DOI: 10.1016/j.ajp.2025.104666

Zi-han Zhang , Ke-xin Hu , Yi-chen Shi , Han-yu Zhou

{"title":"Aberrant predictive learning along the positive schizotypy - autistic traits continuum: evidence from ambiguous social information processing","authors":"Zi-han Zhang , Ke-xin Hu , Yi-chen Shi , Han-yu Zhou","doi":"10.1016/j.ajp.2025.104666","DOIUrl":"10.1016/j.ajp.2025.104666","url":null,"abstract":"<div><div>Deficits in social information processing have been observed in both schizophrenia spectrum disorders (SSD) and autism spectrum disorder (ASD), though the underlying mechanisms may differ. From a predictive coding perspective, such deficits are thought to arise from an overreliance on prior expectations in SSD, whereas individuals with ASD may exhibit difficulties in forming or using such expectations. However, very few studies have investigated the behavioral markers underlying social predictive learning along the ASD-SSD continuum. Using a novel cue–outcome associative learning task, this study examined how prior expectations influence the perception of ambiguous social information. A total of 121 healthy participants (aged 17–25) completed the task, along with self-report measures of positive schizotypal (Schizotypal Personality Questionnaire, SPQ; Community Assessment of Psychic Experiences, CAPE) and autistic traits (Autism Spectrum Quotient, AQ). Computational modeling using the Hierarchical Gaussian Filter (HGF) and correlational analyses revealed that higher levels of positive schizotypal traits were associated with greater reliance on prior beliefs and reduced flexibility in updating prediction errors. In contrast, expected inverse associations for autistic traits were not consistently observed. These results support the hyper-prior hypothesis of schizophrenia and highlight aberrant predictive mechanisms in positive schizotypy. The predictive coding framework might be useful for differentiating between SSD- and ASD-related social cognitive difficulties, with implications for targeted intervention strategies.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104666"},"PeriodicalIF":4.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing perinatal mental health with perinatal liaison nurses: A hospital-based study 围产期联络护士管理围产期心理健康：一项基于医院的研究

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-14 DOI: 10.1016/j.ajp.2025.104661

Kyoko Yamada, Kyohei Otani, Nobuyasu Imbe, Ryota Shindo, Go Inokuchi, Shogo Kurushima, Mitsunobu Moriwaki

引用次数: 0

Lost in translation: Bridging the gap between Indonesia’s National mental health plan and adolescent needs 迷失在翻译中：弥合印度尼西亚国家精神卫生计划与青少年需求之间的差距

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-14 DOI: 10.1016/j.ajp.2025.104663

Erma Pratiwi Nufi

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Mind the gap between natural phenomena and human constructs in psychiatric diagnostic frameworks 注意精神病学诊断框架中自然现象和人类构造之间的差距

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-14 DOI: 10.1016/j.ajp.2025.104662

Seon-Cheol Park , Masoud Kamali , Andrew A. Nierenberg

引用次数: 0

Neuroimaging biomarkers distinguishing medication-naïve adolescents with major depressive disorder and bipolar disorder during depressive episodes 神经成像生物标志物区分medication-naïve青少年抑郁症和双相情感障碍在抑郁发作期间

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-14 DOI: 10.1016/j.ajp.2025.104660

Shijie Luo , Shunkai Lai , Xiaoxiao Liao , Ying Wang , Pan Chen , Yuran Pei , Jianzhao Zhang , Yiliang Zhang , Shuming Zhong , Yanbin Jia

{"title":"Neuroimaging biomarkers distinguishing medication-naïve adolescents with major depressive disorder and bipolar disorder during depressive episodes","authors":"Shijie Luo , Shunkai Lai , Xiaoxiao Liao , Ying Wang , Pan Chen , Yuran Pei , Jianzhao Zhang , Yiliang Zhang , Shuming Zhong , Yanbin Jia","doi":"10.1016/j.ajp.2025.104660","DOIUrl":"10.1016/j.ajp.2025.104660","url":null,"abstract":"<div><h3>Background</h3><div>The adolescent period represents a critical window of heightened vulnerability for the onset of major depressive disorder (MDD) and bipolar disorder (BD). Nevertheless, the neuro-metabolic abnormalities in adolescents with MDD and BD remain incompletely understood, and the early differentiation between MDD and BD in depressive episodes continues to pose significant clinical challenges.</div></div><div><h3>Method</h3><div>This study involved the recruitment of 60 adolescent MDD, 50 adolescent BD patients in depressed episodes, and 48 demographically matched healthy controls (HCs). Proton magnetic resonance spectroscopy (1H-MRS) was used to measure N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine (Cr) in the prefrontal white matter (PWM), putamen, and thalamus.</div></div><div><h3>Results</h3><div>The results showed that both MDD and BD in depressive episodes exhibited extensive neurometabolic differences compared to HCs, and post hoc comparisons between MDD and BD revealed that adolescent patients with BD had higher left Putamen NAA/Cr ratios (P = 0.002) and lower left Thalamus NAA/Cr ratios (P = 0.018) compared to MDD. By developing a multivariate logistic regression model based on the NAA/Cr ratios of these two brain regions, an ROC curve was constructed (AUC=0.735), which can to some extent distinguish BD in depressive episodes from MDD.</div></div><div><h3>Conclusion</h3><div>Adolescent MDD patients and BD patients exhibit both similarities and differences in neurometabolism. The neurometabolic differences in left Putamen NAA/Cr ratios and left Thalamus NAA/Cr ratios between adolescent MDD patients and BD patients in depressive episodes may help in identifying adolescent BD patients early through 1H-MRS.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104660"},"PeriodicalIF":4.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world signal detection of adverse events associated with Auvelity(bupropion-dextromethorphan): A pharmacovigilance study based on the FAERS database 与Auvelity（安非他酮-右美沙芬）相关的不良事件的真实信号检测：基于FAERS数据库的药物警戒研究

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-12 DOI: 10.1016/j.ajp.2025.104657

Kaidi Zhao, Jiashu Liu

引用次数: 0

Julius Caesar: A neuropsychological profile and lessons in power and personality 尤利乌斯·凯撒：一个神经心理学的侧面和权力和个性的教训

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-10 DOI: 10.1016/j.ajp.2025.104659

Jaikumar Velayudham

引用次数: 0

Rethinking feasibility in digital psychiatric interventions: A cautionary appraisal of HOPE4Schizophrenia in Indonesia 重新思考数字精神病学干预的可行性：印度尼西亚对HOPE4Schizophrenia的警世评价

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-10 DOI: 10.1016/j.ajp.2025.104658

Hartati Inaku, Edi Setiawan

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Functional brain networks predicting different symptoms of schizophrenia based on connectome-based predictive modeling: A multi-site fMRI study 基于连接体预测模型的脑功能网络预测精神分裂症的不同症状：一项多位点fMRI研究

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-08 DOI: 10.1016/j.ajp.2025.104656

Yangpan Ou , Leyi Zhang , Xijia Xu , Hongxing Zhang , Yiqun He , Guojun Xie , Huabing Li , Feng Liu , Ping Li , Jingping Zhao , Wenbin Guo

{"title":"Functional brain networks predicting different symptoms of schizophrenia based on connectome-based predictive modeling: A multi-site fMRI study","authors":"Yangpan Ou , Leyi Zhang , Xijia Xu , Hongxing Zhang , Yiqun He , Guojun Xie , Huabing Li , Feng Liu , Ping Li , Jingping Zhao , Wenbin Guo","doi":"10.1016/j.ajp.2025.104656","DOIUrl":"10.1016/j.ajp.2025.104656","url":null,"abstract":"<div><div>Previous findings on brain functional alterations across different symptoms of schizophrenia (SCZ) patients had yielded inconsistent results. Small sample sizes could contribute to this inconsistency. To overcome this limitation, we conducted a multi-site study to explore the neural mechanisms underlying different symptoms in SCZ. This multi-site study included four datasets from three sites, comprising 258 SCZ patients and 222 healthy controls. A four-factor model based on the Positive and Negative Syndrome Scale (PANSS) was applied to identify four symptom dimensions of SCZ: negative, positive, emotional, and cognitive symptoms. Connectome-based predictive modeling (CPM) and node-based network analysis were conducted. Then, the support vector machine was used to classify SCZ patients and HCs. CPM models could successfully predict negative, positive, affective, and cognitive symptoms in SCZ patients, with correlation coefficients ranging from −0.339 to −0.057. Models for negative and affective symptom prediction were validated by two independent SCZ cohorts. Most predictive edges were connected between the Motor/Sensory (Mot), Fronto-Parietal, Default Mode, Salience, and other networks. The Mot network was involved in the CPM models across all symptom dimensions. Of the predictive edges, three edges exhibited increased FC, while six ones demonstrated decreased FC compared to HCs. These abnormal FCs could classify patients and HCs with an accuracy of 91.2 %. The predictive networks were primarily involved in sensory processing and high-level cognition, which could be a functional basis of SCZ. The Mot network may serve as a key hub across all symptom dimensions.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"111 ","pages":"Article 104656"},"PeriodicalIF":4.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to transitioning from monthly to 3-monthly paliperidone palmitate formulation: Patient characteristics and physician intentions 从每月一次的棕榈酸帕利哌酮配方过渡到3个月一次的障碍：患者特征和医生意图

IF 4.5 4区医学

Asian journal of psychiatry Pub Date : 2025-08-05 DOI: 10.1016/j.ajp.2025.104646

Fuminari Misawa , Mayu Ogihara, Hiroyoshi Takeuchi

引用次数: 0