Asian Journal of Research in Pharmaceutical Sciences最新文献_第8页

Formulation Development and Evaluation of a Novel Emulsion Composition Embracing Aspirin and Glycerol in the Treatment of Ischemic Stroke 含阿司匹林和甘油的新型乳剂治疗缺血性脑卒中的配方开发与评价

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-08-10 DOI: 10.52711/2231-5659.2022.00030

Koteswari Poluri, Swetha Tippani, Laxmi Prasanna P, Swapna Saha, A. D., Sana Saneela

{"title":"Formulation Development and Evaluation of a Novel Emulsion Composition Embracing Aspirin and Glycerol in the Treatment of Ischemic Stroke","authors":"Koteswari Poluri, Swetha Tippani, Laxmi Prasanna P, Swapna Saha, A. D., Sana Saneela","doi":"10.52711/2231-5659.2022.00030","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00030","url":null,"abstract":"An ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients. Brain cells begin to die in minutes. Ischemic stroke can be treated by using Antiplatelet drug such as aspirin as an immediate treatment which may prevent blood clots and improve recovery after stroke. Glycerol is also used as it decreases the edema in ischemic stroke. The aim of the present investigation is to develop a novel formulation of oil in Glycerol emulsion comprising aspirin in the treatment of ischemic stroke and in vitro evaluation. The oil in glycerol emulsion was prepared by high shear homogenization and prepared emulsions were evaluated for particle size, drug content, in vitro drug release and stability. Based on log P values of aspirin, olive oil is selected as oil phase and tween 80 was used as emulsifying agent. Total 10 formulations F1to F10 were prepared and among these, in F1-F6 phase separation was observed within 24 hrs whereas F8 to F10 were stable for one week and later creaming was observed and it is re-dispersible. The particle size was determined by optical microscopy and the average particle size for F8, F9 and F10 were 6.04, 3.38 and 7.8 µm respectively. Drug content was determined as 68±3.95%,108±5.816%, 103±4.61% respectively in compositions F8, F9 and F10. Rate of drug release followed first order kinetics and an immediate burst release effect was observed within 15 minutes. It is concluded that olive oil and glycerol emulsions containing aspirin is prepared successfully and evaluated. It is a promising formulation approach for co administration of aspirin and glycerol in the treatment of ischemic stroke. The formulations were physically and chemically stable. In vivo application of this formulation will be done in suitable animal models in future.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79704140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Perspective of Fungi - A Review 真菌研究进展综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-08-10 DOI: 10.52711/2231-5659.2022.00044

S. D. Mankar, Shrutika Vikhe, Tanishka Pawar, S. Bhawar

引用次数: 0

Post covid calamity- Mucormycosis: An overview 后冠灾难-毛霉病:概述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-08-10 DOI: 10.52711/2231-5659.2022.00040

Poonam Patil, Rutuja R. Shah, Anwar Shaikh, Smita Nayak, V. Bhaskar

{"title":"Post covid calamity- Mucormycosis: An overview","authors":"Poonam Patil, Rutuja R. Shah, Anwar Shaikh, Smita Nayak, V. Bhaskar","doi":"10.52711/2231-5659.2022.00040","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00040","url":null,"abstract":"Corona virus disease (Covid-19) it had declared an emergency global pandemic1,2,3 that cause terrible effects on respiratory system and killing more than half billion lives.4,5,6 Diabetes has been reported as a risk factor for mucormycosis in 73.5% of cases in India.7 People with diabetes and obesity tend to develop more severe Covid-19 infections. This means they're more expected to take corticosteroids, which are frequently used to treat Covid-19. But the corticosteroids along with diabetes increase the risk of mucormycosis because it has been observed that peoples are affected with mucormycosis due to weekend immunity. Even a short course of steroid (5-14 days) results in mucormycosis.8 Mucormycosis, colloquially known as black fungus, is an infection from the mucormycetes group of fungi. The virus that causes Covid-19 can damage lung tissue and blood vessels, which could also increase susceptibility to different fungal infection. brain, causing headaches or seizures. So, damage to tissue and blood vessels from Covid-19 infection, treatment with corticosteroids, high background rates of diabetes in the population most brutally affected by the coronavirus are also getting affected by life threating fungal infection called as mucormycosis. Several methods have deferred the mortality but still have a challenge in curing mucorales.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75269046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Overview on Nanosponges 纳米海绵研究综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-08-10 DOI: 10.52711/2231-5659.2022.00037

Vaishnavi G. Gole, S. Patwekar, Ankush Doiphode, Ashwini Rode, Suleman Shaikh

引用次数: 1

Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin 槲皮素固体自纳米乳化给药体系的研制

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-08-10 DOI: 10.52711/2231-5659.2022.00031

Roma Mathew, Joyamma Varkey

{"title":"Development of Solid Self Nanoemulsifying Drug Delivery System of Quercetin","authors":"Roma Mathew, Joyamma Varkey","doi":"10.52711/2231-5659.2022.00031","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00031","url":null,"abstract":"This work aims to develop Solid Self Emulsifying Drug Delivery System of Quercetin for enhancing its bioavailability. From the perspective of dosage forms, Solid Self Emulsifying Drug Delivery System mean solid dosage forms with self-emulsification properties. Liquid Self Emulsifying Drug Delivery System containing 15 mg/ml of Quercetin was prepared and converted to Solid Self Emulsifying Drug Delivery System by adsorption onto various solid carriers. Based on micromeritic properties and drug content analysis Aerosil ® 200 was selected as the adsorbent for development of Solid Self Emulsifying Drug Delivery System of Quercetin.Various formulation were prepared by variying amounts of the components and optimized fornulation showed particle size of 264.2 nm and drug content of 93.95 %.Optimized Solid Self Emulsifying Drug Delivery System of Quercetin showed good self emulsification ,absence of interactions(FTIR analyis), solubilization of the drug in the mixture (DSC and XRD analysis)and smooth surface (SEM analysis ) . In-vitro drug release of Solid Self Emulsifying Drug Delivery System of Quercetin revealed percentage drug release of 99.70±0.227% within 30 min . Results of the study indicates the Solid Self emulsification technique is a promising approach for development of stable dosage form of drugs with poor oral absorption.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81050970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Application of Steroids in Clinical practice 类固醇在临床中的应用

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-03-05 DOI: 10.52711/2231-5659.2022.00002

T. N. Sonawane, Rajesh. D. Ahire, Pradip D. Dhangar, Dhananjay D. Chaudhari

引用次数: 0

Formulation and Characterization of Mucoadhesive Microspheres of Oxazolidines Class Drug for the Treatment of Loosen Enteritis 治疗松散性肠炎的恶唑烷类黏附微球的制备与表征

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-03-05 DOI: 10.52711/2231-5659.2022.00001

Rahul R. Rajge, SaadA. Khan

{"title":"Formulation and Characterization of Mucoadhesive Microspheres of Oxazolidines Class Drug for the Treatment of Loosen Enteritis","authors":"Rahul R. Rajge, SaadA. Khan","doi":"10.52711/2231-5659.2022.00001","DOIUrl":"https://doi.org/10.52711/2231-5659.2022.00001","url":null,"abstract":"This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88975456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An Opportunities and Challenges in Vaccine Development 疫苗开发的机遇与挑战

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-03-05 DOI: 10.52711/2231-5659.2022.00014

Roshan Kumbhar, S. S. Suryawanshi, P. P. Patil, Sachinkumar V. Patil

引用次数: 2

Drug Delivery Systems Based on Polymeric Micelles 基于高分子胶束的药物输送系统

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-03-05 DOI: 10.52711/2231-5659.2022.00007

P. Khot, K. Nangare, Vaishali S. Payghan, Tejashree Kamble, Payghan Santosh

引用次数: 1

Review on Idiopathic Pulmonary Fibrosis 特发性肺纤维化研究进展

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2022-03-05 DOI: 10.52711/2231-5659.2022.00008

Sonam Kuchekar, Rupali V. Jadhav

引用次数: 0