Asian Journal of Research in Pharmaceutical Sciences最新文献_第10页

Formulation and Evaluation of Orodispersble Tablet 口腔分散片的配方及评价

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00042

Pratiksha S. Deore, Yashpal M. More, A. Maru

引用次数: 3

Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor 盐酸维拉帕米片快崩解缓释微丸的流化床工艺研究与评价

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00041

Jagruti J. Pansare, R. K. Surawase

{"title":"Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor","authors":"Jagruti J. Pansare, R. K. Surawase","doi":"10.52711/2231-5659.2021.00041","DOIUrl":"https://doi.org/10.52711/2231-5659.2021.00041","url":null,"abstract":"This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77396530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-Pharmacological Profile of Wrightia tinctoria 白桦植物药理研究概况

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00047

Niraj Kale, Sanket Rathod, S. More, N. Shinde

引用次数: 4

Review on Nanotechnology and its utilization in Pharmaceuticals 纳米技术及其在医药领域的应用综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00050

Kiran P. Patole, Anil A. Danane, Amit Nikam, A. Patil

引用次数: 2

Chemical Composition of Aegle marmelos: A Review 安吉尔甜瓜的化学成分研究进展

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00044

Y. Chowdhary

{"title":"Chemical Composition of Aegle marmelos: A Review","authors":"Y. Chowdhary","doi":"10.52711/2231-5659.2021.00044","DOIUrl":"https://doi.org/10.52711/2231-5659.2021.00044","url":null,"abstract":"Aegle marmelos (Bilva) is being used in Ayurveda for the treatment of several inflammatory disorders. The plant is a member of a fixed dose combination of Dashamoola in Ayurveda. However, the usage of roots/root bark or stems is associated with sustainability concerns. Bael (Aegle marmelos (L.) Corr.) is an important medicinal plant of India. Leaves, fruits, stem and roots of A. marmelos have been used in ethno medicine to exploit its' medicinal properties including astringent, antidiarrheal antidysenteric, demulcent, antipyretic and anti-inflammatory activities. Compounds purified from bael have been proven to be biologically active against several major diseases including cancer, diabetes and cardiovascular diseases. Preclinical studies indicate the therapeutic potential of crude extracts of A. marmelos in the treatment of many microbial diseases, diabetes and gastric ulcer. This review covers the biological activities of some isolated chemical constituents of A. marmelos and preclinical studies on some crude extracts and pure compounds to explore novel bioactive compounds for therapeutic application. Aegle marmelos (L.) is a seasonal fruit that contains significant amounts of bioactives like, phenolic acids (gallic acids, 2,3-dihydroxy benzoic acid, chlorogenic acid, p-coumaric acid, vanillic acid), flavonoid (rutin), organic acids (oxalic acid, tartaric acid, malic acid, lactic acid, acetic acid, citric acid, propionic acid, succinic acid, fumaric acid), vitamin C, vitamin B group (thiamine, niacin, pyridoxine, pantothenic acid, biotin, cobalamins, riboflavin), tocopherols (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol), carotenes (α-carotene, β-carotene, γ-carotene, δ-carotene) and also rich in essential minerals (potassium, calcium, phosphorus, sodium, iron, copper, manganese). Hence the use of aegle plays important role as anti-inflammatory.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85806683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride 格列美脲-盐酸二甲双胍双层基质缓释片的研制与评价

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00043

Mayuri B. Patil, A. Maru, Jayshree S. Bhadane

{"title":"Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride","authors":"Mayuri B. Patil, A. Maru, Jayshree S. Bhadane","doi":"10.52711/2231-5659.2021.00043","DOIUrl":"https://doi.org/10.52711/2231-5659.2021.00043","url":null,"abstract":"The aim of the present study was to design and evaluate bilayer tablets of metformin hydrochloride as sustained release form for the treatment of Type-II diabetes mellitus. The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action of tablet. They are many drugs for treating type-II diabetes. Sulphonyl urea and biguanides are used commonly by a wide section of patients. Melt granulation process was used for the formulation of sustained comprising metformin layer and wet granulation of immediate comprising layer of glimepiride. The precompression studies like bulk density, tapped density, angle of repose, compressible index and post formulation studies includes weight variation, hardness, thickness, friability and dissolution study. The in-vitro release profile of Glimepiride was dissolved within 45 min, and Metformin Hydrochloride was able to release more than 12 hrs. They all the formulation was optimized formula due to its higher rate of dissolution and collate all other parameters with the official specifications.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91419604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Melphalan flufenamide is an Anticancer medication used to treat multiple Myeloma: A Review Melphalan flufenamide是一种用于治疗多发性骨髓瘤的抗癌药物

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00045

M. Jain, Mayur Bhurat, S. Bavaskar

引用次数: 3

Floating Drug Delivery System: An Overview 漂浮给药系统:综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00046

Azhar Danish Khan, Meenakshi Bajpai, Raj Kumar Goel

{"title":"Floating Drug Delivery System: An Overview","authors":"Azhar Danish Khan, Meenakshi Bajpai, Raj Kumar Goel","doi":"10.52711/2231-5659.2021.00046","DOIUrl":"https://doi.org/10.52711/2231-5659.2021.00046","url":null,"abstract":"In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80795635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Review on Mucormycosis: It is a life Threatening infection 毛霉病是一种危及生命的感染

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-11-26 DOI: 10.52711/2231-5659.2021.00049

S. D. Mankar, Waditake Poonam, P. Jejurkar

引用次数: 5

A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet 片剂剂型研究进展——以快速崩解片为重点

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2021-08-14 DOI: 10.52711/2231-5659.2021.00038

Vishal Kumar, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, Shammy Jindal

{"title":"A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet","authors":"Vishal Kumar, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, Shammy Jindal","doi":"10.52711/2231-5659.2021.00038","DOIUrl":"https://doi.org/10.52711/2231-5659.2021.00038","url":null,"abstract":"\u0000 Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet, stable over extended and diverse storage conditions, can be produced on high-speed compression, labelling, and packaging equipment. Advancements in technology and modification in standard compressed tablet are to achieve better acceptability as well as bioavailability. Various types of newer and more efficient tablets are developed to create a delivery system that is relatively simple to administration. In one sense osmotic pump systems are another type of membrane-controlled release drug delivery system and work in the following way. Drug is incorporated in a tablet core which is water soluble, and which will solubilize or suspend the drug in the presence of water. Also, a multi-layer tablet dosage form over a more conventional mono-layer tablet is useful. In FDDS Gastro retentive dosage form improves bioavailability, therapeutic efficacy and allows a reduction in the dose because of steady therapeutic levels of drug. The another system is MADDS Mucoadhesion is commonly used to describe an interaction between the mucin layer, which lines the entire GI tract, and a bio adhesive polymer, which could be natural or synthetic in origin. An ideal controlled drug delivery system is one which delivers the drugs at a predetermined rate, locally or systematically, for a specified period of time and an ideal targeted drug delivery system is the one which delivers the drugs only to its sites of action and not to the non-targeted organs or tissues. So, in this review article we will study the basic fundamentals of tablets their technologies, and types of systems with available marketed products of various dosage forms. \u0000","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87999302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3