片剂剂型研究进展——以快速崩解片为重点

Vishal Kumar, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, Shammy Jindal
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引用次数: 3

摘要

片剂是最常用的处方剂型,因为它提供了一种方便的给药形式,片剂之间的剂量均匀,在延长和多样化的储存条件下稳定,可以在高速压缩,标签和包装设备上生产。技术的进步和标准压缩片剂的修改是为了获得更好的可接受性和生物利用度。各种更新、更有效的片剂被开发出来,以创建一个相对简单管理的给药系统。从某种意义上说,渗透泵系统是另一种膜控释放给药系统,其工作方式如下。将药物掺入水溶性片剂芯中,该片剂芯在水的存在下可使药物溶解或悬浮。此外,在更常规的单层片剂之上的多层片剂剂型是有用的。在FDDS中,胃保留剂型提高了生物利用度,治疗效果,并且由于药物的治疗水平稳定,可以减少剂量。另一种系统是MADDS黏附通常用于描述粘蛋白层与生物黏附聚合物之间的相互作用,粘蛋白层排列在整个胃肠道中,生物黏附聚合物可以是天然的或合成的。理想的受控药物传递系统是在规定的时间内以预定的速率局部或系统地传递药物的系统,理想的靶向药物传递系统是将药物仅传递到其作用部位而不传递到非靶向器官或组织的系统。因此,在这篇综述文章中,我们将研究片剂的基本原理,它们的技术,以及各种剂型的可用市场产品的系统类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet
Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet, stable over extended and diverse storage conditions, can be produced on high-speed compression, labelling, and packaging equipment. Advancements in technology and modification in standard compressed tablet are to achieve better acceptability as well as bioavailability. Various types of newer and more efficient tablets are developed to create a delivery system that is relatively simple to administration. In one sense osmotic pump systems are another type of membrane-controlled release drug delivery system and work in the following way. Drug is incorporated in a tablet core which is water soluble, and which will solubilize or suspend the drug in the presence of water. Also, a multi-layer tablet dosage form over a more conventional mono-layer tablet is useful. In FDDS Gastro retentive dosage form improves bioavailability, therapeutic efficacy and allows a reduction in the dose because of steady therapeutic levels of drug. The another system is MADDS Mucoadhesion is commonly used to describe an interaction between the mucin layer, which lines the entire GI tract, and a bio adhesive polymer, which could be natural or synthetic in origin. An ideal controlled drug delivery system is one which delivers the drugs at a predetermined rate, locally or systematically, for a specified period of time and an ideal targeted drug delivery system is the one which delivers the drugs only to its sites of action and not to the non-targeted organs or tissues. So, in this review article we will study the basic fundamentals of tablets their technologies, and types of systems with available marketed products of various dosage forms.
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