Asian Journal of Research in Pharmaceutical Sciences最新文献

{"title":"An in-Depth Review of Dercum’s disease: Aetiology, Epidemiology, and Treatment","authors":"Bhagya Sri Palisetty, Apoorva Pinisetti, Vinod Kumar Mugada, Srinivasa Rao Yarguntla","doi":"10.52711/2231-5659.2023.00049","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00049","url":null,"abstract":"The purpose of the present review is to proffer a comprehensive overview of Dercum's disease (DD), a rare medical condition typified by the presence of excruciating subcutaneous adipose tissue deposits. The ambit of this exposition encompasses the delineation of the clinical features, diagnostic criteria, and treatment options for DD. DD is a complex and poorly understood ailment, thereby rendering its diagnosis a daunting task, primarily on account of the indeterminate character of its symptoms. Nonetheless, the timely identification of DD is crucial to stave off its advancement and ameliorate the standard of living of those afflicted by it. Diagnostic criteria have been posited for DD, and diagnostic imaging modalities, such as magnetic resonance imaging (MRI), have proven efficacious in facilitating the diagnosis of this malady. The treatment of DD is primarily palliative, geared toward assuaging pain and enhancing the overall quality of life. Therapeutic options comprise the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, local anesthetics, weight management strategies, and alterations to lifestyle choices.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"154 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mikulicz Disease in Males: A Comprehensive Review","authors":"Venkata Triveni Devi Yerra, Stephanie Margaret Puvvada, Vinod Kumar Mugada, Srinivasa Rao Yarguntla","doi":"10.52711/2231-5659.2023.00054","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00054","url":null,"abstract":"IgG4-related disease (IgG4-RD) is an intricate autoimmune disorder that have an effect on multiple organs in the body, including the lachrymal and salivary glands, liver, biliary duct, thyroid, pancreas, gastrointestinal tract, kidney, aorta, prostate and retroperitoneum. Mikulicz disease, a subtype of IgG4-RD, specifically targets the lachrymal and salivary glands, leading to glandular swelling, xerostomia, and xerophthalmia. Diagnosis of Mikulicz disease is established on the presence of proportional and persistent inflammation of at least two pairs of lachrymal, submandibular, and parotid glands, along with exalted serum IgG4 levels and/or marked penetration of IgG4-positive plasmacytes into the affected glandular tissues. Treatment with glucocorticoids has shown to be beneficial in managing IgG4-related MD, but the efficacy of combination therapy in preventing relapse is still a topic of debate. The underlying causes of the disease can vary, but lymphoepithelial sialadenitis is the widespread cause. The disease typically presents in individuals with an average age ranging from 55 to 65 years, and the incidence among individuals under the age of 20 is exceedingly rare. Mikulicz disease is an enigmatic ailment that is still being researched. However, identifying its hallmark symptoms and distinguishing it from other similar conditions is essential for effective diagnosis and treatment. Further research is essential to better comprehend the fundamental causes of the disease and to promote more effective treatment options for patients with Mikulicz disease and other subtypes of IgG4-RD.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systemic Review on Nanoemulsion based Transdermal Drug Delivery System: A Novel Drug Delivery System","authors":"Sharma Kruti, Musaratafrin Saiyed","doi":"10.52711/2231-5659.2023.00051","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00051","url":null,"abstract":"The transdermal drug delivery system provides an attractive alternative to traditional methods like oral administration and injections for delivering drugs. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Recently, researchers have suggested and demonstrated that incorporating nanoemulsion into a transdermal patch can significantly enhance skin permeability and improve transdermal delivery. Studies have shown that nanoemulsion is a more effective drug delivery system compared to other incorporated transdermal methods. The effectiveness of the nanoemulsion is influenced by the choice and properties of the surfactant and co-surfactant used. Therefore, this review article examines the ability of nanoemulsion incorporated in transdermal patch for drug delivery system.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"62 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoroquinolones for the Treatment of Tuberculosis: An Overview","authors":"Sourabh D Jain, Sumeet Prachand, Arun K Gupta, Sanjay Jain","doi":"10.52711/2231-5659.2023.00057","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00057","url":null,"abstract":"According to the World Health Organization (WHO), tuberculosis (TB) remains one of the top 10 causes of death worldwide. Tuberculosis is a major global health threat. In 2022, an estimated 10 million people worldwide developed TB disease, and there were about 1.5 million TB-related deaths. TB primarily affects low- and middle-income countries, with the highest burden in Africa, Asia, and the Western Pacific regions. The WHO has launched the \"End TB Strategy\" with the aim of eliminating TB as a public health problem by 2035. Early diagnosis and prompt initiation of treatment are essential for effective TB control. WHO recommends a package of interventions known as \"Directly Observed Treatment, Short-course\" (DOTS) for TB control, which includes standardized diagnostic approaches, access to quality-assured drugs, and supportive treatment adherence measures. Tuberculosis (TB) remains a global health burden, necessitating the development of new therapeutic strategies. Fluoroquinolones (FQs) have emerged as promising agents in the treatment of TB due to their potent antimicrobial activity against Mycobacterium tuberculosis (Mtb) and their ability to penetrate intracellular compartments. This review aims to summarize the current knowledge on the use of FQs as antitubercular agents, highlighting their mechanisms of action, efficacy and limitations.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"53 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Assessment of Phyto and Physico-chemical Parameters of Laboratory prepared Two Renowned Samples of Polyherbal Formulation “Arq Aswad Barid” by Adopting Two Different Methods (Classical and Modern) for the Step of Fermentation Process with the Preliminary Study of Its Ingredients","authors":"Akhlaq Mustafa, Mushtehasan Mushtehasan, Kiran Negi, Anas Iqbal Alvi, Ghazala Javed","doi":"10.52711/2231-5659.2023.00047","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00047","url":null,"abstract":"There is an increasing awareness and general acceptability of indigenous drugs in today’s medical practice and over 80% of the world population depends on herbal drugs and products for healthy living due to their no side effects. Unani formulations are based on herbal, mineral, and animal origin and have been practiced in India for hundreds of years for treating various ailments by its holistic approach with natural means and drugs. Research is a creative work using existing knowledge for further development and advancement of knowledge and the approach, methodology and technique of research should be consistent with the ultimate objective because the scientific method of research is a combination of hypothesis, experimentation, observation, and reasoning. Therefore, the criteria of real scientific research are that its result should be reproducible under similar conditions. The paper deals with the objective of standardization and makes experimentation, and observation and particularly to check out Physico-chemical data of two in-house prepared samples of compound Unani formulation ArqAswadBaridunderSOP guidelines by adopting two different methods(classical and modern) of fermentation process separately and the content so obtained after distillation from fermented materials were utilized further to prepare two separate samples of the finished products i.e. Arq-e-Aswad Barid and underwent for the comparative assessment by following some Physico-chemical and quality control parameters like viscosity, specific gravity, refractive index, weight per ml, detection of aflatoxin, microbial load, pesticide residue, etc. of both the samples to achieve the objective of study. Besides, the preliminary physicochemical study of all ingredients used as raw material in the preparation of Arq-e-Aswad Barid was also conducted.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"10 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Nanofiber for Topical Drug Delivery of Therapeutic Skin Disorder","authors":"Ankush Bhadane, S. Mankar","doi":"10.52711/2231-5659.2023.00058","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00058","url":null,"abstract":"Nanofibers for topical drug Delivery of Therapeutic Skin Disorders are the Provide Physiological and Machincal Support to the underlying Cells and oragns any kind of damage and Infection can kind of damage and Infection can destroy this Protective layer. They also some skin disorders like. A Topic, dermaritis, Ichthyosis, Acne, Vitillgo etc. A Nanomaterial with one dimension under 100nm is called a nanofiber. They are the various Properties also include: thermal Properties, Mechanical, Physical are Properties are the include. Some drug loading Method also added like, Blend Elcetrospinning, Coaxial, Immobilizing after electrospinning are the method are loading metho use. And also the Manufacturing of Nanofiber are the added one of the Most Popular method. they also the Critical Parameter of Electrospinning Process like, Surface tension and Viscosity, Applied Voltage, Needle and Collector Distance are the Process include. Nanofiber are the using some various Material of Polymeric (1) Natural Polymers (2) Synthetic Polymers are using. they also some therapeutic application of Nanofiber(1) Nanofibers in wound healing and surgical (2) Nanofiber in treatment of fungal infection (3) Nanofiber in treatment of Acne. (3) Nanofiber in treatment of Skin Cancer. and last one added Electrospun Nanofiber as topical drug delivery system how to the added favourable some Characteristics.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on Anticancer Phytosomal Flavonoids","authors":"Pankaj B. Bhogam, Sushant A. Gharal, Tushar B. Patil, Aarti A. Varne, Priyanka S. Lad","doi":"10.52711/2231-5659.2023.00059","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00059","url":null,"abstract":"Now a days phytochemicals present in medicinal plant have great therapeutic optionin many diseases. Consequently, plant research has become more important globally. Large number of crude drugs are available but they are constrained by their inadequate bioavailability and low absorption upon administration by oral route. The bioavailability of a medicine can be enhanced by developing a drug delivery system that can quicken and expand drug absorption through lipid membranes. This review includes the information related to phytosomes introductions, as well as its method of preparation. The second part of this provide overview of different flavonoids which have anticancer activity.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139254670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview on Emulgel and their marketed Formulations","authors":"Sakshi Sanjay Patil., Pallavi Arjun Patil., Rutuja. R. Shah","doi":"10.52711/2231-5659.2023.00056","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00056","url":null,"abstract":"Background: Emulgel is a topical preparation prepared by the mixture of an emulsion and a gel. Emulgel is considered as one of the most important topical delivery systems because it consists of two release control systems, i.e., a gel and an emulsion. The primary intention of this new topical delivery system is to deliver hydrophobic drugs into systemic circulation through the skin. By applying a suitable statistical design, different grades of emulgel can be prepared. There are various favorable properties. Therefore, emulgel is considered as the most conventional system available in the market over other topical drug delivery systems. Objectives: In the present work an attempt was made to prepare emulgel of garlic oil and ajwain oil for enhancing its topical delivery. Material and Method: Emulgel formulation was characterized by various parameters like pH, viscosity, spredability, Extrudability, microbiological Assay.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Polymer as Multifunctional Excipient in Drug Delivery System","authors":"Dushing Kiran R, Siddheshwar S S","doi":"10.52711/2231-5659.2023.00055","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00055","url":null,"abstract":"Polymer-based drug delivery systems have gained significant attention in the field of pharmaceutical research due to their multifunctional nature. These systems utilize various polymers to encapsulate and deliver therapeutic agents, providing enhanced drug stability, controlled release, and targeted delivery to specific sites within the body. Here, we’ll discuss the multifunctionality of polymers in drug delivery systems and their potential applications.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"191 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of Alanine Aminotransferase in Pheasant Blood Plasma during the Complex use of Vitamins and an Antistress Drug","authors":"T. Sh. A.","doi":"10.52711/2231-5659.2023.00048","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00048","url":null,"abstract":"The article presents the results of experimental studies on the effect of vitamins and an anti-stress drug on the biochemical parameters of the blood of pheasants. The purpose of the work is to identify the kinetics of age-related changes in blood alanine aminotransferase in pheasants with the complex use of vitamins and an anti-stress drug. Based on the experimental data obtained, it was found that after the inclusion of a complex of vitamins (A-20000 IU, D3 - 1250 IU, E - 50mg) and an anti-stress drug (succinic acid) in a dose of 0.05g per 1 kg of body weight into the diet of pheasants per day, in all experimental groups of pheasants, a change in the biochemical parameters of the activity of the enzyme ALT was detected. Based on the experimental data, a decrease in the activity of the ALT enzyme was revealed. It was found that the enzyme activity of the experimental groups of partridges was 2, 1.5, 1.0, 1.67, 1.17, 1.5 times less compared to the indicators of the control groups of pheasants. It was experimentally established that the indicators of ALT activity are in the range from 0.01 to 0.08 U/l, reaching a maximum value at 30 days of age.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}