Asian Journal of Research in Pharmaceutical Sciences最新文献_第4页

Hepatocellular Carcinoma: A Review 肝细胞癌:综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-05-22 DOI: 10.52711/2231-5659.2023.00030

Dhandhukiya Manavkumar Kanubhai, Saiyed Musaratafrin Sabirali

引用次数: 0

Analytical Method Development and Validation for the Simultaneous Estimation of Bilastine and Montelukast by RP-HPLC 反相高效液相色谱法同时测定比拉斯汀和孟鲁司特的分析方法建立及验证

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-05-22 DOI: 10.52711/2231-5659.2023.00015

Sudhakar B., Akshaya Karipe, R. Sri. S

引用次数: 0

Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine 氯氮平Niosomal透皮贴剂的制备与评价

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00003

K. Nagasree, K. Pallavi, R. Sri. S

{"title":"Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine","authors":"K. Nagasree, K. Pallavi, R. Sri. S","doi":"10.52711/2231-5659.2023.00003","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00003","url":null,"abstract":"Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81115989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short Review on Hospital Pharmacy 医院药学研究综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00011

Vaishnavi J. Chaudhari, Dhananjay D. Chaudhari

引用次数: 0

A Review on Fluidized Bed Dryer 流化床干燥器研究进展

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00012

Mayur M. More, Nilesh K. Nerkar

引用次数: 0

Drug Regulatory Affairs: Short Review 药品监管事务:简要回顾

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00014

Dhananjay D. Chaudhari, Mohit R. Koli

引用次数: 0

A Short Review on Recent Approches in Targeted Drug Dilvairy System (TDDS) 靶向药物开发系统(TDDS)研究进展综述

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00008

Dhananjay D. Chaudhari, Satish D. Mali, Vaishnavi Chaudhari

{"title":"A Short Review on Recent Approches in Targeted Drug Dilvairy System (TDDS)","authors":"Dhananjay D. Chaudhari, Satish D. Mali, Vaishnavi Chaudhari","doi":"10.52711/2231-5659.2023.00008","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00008","url":null,"abstract":"Targeted drug delivery is an advanced method of delivering drugs to patients in such a targeted order that increases the concentration of the delivered drug only on the body part of interest (organs/tissues/cells), which in turn improves the effectiveness of the treatment while reducing side effects of drug administration. Basically, drug targeting should help the drug molecule to preferentially reach the desired site. The inherent advantage of this technique results in the administration of the required drug with its reduced dose and reduced side effect. This inherent advantage of a targeted drug delivery system is also strongly recognized by research and development in the clinical and pharmaceutical fields as the backbone of therapeutics and diagnostics. Various drug carriers that can be used in this advanced delivery system are soluble polymers, biodegradable microsphere polymers (synthetic and natural), neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles, and immune micelles. The goal of a targeted drug delivery system is to prolong, localize, target, and have a protected drug interaction with the diseased.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86524997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Brief Review on Nanorobotics Applications in Medicine and Future Prospects 纳米机器人在医学上的应用及展望

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00004

Sanjay S. Patel, Poojan N. Patel

{"title":"A Brief Review on Nanorobotics Applications in Medicine and Future Prospects","authors":"Sanjay S. Patel, Poojan N. Patel","doi":"10.52711/2231-5659.2023.00004","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00004","url":null,"abstract":"Nanorobotics is the technology of creating machines or robots at or close to the microscopic scale of a nanometer. These devices are ranging in size from 0.1-10 micrometers and constructed of nanoscale. Due to their small size and wide functional properties, nanorobots have created exceptional prospects in medical, biomedical and pharmaceutical applications. The names nanobots, nanoids, nanites or nanomites have also been used to describe these hypothetical devices. Nanorobots are capable of performing task like actuating, sensing, signalling, information processing and intelligence at the nanoscale. Nanotechnology promises futuristic applications such as microscopic robots that assemble other machines or travel inside the body to deliver drugs or do microsurgery. Nanorobots could carry and deliver large amounts of anti-cancer drugs into cancerous cells without harming healthy cells, reducing the side effects related to current therapies like damage of the conventional chemotherapy. They are well used to cure HIV, cancer and other harmful diseases; they can restore lost tissue at the cellular level, useful for monitoring, diagnosing and fighting sickness. A recent discovery in the field of drug delivery is target therapy, which improves the diagnostic tests and medical devices.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73217762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Physico and phytochemical standardization of nutritionally rich mulberry fruits (Morus indica Linn) 营养丰富的桑树果实理化标准

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00002

Akhlaq Mustafa, Anas Iqbal Alvi, Mahesh Chandera, G. Javed, Asim Ali Khan

{"title":"Physico and phytochemical standardization of nutritionally rich mulberry fruits (Morus indica Linn)","authors":"Akhlaq Mustafa, Anas Iqbal Alvi, Mahesh Chandera, G. Javed, Asim Ali Khan","doi":"10.52711/2231-5659.2023.00002","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00002","url":null,"abstract":"Due to their sweet flavor, impressive nutritional value, and various health benefits, mulberries are gaining popularity worldwide. Mulberries are colorful berries that are eaten both fresh and dried. They're a good source of iron, vitamin C, and several plant compounds and have been linked to lower cholesterol, blood sugar, and cancer risk. Mulberries are the fruits of mulberry trees (Morus sp.) and are related to figs and breadfruit. The trees are traditionally grown for their leaves mainly in Asia and North America as they’re the only food that silkworms eat. They carry colorful berries most commonly black, white, or red that are often made into wine, fruit juice, tea, jam, or canned foods, but can also be dried and eaten as a snack. Mulberries have a decent amount of fiber. The present communication carries an attempt to evaluate the study of phytochemical physicochemical parameters e. g. successive extractive values in different solvents, ash values, alcohol, water, and hexane soluble extractives, moisture contents, loss of weight on drying at 105oC, pH values of 1% and 10 % aqueous solutions, qualitative and quantitative mineral contents, and thin layer chromatography of different extracts. Besides, the qualitative and quantitative analysis of Phyto-constituents like alkaloids, total phenolics, tannins, sugar contents, crude fibers, proteins, and estimation of heavy metals, microbial loads, pesticide residues, and aflatoxins were also carried out which will be useful in the identification and control of the possible adulterations of the raw drug.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77559308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Science of Aging and Longevity 衰老与长寿的科学

Asian Journal of Research in Pharmaceutical Sciences Pub Date : 2023-03-21 DOI: 10.52711/2231-5659.2023.00006

Sara Sunil Mohite, Shahbaz Akhtar Momin, Samip Anant Niwate, Riya Madanlal Paliwal, Khushboo Chhotelal Yadav, S. Shukla, Dileep Kumar Bharati

{"title":"The Science of Aging and Longevity","authors":"Sara Sunil Mohite, Shahbaz Akhtar Momin, Samip Anant Niwate, Riya Madanlal Paliwal, Khushboo Chhotelal Yadav, S. Shukla, Dileep Kumar Bharati","doi":"10.52711/2231-5659.2023.00006","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00006","url":null,"abstract":"Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89512437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0