Asia Oceania Journal of Nuclear Medicine and Biology最新文献

{"title":"Non-Cutaneous Melanoma, Findings and Prognostic Value of FDG PET/CT: A Case Series of 23 patients and review of the literature.","authors":"Bahare Saidi,&nbsp;Babak Fallahi,&nbsp;Armaghan Fard-Esfahani,&nbsp;Alireza Emami-Ardekani,&nbsp;Mohammad Eftekhari","doi":"10.22038/AOJNMB.2022.61517.1433","DOIUrl":"https://doi.org/10.22038/AOJNMB.2022.61517.1433","url":null,"abstract":"<p><strong>Objectives: </strong>Non-cutaneous malignant melanomas (NCM) are rare malignancies. Due to their nonspecific symptoms, they present later in life. The value of FDG PET/CT in this group of patients is not clear. The aim of this study is to assess the role of FDG PET/CT in the management of NCM and its prognostic implication.</p><p><strong>Methods: </strong>We retrospectively selected twenty-three patients with a diagnosis of NCM evaluated with FDG PET/CT in Shariati hospital between 2019 and 2021. The PET/CT data were reviewed and compared with available conventional imaging findings. Five patients died within five months. The surviving patients were followed within a time interval of 7 to 27.5 months after their PET/CT study, regarding their disease status.</p><p><strong>Results: </strong>Among 23 patients (8 ocular, 5 sinonasal, 3 pharyngeal, 2 anorectal, 2 vulvovaginal, and 3 unknown primaries), PET/CT was able to detect residual primary disease, assess treatment response, and reveal or exclude metastases. Additional lesions compared to conventional imaging were found in five, while in one with brain metastases PET/CT was unable to detect lesions on MRI. Thirteen patients had negative PET/CT finding of which 11 (85%) did not have remarkable finding on follow-up. Metastatic disease was recognized in eight. Patients with extensive metastases on FDG PET/CT had a poorer outcome.</p><p><strong>Conclusion: </strong>Similar to cutaneous melanoma, PET/CT is valuable in the management of NCM patients and is superior to conventional imaging modalities, with the exception of brain metastases. Patients with negative PET/CT findings have a better outcome as opposed to patients with significant positive PET/CT findings.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"10 2","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse FDG uptake in the bilateral lungs: hypersensitivity pneumonitis supported by low-dose CT findings.","authors":"Shun Goto,&nbsp;Yohji Matsusaka,&nbsp;Tomohiko Yamane,&nbsp;Yuki Hoshino,&nbsp;Ichiei Kuji","doi":"10.22038/AOJNMB.2021.56000.1393","DOIUrl":"https://doi.org/10.22038/AOJNMB.2021.56000.1393","url":null,"abstract":"<p><p>Hypersensitivity pneumonitis (HP) is an interstitial lung disease resulting from an immune-mediated response in susceptible and sensitized individuals to various inhaled antigens in the environment. Imaging diagnosis is usually based on high-resolution CT findings. Here, we present a 49-year-old man with a history of diffuse large B-cell lymphoma presented with fever and occasional cough. ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) revealed diffuse FDG uptake in the bilateral lungs. Expiratory low-dose CT simultaneously performed in PET scanning revealed centrilobular nodules and air trapping in ground glass opacities (GGO). Our imaging diagnosis was acute hypersensitivity pneumonitis (HP). Based on the results of his clinical course, blood laboratory tests, and bronchoscopy, he was diagnosed with acute HP. Diffuse pulmonary FDG uptake can be seen in the patients with acute HP. In addition, expiratory low-dose CT findings of centrilobular nodules and air trapping in GGO may be helpful for accurate diagnosis of acute HP.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"10 1","pages":"43-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET-CT incidental lung findings in asymptomatic COVID-19 patients: evidences from the Italian core of the first pandemic peak.","authors":"Bonanomi Alice,&nbsp;Bonaffini Pietro Andrea,&nbsp;Spallino Marianna,&nbsp;Dulcetta Ludovico,&nbsp;Franco Paolo Niccolò,&nbsp;Valle Clarissa,&nbsp;Marra Paolo,&nbsp;Bruno Andrea,&nbsp;Sironi Sandro","doi":"10.22038/AOJNMB.2021.58035.1405","DOIUrl":"https://doi.org/10.22038/AOJNMB.2021.58035.1405","url":null,"abstract":"<p><strong>Objectives: </strong>To illustrate incidental ¹⁸F-FDG PET-CT findings and related CT alterations of suspicious pulmonary interstitial involvement in asymptomatic oncologic patients during the first COVID-19 outbreak in the core of Italian peak.</p><p><strong>Methods: </strong>We retrospectively evaluated the ¹⁸F-FDG PET-CT follow-up examinations performed during the first Italian COVID-19 outbreak (March 3rd-April 15th, 2020) in 10 asymptomatic oncologic patients with a highly suspicious interstitial pulmonary involvement on CT. Six cases were confirmed SARS-CoV-2 by molecular tests. The following parameters were assessed: 1) lung involvement on co-registration CT as extension (laterality, number of lobes), pattern (ground-glass opacities/GGO, consolidations, mixed) and stage (early, progressive, peak, and absorption); 2) the maximum standardized uptake value (SUV_max) of lung lesions on ¹⁸F-FDG PET.</p><p><strong>Results: </strong>The involved lobes were 5 in 5 cases (3 confirmed SARS-CoV-2), 2-4 in 4 cases and 1 in 1 case. GGO were found in all patients; 3 cases also showed a combination of GGO and peripheral consolidations (mixed). Five cases were suggestive for an early stage of interstitial pneumonia, 4 for progressive and 1 for peak. All the lung lesions showed increased FDG uptake. In early stages SUV_max ranged from 1.5 to 11, in progressive from 3.3 to 6.8, in peak from 2.4 to 7.7. SUV_max ranged 1.5-11 in patients with only GGO and 2.8-7.7 in those with mixed pattern.</p><p><strong>Conclusions: </strong>¹⁸F-FDG PET-CT findings in suspected COVID-19 pulmonary involvement of asymptomatic oncologic patients showed an increase in FDG uptake of GGO and consolidations, but with a wide and apparently nonspecific range of SUV_max values.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"10 1","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sectional Anatomy Quiz - VII.","authors":"Nina Li,&nbsp;Rashid Hashmi","doi":"10.22038/AOJNMB.2021.55113.1381","DOIUrl":"https://doi.org/10.22038/AOJNMB.2021.55113.1381","url":null,"abstract":"<p><p>This series involves a quiz pertaining to the identification of key anatomical landmarks and normal structures present at a given level on the computed tomography (CT) image. The current quiz demonstrates examples of normal and abnormal axial CT images at the level of origin of the coeliac artery. The representative image is subsequently followed by further images demonstrating various commonly encountered pathologies found at this level in clinical practice. In each image, readers are expected to identify highlighted anatomical structures and appreciate how given pathologies can alter the appearance of normal structures. This series aims to advance understanding of sectional anatomy and aid nuclear physicians in the interpretation of the CT component of single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"10 1","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidentally Detected Celiac Disease with Splenomegaly on ¹⁸F FDG PET/CT: A Potential Lymphoma Mimic.","authors":"Ananya Panda,&nbsp;Michael R McCarthy,&nbsp;Joseph A Murray,&nbsp;Rosalind F Sharain,&nbsp;Min Shi,&nbsp;Ayse Tuba Kendi","doi":"10.22038/AOJNMB.2020.49000.1333","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.49000.1333","url":null,"abstract":"<p><p>Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical ¹⁸F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701229/pdf/AOJNMB-9-51.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38776327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital and brain metastases on ⁶⁸Ga-PSMA PET/CT in a patient with prostate carcinoma refractory to ¹⁷⁷Lu-PSMA and ²²⁵Ac-PSMA therapy.","authors":"Ashwin Singh Parihar,&nbsp;Kunal Ramesh Chandekar,&nbsp;Harpreet Singh,&nbsp;Ashwani Sood,&nbsp;Bhagwant Rai Mittal","doi":"10.22038/AOJNMB.2020.50820.1347","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.50820.1347","url":null,"abstract":"<p><p>We present a case of metastatic prostate cancer with rare metastases involving the brain and orbit, in addition to liver, skeletal and nodal metastases. The patient had undergone prior hormonal therapy and chemotherapy and had disease progression despite 2 cycles of ¹⁷⁷Lu-Prostate specific membrane antigen (¹⁷⁷Lu-PSMA) based radioligand therapy. He had a partial response after 2 cycles of ²²⁵Ac-PSMA based targeted alpha therapy, as demonstrated on the ⁶⁸Ga-PSMA PET/CT study. However, the patient had disease progression at the end of 4 cycles of ²²⁵Ac-PSMA therapy, evident by rising prostate specific antigen levels and imaging findings. The end of treatment ⁶⁸Ga-PSMA PET/CT showed additional sites of metastases in the orbit and brain apart from overall disease progression. These are rare sites of distant spread in prostate cancer and require urgent evaluation and local treatment to prevent potential complications. The importance of detection of metastatic sites in closed cavities is because of the requirement for urgent intervention to avoid compression related complications.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 1","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701233/pdf/AOJNMB-9-67.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38776330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of cardiac amyloidosis incidentally detected by bone scintigraphy.","authors":"Hiroki Tanaka,&nbsp;Makoto Hosono,&nbsp;Mitsunori Kanagaki,&nbsp;Marina Shimizu,&nbsp;Naoko Matsubara,&nbsp;Kazuna Kawabata,&nbsp;Tadashi Miyamoto,&nbsp;Kazumi Itoi","doi":"10.22038/AOJNMB.2020.50508.1350","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.50508.1350","url":null,"abstract":"<p><p>A 73-year-old man with lung cancer underwent bone scintigraphy for disease staging. Diffuse myocardial technetium hydroxymethylene diphosphonate (^99mTc-HMDP) uptake was incidentally found. A diagnosis of amyloid transthyretin (ATTR) cardiac amyloidosis was suspected, although the patient had no symptoms at this time. Single-photon emission computed tomography (SPECT) showed particularly strong uptake in the ventricular septum. Cardiac magnetic resonance imaging (CMR) showed widespread subendocardial and partly transmural enhancement of the left ventricular myocardium on delayed postcontrast T1-weighted images. These findings were consistent with ATTR cardiac amyloidosis. ¹⁸F-FDG uptake in the left ventricle wall was observed on PET/CT. He was finally diagnosed with ATTR by endomyocardial biopsy. There are two major subtypes of cardiac amyloidosis: ATTR amyloidosis and amyloid light-chain (AL) amyloidosis. Endomyocardial biopsy is the gold standard for diagnosis. Recently, however, several reports have shown that bone scintigraphy using a ^99mTc-labelled bone-seeking agent can detect ATTR cardiac amyloidosis and differentiate it from AL amyloidosis. Bone scintigraphy may play an important role in the detection and differentiation of ATTR cardiac amyloidosis.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 1","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701224/pdf/AOJNMB-9-71.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38776331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes zoster infection mimicking pelvic lymph node metastasis on FDG-PET/CT in a patient with cervical cancer.","authors":"Kazutaka Harashima,&nbsp;Shiro Watanabe,&nbsp;Nanase Okazaki,&nbsp;Daisuke Endo,&nbsp;Yuko Uchiyama,&nbsp;Fumi Kato,&nbsp;Kenji Hirata,&nbsp;Kohsuke Kudo","doi":"10.22038/AOJNMB.2021.55050.1378","DOIUrl":"https://doi.org/10.22038/AOJNMB.2021.55050.1378","url":null,"abstract":"<p><p>Although ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is an established method for the staging of malignancies, benign lesions (e.g, active inflammatory lesions) often show increased metabolic activity. Herpes zoster is the clinical manifestation of the activation and replication of dormant varicella-zoster virus (VZV) in individuals with decreased cell-mediated immunity. Although the diagnosis of herpes zoster is clinical, it is sometimes observed incidentally during imaging for another disease. We describe the case of a 67-year-old Japanese female patient diagnosed with cervical cancer in whom FDG-PET/CT revealed herpes zoster manifestations: hypermetabolic cutaneous lesions in the buttock and pelvic lymph node involvement. The resected lymph nodes showed no malignant lesions but revealed lymphoid follicle formation, probably related to viral infection. There has been no report comparing FDG-PET findings of lymph nodes with histologic findings; the present findings are compatible with a clinically VZV-induced inflammatory reaction in regional lymph nodes, which increased FDG accumulation. Active infection with VZV displays increased FDG uptake in regional lymph nodes and may lead to incorrect malignant disease management in oncology. Misdiagnoses can be avoided by a careful interpretation by experienced nuclear medicine physicians as well as proper clinical evaluation.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 2","pages":"183-187"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255524/pdf/AOJNMB-9-183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39174984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological FDG uptake in growth plate on pediatric PET.","authors":"Tomoaki Otani,&nbsp;Yuji Nakamoto,&nbsp;Takayoshi Ishimori","doi":"10.22038/AOJNMB.2020.49638.1339","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.49638.1339","url":null,"abstract":"<p><strong>Objectives: </strong>¹⁸F-Fluorodeoxyglucose (FDG) uptake in children is different from that in adults. Physiological accumulation is known to occur in growth plates, but the pattern of distribution has not been fully investigated. Our aim was to evaluate the metabolic activity of growth plates according to age and location.</p><p><strong>Methods: </strong>We retrospectively evaluated 89 PET/CT scans in 63 pediatric patients (male : female=25 : 38, range, 0-18 years). Patients were classified into four age groups (Group A: 0-2 years, Group B: 3-9 years, Group C: 10-14 years and Group D: 15-18 years). The maximum standardized uptake value (SUV_max) of the proximal and distal growth plates of the humerus, the forearm bones and the femur were measured. The SUV_max of each site and each age group were compared and statistically analyzed. We also examined the correlations between age and SUV_max.</p><p><strong>Results: </strong>As for the comparison of SUV_max in each location, the SUV_max was significantly higher in the distal femur than those in the other sites (p< 0.01). SUV_max in the distal humerus and the proximal forearm bones were significantly lower than those in the other sites (p< 0.01). In the distal femur, there was large variation in SUV_max, while in the distal humerus and the proximal forearm bones, there was small variation. As for the comparison of SUV_max in each age group, the SUV_max in group D tended to be lower than those in the other groups, but in the distal femur, there was no significant difference among each age group.</p><p><strong>Conclusion: </strong>Our data indicate that FDG uptake in growth plates varies depending on the site and age with remarkable uptake especially in the distal femur.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701234/pdf/AOJNMB-9-15.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39123959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain hypometabolism in rare genetic neurodegenerative disease: Niemann-Pick disease type C, spinocerebellar ataxia and Huntington disease assessed by FDG PET.","authors":"Yung Hsiang Kao,&nbsp;Melissa Cheng,&nbsp;Dennis Velakoulis,&nbsp;Mark Walterfang,&nbsp;Dinesh Sivaratnam","doi":"10.22038/AOJNMB.2020.52511.1362","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.52511.1362","url":null,"abstract":"<p><p>Brain metabolic imaging using ¹⁸F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) with contemporaneous low-dose CT may be used to assess neurodegenerative diseases. In contrast to oncology whole-body FDG PET, qualitative assessment alone in brain FDG PET is subjective and vulnerable to visual interference due to high physiologic background activity. Therefore, mild changes in brain metabolism may be visually undetectable by qualitative interpretation alone, resulting in diagnostic inaccuracy. To overcome this, some institutions may employ an objective comparison to a normal reference database. To date, there is limited literature describing brain metabolic changes in rare genetic neurodegenerative diseases such as Niemann-Pick disease Type C, spinocerebellar ataxia and Huntington disease. In this case series, we illustrate the typical FDG PET findings in the cortex and deep grey matter for these rare diseases, utilising normal database comparison including three dimensional Stereotactic Surface Projection (3D-SSP) mapping. These comparisons can generate 3D-SSP maps where metabolic changes may be expressed in standard deviations from normal (z-score) and visually depicted in a scale of colours to improve diagnostic accuracy.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"9 2","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255525/pdf/AOJNMB-9-167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39174980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}