Asia Pacific journal of clinical nutrition最新文献

{"title":"Phase-dependent intake and 90-day mortality by nutrition status in invasive mechanical ventilation critically ill adults: A retrospective cohort study.","authors":"Ah Ron Lee, Bo-Eun Kim, Eun-Mee Kim, Chi-Min Park, Sung Nim Han","doi":"10.6133/apjcn.202606_35(3).0004","DOIUrl":"10.6133/apjcn.202606_35(3).0004","url":null,"abstract":"<p><strong>Background and objectives: </strong>There has been a debate regarding appropriate nutrition support during the ear-ly stages of intensive care unit (ICU) admission. This study investigated nutrition support implementation and its relationship with clinical outcomes based on nutrition status.</p><p><strong>Methods and study design: </strong>We performed a retrospective cohort study of 595 critically ill adults receiving invasive mechanical ventilation. Patients were assessed by Global Leadership Initiative on Malnutrition criteria. Stages following ICU admission were cate-gorized as early acute phase (days 1-3), late acute phase (days 4-6), and recovery phase (days 7-10). Patients were divided into energy intake categories (<10, 10-20, and >20 kcal/kg/day) and protein intake cate-gories (<0.8, 0.8-1.2, and >1.2 g/kg/day). We examined differences in 90-day mortality at each stage using Cox proportional hazards analyses for total cohort, well-nourished, and malnourished groups.</p><p><strong>Results: </strong>Mortality was not associated with nutrition intakes during the early and late acute phases. However, higher energy intake during the recovery phase was associated with lower mortality in total cohort (p = 0.002). Significant associations between energy intake and mortality during the recovery phase were observed in both well-nourished and malnourished patients (p = 0.007 and p = 0.05, respectively). Additionally, protein intake during the recovery phase was associated with mortality, specifically in malnourished patients (p = 0.007), but not in well-nourished patients.</p><p><strong>Conclusions: </strong>Energy intake after 7 days in ICU was associated with mortality in both nutrition status groups, while protein intake showed benefit only in malnourished patients. Therefore, phase-dependent nutrition intake depending on nutrition status may be applicable for optimizing ICU nutri-tion support strategies.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"412-420"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary assessment from inflammation and gut microbiota perspectives in urban Chinese adults aged 40-69 years: Association with chronic diseases.","authors":"Yuebao Fu, Wenjing Wang, Qiongxi Lin, Yunqing Yang, Jialu You, Rong Xiao, Yongye Sun, Yuandi Xi","doi":"10.6133/apjcn.202606_35(3).0011","DOIUrl":"10.6133/apjcn.202606_35(3).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>Current evidence suggests that gut microbiota dysbiosis accelerates aging and aging-related diseases through pro-inflammatory pathways. This study aimed to evaluate dietary quality in relation to inflammation and gut microbiota, and to explore their relationship with chronic diseases among urban Chinese adults aged 40-69 years.</p><p><strong>Methods and study design: </strong>A cross-sectional study was conducted among urban Chinese adults aged 40-69 years. Dietary quality was assessed by dietary intake, dietary inflammation index (DII), and dietary index for gut microbiota (DI-GM). Log-binomial regression was per-formed to examine the associations between DII, DI-GM and chronic diseases.</p><p><strong>Results: </strong>An excessive energy proportion from fat (37.4%) and an insufficient contribution from carbohydrates (44.7%) indicated an imbalance in macronutrient intake. The medians and interquartile ranges for DII and DI-GM of the participants were 1.3 (0.2, 2.5) and 3.0 (2.0,5.0), respectively, suggesting a pro-inflammatory and gut microbiota-unfavorable dietary tendency. Livestock contributed most to dietary inflammation in the population (standardized β = 0.251), whereas vegetables showed the strongest inverse effect (standardized β = -0.500). A higher DI-GM score was suggested to be a protective factor against self-reported dysglycemia (OR = 0.311; 95%CI: 0.118, 0.818).</p><p><strong>Conclusions: </strong>The participants exhibited an imbalance in macronutrient intake and a dietary tendency that was pro-inflammatory and unfavorable to gut microbiota. Notably, this study revealed a negative relationship between DI-GM and dysglycemia in middle-aged and elderly population, which under-scores the potential of targeting gut microbiota through diet for chronic disease prevention in this population.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"485-493"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of nutrigenomic retreats: Integrating culinary education, wellness, and personalized nutrition in the era of genomic health.","authors":"Recep Caglas, Vural Yilmaz","doi":"10.6133/apjcn.202606_35(3).0002","DOIUrl":"10.6133/apjcn.202606_35(3).0002","url":null,"abstract":"<p><strong>Background and objectives: </strong>The convergence of genomic science and culinary arts has led to a new paradigm in wellness tourism: nutrigenomic retreats. These programs merge genetic insights with tailored diets, immersive culinary education, and holistic wellness practices. While nutrigenomics and personalized nutrition are advancing rapidly, translation of gene-diet knowledge into structured, real-world experiential models remains underexplored. This paper proposes a conceptual and translational framework for nutrigenomic retreats, integrating scientific advances in personalized nutrition with gastronomy-driven wellness experiences.</p><p><strong>Methods and study design: </strong>A narrative review of peer-reviewed literature was conducted, focusing on nutrigenomics, culinary medicine, functional foods, and wellness tourism. Insights from nutritional genomics databases and publicly available transcriptomic resources are used illustratively to highlight gene-diet interactions relevant to retreat settings. Conceptual models, including retreat agendas, gene-informed dietary personalization, and culinary education formats, are presented.</p><p><strong>Results: </strong>Nutrigenomic retreats are proposed as a multidisciplinary platform for health optimization by combining: interpretation of common genetic variants associated with nutrient metabolism and dietary response (e.g., FTO, MTHFR, CYP1A2); personalized menus aligned with gene-diet interactions; culinary instruction emphasizing nutrient-dense, culturally diverse, functional foods; and complementary wellness interventions such as mindfulness, physical activity, and biofeed-back. These illustrative elements may enhance scientific literacy, empowering participants to better understand individual nutritional variability and adopt sustainable health behaviors.</p><p><strong>Conclusions: </strong>Nutrigenomic retreats represent a novel fusion of science, culinary innovation, and wellness culture. As interest in personalized health continues to expand, this model may offer an experiential pathway for preventive health education and functional gastronomy, while fostering public engagement with genomics.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"389-397"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural adaptations of food exchange lists: A scoping review of applications in non-communicable disease management.","authors":"Safa Abdul Majeed, Ala Al Rajabi, Reema Tayyem","doi":"10.6133/apjcn.202606_35(3).0001","DOIUrl":"10.6133/apjcn.202606_35(3).0001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Non-communicable diseases (NCDs), including diabetes, cardiovascular diseases, and obesity, remain major global health challenges largely driven by suboptimal dietary patterns. The Food Exchange List (FEL) is a structured dietary planning tool originally developed for diabetes management to support balanced nutrient intake. Although FELs are widely used across diverse cultural and clinical contexts, evidence regarding their direct role in NCD prevention and management is limited. This scoping review examines the historical development, core principles, and global applications of FELs, with a focus on their use in dietary planning and NCD control, aiming to identify gaps in the existing literature.</p><p><strong>Methods and study design: </strong>Following Joanna Briggs Institute (JBI) methodology and the PRISMA-ScR checklist, four databases (PubMed, ProQuest, Web of Science, and Cochrane Library) were searched between November 18, 2024, and January 2, 2026, to identify primary research published from 1990 to 2026. Of 500 records screened, 38 studies met the inclusion criteria. Notably, 60% (n = 24) focused exclusively on FEL development without evaluating clinical or behavioral outcomes.</p><p><strong>Results: </strong>Findings from randomized and quasi-experimental studies, as well as small pilot interventions, suggest that FELs can support meal planning, nutritional adequacy, and attainment of specific dietary targets. However, their cognitive complexity may negatively affect adherence and contribute to higher dropout rates. Evidence for FEL effectiveness in NCD management remains limited, particularly among low-literacy populations.</p><p><strong>Conclusions: </strong>Overall, there is a clear need for long-term studies evaluating culturally adapted and simplified FELs and their independent effects on clinical outcomes, including glycemic control, cardiovascular risk, quality of life, and medication use.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"369-388"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring a tolerable and effective dosage of omega-3 fatty acids as a supplement in enterally fed patients with severe pneumonia: A pilot study.","authors":"Qian You, Yingyi Chen, He Yu, Yulian Zhang, Na Tang, Zhiyong Rao","doi":"10.6133/apjcn.202606_35(3).0010","DOIUrl":"10.6133/apjcn.202606_35(3).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Severe community-acquired pneumonia (CAP) is one of the most common di-agnoses in the medical intensive care unit. The objective of this study is to seek an effective and clinically tolerable dosage of ω-3 (EPA+DHA) fatty acids (FA) in enterally fed patients with severe pneumonia.</p><p><strong>Methods and study design: </strong>A total of 84 patients were randomly assigned to a control group or two experimental groups from January 2022 to June 2024, each receiving 3.50g and 8.75g of ω-3 FA daily for 7 days, and clinical outcomes and tolerance parameters were collected.</p><p><strong>Results: </strong>ω-3 FA supplementation significantly reduced mechanical ventilation (MV) duration, hospital expenses, and daily hospital costs. Mechanistically, the anticipated anti-inflammatory effect was not observed but a trend of immune enhancement was noted. The addition of 3.50g and 8.75g of ω-3 FA daily was relatively well-tolerated in patients with severe pneumonia.</p><p><strong>Conclusions: </strong>In this pilot study, ω-3 FA supplementation at 3.50-8.75 g/day to enterally fed patients with severe pneumonia for 7 days was relatively well-tolerated, shortened days of MV, and decreased hospital cost. Further investigation with adequate statistical power and larger sample size is warranted to confirm these clin-ical benefits and establish the optimal dosage for this supplementation strategy.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"475-484"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the Dietary Inflammatory Index and lung function in exacerbated chronic obstructive pulmonary disease: The mediating role of inflammatory indicators.","authors":"Yulian Sun, Chaoqun Yang, Luyao Li, Xin Xu, Mingxin Li, Liangjie Zhao, Quanguo Li, Xiaoqi Zhang, Haichao Wen, Yang Yang, Aiguo Ma, Jing Cai","doi":"10.6133/apjcn.202606_35(3).0005","DOIUrl":"10.6133/apjcn.202606_35(3).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Background and Objectives: This study explored the association between the dietary inflammatory index (DII) and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and the potential mediating role of blood inflammatory markers.</p><p><strong>Methods and study design: </strong>In this cross-sectional study of 507 patients with AECOPD, dietary intake was assessed through 24-hour dietary recalls, and the DII was determined. Generalized linear models, logistic regression and mediation analysis were used to evaluate associations between DII, inflammatory markers [white blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammatory response index (SIRI)], and lung function [forced expiratory volume in one second (FEV1), forced vital capacity (FVC)].</p><p><strong>Results: </strong>DII was 2.81and showed a significant negative linear correlation with FVC (p <0.05) and with FEV1 (p <0.05). After adjusting for confounding factors, each unit increase in DII was associated with a decrease of 0.053 L in FEV1 and 0.078 L in FVC. Additionally, FEV1 showed negative associations with SII, SIRI, NLR, PLR, and WBC (all p <0.05). Mediation analysis revealed that WBC exerted a statistically significant mediating effect between DII and FEV1 (ACME = -7.54 × 10⁻³, p <0.05).</p><p><strong>Conclusions: </strong>It was indicated that a pro-inflammatory diet is associated with reduced lung function in AECOPD patients, with lung function showing a significant negative correlation with inflammatory markers. WBC serves as a key mediator between the DII and FEV1.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"421-432"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index and unfavorable dietary patterns associated with ischemic stroke in China.","authors":"Jianchun Yu, Wei Chen, Gang Xiao, Qi An, Ziyu Li, Bin Liang, Yuanxin Li, Dongbing Zhao, Junsheng Peng, Yanbing Zhou, Guole Lin, Weiming Kang, Zijian Li, Chao Yan, Yuanpei Lin, Changzhen Zhu, Hu Ren, Yijia Lin, Yulong Tian","doi":"10.6133/apjcn.202606_35(3).0009","DOIUrl":"10.6133/apjcn.202606_35(3).0009","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to evaluate the safety and efficacy of a fish oil-enriched food for special medical purposes (FSMP, ProSure) compared to an oncology-specific enteral nutrition product (TPF-T).</p><p><strong>Methods and study design: </strong>This multicenter, randomized, open-label, non-inferiority phase III trial (NCT05301556) included patients with gastrointestinal tumors scheduled for surgery and at high risk for malnutrition. Participants were randomized 1:1 to receive either FSMP or TPF-T as a sole nutritional source from 4±2 days before surgery to 9±3 days postoperatively. The primary endpoint was the change in serum pre-albumin levels from baseline to 9±3 days post-surgery (non-inferiority margin: 20.807 mg/L).</p><p><strong>Results: </strong>Of the 325 patients randomized (FSMP: n = 162; TPF-T: n = 163), FSMP demonstrated non-inferiority to TPF-T in maintaining serum pre-albumin levels in the perioperative patients (least square [LS] mean differ-ence: 6.9 mg/L, 95% CI: -5.0 to 18.8). FSMP showed a greater reduction in serum triglycerides (LS mean difference: -0.133 mmol/L, 95% CI: -0.239 to -0.027, p = 0.014), while comparable changes in other lipid parameters, serum albumin, body weight, or grip strength from baseline to 9±3 days post-surgery, and the length of hospital stay were observed between groups (all p >0.05). The most common treatment-emergent adverse events were gastrointestinal disorders, including abdominal distension (FSMP: 17.3% vs. TPF-T: 18.4%), di-arrhea (21.0% vs. 11.0%), and nausea (6.8% vs. 5.5%).</p><p><strong>Conclusions: </strong>ProSure, an FSMP, when used as a sole nutritional source, is not inferior to TPF-T in maintaining perioperative nutritional status in patients with gastrointestinal tumors, demonstrating comparable efficacy and safety.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"463-474"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.","authors":"Ying Jiang, Weiqi Hong, Tianwei Xu, Jialu Wang, Molian Tang, Qin Cao, Yun Li, Renying Xu","doi":"10.6133/apjcn.202606_35(3).0017","DOIUrl":"10.6133/apjcn.202606_35(3).0017","url":null,"abstract":"<p><strong>Background and objectives: </strong>As the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) rises, identifying reliable biomarkers for risk prediction is essential. This study assessed baseline triglyceride glucose (TyG) index and TyG-derived parameters as predictors of future MASLD risk in older adults.</p><p><strong>Methods and study design: </strong>We analyzed data from 2,757 Chinese adults (60-91 years) undergoing annual health checks (2017-2023). Incident MASLD was detected using ultrasound after excluding baseline cases. Cox proportional hazards models (with parameters in quartiles) and time-dependent ROC curves quan-tified associations and time-varying predictive performance among TyG-related parameters. The predictive performance of TyG-BMI was also compared with the hepatic steatosis index (HSI) in ROC analysis.</p><p><strong>Results: </strong>Over a median six-year follow-up, 584 incident MASLD cases occurred. TyG-derived parameters showed stronger associations than TyG index. Specifically, triglyceride glucose-body mass index (TyG-BMI) demon-strated the highest risk, with an adjusted hazard ratio of 6.42 (95% CI: 5.33-7.73) for the highest versus lowest quartile. This association remained robust in sensitivity analysis. TyG-BMI demonstrated numerically higher AUC values than the HSI (Men: TyG-BMI 0.758 vs. HSI 0.747; Women: TyG-BMI 0.759 vs. HSI 0.756), with overlapping confidence intervals. Time-dependent ROC analysis confirmed TyG-BMI's superior predictive accuracy over time. The optimal TyG-BMI cut-offs were 187.97 for men and 191.33 for women.</p><p><strong>Conclusions: </strong>TyG-BMI demonstrated superior predictive performance compared to TyG index itself, other TyG-derived parameters, and the HSI, supporting its utility as a practical screening tool in primary care.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"541-551"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy intake and nutritional status in older adults undergoing long-term rehabilitation for chronic diseases: A multicentre prospective study.","authors":"Takahiro Yamamoto, Kenichiro Yasutake, Shoji Ando, Akiko Toriyama, Masayuki Nishida, Atsushi Moriwaki","doi":"10.6133/apjcn.202606_35(3).0018","DOIUrl":"10.6133/apjcn.202606_35(3).0018","url":null,"abstract":"<p><strong>Background and objectives: </strong>In this multicentre prospective observational study, we aimed to investigate changes in energy intake and nutritional indices, including cardiovascular, cerebrovascular, respiratory, and musculoskeletal conditions, among older adults hospitalised in general hospitals who required long-term rehabilitation.</p><p><strong>Methods and study design: </strong>This study included patients aged ≥65 years who were admitted to 41 National Hospital Organization hospitals between September 2019 and March 2020 with cardiovascular, cerebrovascular, respiratory, or musculoskeletal diseases. Physical measurements, blood test values, energy intake, and activities of daily living were evaluated at admission and discharge.</p><p><strong>Results: </strong>The analysis includ-ed 222 patients (125 men, 97 women; mean age, 78.9 years). On admission, 75.7% of patients were malnourished or at risk of malnutrition based on the Mini Nutritional Assessment-Short Form score, with the highest prevalence (84.1%) observed in patients with respiratory disease. Although energy intake significantly increased during hospitalisation in all disease groups, only 31.1% of patients met the estimated energy requirements at discharge, and their body mass index and nutritional indices decreased. Logistic regression analysis showed that older age, female sex, higher energy intake at admission, and lower inflammation were associated with sufficient energy intake at discharge. Energy intake at admission was consistently associated with sufficient energy intake at discharge regardless of disease category, whereas other associated factors dif-fered by disease.</p><p><strong>Conclusions: </strong>Nutritional management in general hospitals may be inadequate for older adults requiring long-term rehabilitation. These findings suggest the need for early individualised nutritional management in hospitalised older adults undergoing long-term rehabilitation.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"552-567"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and osteoporosis in type 2 diabetes with MASLD.","authors":"Shuyun Li, Ying Yang, Gang Tian, Yangyang Zhang, Jia Bai, Tongqian Zhang, Aihong Wang, Peiyan Du, Haihong Lv","doi":"10.6133/apjcn.202606_35(3).0006","DOIUrl":"10.6133/apjcn.202606_35(3).0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Uric acid to high-density lipoprotein cholesterol ratio (UHR) plays a significant role in metabolic and inflammatory responses. However, the association between UHR and osteoporosis (OP) remains unclear in type 2 diabetes mellitus (T2DM) with metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to investigate this association and identify potential biomarkers for early OP screening.</p><p><strong>Methods and study design: </strong>A total of 420 T2DM patients with MASLD aged ≥50 years were en-rolled in this retrospective study. All subjects underwent dual energy X-ray absorptiometry (DXA) examination to measure bone mineral density (BMD) and were divided into three groups according to UHR tertiles, and the differences in BMD levels and OP prevalence among the three groups were compared. Logistic regression was used to analyze the relationship between UHR and OP.</p><p><strong>Results: </strong>Patients in the highest tertile of UHR group (UHR >363.46) had lower BMD and a higher incidence of OP than those in the lower tertiles. In the UHR >363.46 group, UHR was negatively correlated with lumbar spine, whole body, and femoral neck BMD (p <0.05). After adjusting for confounding factors, UHR >363.46 was associated with a significantly increased risk of OP compared to UHR ≤312.35 (OR = 3.341, 95%CI: 1.129-9.887, p = 0.029). ROC curve indicated that UHR combined with Age, HOMA-IR and 25(OH)D had a high predictive value for OP, with an area under the curve of 0.837 (p <0.001).</p><p><strong>Conclusions: </strong>Increased UHR is significantly associated with higher risk of OP, suggesting that clinical monitoring of UHR is valuable for early detection of OP in T2DM with MASLD.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"433-440"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}