Artery Research最新文献_第5页

Association between Life Stressors and Arterial Stiffness: The Finnish Retirement and Aging Study 生活压力与动脉硬化的关系：芬兰退休和老龄化研究

IF 0.6 4区医学

Artery Research Pub Date : 2021-06-01 DOI: 10.2991/ARTRES.K.210608.001

Saana Karelius, J. Vahtera, O. Heinonen, T. Niiranen, S. Stenholm

引用次数: 1

K_Ca3.1 Inhibition Decreases Size and Alters Composition of Atherosclerotic Lesions Induced by Low, Oscillatory Flow. KCa3.1抑制降低低振荡血流诱导的动脉粥样硬化病变的大小并改变其组成。

IF 0.6 4区医学

Artery Research Pub Date : 2021-06-01 Epub Date: 2021-02-13 DOI: 10.2991/artres.k.210202.001

Darla L Tharp, Douglas K Bowles

{"title":"KCa3.1 Inhibition Decreases Size and Alters Composition of Atherosclerotic Lesions Induced by Low, Oscillatory Flow.","authors":"Darla L Tharp, Douglas K Bowles","doi":"10.2991/artres.k.210202.001","DOIUrl":"https://doi.org/10.2991/artres.k.210202.001","url":null,"abstract":"Low, oscillatory flow/shear patterns are associated with atherosclerotic lesion development. Increased expression of KCa3.1 has been found in Vascular Smooth Muscle (VSM), macrophages and T-cells in lesions from humans and mice. Increased expression of KCa3.1, is also required for VSM cell proliferation and migration. Previously, we showed that the specific KCa3.1 inhibitor, TRAM-34, could inhibit coronary neointimal development following balloon injury in swine. Atherosclerosis develops in regions with a low, oscillatory (i.e. atheroprone) flow pattern. Therefore, we used the Partial Carotid Ligation (PCL) model in high-fat fed, Apoe-/- mice to determine the role of KCa3.1 in atherosclerotic lesion composition and development. PCL was performed on 8-10 week old male Apoe-/- mice and subsequently placed on a Western diet (TD.88137, Teklad) for 4 weeks. Mice received daily s.c. injections of TRAM-34 (120 mg/kg) or equal volumes of vehicle (peanut oil, PO). 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34) treatment reduced lesion size ~50% (p < 0.05). In addition, lesions from TRAM-34 treated mice contained less collagen (6% ± 1% vs. 15% ± 2%; p < 0.05), fibronectin (14% ± 3% vs. 32% ± 3%; p < 0.05) and smooth muscle content (19% ± 2% vs. 29% ± 3%; p < 0.05). Conversely, TRAM-34 had no effect on total cholesterol (1455 vs. 1334 mg/dl, PO and TRAM, resp.) or body weight (29.1 vs. 28.8 g, PO and TRAM, resp.). Medial smooth muscle of atherosclerotic carotids showed diminished RE1-Silencing Transcription Factor (REST)/Neural Restrictive Silencing Factor (NRSF) expression, while REST overexpression in vitro inhibited smooth muscle migration. Together, these data support a downregulation of REST/NRSF and upregulation of KCa3.1 in determining smooth muscle and matrix content of atherosclerotic lesions.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":"27 2","pages":"93-100"},"PeriodicalIF":0.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/08/nihms-1718074.PMC8388312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pre-existing Cerebral Small Vessel Disease in Young Patients with Acute Ischemic Stroke caused by Large Artery Atherosclerosis or Small Artery Occlusion 大动脉硬化或小动脉闭塞引起的青年急性缺血性脑卒中患者早期存在的脑小血管疾病

IF 0.6 4区医学

Artery Research Pub Date : 2021-05-01 DOI: 10.2991/ARTRES.K.210511.001

Hui Li, Danhua Du, Juan Chen, Xiangheng Wang, Yuanliang Xie

引用次数: 0

Corrigendum to "Estimation of maximal oxygen consumption and heart rate recovery using the Tecumseh sub-maximal step test and their relationship to cardiovascular risk factors" [Artery Research 18 (June 2017) 29-35]. “使用Tecumseh次最大步试验估计最大耗氧量和心率恢复及其与心血管危险因素的关系”的勘误表[动脉研究18（2017年6月）29-35]。

IF 0.9 4区医学

Artery Research Pub Date : 2021-03-01 DOI: 10.2991/artres.k.210210.001

Alun D Hughes, Nish Chaturvedi

引用次数: 0

Reliability of Finger Photoplethysmogram Assessment: Effect of Mental Stress and Day-to-Day Variability 手指光体积描记图评估的可靠性:精神压力和日常变异性的影响

IF 0.6 4区医学

Artery Research Pub Date : 2021-02-01 DOI: 10.2991/ARTRES.K.210208.001

Marina Fukuie, T. Tarumi, Takayuki Yamabe, J. Sugawara

{"title":"Reliability of Finger Photoplethysmogram Assessment: Effect of Mental Stress and Day-to-Day Variability","authors":"Marina Fukuie, T. Tarumi, Takayuki Yamabe, J. Sugawara","doi":"10.2991/ARTRES.K.210208.001","DOIUrl":"https://doi.org/10.2991/ARTRES.K.210208.001","url":null,"abstract":"The frequent assessment of vascular health may contribute to increased awareness and prevention of cardiovascular events in general populations. It has been well recognized that arterial stiffness and wave reflection measured by the aortic pulse wave velocity and Augmentation Index (AIx) are the strong predictors of future Cardiovascular events and all-cause mortality [1,2]. However, these measures require technical expertise and knowledge. In this context, the Second Derivative waveform of fingertip Photoplethysmography (SDPTG) can be measured easily from a fingertip placed on the photoplethysmography (PTG) sensor and has the potential for selfmonitoring of vascular health during daily living [3]. Previously, several studies have demonstrated clinical and pathophysiological importance of SDPTG indices such as the SDPTG Aging Index (SDPTGAI) [4–6]. Since SDPTGAI is strongly correlated with age, it can be rescaled to years of age which is easily comprehended by general populations [3]. For these reasons, SDPTG indices including the vascular aging index have recently been implemented for ambulatory monitoring devices, but its usability and reliability are not well documented. Mental stress is an external stimulus that can affect physiological parameters such as arterial tone [5,7], blood viscosity [8], and heart rate [9]. It is reported that pulse wave velocity and AIx are increased with acute mental stress [10,11]. Moreover, skin blood flow shows transient reflex changes in response to various external stimuli (e.g., arousing or painful stimuli, emotional stress) [12]. Since photoplethysmogram optically evaluates blood volume changes in the microvascular bed of cutaneous tissue, SDPTG may be influenced by mental stressor independent of changes in vascular tone and stiffness of the relatively proximal vessels.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69872192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis 介入治疗与保守治疗对下肢动脉硬化闭塞症的疗效及预后危险因素分析

IF 0.6 4区医学

Artery Research Pub Date : 2021-02-01 DOI: 10.2991/ARTRES.K.210204.001

Ling-Xiao Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Ji-ke Xue, Chengmei Ruan, Lijiao Xie

{"title":"Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis","authors":"Ling-Xiao Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Ji-ke Xue, Chengmei Ruan, Lijiao Xie","doi":"10.2991/ARTRES.K.210204.001","DOIUrl":"https://doi.org/10.2991/ARTRES.K.210204.001","url":null,"abstract":"Background: Arteriosclerosis Obliterans (ASO) is an important cause for lower limb amputation. We aimed to compare the effects of interventional and conservative therapies on lower extremity ASO, and to analyze the risk factors for prognosis. Methods: Ninety-eight eligible patients were randomly divided into experimental ( n = 50) and control groups ( n = 48). Conservative therapy was conducted for control group, and experimental group was given conservative and interventional therapies. Their baseline clinical data, hospital stay length, claudication distance, Rutherford stage, diseased arteries, Ankle-Brachial Index (ABI), clinical outcomes and adverse events were recorded. Then they were divided into poor ( n = 31) and good prognosis groups ( n = 67), and risk factors were explored by univariate and multivariate analyses. Results: The hospital stay length of experimental group was significantly shorter than that of control group ( p < 0.05). After treatment, Rutherford stage decreased, and vascular patency rate and total response rate rose in experimental group ( p < 0.05). Claudication distance and ABI significantly increased in both groups compared with those before treatment, especially in experimental group ( p < 0.05). The incidence rates of cardiovascular and cerebrovascular events, amputation and death were significantly lower in experimental group ( p < 0.05). Age, conservative therapy, smoking, hypertension, diabetes mellitus, hyperlipidemia and fibrinogen were independent risk factors for poor prognosis ( p < 0.05). Age of >70 years old and fibrinogen level of >4 g/L had greater effects on prognosis. Conclusion: Interventional therapy works well for lower extremity ASO, with high safety, easy recovery and mild complications. Poor prognosis is caused by old age, conservative therapy, smoking,","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44873544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Birth Weight in Relation to Post-Natal Growth Patterns as Predictor of Arterial Stiffness and Central Hemodynamics in Young Adults from a Population-based Study 一项以人群为基础的研究:出生体重与出生后生长模式的关系作为年轻人动脉僵硬和中央血流动力学的预测因子

IF 0.6 4区医学

Artery Research Pub Date : 2021-02-01 DOI: 10.2991/ARTRES.K.210215.001

Johannes Sperling, S. Sharma, P. Nilsson

引用次数: 2

Statistical Inferences Using Effect Sizes in Human Endothelial Function Research. 在人体内皮功能研究中使用效应大小进行统计推断。

IF 0.6 4区医学

Artery Research Pub Date : 2021-01-01 Epub Date: 2021-10-27 DOI: 10.1007/s44200-021-00006-6

Joshua M Cherubini, Maureen J MacDonald

{"title":"Statistical Inferences Using Effect Sizes in Human Endothelial Function Research.","authors":"Joshua M Cherubini, Maureen J MacDonald","doi":"10.1007/s44200-021-00006-6","DOIUrl":"10.1007/s44200-021-00006-6","url":null,"abstract":"Introduction: Magnitudes of change in endothelial function research can be articulated using effect size statistics. Effect sizes are commonly used in reference to Cohen's seminal guidelines of small (d = 0.2), medium (d = 0.5), and large (d = 0.8). Quantitative analyses of effect size distributions across various research disciplines have revealed values differing from Cohen's original recommendations. Here we examine effect size distributions in human endothelial function research, and the magnitude of small, medium, and large effects for macro and microvascular endothelial function.Methods: Effect sizes reported as standardized mean differences were extracted from meta research available for endothelial function. A frequency distribution was constructed to sort effect sizes. The 25th, 50th, and 75th percentiles were used to derive small, medium, and large effects. Group sample sizes and publication year from primary studies were also extracted to observe any potential trends, related to these factors, in effect size reporting in endothelial function research.Results: Seven hundred fifty-two effect sizes were extracted from eligible meta-analyses. We determined small (d = 0.28), medium (d = 0.69), and large (d = 1.21) effects for endothelial function that corresponded to the 25th, 50th, and 75th percentile of the data distribution.Conclusion: Our data indicate that direct application of Cohen's guidelines would underestimate the magnitude of effects in human endothelial function research. This investigation facilitates future a priori power analyses, provides a practical guiding benchmark for the contextualization of an effect when no other information is available, and further encourages the reporting of effect sizes in endothelial function research.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":"27 4","pages":"176-185"},"PeriodicalIF":0.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Sensitivity of Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Index for Cardiovascular Risk Assessment in Elderly Chinese: A Cross-Sectional Study 肱-踝脉搏波速度和踝-肱指数在中国老年人心血管风险评估中的差异敏感性:一项横断面研究

IF 0.6 4区医学

Artery Research Pub Date : 2021-01-01 DOI: 10.2991/ARTRES.K.201225.002

G. Fu, Y. Zhong, Feng-feng Pan, Chan-chan Xu

引用次数: 1

Selected Abstracts from Artery 21: Thursday 21 - Saturday 23 October 2021, Hôpital Européen Georges-Pompidou, Paris, France. 动脉21的精选摘要:2021年10月21日星期四至23日星期六，Hôpital europembroen乔治-蓬皮杜，法国巴黎。

IF 0.6 4区医学

Artery Research Pub Date : 2021-01-01 DOI: 10.1007/s44200-021-00008-4

引用次数: 1