P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring

IF 0.9 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.047

E. Selivanova, A. Shvetsova, V. Potekhina, D. Gaynullina, A. A. Borzykh, O. O. Kiryukhina, V. Kuzmin, O. Tarasova

引用次数: 0

Abstract

Methods: We induced preeclampsia in pregnant rats by L-NAME (nitric oxide synthase inhibitor) supplementation (250 mg/l in drinking water from gestation day 10 to delivery, daily dose 39 mg/kg). The model was verified by the dam’s blood pressure (BP) elevation (tail-cuff) and creatinine clearance reduction (metabolic cages) compared to control dams. Male offspring 16-18day old were used for BP recording (catheter technique under urethane anesthesia); their isolated arteries were studied by wire myography. Adrenergic nerve plexus was visualized by glyoxylic acid staining.

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P.34先兆子痫导致后代心血管系统交感神经控制发育迟缓

方法:用l - name(一氧化氮合酶抑制剂)诱导妊娠大鼠子痫前期(从妊娠第10天至分娩，每日剂量39 mg/kg)。与对照坝相比，大坝的血压(BP)升高(尾袖)和肌酐清除率降低(代谢笼)验证了该模型。雄性子代16 ~ 18日龄进行血压记录(尿氨麻醉下导管技术);用钢丝肌造影观察离体动脉。乙醛酸染色显示肾上腺素能神经丛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.