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Increased Trend of Adenovirus Activity After the COVID-19 Pandemic in South Korea: Analysis of National Surveillance Data. 韩国 COVID-19 大流行后腺病毒活动呈上升趋势：全国监测数据分析。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.3343/alm.2023.0484
Nam-Joo Lee, SangHee Woo, Jee Eun Rhee, Jaehee Lee, Sangwon Lee, Eun-Jin Kim
{"title":"Increased Trend of Adenovirus Activity After the COVID-19 Pandemic in South Korea: Analysis of National Surveillance Data.","authors":"Nam-Joo Lee, SangHee Woo, Jee Eun Rhee, Jaehee Lee, Sangwon Lee, Eun-Jin Kim","doi":"10.3343/alm.2023.0484","DOIUrl":"10.3343/alm.2023.0484","url":null,"abstract":"<p><p>The adenovirus detection rate is <10% throughout the year in South Korea; however, during the summer of 2023, it showed an unusual increase. We analyzed the adenovirus detection rate using data from the Korea Respiratory Integrated Surveillance System before and after coronavirus disease (COVID-19) collected from 2019 to week 36 of 2023. Before the COVID-19 outbreak in 2019, the mean detection rate was 8.2%, which decreased to 6.1% during the COVID-19 pandemic from 2020 to 2022. In 2023, the mean detection rate was 14.3% in week 36 and the highest in week 34, at 42.2%, and adenovirus was predominantly detected in the summer. The detection rate by age group showed substantially high activity among 0-12-yr-olds after the pandemic. This age group had a steady mean rate of 9.5% during the pandemic, without seasonality. In 2023, the detection rate surged in the 0-6-yr and 7-12-yr age groups, peaking at 61.6% and 57.1%, respectively. The dominant epidemic serotypes were HAdV-1 and HAdV-2 during and HAdV-3 after the pandemic. The multifaceted non-pharmaceutical interventions during the COVID-19 pandemic considerably impacted the prevalence of common respiratory viruses and complicated respiratory virus patterns after the pandemic. Constant surveillance is crucial for epidemic preparedness to monitor the possible surge of certain respiratory viruses.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"581-585"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Customized Quality Assessment of Healthcare Data. 医疗数据的定制质量评估。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.3343/alm.2024.0084
Jieun Shin, Jong-Yeup Kim
{"title":"Customized Quality Assessment of Healthcare Data.","authors":"Jieun Shin, Jong-Yeup Kim","doi":"10.3343/alm.2024.0084","DOIUrl":"10.3343/alm.2024.0084","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"472-477"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Clonal Hematopoiesis of Indeterminate Potential and Brain β-Amyloid Deposition in Korean Patients With Cognitive Impairment. 韩国认知障碍患者的不确定潜能克隆性造血与脑β-淀粉样蛋白沉积之间的关系
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-05-28 DOI: 10.3343/alm.2024.0086
Jiwon Yun, Young Chul Youn, Hye Ryoun Kim
{"title":"Association Between Clonal Hematopoiesis of Indeterminate Potential and Brain β-Amyloid Deposition in Korean Patients With Cognitive Impairment.","authors":"Jiwon Yun, Young Chul Youn, Hye Ryoun Kim","doi":"10.3343/alm.2024.0086","DOIUrl":"10.3343/alm.2024.0086","url":null,"abstract":"<p><p>Few studies have focused on the association between clonal hematopoiesis of indeterminate potential (CHIP) and β-amyloid (Aβ) deposition in the brain, which causes Alzheimer's disease. We aimed to investigate the potential role of CHIP in brain Aβ deposition in Korean patients. We enrolled 58 Korean patients over 50 yrs of age with cognitive impairment who underwent brain Aβ positron emission tomography. We explored CHIP in their peripheral blood using deep-targeted next-generation sequencing. Irrespective of the presence or absence of brain Aβ deposition, mutations in <i>DNMT3A</i> and the C:G>T:A single-nucleotide variants were identified as the primary characteristics, which reflect aged hematopoiesis in the study population. Multivariate logistic regression revealed that the presence of CHIP was not associated with brain Aβ deposition. As both CHIP and brain Aβ deposition are associated with aging, further research is required to elucidate their possible interplay.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"576-580"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Various Concentrations of Pronase on Flow Cytometric Crossmatching Patients Treated With Rituximab and Donor HLA-Specific Antibodies. 不同浓度的 Pronase 对使用利妥昔单抗和供体 HLA 特异性抗体治疗的流式细胞术交叉配血患者的影响
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-12 DOI: 10.3343/alm.2024.0132
Tae-Shin Kim, Inseong Oh, Yu Jung Choi, Minjeong Nam, Hajeong Lee, Eun Young Song
{"title":"Effects of Various Concentrations of Pronase on Flow Cytometric Crossmatching Patients Treated With Rituximab and Donor HLA-Specific Antibodies.","authors":"Tae-Shin Kim, Inseong Oh, Yu Jung Choi, Minjeong Nam, Hajeong Lee, Eun Young Song","doi":"10.3343/alm.2024.0132","DOIUrl":"10.3343/alm.2024.0132","url":null,"abstract":"<p><strong>Background: </strong>Pronase pretreatment can reduce rituximab (RTX) interference by degrading CD20 in B-cell flow cytometry crossmatch (FCXM) testing. However, it may also reduce the assay sensitivity by degrading HLA molecules. We investigated the effects of various pronase concentrations on RTX interference and the analytical sensitivity of B-cell FCXM testing.</p><p><strong>Methods: </strong>Using 59 patient serum samples and 38 donor lymphocyte samples, we designed 97 recipient-donor pairs and divided them into three groups according to RTX use and the presence of weak-to-moderate donor HLA-specific antibody (DSA) reactions: RTX+/DSA-, RTX+/DSA+, and RTX-/DSA+. FCXM was performed after pretreating lymphocytes with six different pronase concentrations (0, 0.5, 1, 2, 3, and 4 mg/mL).</p><p><strong>Results: </strong>With B-FCXM testing, false-positive results due to RTX in the RTX+/DSA- group markedly decreased with increasing pronase concentrations. The median channel shift values in the RTX+/DSA+ and RTX-/DSA+ groups did not significantly decrease when the pronase concentration was increased from 1 mg/mL to 2 or 3 mg/mL. All eight RTX+/DSA+ cases that were positive at 1 mg/mL pronase but negative at 2 or 3 mg/mL had mean fluorescence intensity (MFI) DSA values of less than 3,000 except for DQ5 (MFI: 5,226). With T-cell FCXM, false-positive results were observed in 2.9% of 315 FCXM tests with pronase pretreatment.</p><p><strong>Conclusions: </strong>Higher concentrations (2 or 3 mg/mL) of pronase effectively eliminated RTX interference but still carried a risk for false negativity for weak DSA reactions in B-cell FCXM. Higher pronase concentrations can be used as an auxiliary method to detect moderate-to-strong DSA reactions in RTX-treated patients.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"545-552"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a False-positive Multiplex Ligationdependent Probe Amplification Result in BRCA1 Using a Copy Number Variation Algorithm Under Development for a Commercial Next-Generation Sequencing-based Homologous Recombination Deficiency Assay. 利用正在开发的基于商用下一代测序的同源重组缺陷测定的拷贝数变异算法识别 BRCA1 的多重连接依赖性探针扩增假阳性结果。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI: 10.3343/alm.2024.0051
Paola Concolino, Elisa De Paolis, Martina Rinelli, Giulia Maneri, Francesca Brisighelli, Rita Trozzi, Simona Duranti, Luciano Giacò, Maria Piane, Alessia Preziosi, Arianna Panfili, Giovanni Scambia, Camilla Nero, Maria De Bonis, Angelo Minucci
{"title":"Identification of a False-positive Multiplex Ligationdependent Probe Amplification Result in <i>BRCA1</i> Using a Copy Number Variation Algorithm Under Development for a Commercial Next-Generation Sequencing-based Homologous Recombination Deficiency Assay.","authors":"Paola Concolino, Elisa De Paolis, Martina Rinelli, Giulia Maneri, Francesca Brisighelli, Rita Trozzi, Simona Duranti, Luciano Giacò, Maria Piane, Alessia Preziosi, Arianna Panfili, Giovanni Scambia, Camilla Nero, Maria De Bonis, Angelo Minucci","doi":"10.3343/alm.2024.0051","DOIUrl":"10.3343/alm.2024.0051","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"617-620"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unexpected Encounter During a Screening Colonoscopy in a Medical Tourist: A Diagnosis of Hymenolepis nana Infection. 一名医疗游客在接受结肠镜检查时的意外遭遇：诊断为 "海门螺杆菌（Hymenolepis nana）感染"。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-22 DOI: 10.3343/alm.2024.0167
Bosung Park, Hye Won Park, Hyun Jung Park, Eun Jeong Won, Heungsup Sung, Mi-Na Kim
{"title":"An Unexpected Encounter During a Screening Colonoscopy in a Medical Tourist: A Diagnosis of <i>Hymenolepis nana</i> Infection.","authors":"Bosung Park, Hye Won Park, Hyun Jung Park, Eun Jeong Won, Heungsup Sung, Mi-Na Kim","doi":"10.3343/alm.2024.0167","DOIUrl":"10.3343/alm.2024.0167","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"608-610"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Blood Collection Tubes on Vitamin D Immunoassay Results. 采血管对维生素 D 免疫测定结果的影响
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.3343/alm.2024.0234
Hyojin Chae, Sangyoon Lee, Ae-Ran Choi, Sung-Eun Cho, Eun-Jee Oh
{"title":"Effect of Blood Collection Tubes on Vitamin D Immunoassay Results.","authors":"Hyojin Chae, Sangyoon Lee, Ae-Ran Choi, Sung-Eun Cho, Eun-Jee Oh","doi":"10.3343/alm.2024.0234","DOIUrl":"10.3343/alm.2024.0234","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"611-613"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Ionized Magnesium Correlates With Total Blood Magnesium in Pediatric Patients Following Kidney Transplant". 关于 "肾移植后小儿患者电离镁与血镁总量的相关性 "的评论
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.3343/alm.2024.0153
Naveen Bangia, Dennis Begos, Bogdan Milojkovic
{"title":"Comment on \"Ionized Magnesium Correlates With Total Blood Magnesium in Pediatric Patients Following Kidney Transplant\".","authors":"Naveen Bangia, Dennis Begos, Bogdan Milojkovic","doi":"10.3343/alm.2024.0153","DOIUrl":"10.3343/alm.2024.0153","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"598-599"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why Terminology Standards Matter for Data-driven Artificial Intelligence in Healthcare. 为什么术语标准对医疗保健领域的数据驱动型人工智能至关重要？
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-03 DOI: 10.3343/alm.2024.0105
Hyeoun-Ae Park
{"title":"Why Terminology Standards Matter for Data-driven Artificial Intelligence in Healthcare.","authors":"Hyeoun-Ae Park","doi":"10.3343/alm.2024.0105","DOIUrl":"10.3343/alm.2024.0105","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"467-471"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Droplet Digital PCR for the Detection of BRAF V600E in Fine-Needle Aspiration Specimens of Thyroid Nodules. 评估用于检测甲状腺结节细针抽吸标本中 BRAF V600E 的液滴数字 PCR。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2024-11-01 Epub Date: 2024-06-14 DOI: 10.3343/alm.2023.0405
Young Kyu Min, Jae Kyung Kim, Kyung Sun Park, Jong-Won Kim
{"title":"Evaluation of Droplet Digital PCR for the Detection of <i>BRAF</i> V600E in Fine-Needle Aspiration Specimens of Thyroid Nodules.","authors":"Young Kyu Min, Jae Kyung Kim, Kyung Sun Park, Jong-Won Kim","doi":"10.3343/alm.2023.0405","DOIUrl":"10.3343/alm.2023.0405","url":null,"abstract":"<p><strong>Background: </strong>Droplet digital (dd)PCR is a new-generation PCR technique with high precision and sensitivity; however, the positive and negative droplets are not always effectively separated because of the \"rain\" phenomenon. We aimed to develop a practical optimization and evaluation process for the ddPCR assay and to apply it to the detection of <i>BRAF</i> V600E in fine-needle aspiration (FNA) specimens of thyroid nodules, as an example.</p><p><strong>Methods: </strong>We optimized seven ddPCR parameters that can affect \"rain.\" Analytical and clinical performance were analyzed based on histological diagnosis after thyroidectomy using a consecutive prospective series of 242 FNA specimens.</p><p><strong>Results: </strong>The annealing time and temperature, number of PCR cycles, and primer and probe concentrations were found to be more important considerations for assay optimization than the denaturation time and ramp rate. The limit of blank and 95% limit of detection were 0% and 0.027%, respectively. The sensitivity of ddPCR for histological papillary thyroid carcinoma (PTC) was 82.4% (95% confidence interval [CI], 73.6%-89.2%). The pooled sensitivity of <i>BRAF</i> V600E in FNA specimens for histological PTC was 78.6% (95% CI, 75.9%-81.2%, I<sup>2</sup>=60.6%).</p><p><strong>Conclusions: </strong>We present a practical approach for optimizing ddPCR parameters that affect the separation of positive and negative droplets to reduce rain. Our approach to optimizing ddPCR parameters can be expanded to general ddPCR assays for specific mutations in clinical laboratories. The highly sensitive ddPCR can compensate for uncertainty in cytological diagnosis by detecting low levels of <i>BRAF</i> V600E.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"553-561"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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