Annals of Laboratory Medicine最新文献

{"title":"Prognostic Impact of Sequential Measurable Residual Disease and <i>KIT</i> Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group.","authors":"Ting-Chi Yeh, Tang-Her Jaing, Hsi-Che Liu, Shih-Hsiang Chen, Shih-Chung Wang, Chih-Cheng Hsiao, Shyh-Shin Chiou, Jen-Yin Hou, Pei-Chin Lin, Fang-Liang Huang, Shang-Hsien Yang, Ting-Yu Huang, Chao-Ping Yang, Lee-Yung Shih","doi":"10.3343/alm.2025.0573","DOIUrl":"10.3343/alm.2025.0573","url":null,"abstract":"<p><strong>Background: </strong>Although measurable residual disease (MRD) is an established prognostic marker in pediatric acute myeloid leukemia (AML), its dynamic prognostic value during treatment and its integration with the <i>KIT</i> variant status in core-binding factor (CBF)-AML remain incompletely defined. We evaluated the prognostic impact of sequential MRD and <i>KIT</i> variants in pediatric CBF-AML.</p><p><strong>Methods: </strong>We retrospectively analyzed 112 children with CBF-AML. We assessed MRD in bone marrow samples collected at diagnosis, the end of induction (EOI), the end of second consolidation (EO2C), and the end of consolidation (EOC) using quantitative reverse transcription PCR with TaqMan assays targeting two fusion transcripts.</p><p><strong>Results: </strong>In <i>RUNX1::RUNX1T1</i> AML, a ≥ 3-log reduction (LR) in MRD at EO2C or a ≥ 4-LR at EOC was associated with favorable outcomes, regardless of the MRD at EOI. Conversely, <i>RUNX1::RUNX1T1</i> AML with an MRD of <4-LR and a normalized copy number of >500 at EOC was associated with extremely poor survival. CBFB::MYH11 AML with an MRD at EOI of ≥ 2-LR and an MRD of ≥ 4-LR at EOC was associated with better 5-yr overall survival and relapse-free survival (RFS), respectively. <i>RUNX1::RUNX1T1</i> AML with a <i>KIT</i> D816 variant showed significantly lower 5-yr RFS (<i>P</i> =0.017). In patients with CBF-AML harboring a <i>KIT</i> variant, those who achieved MRD of ≥ 4-LR at EOC had significantly more favorable outcomes.</p><p><strong>Conclusions: </strong>Our findings highlight the importance of sequential MRD monitoring in pediatric patients with <i>RUNX1::RUNX1T1</i> AML and show that integrating the <i>KIT</i> variant status with MRD assessment provides additional prognostic value during treatment.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"672-681"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Analytical Performance and Standardizing Lipid Measurements-Sometimes a Conundrum.","authors":"Hubert W Vesper, Uliana Danilenko, Otoe Sugahara, Sollip Kim, Yeo-Min Yun, Alicia N Lyle","doi":"10.3343/alm.2026.0111","DOIUrl":"10.3343/alm.2026.0111","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"666-668"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Medicine in Immune Checkpoint Inhibitor-Induced Autoimmune Disorders: Baseline Assessment, Diagnostic Algorithms, Monitoring, and Predictive Biomarkers.","authors":"Cecilia Matteoli, Antonino Mazzone, Roberto Verna","doi":"10.3343/alm.2025.0733","DOIUrl":"10.3343/alm.2025.0733","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have substantially improved clinical outcomes across multiple malignancies, but they can disrupt self-tolerance and induce immune-related adverse events resembling autoimmune disorders. In many cases, laboratory abnormalities precede overt clinical manifestations, placing laboratory medicine at the center of baseline evaluation, early recognition, diagnostic confirmation, longitudinal monitoring, and treatment follow-up. This review provides a laboratory-focused overview of ICI-induced autoimmune disorders, focusing on baseline laboratory assessment, monitoring strategies during therapy, organ-specific diagnostic algorithms, ICI-specific toxicity patterns, and candidate predictive biomarkers. Particular attention is paid to endocrine, hepatic, metabolic, cardiac, rheumatologic, and neurologic toxicities and to pre-analytical and analytical issues that can confound interpretation. The potential contribution of digital tools and artificial intelligence to accelerating laboratory-based detection is also discussed. Standardized laboratory pathways integrating baseline testing, reflex and confirmatory algorithms, trend-based surveillance, and multidisciplinary interpretation can improve safety and support personalized decisions regarding immunotherapy continuation and management.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"655-665"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a Pathogenic <i>RECQL4</i> 1.6-kb Deletion-Insertion in a Neonate with Atypical Skeletal Phenotype of Baller-Gerold Syndrome Using Rapid Whole-Genome Sequencing.","authors":"Mi-Ae Jang, Ja-Hyun Jang, Jin Kyu Kim, Joonhong Park, Go Hun Seo, Misun Yang, Yun Sil Chang, Hyun Ho Kim","doi":"10.3343/alm.2026.0102","DOIUrl":"10.3343/alm.2026.0102","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"743-746"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Sero-immunological Profiles of Solid Organ Transplant Candidates in Korea.","authors":"Hyeyoung Lee, Eun-Jee Oh","doi":"10.3343/alm.2026.0589","DOIUrl":"10.3343/alm.2026.0589","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"652-654"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Favorable-Risk Label: Sequential Measurable Residual Disease and <i>KIT</i> Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia.","authors":"Bohyun Kim","doi":"10.3343/alm.2026.0601","DOIUrl":"10.3343/alm.2026.0601","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"647-649"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Species Identification: Clinical Implications of <i>Candida auris</i> Clade Differentiation.","authors":"Mi-Kyung Lee","doi":"10.3343/alm.2026.0605","DOIUrl":"10.3343/alm.2026.0605","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"650-651"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synonymous Exonic Variant c.255C>T (p.Leu85=) in <i>ABO*B.01</i> Might Contribute to the B_weak Phenotype.","authors":"Lin-Nan Shao, Li-Ying Wang, Yi-Cheng Yang, Yue-Xin Xia, Ning Li, Chun-Xiang Li, Shi-Hang Zhou, Xiao-Hua Liang","doi":"10.3343/alm.2026.0180","DOIUrl":"10.3343/alm.2026.0180","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"739-742"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Clinical Microbiological Characteristics of <i>Staphylococcus argenteus</i> Isolated from a Tertiary Care Hospital in Korea in 2021-2024.","authors":"Jihoon Yoo, Kwangjin Ahn, Young Uh","doi":"10.3343/alm.2026.0127","DOIUrl":"10.3343/alm.2026.0127","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"736-738"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining RhIG Prophylaxis Guidelines: Asian-Type DEL as RhD-Positive and Unresolved Dosing Challenges in RhD Epitope-Deficient Variants.","authors":"Jeonghun Jo, Eun Suh Sung, Minjeong Nam, Duck Cho","doi":"10.3343/alm.2026.0264","DOIUrl":"10.3343/alm.2026.0264","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"669-671"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}