Annals of Laboratory Medicine最新文献

筛选
英文 中文
Chromosomal Rearrangements in 1,787 Cases of Acute Leukemia in Korea over 15 years. 韩国15年来1787例急性白血病的染色体重排。
IF 4.9 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-12 DOI: 10.3343/alm.2024.0570
DongGeun Son,Ho Cheol Jang,Young Eun Lee,Yong Jun Choi,Joo Heon Park,Ha Jin Lim,Hyun-Jung Choi,Hee Jo Baek,Hoon Kook,Mihee Kim,Ga-Young Song,Seo-Yeon Ahn,Sung-Hoon Jung,Deok-Hwan Yang,Je-Jung Lee,Hyeonug-Joon Kim,Jae-Sook Ahn,Myung-Geun Shin
{"title":"Chromosomal Rearrangements in 1,787 Cases of Acute Leukemia in Korea over 15 years.","authors":"DongGeun Son,Ho Cheol Jang,Young Eun Lee,Yong Jun Choi,Joo Heon Park,Ha Jin Lim,Hyun-Jung Choi,Hee Jo Baek,Hoon Kook,Mihee Kim,Ga-Young Song,Seo-Yeon Ahn,Sung-Hoon Jung,Deok-Hwan Yang,Je-Jung Lee,Hyeonug-Joon Kim,Jae-Sook Ahn,Myung-Geun Shin","doi":"10.3343/alm.2024.0570","DOIUrl":"https://doi.org/10.3343/alm.2024.0570","url":null,"abstract":"BackgroundChromosomal alterations serve as diagnostic and prognostic markers in acute leukemia. Given the evolving landscape of chromosomal abnormalities in acute leukemia, we previously studied these over two periods. In this study, we investigated the frequency of these abnormalities and clinical trends in acute leukemia in Korea across three time periods.MethodsWe retrospectively analyzed data from 1,787 patients with acute leukemia (319 children and 1,468 adults) diagnosed between 2006 and 2020. Conventional cytogenetics, FISH, and multiplex quantitative PCR were used for analysis. The patient groups were divided according to the following three study periods: 2006-2009 (I), 2010-2015 (II), and 2016-2020 (III).ResultsChromosomal aberrations were detected in 92% of patients. The PML::RARA translocation was the most frequent. Over the 15-yr period, chromosomal aberrations showed minimal changes, with specific fusion transcripts being common among patients. ALL was more prevalent in children than in adults and correlated significantly with the ETV6::RUNX1 and RUNX1::RUNX1T1 aberrations. The incidence of ALL increased during the three periods, with PML::RARA remaining common.ConclusionsThe frequency of chromosomal abnormalities in acute leukemia has changed subtly over time. Notably, the age of onset of adult AML has continuously increased. Our results may help in establishing diagnoses and clinical treatment strategies and developing various molecular diagnostic platforms.","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":"76 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Performance of Eight Blood-based Biomarkers in a Well-characterized Korean Cohort of Preclinical Alzheimer's Disease. 8种基于血液的生物标志物在韩国临床前阿尔茨海默病队列中的诊断性能
IF 4.9 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-12 DOI: 10.3343/alm.2024.0498
Hyojin Chae,Hyejeong Kim,Yoon-Joo Kim,HyunYoung Ji,Eun-Jee Oh,Dong Won Yang
{"title":"Diagnostic Performance of Eight Blood-based Biomarkers in a Well-characterized Korean Cohort of Preclinical Alzheimer's Disease.","authors":"Hyojin Chae,Hyejeong Kim,Yoon-Joo Kim,HyunYoung Ji,Eun-Jee Oh,Dong Won Yang","doi":"10.3343/alm.2024.0498","DOIUrl":"https://doi.org/10.3343/alm.2024.0498","url":null,"abstract":"BackgroundWith the introduction of disease-modifying treatments for Alzheimer's disease (AD), less invasive and widely accessible screening tests are urgently needed. We assessed eight blood-based biomarkers in a well-defined cohort of preclinical AD, including participants with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).MethodsAmyloid beta (Aβ) oligomerization tendency, Aβ42, Aβ40, Aβ42/Aβ40 ratio, phosphorylated tau (p-tau)181, p-tau217, glial fibrillary acidic protein (GFAP), and neurofilament light (Nf-L) were assessed for distinguishing between SCD and MCI, for correlations, and for predicting Aβ positron emission tomography (PET) positivity.ResultsPlasma p-tau181, p-tau217, and GFAP levels were significantly higher in participants with MCI than in those with SCD (P <0.05) and in Aβ PET-positive versus Aβ PET-negative participants (P <0.0001), whereas plasma Aβ42 and Aβ42/40 ratio levels were significantly lower in Aβ PET-positive than in Aβ PET-negative participants (P <0.001). Logistic regression analysis revealed that plasma Aβ42 and p-tau217 levels predicted Aβ PET positivity with an area under the ROC curve (AUC) of 0.930 (95% confidence interval [CI], 0.848-0.976) in the entire cohort, and p-tau217 alone predicted Aβ PET-positivity with an AUC of 0.887 (95% CI, 0.779-0.954) in the MCI subgroup.ConclusionsPlasma p-tau217 levels outperform plasma p-tau181 levels in predicting Aβ PET-positivity in participants with preclinical AD. Plasma GFAP levels, along with different p-tau isoforms (p-tau181 and p-tau217), effectively differentiate MCI from SCD. The predictive accuracy of blood-based biomarkers for Aβ PET-positivity strongly supports their clinical implementation, particularly with the introduction of disease-modifying therapies.","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increase in Sapovirus Infection in Korea After the COVID-19 Pandemic: A Six-and-a-half-year Retrospective Study. COVID-19大流行后韩国病毒感染增加:六年半的回顾性研究
IF 4.9 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-08 DOI: 10.3343/alm.2024.0458
Su-Kyung Lee,You La Jeon,Eun-Jung Cho,Han-Sung Kim,Jae-Seok Kim,Wonkeun Song,Hyun Soo Kim
{"title":"Increase in Sapovirus Infection in Korea After the COVID-19 Pandemic: A Six-and-a-half-year Retrospective Study.","authors":"Su-Kyung Lee,You La Jeon,Eun-Jung Cho,Han-Sung Kim,Jae-Seok Kim,Wonkeun Song,Hyun Soo Kim","doi":"10.3343/alm.2024.0458","DOIUrl":"https://doi.org/10.3343/alm.2024.0458","url":null,"abstract":"BackgroundSapovirus is an increasingly recognized cause of acute gastroenteritis (AGE). Despite its significance, data on sapovirus epidemiology and genetic diversity in Korea are limited. Therefore, we examined sapovirus positivity rates over a 6.5-yr period and analyzed the genetic diversity of strains detected in 2022 in Korea.MethodsWe retrospectively analyzed 204,563 sapovirus multiplex PCR test results from suspected AGE cases collected between 2017 and 2023 at two institutions. Monthly and age-specific positive rates were evaluated. Forty sapovirus-positive samples from 2022 were genotyped using reverse transcription PCR and sequencing. The sequences were compared with those in the National Center for Biotechnology Information Virus database, and a phylogenetic tree was constructed to assess genetic relationships among sapovirus strains.ResultsThe overall sapovirus positivity rate from 2017 to 2023 was 2.2%, with an increasing trend in summer and autumn, except during the coronavirus disease 2019 (COVID-19) pandemic in 2020 and 2021, when sapovirus was rarely detected. Positivity markedly increased in the summer and autumn of 2022 and 2023 following the COVID-19 pandemic. The predominant genotypes in 2022 were GI.1 and GII.3. Phylogenetic analysis revealed genetic diversity among circulating strains.ConclusionsThis study highlights the rising incidence of sapovirus in Korea, particularly after the COVID-19 pandemic. Despite focusing on genotyping data from a single year, these findings emphasize the need for ongoing surveillance to monitor sapovirus evolution and its public health impact. Additionally, our findings provide essential baseline data for future research into the epidemiology and genetics of sapovirus.","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":"10 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Implications of Circulating Tumor DNA in Multiple Myeloma and Its Precursor Diseases. 循环肿瘤DNA在多发性骨髓瘤及其前驱疾病中的临床意义。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.3343/alm.2024.0424
Sung-Soo Park, Na Yung Kim, Ji-Young Lim, Jung Yeon Lee, Sujin Yun, Yeun-Jun Chung, Seung-Hyun Jung, Chang-Ki Min
{"title":"Clinical Implications of Circulating Tumor DNA in Multiple Myeloma and Its Precursor Diseases.","authors":"Sung-Soo Park, Na Yung Kim, Ji-Young Lim, Jung Yeon Lee, Sujin Yun, Yeun-Jun Chung, Seung-Hyun Jung, Chang-Ki Min","doi":"10.3343/alm.2024.0424","DOIUrl":"10.3343/alm.2024.0424","url":null,"abstract":"<p><strong>Background: </strong>Genetic alterations play a pivotal role in multiple myeloma (MM) development and therapeutic resistance. Traditionally, the genetic profiling of MM requires invasive bone marrow (BM) procedures; however, these procedures are associated with patient discomfort and cannot fully capture the spatial and temporal heterogeneity of the disease. Therefore, we investigated the clinical implications of liquid biopsy using targeted deep sequencing.</p><p><strong>Methods: </strong>We analyzed the genetic profiles of circulating tumor DNA (ctDNA) by targeted deep sequencing from 102 patients, including those with monoclonal gammopathy of undetermined significance (MGUS, N=7), smoldering MM (N=6), and symptomatic MM (N=89).</p><p><strong>Results: </strong>The number of ctDNA mutations increased with disease progression from MGUS to MM, with averages of 1.0 mutations in MGUS, 1.8 mutations in smoldering MM, and 1.9 mutations in MM, respectively. Shared mutations between BM and ctDNA were more prevalent in MM (68.9%) than in MGUS (25.0%). RAS/RAF and <i>TP53</i> mutations were significantly enriched in MM ctDNA. Specific mutations were associated with clinical features in patients with MM: hypercalcemia and <i>TET2</i> (<i>P</i> =0.006), renal insufficiency and <i>NRAS</i> (<i>P</i> =0.012), paramedullary myeloma and <i>TP53</i> (<i>P</i> =0.02), and extramedullary myeloma and NRAS (<i>P</i> =0.007). <i>TET2</i> mutations significantly affected 2-yr progression-free survival (hazard ratio=7.11, <i>P</i> =0.003). Serial ctDNA profiling accurately predicted treatment response in patients with MM.</p><p><strong>Conclusions: </strong>Our findings highlight the potential of liquid biopsy for understanding MM progression and prognosis utilizing a minimally invasive approach, paving the way for its integration into personalized treatment strategies and real-time disease monitoring.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"279-290"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Metabolic Biomarkers in Breast Cancer: A Literature Review. 代谢生物标志物在乳腺癌中的应用:文献综述。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI: 10.3343/alm.2024.0482
Anbok Lee, Ching-Wan Lam
{"title":"Application of Metabolic Biomarkers in Breast Cancer: A Literature Review.","authors":"Anbok Lee, Ching-Wan Lam","doi":"10.3343/alm.2024.0482","DOIUrl":"10.3343/alm.2024.0482","url":null,"abstract":"<p><p>Breast cancer is the most common cancer and the second leading cause of cancer death in women worldwide. Novel biomarkers for early diagnosis, treatment, and prognosis in breast cancer are needed and extensively studied. Metabolites, which are small molecules produced during metabolic processes, provide links between genetics, environment, and phenotype, making them useful biomarkers for diagnosis, prognosis, and disease classification. With recent advancements in metabolomics techniques, metabolomics research has expanded, which has led to significant progress in biomarker research. In breast cancer, alterations in metabolic pathways result in distinct metabolomic profiles that can be harnessed for biomarker discovery. Studies using mass spectrometry and nuclear magnetic resonance spectroscopy have helped identify significant changes in metabolites, such as amino acids, lipids, and organic acids, in the tissues, blood, and urine of patients with breast cancer, highlighting their potential as biomarkers. Integrative analysis of these metabolite biomarkers with existing clinical parameters is expected to improve the accuracy of breast cancer diagnosis and to be helpful in predicting prognosis and treatment responses. However, to apply these findings in clinical practice, larger cohorts for validation and standardized analytical methods for QC are necessary. In this review, we provide information on the current state of metabolite biomarker research in breast cancer, highlighting key findings and their clinical implications.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"229-246"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing Fluorescence-activated Cell Sorting for Multiple Myeloma Fluorescence in situ Hybridization: Real-world Experience. 影响多发性骨髓瘤荧光原位杂交荧光活化细胞分选的因素:现实世界的经验。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.3343/alm.2024.0582
Jaeguk Choi, Kyunghee Yu, Seung-Tae Lee, Saeam Shin, Jong Rak Choi
{"title":"Factors Influencing Fluorescence-activated Cell Sorting for Multiple Myeloma Fluorescence <i>in situ</i> Hybridization: Real-world Experience.","authors":"Jaeguk Choi, Kyunghee Yu, Seung-Tae Lee, Saeam Shin, Jong Rak Choi","doi":"10.3343/alm.2024.0582","DOIUrl":"10.3343/alm.2024.0582","url":null,"abstract":"<p><strong>Background: </strong>FISH is the standard method for detecting cytogenetic abnormalities (CAs) in patients with multiple myeloma, and pre-enrichment of plasma cells is recommended to increase detection rates. However, optimal strategies to ensure sufficient plasma cell retrieval when standard enrichment techniques fail remain underexplored. We investigated factors influencing the success of fluorescence-activated cell sorting (FACS) and assessed the use of direct FISH in cases in which FACS failed.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 457 bone marrow samples submitted for FISH between November 2016 and May 2022. FACS was considered successful when plasma cells (CD38+ and CD138+ cells) constituted >1% of the total number of cells. Direct FISH was performed for samples with FACS failure.</p><p><strong>Results: </strong>FACS was successful in 70.9% of cases and had a high positivity rate (94.8%). Shorter sample transfer times significantly improved FACS success, with a 77.1% success rate for transfer times <2 hrs, compared with 67.8% for longer times (<i>P</i> =0.0388). Plasma cell percentage was a strong determinant of FACS success, with a median of 31.2% in successful cases versus 8.5% in failures (<i>P</i> <0.0001). Even when FACS failed, direct FISH detected CAs in 43.6% of cases.</p><p><strong>Conclusions: </strong>Plasma cell percentage and sample transfer time are critical factors influencing FACS success. While FACS-FISH demonstrates superior sensitivity in detecting CAs, direct FISH serves as a valuable alternative when FACS fails. These findings highlight the importance of optimizing sample handling and FISH protocols for accurate cytogenetic analysis of multiple myeloma.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"322-328"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Values of Combined Detection of Serum Cystatin C, β2-Microglobulin, and Urine Transferrin in Diagnosing Early Primary Glomerulonephritis. 联合检测血清胱抑素 C、β2-微球蛋白和尿转铁蛋白对诊断早期原发性肾小球肾炎的临床价值
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.3343/alm.2024.0489
Xueqi Zhang, Xueying Bao, Cuicui Wu, Binxian Li, Mingcheng Li
{"title":"Clinical Values of Combined Detection of Serum Cystatin C, β2-Microglobulin, and Urine Transferrin in Diagnosing Early Primary Glomerulonephritis.","authors":"Xueqi Zhang, Xueying Bao, Cuicui Wu, Binxian Li, Mingcheng Li","doi":"10.3343/alm.2024.0489","DOIUrl":"10.3343/alm.2024.0489","url":null,"abstract":"<p><p>Despite primary glomerulonephritis (PGN) being a leading cause of chronic kidney disease and end-stage renal disease, specific and sensitive biomarkers for the early detection and monitoring of this condition are lacking. We evaluated the value of the combined detection of serum cystatin C (CYSC), β2-microglobulin (β2-MG), and urine transferrin (TRF) for diagnosing early-stage PGN. From May 2021 to May 2023, we enrolled 105 patients in our hospital as the observation group and 50 healthy volunteers as the control group. Their serum expression levels of CYSC, β2-MG, and TRF were evaluated. We plotted separate ROC curves and calculated the area under the curve (AUC) values of CYSC, β2-MG, and TRF to assess their diagnostic performance in PGN. The levels of CYSC, β2-MG, and TRF were significantly higher (<i>P</i> <0.05) in the observation group than in the healthy control group. CYSC, β2-MG, and TRF were expressed at significantly higher levels in G2, G3a, and G3b of PGN than in G1. The combined use of CYSC, β2-MG, and TRF as biomarkers could significantly improve the early diagnosis and monitoring of PGN and may lead to better patient outcomes by facilitating earlier intervention and treatment strategies.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"329-333"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Nontyphoidal Salmonella Infections in Korean Children and Genetic Factors Associated with Extra-intestinal Invasion: A Whole-genome Sequencing Analysis. 韩国儿童非伤寒沙门氏菌感染的流行病学和与肠道外侵袭相关的遗传因素:全基因组测序分析。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.3343/alm.2024.0378
Hyun Mi Kang, Jiyon Chu, In Hyuk Yoo, In Young Yoo, Jeong-Ih Shin, Mi-Ran Seo, Yeun-Jun Chung, Seung-Hyun Jung, Yeon Joon Park
{"title":"Epidemiology of Nontyphoidal <i>Salmonella</i> Infections in Korean Children and Genetic Factors Associated with Extra-intestinal Invasion: A Whole-genome Sequencing Analysis.","authors":"Hyun Mi Kang, Jiyon Chu, In Hyuk Yoo, In Young Yoo, Jeong-Ih Shin, Mi-Ran Seo, Yeun-Jun Chung, Seung-Hyun Jung, Yeon Joon Park","doi":"10.3343/alm.2024.0378","DOIUrl":"10.3343/alm.2024.0378","url":null,"abstract":"<p><strong>Background: </strong>Understanding the virulence and pathogenicity of invasive nontyphoidal <i>Salmonella</i> (iNTS) in children may support timely treatment and enable closer monitoring of chronic infections. iNTS epidemiology in Asia remains inadequately described. We analyzed the genetic diversity and virulence genes associated with extra-intestinal invasion in Korean children.</p><p><strong>Methods: </strong>Salmonella isolates from children <18 yrs of age diagnosed with moderate-to-severe salmonellosis between January 2019 and December 2021 were subjected to antibiotic susceptibility testing and whole-genome sequencing.</p><p><strong>Results: </strong>In total, 58 cases were included. We identified 20 serotypes, the most prevalent being <i>Salmonella</i> Enteritidis (N=21), followed by Infantis (N=6), I 4,[5],12:i:- (N=5), and Bareilly (N=5). Extra-intestinal invasion occurred in 12 (20.7%) cases involving <i>Salmonella</i> Oranienburg (2/2), Give (1/1), Javiana (1/1), Paratyphi B var. L(+) tartrate+ (1/1), Schwarzengrund (1/1), Singapore (1/1), Montevideo (1/2), Saintpaul (1/2), I 4:b:- (1/2), Infantis (1/6), and Enteritidis (1/21). While the numbers of total virulence genes and genes belonging to major virulence categories did not significantly differ between iNTS and non-iNTS, several genetic factors, including <i>Salmonella</i> pathogenicity island (SPI)-1 (<i>P</i> =0.039), SPI-2 (<i>P</i> =0.020), SPI-5 (<i>P</i> =0.014), SPI-13 (<i>P</i> =0.010), cytolethal distending toxin-related genes (<i>P</i> =1.4×10<sup>-4</sup>), <i>fepC</i> (<i>P</i> =0.021), and <i>tcpC</i> (<i>P</i> =0.040) were more frequent in invasive isolates.</p><p><strong>Conclusions: </strong><i>Salmonella</i> Enteritidis-ST11 predominated in infections among Korean children, but invasive isolates were rare. Early detection of genetic factors associated with extra-intestinal invasion will be helpful for prompt and appropriate treatment.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"312-321"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Status of Standardization of Glomerular Filtration Rate Markers in Korea. 韩国肾小球滤过率指标标准化现状。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI: 10.3343/alm.2024.0702
Tae-Dong Jeong
{"title":"Current Status of Standardization of Glomerular Filtration Rate Markers in Korea.","authors":"Tae-Dong Jeong","doi":"10.3343/alm.2024.0702","DOIUrl":"10.3343/alm.2024.0702","url":null,"abstract":"","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"272-275"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ABO Antibody Titer Testing Harmonization in Korea: A 5-Year Analysis of External Quality Control Data. ABO抗体滴度检测在韩国的统一:一个5年的外部质量控制数据分析。
IF 4 2区 医学
Annals of Laboratory Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.3343/alm.2024.0521
Han Joo Kim, Yousun Chung, Sang-Hyun Hwang, Heung-Bum Oh, Hyungsuk Kim, Dae-Hyun Ko
{"title":"ABO Antibody Titer Testing Harmonization in Korea: A 5-Year Analysis of External Quality Control Data.","authors":"Han Joo Kim, Yousun Chung, Sang-Hyun Hwang, Heung-Bum Oh, Hyungsuk Kim, Dae-Hyun Ko","doi":"10.3343/alm.2024.0521","DOIUrl":"10.3343/alm.2024.0521","url":null,"abstract":"<p><p>Current ABO titration methods lack standardization and harmonization. We analyzed the consistency of ABO antibody titer testing among Korean laboratories and discussed future directions for standardization by analyzing external quality control data collected by the Korean Association of External Quality Assessment Service over 5 yrs (2019-2023). The analysis included the number of participating institutions and methods, as well as the proportion of acceptable results. To compare column agglutination technology (CAT) and tube methods, we created a normalized variable: ([log<sub>2</sub> titer of laboratory test result]-[mean of log<sub>2</sub> titer for the peer group]). The number of participating institutions and methods increased over time. The use of CAT methods expanded, whereas that of tube methods declined. The proportion of acceptable results ranged from 84.0% to 100%, with no significant differences between CAT and tube methods. An F-test revealed no significant variance differences among institutions using these methods. Tube methods demonstrated lower variance in anti-human globulin testing, and room temperature tube methods exhibited lower variance than that of CAT methods. Domestic laboratories demonstrated highquality performance in ABO antibody titer testing, with no significant differences in acceptable result rates or variance across methods. Continuous efforts toward standardization remain essential.</p>","PeriodicalId":8421,"journal":{"name":"Annals of Laboratory Medicine","volume":" ","pages":"334-338"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信