Archives of Women's Mental Health最新文献

{"title":"Multidimensional psychological and neurophysiological effects of moderate- and low-intensity exercise on pregnant women: an integrative systematic review and Bayesian framework network meta-analysis","authors":"Lei He,&nbsp;Shiping Wang,&nbsp;Yuang Cao,&nbsp;Bolun Wang,&nbsp;Hongyang Liu,&nbsp;Jia Zhang,&nbsp;Feng Xu,&nbsp;Junfeng Jiao","doi":"10.1007/s00737-026-01709-y","DOIUrl":"10.1007/s00737-026-01709-y","url":null,"abstract":"<div><h3>Background</h3><p>Pregnancy-related mental health disorders are an increasingly important global public health concern. Exercise interventions have gained attention as safe, non-pharmacological strategies for improving maternal psychological and neurophysiological well-being. However, comparative evidence regarding different exercise modalities and intensities remains limited.</p><h3>Objective</h3><p>This study aimed to systematically evaluate and rank the effects of different prenatal exercise modalities and compare moderate- versus low-intensity exercise protocols on maternal mental health and neurophysiological outcomes during pregnancy.</p><h3>Methods</h3><p>A Bayesian network meta-analysis was conducted following PRISMA-NMA guidelines. PubMed, Embase, Cochrane Central, and PsycINFO were systematically searched. Thirty-six randomized controlled trials involving 4,577 pregnant participants were included. Methodological quality was assessed using the Cochrane RoB 2.0 tool. Treatment effects were ranked using the surface under the cumulative ranking curve method.</p><h3>Results</h3><p>Moderate-intensity aerobic training showed the strongest effect on reducing prenatal depression, with a SUCRA value of 0.89. Yoga-based interventions were particularly effective for anxiety reduction, with a SUCRA value of 0.76, and ranked second in the overall outcome evaluation, with a SUCRA value of 0.82. Neurophysiological findings indicated that yoga showed the greatest benefit for cortisol regulation, whereas aquatic exercise demonstrated distinctive anti-inflammatory effects. Subgroup analyses suggested that moderate-intensity exercise tended to produce greater reductions in depression, while low-intensity exercise showed comparable or superior effects on anxiety and cortisol modulation. Meta-regression further indicated that interventions conducted three times per week and lasting more than 12 weeks were associated with larger effect sizes. The certainty of evidence ranged from moderate to high across primary comparisons.</p><h3>Conclusion</h3><p>This network meta-analysis provides a preliminary evidence hierarchy for prenatal exercise interventions. Moderate-intensity aerobic exercise may be most beneficial for reducing prenatal depression, while yoga appears particularly suitable for anxiety and cortisol regulation. These findings offer clinicians a reference framework for individualized prenatal exercise recommendations and support the integration of exercise into maternal mental healthcare.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147938464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Beyond reductionism in postpartum depression treatment and toward systems-oriented maternal mental health care","authors":"Gnana Prasoona Rupanagunta,&nbsp;Mukesh Nandave,&nbsp;Jodi L. Pawluski,&nbsp;Jyoti Upadhyay","doi":"10.1007/s00737-026-01710-5","DOIUrl":"10.1007/s00737-026-01710-5","url":null,"abstract":"<div><p>Postpartum depression (PPD) is a heterogeneous mood disorder emerging within the first year after childbirth and shaped by interacting biological, psychological, and social factors. Although treatment is commonly adapted from major depressive disorder, the postpartum period represents a distinct and dynamically regulated physiological state. Rapid hormonal withdrawal, neuroendocrine recalibration, immune shifts, and adaptive neuroplastic changes occur concurrently, contributing to variable treatment response and clinical heterogeneity. Viewing PPD as a disorder of systems-level dysregulation has important implications for research and therapy. Single-target pharmacological approaches may have limited effectiveness when multiple interconnected pathways are involved. Interventions capable of modulating interacting physiological systems, including carefully evaluated multi-component and herbal therapies, warrant rigorous investigation. Future research should incorporate biological stratification, biomarker-informed trial designs, postpartum-specific models, and stringent safety evaluation. Advancing systems-oriented research frameworks may support more precise, effective, and biologically coherent therapeutic strategies for maternal mental health.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147938418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major depressive disorder attributed to intimate partner violence against women in North Africa and the Middle East: Global Burden of Disease Study","authors":"Sohrab Amiri,&nbsp;Moien AB Khan","doi":"10.1007/s00737-026-01717-y","DOIUrl":"10.1007/s00737-026-01717-y","url":null,"abstract":"<div><h3>Objectives</h3><p>Intimate partner violence (IPV) in the Middle East and North Africa represents a significant issue with both clinical and societal implications. This study aimed to highlight the prevalence of major depressive disorder (MDD) linked to IPV against women in these regions, using data from the Global Burden of Disease 2021.</p><h3>Methods</h3><p>The prevalence, incidence, Disability-Adjusted Life Years (DALYs), and Years of Life Lost (YLLs) associated with MDD were analyzed across all ages for the period from 1990 to 2021. DALYs due to MDD specifically attributed to intimate partner violence (IPV) against women were assessed and further broken down by country and age group. Results were presented in absolute counts as well as estimates per 100,000 population, accompanied by a 95% uncertainty interval.</p><h3>Results</h3><p>The age-standardized prevalence rate of MDD in 2021 was 4,883 per 100,000 population [95% UI: 4,013 to 5,940], marking a 16% change compared to 1990 levels. Over 14 million women in North Africa and the Middle East were affected by MDD and almost 22 million [21,810,159; 95% UI 17,783,296 to 26,732,692] incidence in 2021, this rate of incidence has nearly doubled compared to 1990. Age-standardized DALYs of MDD attributed to IPV in women in 2021 was 102.87 [95% UI 0.42 to 226.38] per 100,000. All ages count estimates of DALYs of MDD attributed to IPV against women was 314,734 [95% UI 1,307 to 692,580] in 2021. The highest age-standardized DALYs of MDD attributed to IPV was in Palestine, 180.74 [95% UI 1.11 to 416.15], followed by Afghanistan [152.62; 95% UI 0.88 to 347.86], and Tunisia [136.03; 95% UI 0.38 to 317.19] per 100,000.</p><h3>Discussion</h3><p>The findings highlighted a high prevalence of depression in this super region, underscoring the significant burden posed by this mental health condition. Additionally, IPV emerged as a contributing factor to MDD. These insights emphasize the need for health policies that tackle the impact of depressive disorders while addressing the influence of IPV. Therefore it is necessary to move towards preventing the negative consequences of IPV by increasing social awareness.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147938416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal depression symptoms as a context for longitudinal changes in the perinatal brain and infant emotion outcomes","authors":"Marybeth McNamee,&nbsp;Sejal Mistry-Patel,&nbsp;Sarah Peoples,&nbsp;Rebecca Brooker","doi":"10.1007/s00737-026-01707-0","DOIUrl":"10.1007/s00737-026-01707-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Despite theoretical backing, little is known about how contextual factors during pregnancy, which include experiencing increases in symptoms of depression for many women, may affect neural reorganization. We tested within-person stability in a neural process of self-monitoring as a marker of reorganization during pregnancy, whether within-person stability was moderated by maternal depression symptoms, and whether within-person stability had implications for infant postnatal emotion.</p><h3>Methods</h3><p>A neural marker of self-monitoring (Error-Related Negativity; ERN) and depression symptoms were assessed in 91 pregnant women. ERN and infant emotion were observed at 4 months postnatal.</p><h3>Results</h3><p>Perinatal ERN showed high internal consistency and stability at the group level. However, ERN showed greater stability at high than at low levels of depression symptoms. In addition, when levels of depression symptoms were high, greater prenatal ERN predicted more infant fear.</p><h3>Conclusions</h3><p>Results suggest stability in a neural marker of self-monitoring at high levels of depression symptoms, consistent with a possibility that more adverse contexts restrict neuroplasticity. Neural processes sensitive to a context of depression symptoms may have implications for infant emotion.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-026-01707-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receipt of reproductive safety data among pregnant marijuana users and nonusers","authors":"Abigail Ramseyer,&nbsp;Wesley R. White,&nbsp;Clare C. Brown,&nbsp;Stefanie Kennon-McGill,&nbsp;Laura Miron,&nbsp;Cheryl Wells,&nbsp;Kaitlyn Davis,&nbsp;Shona L. Ray-Griffith","doi":"10.1007/s00737-026-01712-3","DOIUrl":"10.1007/s00737-026-01712-3","url":null,"abstract":"<div><h3>Purpose</h3><p>Pregnant patients were surveyed to determine marijuana use, their interest in additional education of the risks marijuana use in pregnancy, and if they had been educated by their providers about these. </p><h3>Methods</h3><p>Fisher’s exact tests were used to determine significant differences in both demographics and survey answers on provider education between those who used and did not use marijuana during pregnancy.</p><h3>Results</h3><p>409 patients were surveyed with 367 completing the survey. 87 participants (23.7%) of those surveyed endorsed marijuana use in their current pregnancy. Significant differences between those who used marijuana and those who did not were seen in race/ethnicity (17.1% among White people versus 38.9% among those of other race/ethnicity; <i>p</i> = 0.017), age (with 33.3% of 18–24 year olds reporting the highest use vs. 0.0% of ≥ 40 year olds reporting the lowest use; <i>p</i> = 0.014) and education level (with those who had not completed high school reporting the highest rates of use, <i>p</i> = 0.001). 15.3% of all respondents received counseling on the risks of marijuana use during pregnancy. Among those who used marijuana, 25.3% received the counseling, compared to 12.1% of those who did not use (<i>p</i> = 0.003). 41.4% of those who used marijuana expressed an interest in additional information on this topic, significantly higher than those who did not use (<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>A gap exists in the area, as only 25%of pregnant patients who used marijuana reported receiving counseling, compared to the 41% who stated a desire for additional information. This emphasizes the need for both accessible resources on how marijuana affects both the pregnant mother and infant, as well as education for providers on this gap in care.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial differences in diagnosis of perinatal mood and anxiety disorders","authors":"Stephanie V. Hall,&nbsp;Angela Montoya,&nbsp;Anca Tilea,&nbsp;Diana Louis,&nbsp;Kara Zivin,&nbsp;Vanessa K. Dalton","doi":"10.1007/s00737-026-01713-2","DOIUrl":"10.1007/s00737-026-01713-2","url":null,"abstract":"<div><h3>Purpose</h3><p>Perinatal mood and anxiety disorders (PMADs) represent a common comorbidity of pregnancy and postpartum with serious consequences. Despite high disease prevalence and burden, PMADs often remain undiagnosed. In recent years, universal screening for perinatal mental health disorders has become standard care and most patients are screened at least once during pregnancy or postpartum. Whether racial differences in PMAD diagnosis persist remains unknown. We aimed to measure and assess temporal trends in racial differences in PMAD diagnosis among symptomatic pregnant and postpartum Medicaid enrollees in Michigan.</p><h3>Methods</h3><p>This serial cross-sectional observational study analyzed data from the Michigan Pregnancy Risk Assessment Monitoring System (MI-PRAMS) and Michigan Medicaid administrative claims for deliveries spanning 2016—2020. We linked MI-PRAMS responses to Medicaid claims from one year before through one year after delivery to determine whether enrollees who reported PMAD symptoms to MI-PRAMS received a PMAD diagnosis in Medicaid claims. We used weighted logistic regression to determine the association between race and PMAD diagnosis among Michigan Medicaid enrollees who reported PMAD symptoms.</p><h3>Results</h3><p>Out of 60,583 Medicaid enrollees with a live birth in Michigan from 2016—2020, 33% were Black and 61% were White. About 70% were between 19—29 years old and 18% were between 30—34 years old. During the perinatal period, 39% had 2 or more co-morbid conditions, and 60% had 2 or more major life stressors. In unadjusted weighted logistic regression, White enrollees had 2.146 times greater odds of PMAD diagnosis than Black enrollees (95% CI: 1.570—2.933). This association remained significant after adjusting for age, ethnicity, co-morbidities, major life stressors, and delivery year. Adjusted weighted logistic regression found that White enrollees had 2.326 times greater odds of PMAD diagnosis than Black enrollees (95% CI: 1.669—3.236).</p><h3>Conclusion</h3><p>White enrollees who reported PMAD symptoms were more than twice as likely to receive a PMAD diagnosis as Black enrollees reporting PMAD symptoms. The magnitude of racial difference in PMAD diagnosis did not improve over the course of the study period. These persistent racial differences are consistent with structural barriers, provider biases, and cultural stigmas that differentially and disproportionately impact non-White patients. Tailored interventions to improve mental health care among Black Medicaid enrollees may be needed to improve PMAD diagnosis, a critical first step in mental health management.</p><h3>Clinical trial number</h3><p>Not applicable.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-026-01713-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the severity of menopausal symptoms and quality of life during the menopause transition: a systematic review","authors":"Khadija Ahmadi,&nbsp;Sareh Dashti,&nbsp;Narjes Bahri","doi":"10.1007/s00737-026-01716-z","DOIUrl":"10.1007/s00737-026-01716-z","url":null,"abstract":"<div><h3>Background</h3><p>Menopausal symptoms are common and can affect all aspects of women’s quality of life. While prior systematic reviews have explored menopausal symptoms and QoL, inconsistencies persist, particularly regarding symptom severity during the menopausal transition. This review synthesizes evidence to clarify this association. However, controversial findings have been reported on the association between menopausal symptoms and quality of life in post-menopausal women. Therefore, it was decided to conduct a systematic review to evaluate the relationship between the severity of menopausal symptoms and quality of life during the transition to menopause.</p><h3>Methods</h3><p>A systematic search was conducted in Web of Science, Scopus, PubMed, Magiran (a Persian database), and the Google Scholar search engine. Search strategy was designed using Menopause, Quality of life intensity, and menopausal symptoms in English and their Persian synonyms. Studies that evaluated the relationship between the severity of menopausal symptoms and quality of life in transition to menopause as the main or secondary objective were included in the study.</p><h3>Results</h3><p>From the 300 primary identified articles, 15 articles that met the inclusion criteria were selected for review. This systematic review found a positive relationship between the severity of menopausal symptoms and the quality of life in studies conducted in most regions. However, this relationship was negative in some areas.</p><h3>Conclusions</h3><p>The findings of this study can be used in interventions to improve the quality of life in menopausal women. These findings inform targeted interventions, such as symptom management programs, to enhance QoL in menopausal women globally.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of adverse childhood experiences and weekly pregnancy stress on postpartum mental health symptoms: a machine learning examination","authors":"Amy K. Nuttall,&nbsp;G. Anne Bogat,&nbsp;Kevin J. Grimm,&nbsp;Maria Muzik,&nbsp;Joseph S. Lonstein,&nbsp;Cecilia Martinez-Torteya,&nbsp;Alytia A. Levendosky","doi":"10.1007/s00737-026-01715-0","DOIUrl":"10.1007/s00737-026-01715-0","url":null,"abstract":"<div><h3>Purpose</h3><p>The goal of this study was to understand how the timing, level, and fluctuation of pregnancy stress affected women’s postpartum mental health while also considering their experiences of early life stress (adverse childhood events; ACEs). We hypothesized that overall stress level, as well as stress during particular pregnancy weeks, would influence postpartum mental health. We further hypothesized that fluctuations in weekly perceived stress levels across pregnancy would influence postpartum mental health among women who had experienced ≥ 4 ACEs.</p><h3>Methods</h3><p>We collected information on ACEs and weekly stress data from our participants during pregnancy (15 weeks until parturition). Women’s depressive and anxiety symptoms were assessed at six-months postpartum. We employed a machine learning approach to explore the predictive utility of timing, level, and fluctuation of pregnancy stress on postpartum mental health symptoms.</p><h3>Results</h3><p>For all women, higher average stress level across all weeks of pregnancy predicted greater postpartum depressive and anxiety symptoms. Additionally, women with a history of ≥ 4 ACEs were susceptible to stress levels in weeks 20 of pregnancy (depressive symptoms only) and 26 (depressive and anxiety symptoms). Lastly, greater variability in stress levels across pregnancy was also associated with greater depressive symptoms for the women with ≥ 4 ACES.</p><h3>Conclusion</h3><p>In addition to overall stress level, timing of pregnancy stress and fluctuations in stress levels across pregnancy are associated with postpartum mental health for women with a history of substantial ACEs, with implications for focused mental health interventions during pregnancy for these women.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who is screened for perinatal mental health? findings from an academic health system in California","authors":"Rebecca Woofter,&nbsp;Rashmi Rao,&nbsp;Misty Richards,&nbsp;May Sudhinaraset","doi":"10.1007/s00737-026-01719-w","DOIUrl":"10.1007/s00737-026-01719-w","url":null,"abstract":"<div><h3>Purpose</h3><p>To identify sociodemographic characteristics, prenatal healthcare utilization, and health factors associated with completed mental health screenings during pregnancy and postpartum, respectively.</p><h3>Methods</h3><p>We examined electronic medical records (EMR) data on documented perinatal mental health screenings from over 6000 patients who delivered singleton infants within one academic healthcare system in California between 2021 and 2023. Dependent variables included having at least one Edinburgh Postnatal Depression Scale (EPDS) score documented in the EMR during (1) pregnancy and (2) postpartum, among those who completed postpartum care within 12 weeks of delivery. We used univariate frequencies to determine rates of completed screenings and logistic regression models to identify patient characteristics associated with completed screenings in each time period.</p><h3>Results</h3><p>Overall, 67% of patients completed screenings in pregnancy and 56% completed screenings in postpartum. In pregnancy, patients who were White, multiparous, did not prefer English, began prenatal care in the third trimester, and completed 10 or fewer prenatal care visits each had lower odds of completed screenings than their counterparts. In postpartum, patients who were White, privately insured, had vaginal deliveries, and had term births (at least 37 weeks of gestation) each had lower odds of completed screenings than their counterparts.</p><h3>Conclusions</h3><p>Although California law requires perinatal mental health screening in pregnancy and postpartum , the identified inequities in screening suggest additional efforts are needed to ensure all perinatal patients are screened for mental health in accordance with the law. These efforts should be tailored to the populations least likely to be screened in order to achieve universal perinatal mental health screening.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women with first-episode psychosis: diagnostic stability and clinical trajectories","authors":"Alba Toll,&nbsp;Beltrán Jiménez-Fernández,&nbsp;Emilio Pechuán,&nbsp;Nicole Motta-Rojas,&nbsp;Daniel Bergé,&nbsp;Amira Trabsa,&nbsp;Víctor Pérez-Solà,&nbsp;Anna Mané","doi":"10.1007/s00737-026-01711-4","DOIUrl":"10.1007/s00737-026-01711-4","url":null,"abstract":"<div><h3>Purpose</h3><p>The aim of this study was to assess the influence of sex on diagnostic stability in first-episode psychosis during the first year of follow-up.</p><h3>Methods</h3><p>This was a prospective, observational study of 256 patients with FEP, of whom 188 (73.4%) completed the 1-year follow-up. Patients were consecutively recruited at a specialized early intervention program. Comprehensive psychiatric evaluations and the Structured Clinical Interview for DSM-IV-TR Axis I disorders were performed at baseline and follow-up. Diagnoses were grouped into affective and non-affective psychoses. Univariate and multivariate logistic regression analyses were conducted to identify predictors of diagnostic shift, with a particular focus on sex.</p><h3>Results</h3><p>At one-year follow-up, 48.9% of patients experienced some form of diagnostic change. Specifically, 14.4% shifted from non-affective to affective psychosis. Female sex was the only independent predictor of diagnostic shift (OR = 0.30; 95% CI = 0.10–0.87; <i>p</i> = 0.027). No other clinical or demographic variables were significantly associated with diagnostic change.</p><h3>Conclusion</h3><p>Female FEP patients were significantly more likely to experience a diagnostic shift toward affective psychosis during the first year of follow-up. These findings highlight the importance of considering sex differences in clinical presentation at illness onset to improve diagnostic accuracy, optimize treatment strategies, and enhance long-term outcomes.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}