Associations between lifetime reproductive events among postmenopausal women with bipolar disorder.

IF 3.2 3区 医学 Q2 PSYCHIATRY
Katherine Gordon-Smith, Amy Perry, Arianna Di Florio, Nicholas Craddock, Ian Jones, Lisa Jones
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Abstract

Purpose: The premenstrual phase of the menstrual cycle, childbirth and perimenopause often coincide with a worsening of mood symptoms in women with bipolar disorder (BD). To date, findings from the limited number of studies investigating associations between these events among women with BD have been inconsistent. This study aimed to investigate associations between episodes in relation to the perimenopause and (i) premenstrual symptoms and (ii) postpartum mood episodes in a large sample of postmenopausal women with BD.

Methods: Among 567 postmenopausal women with BD, recruited as part of the UK Bipolar Disorder Research Network, relationships between reproductive event-associated mood symptoms/episodes were examined. Multivariate binary analyses were carried out to identify if history of premenstrual symptoms and/or postpartum episodes predicted the occurrence of mood episodes in relation to the perimenopause, controlling for potential confounders including number of mood episodes per illness year.

Results: History of premenstrual symptoms was associated with experiencing any type of mood episode, and depression specifically, during the perimenopause (OR 6.189, p < 0.001 and OR 2.709, p = 0.019 respectively). History of postpartum depression within 6 weeks of delivery was associated with depressive episodes during the perimenopause (OR 2.635, p = 0.027). Postpartum mania was not a significant predictor.

Conclusions: Our findings suggest that women with BD with a history of premenstrual symptoms and postpartum depression are potentially at increased risk of experiencing episodes of depression in relation to the perimenopause. There are clinical and self-management implications in identifying a subgroup of women with BD who may be particularly vulnerable to episodes of mood disturbance during reproductive events.

躁郁症绝经后妇女一生中生殖事件之间的关联。
目的:月经周期的经前期、分娩和围绝经期往往与双相情感障碍(BD)女性患者的情绪症状恶化同时发生。迄今为止,对躁狂症女性患者中这些事件之间的关联进行调查的研究数量有限,调查结果也不一致。本研究旨在对大量绝经后躁狂症女性样本中与围绝经期有关的发作和(i)经前期症状和(ii)产后情绪发作之间的关联进行调查:在英国躁郁症研究网络(UK Bipolar Disorder Research Network)招募的 567 名绝经后躁狂症女性中,研究人员对生殖事件相关情绪症状/发作之间的关系进行了研究。研究人员进行了多变量二元分析,以确定经前期症状和/或产后发作史是否可预测与围绝经期有关的情绪发作的发生,同时控制潜在的混杂因素,包括每患病年的情绪发作次数:结果:经前期症状史与围绝经期内任何类型的情绪发作,特别是抑郁有关(OR 6.189,P 结论:经前期症状史与围绝经期内任何类型的情绪发作,特别是抑郁有关(OR 6.189,P 结论):我们的研究结果表明,有经前症状和产后抑郁症病史的 BD 妇女在围绝经期出现抑郁发作的风险可能会增加。在临床和自我管理方面,我们发现有一部分患有 BD 的妇女在生育期间特别容易出现情绪障碍。
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来源期刊
Archives of Women's Mental Health
Archives of Women's Mental Health 医学-精神病学
CiteScore
8.00
自引率
4.40%
发文量
83
审稿时长
6-12 weeks
期刊介绍: Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.
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