Archivos De Bronconeumologia最新文献

{"title":"Resectable Non-Small Cell Lung Cancer Heterogeneity and Recurrence Assessed by Tissue Next-Generation Sequencing Genotyping and Circulating Tumor Cell EZH2 Characterization.","authors":"Abel Garcia-Diaz, María José Moyano-Rodríguez, María Del Carmen Garrido-Navas, Diego de Miguel-Perez, Jose Expósito-Hernández, Bernardino Alcázar-Navarrete, Francisco Ortuño, David Landeira, Pedro J Romero, Adrian Garcia-Moreno, Jose A Lorente, Javier Lopez-Hidalgo, Clara Bayarri-Lara, Maria Jose Serrano","doi":"10.1016/j.arbres.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.08.006","url":null,"abstract":"<p><strong>Introduction: </strong>Non-small cell lung cancer (NSCLC) is the most common type of lung neoplasm. Despite surgical resection, it has a high relapse rate, accounting for 30-55% of all cases. Next-generation sequencing (NGS) based on a customized gene panel and the analysis of circulating tumor cells (CTCs) can help identify heterogeneity, stratify high-risk patients, and guide treatment decisions. In this descriptive study involving a small prospective cohort, we focus on the phenotypic characterization of CTCs, particularly concerning EZH2 expression (a member of the Polycomb Repression Complex 2), as well as on the mutation profiles of the tissue using a customized gene panel and their association with poor outcomes in NSCLC.</p><p><strong>Methods: </strong>Isolation and characterization of EZH2 on CTCs were evaluated before surgical resection (CTC1) and one month after surgery (CTC2) in resectable NSCLC patients. Targeted NGS was performed using a customized 50-gene panel on tissue samples from a subset of patients.</p><p><strong>Results: </strong>76 patients with resectable NSCLC were recruited. The top mutated genes in the cohort included TP53, FLT1, MUC5AC, EGFR, and NLRP3. Pair of genes that had mutually exclusive mutations was TP53-RIN3, and pairs of genes with co-occurring mutations were CD163-TLR4, FGF10-FOXP2, ADAMTSL3-FLT1, ADAMTSL3-MUC5AC and MUC5AC-NLRP3. CTCs decreased significantly between the two time points CTC1 and CTC2 (p<0.0001), and CTCs+ patients with high EZH2 expression had an 87% increased risk of death (p=0.018).</p><p><strong>Conclusions: </strong>Integrating molecular profiling of tumors and CTC characterization can provide valuable insights into tumor heterogeneity and improve patient stratification for resectable NSCLC.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Review on the Role of Probiotics in Lung Cancer Biology and Prognosis","authors":"","doi":"10.1016/j.arbres.2024.04.030","DOIUrl":"10.1016/j.arbres.2024.04.030","url":null,"abstract":"<div><div><span>Lung cancer remains the leading cause of cancer-related deaths worldwide. According to the American Cancer Society (ACS), it ranks as the second most prevalent type of cancer globally. Recent findings have highlighted bidirectional gut–lung interactions, known as the gut–lung axis, in the pathophysiology<span> of lung cancer. Probiotics are live microorganisms that boost host immunity when consumed adequately. The immunoregulatory mechanisms of probiotics are thought to operate through the generation of various metabolites that impact both the gut and distant organs (</span></span><em>e.g.</em><span>, the lungs) through blood. Several randomized controlled trials<span><span> have highlighted the pivotal role of probiotics in gut health especially for the prevention and treatment of malignancies, with a specific emphasis on lung cancer. Current research indicates that probiotic supplementation positively affects patients, leading to a suppression in cancer symptoms and a shortened </span>disease course<span>. While clinical trials validate the therapeutic benefits of probiotics, their precise mechanism of action remains unclear. This narrative review aims to provide a comprehensive overview of the present landscape of probiotics in the management of lung cancer.</span></span></span></div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 ","pages":"Pages S46-S58"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endobronchial Hamartoma Resected by Flexible Bronchoscopy: A Complex Approach","authors":"","doi":"10.1016/j.arbres.2024.05.014","DOIUrl":"10.1016/j.arbres.2024.05.014","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Pages 666-667"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organizing Pneumonia Secondary to ASIA Syndrome","authors":"","doi":"10.1016/j.arbres.2024.05.035","DOIUrl":"10.1016/j.arbres.2024.05.035","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Pages 658-659"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141403207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep–Wake Cycle in a Female Crew During an Earth-Based Martian Analogue Mission","authors":"","doi":"10.1016/j.arbres.2024.05.034","DOIUrl":"10.1016/j.arbres.2024.05.034","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Pages 649-651"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Diagnostic Delay and its Impact on Lung Cancer Survival: Results From the Spanish Thoracic Tumor Registry","authors":"Cristina Candal-Pedreira ,&nbsp;Alberto Ruano-Ravina ,&nbsp;Virginia Calvo de Juan ,&nbsp;Manuel Cobo ,&nbsp;Alexandra Cantero ,&nbsp;Delvys Rodríguez-Abreu ,&nbsp;Anna Estival ,&nbsp;Enric Carcereny ,&nbsp;Ainhoa Hernandez ,&nbsp;Rafael López Castro ,&nbsp;Andrea Medina ,&nbsp;Rosario García Campelo ,&nbsp;Manuel Fernández Bruno ,&nbsp;Reyes Barnabé ,&nbsp;Joaquim Bosch-Barrera ,&nbsp;Bartomeu Massutí ,&nbsp;Manuel Dómine ,&nbsp;Carlos Camps ,&nbsp;Ana Laura Ortega ,&nbsp;Mariano Provencio","doi":"10.1016/j.arbres.2024.07.006","DOIUrl":"10.1016/j.arbres.2024.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Early detection is crucial to improve lung cancer survival rates. Delays in diagnosis might negatively impact the prognosis of the disease. This study aims to analyze the diagnostic delay in lung cancer patients and describe if there is an association between delay and survival.</div></div><div><h3>Methods</h3><div>The data source used was the Thoracic Tumor Registry of the Spanish Lung Cancer Group. This analysis was restricted to lung cancer cases with information on the first date of consultation by symptoms and date of diagnosis. The delay was calculated as the number of days between the two dates. A descriptive analysis was performed, and ordinal logistic regressions were fitted with delay as the dependent variable. Kaplan–Meier survival analysis and Cox regression were performed.</div></div><div><h3>Results</h3><div>22,755 lung cancer cases were included. Never smokers were 1.16 (95%CI: 1.06–1.27) times more likely to register longer delay than smokers. Stage 0–I–II cases had a 3.09 (95%CI: 2.88–3.32) higher risk of longer delay compared to III–IV stages. Overall, 5-year survival rate after diagnosis was 23.64% (95%CI: 22.88–24.41). In those categorized as having the shortest delay 5-year survival was 17.67% (95%CI: 16.31–19.07) and in the extreme delay it was 32.98% (95%CI: 31.28–34.69) (<em>p</em> <!-->&lt;<!--> <!-->0.001). Adjusted mortality risk was higher in those with the shortest delay (HR 1.36, CI95%: 1.30–1.43) in comparison with the extreme delay.</div></div><div><h3>Conclusions</h3><div>Diagnostic delay is short among Spanish lung cancer patients, indicating a relatively quick diagnostic process. Extreme delays appear to be associated with higher survival rates, possibly attributed to slow-growing tumors, earlier stage at diagnosis or basically the natural history of this disease.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 ","pages":"Pages S38-S45"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity Pneumonitis in a 5-Year-Old Girl due to Turtledove: A Case Report","authors":"","doi":"10.1016/j.arbres.2024.05.024","DOIUrl":"10.1016/j.arbres.2024.05.024","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Pages 656-657"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sometimes it's What it Doesn’t Look Like: Atypical Dissemination of Lung Adenocarcinoma","authors":"","doi":"10.1016/j.arbres.2024.05.011","DOIUrl":"10.1016/j.arbres.2024.05.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Pages 664-665"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Radiomics and Clinical Data for the Diagnosis of Incidental Pulmonary Nodules and Lung Cancer Screening: Correspondence”","authors":"Sonia Baeza ,&nbsp;Debora Gil ,&nbsp;Antoni Rosell","doi":"10.1016/j.arbres.2024.07.023","DOIUrl":"10.1016/j.arbres.2024.07.023","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 ","pages":"Page S87"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO1","authors":"","doi":"10.1016/S0300-2896(24)00337-5","DOIUrl":"10.1016/S0300-2896(24)00337-5","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 10","pages":"Page CO1"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142426020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}