Archivos De Bronconeumologia最新文献

{"title":"Risk of Exposure for the Caregivers During Aminoglycoside Nebulization: An Observational Study","authors":"Gregory Reychler , Zoé Verdereau , Anne-Sophie Aubriot , Sophie Gohy , Silvia Berardis , Lidvine Boland , Vincent Haufroid , Jean-Christophe Dubus","doi":"10.1016/j.arbres.2025.01.011","DOIUrl":"10.1016/j.arbres.2025.01.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 368-370"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvascular Needle Aspiration Guide for Ultrasound Bronchoscopy by Esophageal Approach (EUS-B-TVNA), Successful Diagnostic Approach","authors":"Iker Fernández-Navamuel, Alan Jhunior Solis, Andrés Giménez Velando","doi":"10.1016/j.arbres.2025.03.008","DOIUrl":"10.1016/j.arbres.2025.03.008","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 386-387"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Oxygen and Non-Invasive Ventilation Useful “Clean Doping Boosters” for Thoracoabdominal Asynchrony During Exertion in Severe COPD?","authors":"Michele Vitacca, Mara Paneroni","doi":"10.1016/j.arbres.2025.02.012","DOIUrl":"10.1016/j.arbres.2025.02.012","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 327-329"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO1","authors":"","doi":"10.1016/S0300-2896(25)00158-9","DOIUrl":"10.1016/S0300-2896(25)00158-9","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Page CO1"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Classifications of COPD Severity Based on Impulse Oscillometry: A SAIO Grade Base on ECOPD Cohort in China","authors":"Lifei Lu ,&nbsp;Qi Wan ,&nbsp;Gaoying Tang ,&nbsp;Fan Wu ,&nbsp;Zhishan Deng ,&nbsp;Jieqi Peng ,&nbsp;Cuiqiong Dai ,&nbsp;Kunning Zhou ,&nbsp;Xiaohui Wu ,&nbsp;Shuqing Yu ,&nbsp;Yongqing Huang ,&nbsp;Changli Yang ,&nbsp;Shengtang Chen ,&nbsp;Pixin Ran ,&nbsp;Yumin Zhou","doi":"10.1016/j.arbres.2024.10.005","DOIUrl":"10.1016/j.arbres.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Recently, the severities of chronic obstructive pulmonary disease (COPD) can also be assessed by impulse oscillometry (IOS). This study aimed to explore a new classification of severity of COPD based on IOS and associations with acute exacerbations (AE) in patients with COPD.</div></div><div><h3>Methods</h3><div>The data of our study were based on the baseline and 2-year follow-up data of a prospective cohort in China. COPD was defined as post-bronchodilator FEV₁/FVC &lt;0.70. A new severity classification (staging of airflow obstruction by IOS, SAIO) was evaluated based on IOS parameters (R5, R5–R20, and X5 <em>z</em>-scores). We quantified using the weighted Bangdiwala B for agreement of severities of COPD between IOS parameters and FEV₁%pred. The differences among SAIO stages were performed in symptom scores and imaging using analysis of covariance, and in the AE using Poisson regression.</div></div><div><h3>Results</h3><div>Overall, 833 patients with COPD were included in this study. The weighted Bangdiwala B of R5, R5–R20, X5 <em>z</em>-scores, and FEV₁%pred for evaluating agreement of the severities of COPD was 0.68, 0.70 and 0.83, respectively. The SAIO classifications system identified a greater number of patients with stage III–IV. SAIO provided significant discrimination between the stage I and stage III, IV for symptom scores, emphysema, and air trapping. SAIO provided significant discrimination between the stage I and other stages for AE.</div></div><div><h3>Conclusions</h3><div>The SAIO classifications provide discrimination between the stage I and stage III, IV for symptom scores, emphysema, air trapping, and AE, similar to the GOLD classifications.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July, 2019.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 334-340"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Adding Blood and Lymphatic Vessel Invasion to the 8th Classification of TNM in Lung Cancer in Stages I and II","authors":"Gemma-María Muñoz-Molina ,&nbsp;Sara Fra-Fernández ,&nbsp;Alberto Cabañero-Sánchez ,&nbsp;Diego Germán Rojas-Tula ,&nbsp;Cristina Cavestany-García-Matres ,&nbsp;Alfonso Muriel-García ,&nbsp;Usue Caballero-Silva ,&nbsp;Luis Gorospe-Sarasúa ,&nbsp;David Saldaña-Garrido ,&nbsp;Amparo Benito-Berlinches ,&nbsp;Nicolás Moreno-Mata","doi":"10.1016/j.arbres.2024.11.006","DOIUrl":"10.1016/j.arbres.2024.11.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Expanding TNM staging system for lung cancer with the addition of new prognostic factors could enhance patient stratification and survival prediction. The goal of this study is to assess if TNM prognosis capacity could be improved by incorporating other pathological characteristics of surgical specimen.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed lung cancer resections, stages I–II, performed between January 1st 2010 and May 1st 2019. We collected clinical variables and pathological characteristics, including vascular, lymphovascular and perineural invasion, STAS, necrosis and stromal features. Mortality and recurrence-free survival were assessed with univariable and multivariable Cox analysis. We explored how these factors would modify the TNM Harrel's index.</div></div><div><h3>Results</h3><div>629 tumors were analyzed. Median overall survival was 53.9 months. Median recurrence-free survival was 47.6 months. Specific survival at 3, 5 and 10 years was 90, 83 and 74%. Recurrence-free survival at 3, 5 and 10 years was 76, 70 and 65%.</div><div>The multivariable analysis showed that overall survival was significantly related to TNM classification (<em>p</em> <!-->&lt;<!--> <!-->0.0002), vascular infiltration (HR 1.93, CI 1.42–2.64, <em>p</em> <!-->&lt;<!--> <!-->0.0001), lymphovascular invasion (HR 1.88, CI 1.30–2.71, <em>p</em> <!-->&lt;<!--> <!-->0.0015) and necrosis (HR 1.74, CI 1.24–2.45, <em>p</em> <!-->&lt;<!--> <!-->0.0025). Harrell's index for TNM was 0.6139. Adding vascular, lymphovascular invasion and necrosis, it increased up to 0.6531.</div><div>The multivariable analysis showed that specific survival was significantly related to TNM classification (<em>p</em> <!-->&lt;<!--> <!-->0.001), vascular infiltration (HR 2.23, CI 1.44–3.46, <em>p</em> <!-->&lt;<!--> <!-->0.001) and lymphovascular invasion (HR 1.85, CI 1.09–3.13, <em>p</em> <!-->&lt;<!--> <!-->0.021). Harrell's index for TNM was 0.6645. Adding vascular and lymphovascular invasion, it increased up to 0.7103. Recurrence-free survival was related to TNM, vascular infiltration (HR 1.48, CI 1.05–2.09, <em>p</em> <!-->&lt;<!--> <!-->0.023) and lymphovascular invasion (HR 2.40, CI 1.64–3.50, <em>p</em> <!-->&lt;<!--> <!-->0.001). Harrell's index for TNM was 0.6264. Adding vascular and lymphovascular invasion, it increased up to 0.6794.</div></div><div><h3>Conclusions</h3><div>Including vascular and angiolymphatic invasion in the staging system classification could better stratify patients at risk of recurrence and tumor-related death.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 341-347"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea","authors":"Thalia Belmonte ,&nbsp;Iván D. Benitez ,&nbsp;María C. García-Hidalgo ,&nbsp;Marta Molinero ,&nbsp;Lucía Pinilla ,&nbsp;Olga Mínguez ,&nbsp;Rafaela Vaca ,&nbsp;Maria Aguilà ,&nbsp;Anna Moncusí-Moix ,&nbsp;Gerard Torres ,&nbsp;Olga Mediano ,&nbsp;Juan F. Masa ,&nbsp;Maria J. Masdeu ,&nbsp;Blanca Montero-San-Martín ,&nbsp;Mercè Ibarz ,&nbsp;Pablo Martinez-Camblor ,&nbsp;Alberto Gómez-Carballa ,&nbsp;Antonio Salas ,&nbsp;Federico Martinón-Torres ,&nbsp;Ferran Barbé ,&nbsp;David de Gonzalo-Calvo","doi":"10.1016/j.arbres.2024.11.011","DOIUrl":"10.1016/j.arbres.2024.11.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Understanding the diverse pathogenetic pathways in obstructive sleep apnea (OSA) is crucial for improving outcomes. microRNA (miRNA) profiling is a promising strategy for elucidating these mechanisms.</div></div><div><h3>Objective</h3><div>To characterize the pathogenetic pathways linked to OSA through the integration of miRNA profiles, machine learning (ML) and bioinformatics.</div></div><div><h3>Methods</h3><div>This multicenter study involved 525 patients with suspected OSA who underwent polysomnography. Plasma miRNAs were quantified via RNA sequencing in the discovery phase, with validation in two subsequent phases using RT-qPCR. Supervised ML feature selection methods and comprehensive bioinformatic analyses were employed. The associations among miRNA targets, OSA and OSA treatment were further explored using publicly available external datasets.</div></div><div><h3>Results</h3><div>Following the discovery and technical validation phases in a subset of patients with and without confirmed OSA (<em>n</em> <!-->=<!--> <!-->53), eleven miRNAs were identified as candidates for the subsequent feature selection process. These miRNAs were then quantified in the remaining population (<em>n</em> <!-->=<!--> <!-->472). Feature selection methods revealed that the miRNAs let-7d-5p, miR-15a-5p and miR-107 were the most informative of OSA. The predominant mechanisms linked to these miRNAs were closely related to cellular events such as cell death, cell differentiation, extracellular remodeling, autophagy and metabolism. One target of let-7d-5p and miR-15a-5p, the <em>TFDP2</em> gene, exhibited significant differences in gene expression between subjects with and without OSA across three independent databases.</div></div><div><h3>Conclusion</h3><div>Our study identified three plasma miRNAs that, in conjunction with their target genes, provide new insights into OSA pathogenesis and reveal novel regulators and potential drug targets.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 348-358"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Haemophilus influenzae in Patients With Steady-State Chronic Obstructive Pulmonary Disease: A Long-Term Longitudinal Study","authors":"Grace Oscullo ,&nbsp;Jose Daniel Gómez-Olivas ,&nbsp;Miguel Ángel Martínez-García","doi":"10.1016/j.arbres.2025.01.013","DOIUrl":"10.1016/j.arbres.2025.01.013","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 371-373"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Alveolar Hemorrhage as a Complication of Severe Bronchopulmonary Dysplasia: A Case Report","authors":"Xiao-ying Zhao ,&nbsp;Xiao-qi Zhang ,&nbsp;Guo-hui Kang ,&nbsp;Chang Chen ,&nbsp;Xin-ai Wang ,&nbsp;Wei Zheng ,&nbsp;Jun Yuan","doi":"10.1016/j.arbres.2025.02.005","DOIUrl":"10.1016/j.arbres.2025.02.005","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 380-381"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Therapeutic Innovations in Pulmonary Hypertension: News From the 2024 World Symposium on Pulmonary Hypertension","authors":"Isabel Blanco ,&nbsp;Gabor Kovacs","doi":"10.1016/j.arbres.2025.02.006","DOIUrl":"10.1016/j.arbres.2025.02.006","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 6","pages":"Pages 325-326"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}