Archivos De Bronconeumologia最新文献

{"title":"EPIMETRIC: A cfDNA Methylation-Based Algorithm for COPD Diagnosis and Stratification","authors":"Abel Garcia-Diaz,&nbsp;Valeria Denninghoff,&nbsp;Cristóbal Fresno,&nbsp;María Pilar Molina-Vallejo,&nbsp;Javier Luis López-Hidalgo,&nbsp;Jose Antonio Lorente,&nbsp;Guillermo Barturen-Briñas,&nbsp;Elena Carnero-Montoro,&nbsp;Marta Alarcon-Riquelme,&nbsp;Diego de Miguel Perez,&nbsp;Juan José Cruz-Rueda,&nbsp;Pedro José Romero-Palacios,&nbsp;Bernardino Alcázar-Navarrete,&nbsp;María José Serrano","doi":"10.1016/j.arbres.2026.03.016","DOIUrl":"10.1016/j.arbres.2026.03.016","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a blood-based algorithm using cell-free DNA (cfDNA) methylation profiles to diagnose and stratify patients with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification.</div></div><div><h3>Methods</h3><div>Between 2021 and 2023, 166 participants were enrolled, including patients with COPD (<em>N</em> <!-->=<!--> <!-->80) and healthy controls (<em>N</em> <!-->=<!--> <!-->86) from three hospitals in Andalusia. Genome-wide cfDNA methylation analysis was performed in 128 individuals to identify CpG sites discriminating COPD from healthy individuals and to stratify COPD patients by GOLD categories. A hierarchical support vector machine (SVM) classifier was implemented, and functional enrichment analyses were conducted to assess biological relevance.</div></div><div><h3>Results</h3><div>Differential methylation analysis identified 354 genes associated with COPD, 496 with GOLD classification, and 125 overlapping genes. The SVM classifier trained on cfDNA methylation features achieved complete separation between COPD and control groups, enabling a hard-margin model. This cfDNA-based classifier (EPIMETRIC) also distinguished GOLD A, B, and D subgroups. Enrichment analysis revealed pathways including glutamatergic synapse, nicotine addiction, tight junction, and Hippo signaling.</div></div><div><h3>Conclusions</h3><div>EPIMETRIC represents the first blood-based cfDNA methylation signature for COPD diagnosis and GOLD stratification. It provides a minimally invasive and highly accurate tool for early detection, personalized treatment, and identification of high-risk patients.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 635-643"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrated Catheter in the Left Pulmonary Artery","authors":"Maitane Pérez Urkiza,&nbsp;Odile Ojanguren Martiarena,&nbsp;Claudia Loidi López","doi":"10.1016/j.arbres.2026.02.009","DOIUrl":"10.1016/j.arbres.2026.02.009","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 678-679"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO1","authors":"","doi":"10.1016/S0300-2896(26)00288-7","DOIUrl":"10.1016/S0300-2896(26)00288-7","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Page CO1"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148870653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screened vs. Non-Screened Lung Cancer: Real-World Evidence of a Stage Shift","authors":"Anna Sánchez-Cucó,&nbsp;Marcela Suárez,&nbsp;Sally Santisteve,&nbsp;Anna Vila,&nbsp;Carlos Manzano,&nbsp;Esther Gracia-Lavedan,&nbsp;Nerea Ramírez-Seco,&nbsp;Wasim el Arfaoui,&nbsp;María Zuil,&nbsp;Sònia Gatius,&nbsp;Carlos A. Rombolá,&nbsp;Marina Pardina,&nbsp;José David González,&nbsp;Ferran Barbé,&nbsp;Jessica González","doi":"10.1016/j.arbres.2026.02.013","DOIUrl":"10.1016/j.arbres.2026.02.013","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (182KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 653-656"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the Diagnostic Utility of the Six-Biomarker Panel in Pulmonary Rapid Diagnosis Units","authors":"Zhangfang Zeng,&nbsp;Wei Chen,&nbsp;Lili Huang","doi":"10.1016/j.arbres.2026.05.004","DOIUrl":"10.1016/j.arbres.2026.05.004","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 670-671"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Public Involvement and Engagement in Research: Building Partnerships for Impact","authors":"Dawn P. Richards,&nbsp;Ferrán Catalá-López,&nbsp;David Moher","doi":"10.1016/j.arbres.2026.04.014","DOIUrl":"10.1016/j.arbres.2026.04.014","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 611-614"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Lungs to Vascular Health: Airflow Obstruction, Not Lung Function Decline, Predicts Atherosclerosis Progression Independent of Smoking Status","authors":"Mario Henríquez-Beltrán,&nbsp;Esther Gracia-Lavedan,&nbsp;Anna Sánchez-Cucó,&nbsp;Gerard Torres,&nbsp;Adriano D.S. Targa,&nbsp;Marcelino Bermúdez-López,&nbsp;José Manuel Valdivielso,&nbsp;Reinald Pamplona,&nbsp;Dídac Mauricio,&nbsp;Eva Castro-Boqué,&nbsp;Elvira Fernández,&nbsp;Albert Lecube,&nbsp;Jordi de Batlle,&nbsp;Ferrán Barbé,&nbsp;Jessica González,&nbsp;on behalf of the ILERVAS project collaborators","doi":"10.1016/j.arbres.2026.04.012","DOIUrl":"10.1016/j.arbres.2026.04.012","url":null,"abstract":"<div><h3>Objectives</h3><div>To prospectively evaluate the relationship between 4-year changes in lung function and the progression of subclinical atherosclerosis among 1623 middle-aged adults with at least one cardiovascular risk factor participating in ILERVAS, and to determine whether individuals who develop airflow obstruction (AO) are especially susceptible to accelerated atherosclerosis progression.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 1623 middle-aged adults from the ILERVAS cohort, recruited in primary care centers in the province of Lleida (Catalonia, Spain), with baseline assessments conducted between 2015 and 2018 and follow-up visits between 2019 and 2021 (mean follow-up, 3.99 [SD, 0.22] years). Pulmonary function was assessed by spirometry at baseline and at 4-year follow-up. Subclinical atherosclerosis was evaluated using vascular ultrasound of 12 carotid and femoral territories at baseline and at follow-up, with total plaque area quantified. Associations were analyzed using multivariable linear regression models, adjusting for clinical variables and baseline plaque burden. Analyses were stratified by smoking status.</div></div><div><h3>Results</h3><div>Median annual declines were −95<!--> <!-->mL (−2.04%) for FVC and −78<!--> <!-->mL (−2.00%) for FEV₁. Categorization of annual pulmonary function decline by tertiles showed no significant association with plaque progression. In contrast, incident AO was associated with greater annual FEV₁ decline (−146.73 vs −74.90<!--> <!-->mL; <em>P</em> <!-->&lt;<!--> <!-->.001) and with greater plaque burden, reflected by an increase in affected vascular territories (0.26 [IQR, 0.00–0.75]; <em>P</em> <!-->&lt;<!--> <!-->.001). Multivariable models confirmed larger annual increases in total (4.40<!--> <!-->mm²; <em>P</em> <!-->&lt;<!--> <!-->.001), carotid (2.33<!--> <!-->mm²; <em>P</em> <!-->&lt;<!--> <!-->.001), and femoral (1.99<!--> <!-->mm²; <em>P</em> <!-->=<!--> <!-->.031) plaque areas among participants with incident AO, with consistent results across smoking strata. Sensitivity analyses using a lower limit of normal-based definition of AO showed similar findings, with effect estimates consistent with the primary fixed-ratio analyses.</div></div><div><h3>Conclusions</h3><div>In this two-time-point analysis, lung function decline was not independently associated with subclinical atherosclerosis progression. In contrast, incident AO was consistently associated with greater plaque progression across smoking strata. These findings support incident AO as a spirometric marker associated with vascular risk.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 618-626"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Assessment of CT-Derived Fibrosis Volume and Pulmonary Function in Identifying Progressive Pulmonary Fibrosis in Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)","authors":"Kyongmin Sarah Beck,&nbsp;Nicola Sverzellati,&nbsp;Nicole Goh,&nbsp;Kyung Hoon Kim,&nbsp;Ji Weon Lee,&nbsp;Ahran Kim,&nbsp;Jung Hyun Nam,&nbsp;Jong Min Lee,&nbsp;Jeewon Lee,&nbsp;Yong Suk Jo","doi":"10.1016/j.arbres.2026.03.002","DOIUrl":"10.1016/j.arbres.2026.03.002","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (150KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 661-664"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home NIV Software: Decision-support Tool or Digital Distraction?","authors":"Antoine Leotard, Patrick Brian Murphy","doi":"10.1016/j.arbres.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.arbres.2026.07.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercapnic Burden Derived From Nocturnal Transcutaneous CO₂ Measurement: A Preliminary Study in Patients With Slowly Progressive Neuromuscular Diseases.","authors":"Siham Benkerrou, Piotr Dolecki, Marie Anne Melone, Pierre Tankéré, Isabelle Bossard, Amélie Pillot, Maxime Patout, Guillaume Bao, Hélène Prigent, Antoine Leotard","doi":"10.1016/j.arbres.2026.07.010","DOIUrl":"https://doi.org/10.1016/j.arbres.2026.07.010","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}