Crhistian-Mario Oblitas, Pablo Demelo-Rodríguez, Francisco Galeano-Valle
{"title":"ECG-Based Reclassification Within the Low-Risk Pulmonary Embolism Population.","authors":"Crhistian-Mario Oblitas, Pablo Demelo-Rodríguez, Francisco Galeano-Valle","doi":"10.1016/j.arbres.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.arbres.2026.09.006","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Cabrera-Cesar, Mercedes Segura Romero, Sara Sánchez Martín
{"title":"Vaping “Smoke-Free,” but Not “Impact-Free”: An Emerging Environmental Contradiction","authors":"Eva Cabrera-Cesar, Mercedes Segura Romero, Sara Sánchez Martín","doi":"10.1016/j.arbres.2026.05.013","DOIUrl":"10.1016/j.arbres.2026.05.013","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 10","pages":"Pages 687-688"},"PeriodicalIF":8.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost-Effectiveness of Targeted Next-Generation Sequencing for Diagnosing Pre-XDR and XDR Tuberculosis in Rifampicin-Resistant Patients Across High-Burden Settings","authors":"Ginenus Fekadu, Tadesse Tolossa, Busha Gamachu Labata, Meseret Belete Fite, Tesfaye Regassa Feyissa, Xinyao Yi, Sze Chai Chan, Yanya Chen, Cemre Arpa, Firomsa Bekele, Lan Gao, Nathorn Chaiyakunapruk, Lianping Yang, Meseret Jeldu, Shanquan Chen, Martin Siegel, Wai-Kit Ming","doi":"10.1016/j.arbres.2026.04.007","DOIUrl":"10.1016/j.arbres.2026.04.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate whether targeted next-generation sequencing (tNGS)—alone or in combination with phenotypic drug susceptibility testing (pDST)—is cost-effective for diagnosing pre-extensively drug-resistant and extensively drug-resistant tuberculosis (pre-XDR/XDR-TB) in rifampicin-resistant tuberculosis (RR-TB) patients across South Africa, India, and Georgia, and to quantify mortality reduction from earlier treatment initiation enabled by rapid molecular diagnostics.</div></div><div><h3>Methods</h3><div>We developed a decision-analytic model combining a short-term decision tree with a 10-year Markov model to simulate outcomes in a hypothetical RR-TB cohort. Three diagnostic strategies were compared: pDST, tNGS, and tNGS<!--> <!-->+<!--> <!-->pDST. Outcomes included costs, quality-adjusted life years (QALYs), early treatment initiation, TB-related mortality, and incremental cost-effectiveness ratios (ICERs). Cost-effectiveness was assessed against country-specific willingness-to-pay (WTP) thresholds. Sensitivity analyses were conducted to characterize uncertainty.</div></div><div><h3>Results</h3><div>Tngs-based strategies improved early treatment initiation (South Africa: +9.8%; India: +19.1%; Georgia: +29.6%) and reduced mortality across all settings. In South Africa, tNGS was cost-effective (ICER, $2805/QALY). In Georgia, the combination strategy was cost-effective (ICER, $6361/QALY). In India, neither tNGS (ICER, $4453/QALY) nor the combination strategy (ICER, $6198/QALY) met the WTP threshold; tNGS would require cost reduction to ≤$116/test. The HR, for delayed treatment and tNGS cost were primary ICER drivers. Probabilistic analysis confirmed robustness, with tNGS cost-effective in 58% of simulations in South Africa and the combination strategy in 42% in Georgia.</div></div><div><h3>Conclusions</h3><div>Tngs is cost-effective in South Africa and Georgia when the survival benefit of earlier treatment initiation is accounted for. In India, tNGS pricing exceeds affordability thresholds, necessitating cost reductions and targeted deployment. These findings provide context-specific guidance for national TB programs.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 10","pages":"Pages 692-700"},"PeriodicalIF":8.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Else A.M.D. ter Haar, Dirk-Jan Slebos, Sonja W.S. Augustijn, Laura E. van der Beek, Marlies van Dijk, Amy Mei, Charmaine H.W. Mei, Sytske W. van Riel, T. David Koster, Karin Klooster, Jorine E. Hartman
{"title":"Impact of Age on Treatment Response to Endobronchial Valve Treatment in Patients With Severe Emphysema","authors":"Else A.M.D. ter Haar, Dirk-Jan Slebos, Sonja W.S. Augustijn, Laura E. van der Beek, Marlies van Dijk, Amy Mei, Charmaine H.W. Mei, Sytske W. van Riel, T. David Koster, Karin Klooster, Jorine E. Hartman","doi":"10.1016/j.arbres.2026.05.005","DOIUrl":"10.1016/j.arbres.2026.05.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Endobronchial valve (EBV) treatment can significantly improve pulmonary function, exercise capacity, and quality of life in patients with advanced emphysema and lung hyperinflation. However, the impact of age on treatment response to EBV remains unclear, despite its increasing relevance in an aging population. This study aimed to assess the effect of age on clinical outcomes following EBV treatment in a real-world population.</div></div><div><h3>Methods</h3><div>Baseline, 6-month, and 12-month follow-up data were obtained from our registry of EBV procedures performed between 2016 and 2024. Patients were stratified according to age: <70 years and ≥70 years. Age-related differences in relative changes in forced expiratory volume in 1 second (FEV1), residual volume (RV), 6-minute walk distance (6MWD), and <em>St George's Respiratory Questionnaire</em> (SGRQ) scores were assessed, together with safety outcomes, achievement of patient-specific goals, and patient satisfaction.</div></div><div><h3>Results</h3><div>A total of 476 patients were included, of whom 79 (17%) were aged ≥70 years (range, 70–80 years). Both age groups demonstrated significant improvements in FEV1, RV, 6MWD, and SGRQ scores at both follow-up visits, with no significant differences between groups. Importantly, adverse events did not occur more frequently among older patients. Additionally, achievement of patient-specific goals was comparable between groups, although patients aged ≥70 years reported slightly greater satisfaction with treatment outcomes than those aged <70 years.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that EBV treatment resulted in comparable clinical improvements and similar safety profiles regardless of patient age. These findings highlight the importance of referral and screening of older patients with emphysema to assess their eligibility for EBV treatment.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 10","pages":"Pages 709-716"},"PeriodicalIF":8.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}