Archivos De Bronconeumologia最新文献

{"title":"Longitudinal Validation of the RADAR Score in Primary Care: Prognostic Value for Exacerbations and Short-term Changes in Health and Control Status","authors":"Myriam Calle Rubio,&nbsp;Soha Esmaili,&nbsp;Imán Esmaili,&nbsp;Medardo Montenegro,&nbsp;Gianna Vargas Centanaro,&nbsp;Norma Doria Carlin,&nbsp;María Carmen Antón Sanz,&nbsp;Elías Ekech Mesa,&nbsp;José Antonio Fernández Ruiz,&nbsp;Patricia Privado Martínez,&nbsp;Alberto Serrano López de las Hazas,&nbsp;Beatriz Garcia Serrano Jiménez,&nbsp;Juan Luis Rodríguez Hermosa","doi":"10.1016/j.arbres.2026.03.014","DOIUrl":"10.1016/j.arbres.2026.03.014","url":null,"abstract":"<div><h3>Introduction</h3><div>The longitudinal validity of the RADAR score for predicting short-term risk in primary care remains unestablished. We aimed to evaluate its prognostic performance for adverse events and to describe short-term changes in control status and patient-reported health status in a real-world prospective cohort.</div></div><div><h3>Methods</h3><div>In this multicenter study, 706 primary care patients with COPD receiving maintenance triple therapy were assessed at baseline and after a median follow-up of 91 days. We analyzed the association between baseline RADAR control status (≥4 vs &lt;4) and 3-month outcomes (all-cause mortality, severe exacerbations, moderate exacerbations, and composite events). We also described 3-month changes in RADAR score (ΔRADAR) and COPD Assessment Test score (ΔCAT).</div></div><div><h3>Results</h3><div>Baseline poor control (RADAR ≥4) was strongly associated with severe exacerbations (16.2% vs 4.9%; OR, 3.75) and composite events (33.8% vs 22.9%; OR, 1.72). No significant difference was observed for moderate exacerbations (18.0% vs 18.9%). However, when modeled as a frequency count, each 1-point increase in RADAR score was associated with a 21% higher rate of moderate exacerbations (incidence rate ratio, 1.21; 95% CI, 1.15–1.27; <em>P</em> <!-->&lt;<!--> <!-->.001). Patients with RADAR ≥4 exhibited a high-risk profile characterized by worse airflow limitation, active smoking, higher symptom burden, and poorer adherence. Over 3 months, significant changes were observed in the distributions of both ΔCAT and ΔRADAR when analyzed by clinical phenotype and risk level.</div></div><div><h3>Conclusions</h3><div>The RADAR score effectively predicts short-term clinical risk in primary care and provides a practical tool for monitoring COPD and guiding clinical decision-making. It demonstrates significant prognostic value for identifying patients at high short-term risk of severe exacerbations and serves as an initial risk stratification tool to identify individuals requiring further assessment. The observed short-term changes highlight the dynamic nature of COPD control.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 627-634"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Pulmonary Alveolar Proteinosis Due to MonoMAC Syndrome Associated With a Novel GATA2 Mutation","authors":"Jesús Fernández Francés,&nbsp;Alejandro Vázquez Ramo,&nbsp;Guillermo Calero Rodríguez","doi":"10.1016/j.arbres.2026.04.010","DOIUrl":"10.1016/j.arbres.2026.04.010","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 674-675"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumonitis and Sacituzumab Govitecan: A Case of Metastatic Triple-Negative Breast Cancer","authors":"Jorge Alberto Fong Gutiérrez,&nbsp;Ana Lopez Gonzalez,&nbsp;Javier Juan Garcia","doi":"10.1016/j.arbres.2026.05.003","DOIUrl":"10.1016/j.arbres.2026.05.003","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 676-677"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilator-associated Brain Injury (VABI): Current Understanding","authors":"Thiago Bassi,&nbsp;Martin Dres","doi":"10.1016/j.arbres.2026.04.016","DOIUrl":"10.1016/j.arbres.2026.04.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 615-617"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrated Catheter in the Left Pulmonary Artery","authors":"Maitane Pérez Urkiza,&nbsp;Odile Ojanguren Martiarena,&nbsp;Claudia Loidi López","doi":"10.1016/j.arbres.2026.02.009","DOIUrl":"10.1016/j.arbres.2026.02.009","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 678-679"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured Approach to Mechanical Ventilation and Training Standardization: Multinational Modified Delphi Survey","authors":"Nirmala Manjappachar,&nbsp;Oguz Kilickaya,&nbsp;Kim Duc Chu,&nbsp;Yue Dong,&nbsp;Dimitrios Kantas,&nbsp;Baiyong Wang,&nbsp;Marko Nemet,&nbsp;Ognjen Gajic,&nbsp;Alexander Niven,&nbsp;Richard A. Oeckler,&nbsp;Amos Lal,&nbsp;on behalf of CERTAIN STOP collaborators","doi":"10.1016/j.arbres.2026.03.009","DOIUrl":"10.1016/j.arbres.2026.03.009","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 665-669"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIMETRIC: A cfDNA Methylation-Based Algorithm for COPD Diagnosis and Stratification","authors":"Abel Garcia-Diaz,&nbsp;Valeria Denninghoff,&nbsp;Cristóbal Fresno,&nbsp;María Pilar Molina-Vallejo,&nbsp;Javier Luis López-Hidalgo,&nbsp;Jose Antonio Lorente,&nbsp;Guillermo Barturen-Briñas,&nbsp;Elena Carnero-Montoro,&nbsp;Marta Alarcon-Riquelme,&nbsp;Diego de Miguel Perez,&nbsp;Juan José Cruz-Rueda,&nbsp;Pedro José Romero-Palacios,&nbsp;Bernardino Alcázar-Navarrete,&nbsp;María José Serrano","doi":"10.1016/j.arbres.2026.03.016","DOIUrl":"10.1016/j.arbres.2026.03.016","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a blood-based algorithm using cell-free DNA (cfDNA) methylation profiles to diagnose and stratify patients with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification.</div></div><div><h3>Methods</h3><div>Between 2021 and 2023, 166 participants were enrolled, including patients with COPD (<em>N</em> <!-->=<!--> <!-->80) and healthy controls (<em>N</em> <!-->=<!--> <!-->86) from three hospitals in Andalusia. Genome-wide cfDNA methylation analysis was performed in 128 individuals to identify CpG sites discriminating COPD from healthy individuals and to stratify COPD patients by GOLD categories. A hierarchical support vector machine (SVM) classifier was implemented, and functional enrichment analyses were conducted to assess biological relevance.</div></div><div><h3>Results</h3><div>Differential methylation analysis identified 354 genes associated with COPD, 496 with GOLD classification, and 125 overlapping genes. The SVM classifier trained on cfDNA methylation features achieved complete separation between COPD and control groups, enabling a hard-margin model. This cfDNA-based classifier (EPIMETRIC) also distinguished GOLD A, B, and D subgroups. Enrichment analysis revealed pathways including glutamatergic synapse, nicotine addiction, tight junction, and Hippo signaling.</div></div><div><h3>Conclusions</h3><div>EPIMETRIC represents the first blood-based cfDNA methylation signature for COPD diagnosis and GOLD stratification. It provides a minimally invasive and highly accurate tool for early detection, personalized treatment, and identification of high-risk patients.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 635-643"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the Diagnostic Utility of the Six-Biomarker Panel in Pulmonary Rapid Diagnosis Units","authors":"Zhangfang Zeng,&nbsp;Wei Chen,&nbsp;Lili Huang","doi":"10.1016/j.arbres.2026.05.004","DOIUrl":"10.1016/j.arbres.2026.05.004","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 670-671"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Public Involvement and Engagement in Research: Building Partnerships for Impact","authors":"Dawn P. Richards,&nbsp;Ferrán Catalá-López,&nbsp;David Moher","doi":"10.1016/j.arbres.2026.04.014","DOIUrl":"10.1016/j.arbres.2026.04.014","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Pages 611-614"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO1","authors":"","doi":"10.1016/S0300-2896(26)00288-7","DOIUrl":"10.1016/S0300-2896(26)00288-7","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 9","pages":"Page CO1"},"PeriodicalIF":8.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148870653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}