Diana Betancor, Manuel Jorge Rial, José María Olaguibel, Victoria Del Pozo, María José Alvarez Puebla, Ebymar Arismendi, Blanca Barroso, Irina Bobolea, Blanca Cárdaba, Jose Antonio Cañas, Javier Domínguez-Ortega, Astrid Crespo-Leshman, María Jesús Cruz, Alberto Garcia de la Fuente, Francisco-Javier González-Barcala, Jose Antonio Luna-Porta, Carlos Martínez-Rivera, Joaquim Mullol, Xavier Muñoz, Vicente Plaza, Santiago Quirce, Lorena Soto-Retes, Marcela Valverde-Monge, Joaquin Sastre
{"title":"Stability of Asthma Biomarkers Over a Two-year Period Using Three Distinct Classifications in the MEGA Cohort.","authors":"Diana Betancor, Manuel Jorge Rial, José María Olaguibel, Victoria Del Pozo, María José Alvarez Puebla, Ebymar Arismendi, Blanca Barroso, Irina Bobolea, Blanca Cárdaba, Jose Antonio Cañas, Javier Domínguez-Ortega, Astrid Crespo-Leshman, María Jesús Cruz, Alberto Garcia de la Fuente, Francisco-Javier González-Barcala, Jose Antonio Luna-Porta, Carlos Martínez-Rivera, Joaquim Mullol, Xavier Muñoz, Vicente Plaza, Santiago Quirce, Lorena Soto-Retes, Marcela Valverde-Monge, Joaquin Sastre","doi":"10.1016/j.arbres.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.06.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mirjam P Roffel, Corry-Anke Brandsma, Alen Faiz, Marnix R Jonker, Wim Timens, Guy F Joos, Guy G Brusselle, Tania Maes, Ken R Bracke, Maarten van den Berge, Irene H Heijink
{"title":"The Role of miR-320d in Regulation of Cigarette Smoke-Induced Pro-Inflammatory Responses in COPD.","authors":"Mirjam P Roffel, Corry-Anke Brandsma, Alen Faiz, Marnix R Jonker, Wim Timens, Guy F Joos, Guy G Brusselle, Tania Maes, Ken R Bracke, Maarten van den Berge, Irene H Heijink","doi":"10.1016/j.arbres.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.06.015","url":null,"abstract":"<p><strong>Introduction: </strong>The mechanisms driving abnormal pro-inflammatory responses to cigarette smoke in COPD remain unclear. MicroRNA (miR)-320d was previously shown to have anti-inflammatory effects, being upregulated by inhaled corticosteroids. Therefore, our objective was to study whether miR-320d suppresses smoke-induced airway epithelial pro-inflammatory responses and if this is compromised in COPD.</p><p><strong>Methods: </strong>We investigated the anti-inflammatory mechanisms of miR-320d in cigarette smoke extract (CSE)-exposed primary bronchial epithelial cells (PBECs), comparing COPD and control cells using a miR-320d mimic. Additionally, we assessed whether miR-320d expression is altered with COPD and its severity, investigating lung tissue from two independent cohorts of non-COPD controls (non/current/ex-smokers) and COPD patients (current/ex-smokers) with mild/moderate and severe disease.</p><p><strong>Results: </strong>MiR-320d overexpression attenuated baseline and CSE-induced pro-inflammatory CXCL8, IL-1α and GM-CSF secretion in non-COPD-derived PBECs. This effect was not observed for CXCL8 and IL-1α in COPD-derived PBECs. RNA-sequencing showed that miR-320d significantly regulates the expression of 137 genes in CSE-exposed epithelium, the upregulated genes being enriched in \"interleukin-33-mediated signaling\" and the downregulated genes in \"response to cytokine\" (including IRAK1) pathways. Higher miR-320d levels were associated with lower IRAK1 expression in control but not COPD-derived PBECs. Finally, miR-320d levels were lower in lung tissue of COPD patients vs non-smoking controls and in severe vs mild/moderate COPD patients.</p><p><strong>Conclusions: </strong>miR-320d's suppressive effect on bronchial epithelial pro-inflammatory responses cells may be compromised in COPD. Additionally, miR-320d expression in lung tissue was lower with COPD severity. Thus, lower miR-320d anti-inflammatory action may contribute to persisting inflammation in COPD.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Romero-Linares, Antonio Cárdenas-Cruz, Jose M Pérez-Villares, Jose A Sánchez-Martínez, Patricia Fuentes-García, Bernardino Alcázar-Navarrete
{"title":"Inclusion of the Intermediate Respiratory Care Unit as a Detection Area for Controlled Donation After Circulatory Death: Results of a Pilot Project.","authors":"Alejandro Romero-Linares, Antonio Cárdenas-Cruz, Jose M Pérez-Villares, Jose A Sánchez-Martínez, Patricia Fuentes-García, Bernardino Alcázar-Navarrete","doi":"10.1016/j.arbres.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.07.004","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Malignant Melanoma of the Right Upper Lobar Bronchus in a 30-Year-old Male.","authors":"Qingping Zhong, Binglin Lai","doi":"10.1016/j.arbres.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.07.002","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matilde Ferreira de Almeida, Inês Estalagem, Carlos Couto
{"title":"Venlafaxine-Induced Eosinophilic Pleural Effusion and Peripheral Eosinophilia: First Reported Case and the Role of an SNRI","authors":"Matilde Ferreira de Almeida, Inês Estalagem, Carlos Couto","doi":"10.1016/j.arbres.2025.02.018","DOIUrl":"10.1016/j.arbres.2025.02.018","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 7","pages":"Pages 443-444"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Gorospe , Abel González-Huete , Rosa Mariela Mirambeaux-Villalona
{"title":"Double Trouble in a Breast Cancer Patient Presenting With Dyspnea","authors":"Luis Gorospe , Abel González-Huete , Rosa Mariela Mirambeaux-Villalona","doi":"10.1016/j.arbres.2025.03.011","DOIUrl":"10.1016/j.arbres.2025.03.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 7","pages":"Pages 448-449"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Álvaro Fuentes-Martín, María Rosa López Pedreira, Ángel Cilleruelo Ramos
{"title":"Right Cardiac Bronchus: An Uncommon Incidental Finding.","authors":"Álvaro Fuentes-Martín, María Rosa López Pedreira, Ángel Cilleruelo Ramos","doi":"10.1016/j.arbres.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.06.012","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariela Alvarado-Miranda , Alberto Solano , Salvatore Marsico , Adriana Núñez-Robainas , Maria Cinta Cumpli-Gargallo , Marina Sáinz , José María Maiques , Esther Barreiro
{"title":"Clinical Implications of Functional Imaging in the Assessment of Bronchiectasis-Associated Sarcopenia","authors":"Mariela Alvarado-Miranda , Alberto Solano , Salvatore Marsico , Adriana Núñez-Robainas , Maria Cinta Cumpli-Gargallo , Marina Sáinz , José María Maiques , Esther Barreiro","doi":"10.1016/j.arbres.2024.11.015","DOIUrl":"10.1016/j.arbres.2024.11.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Bronchiectasis is a complex lung disease with poorly studied systemic manifestations. Patients with bronchiectasis-associated sarcopenia exhibit a specific differential profile of functional muscle phenotype (vastus lateralis, VL), which may be analyzed using imaging (ultrasound and magnetic resonance imaging, MRI).</div></div><div><h3>Methods</h3><div>Ultrasound and MRI were used to explore functional imaging parameters in quadriceps of 20 patients with stable bronchiectasis and 10 healthy controls. In muscle specimens (open biopsy procedures), muscle phenotype (fiber morphometry and structural abnormalities, immunohistochemistry) was also evaluated. Patients and controls were clinically and functionally evaluated.</div></div><div><h3>Results</h3><div>In muscles of patients compared to controls, a significant decline in body composition parameters (BMI and FFMI), muscle function (upper and lower limbs), lung function, and exercise capacity was detected, ultrasonography revealed decreased muscle thickness and area, while MRI demonstrated increased fat infiltration, which positively correlated with the bronchiectasis severity scores. Structural parameters (proportions of hybrid fibers, internal nuclei, abnormal fibers, and apoptotic nuclei) were significantly greater in the VL of patients than in controls and inversely correlated with quadriceps muscle function and exercise capacity in the former.</div></div><div><h3>Conclusions</h3><div>In patients with stable mild-to-moderate bronchiectasis, sarcopenia was clinically evidenced through the significant reduction in muscle mass and upper and lower limb muscle function. Non-invasive ultrasound and MRI techniques showed that features of muscle quality architecture and fat infiltration are hallmarks of bronchiectasis-associated sarcopenia. Functional radiological tools should be implemented in clinical settings to early diagnose and monitor sarcopenia in these patients.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 7","pages":"Pages 398-407"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Betancor , Jose Maria Olaguibel , Victoria del Pozo , Maria Jose Alvarez Puebla , Ebymar Arismendi , Blanca Barroso , Irina Bobolea , Blanca Cárdaba , José Antonio Cañas , Javier Domínguez-Ortega , María-Jesús Cruz , Elena Curto , Alberto Garcia de la Fuente , Francisco Jose González-Barcala , Juan-Alberto Luna-Porta , Cesar Martínez-Rivera , Joaquim Mullol , Xavier Muñoz , César Picado , Vicente Plaza , Joaquin Sastre
{"title":"FEV1Q as a Predictive Metric for Asthma Outcomes","authors":"Diana Betancor , Jose Maria Olaguibel , Victoria del Pozo , Maria Jose Alvarez Puebla , Ebymar Arismendi , Blanca Barroso , Irina Bobolea , Blanca Cárdaba , José Antonio Cañas , Javier Domínguez-Ortega , María-Jesús Cruz , Elena Curto , Alberto Garcia de la Fuente , Francisco Jose González-Barcala , Juan-Alberto Luna-Porta , Cesar Martínez-Rivera , Joaquim Mullol , Xavier Muñoz , César Picado , Vicente Plaza , Joaquin Sastre","doi":"10.1016/j.arbres.2025.02.011","DOIUrl":"10.1016/j.arbres.2025.02.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 7","pages":"Pages 434-437"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}