José G. Yaryura Montero, Rodrigo A. Benavidez, Mario A. Cafaro
{"title":"Mediastinal Venous-Lymphatic Malformations: Thoracoscopic Resection","authors":"José G. Yaryura Montero, Rodrigo A. Benavidez, Mario A. Cafaro","doi":"10.1016/j.arbres.2024.07.002","DOIUrl":"10.1016/j.arbres.2024.07.002","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 725-726"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141714266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sharing of Individual Participant Clinical Trial Data: It is Time to Abandon the “Look the Other Way” Attitude","authors":"Rafael Dal-Ré","doi":"10.1016/j.arbres.2024.07.016","DOIUrl":"10.1016/j.arbres.2024.07.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 673-674"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Increased TGFβ1, VEGF and IFN-γ in the Sputum of Severe Asthma Patients With Bronchiectasis","authors":"","doi":"10.1016/j.arbres.2024.05.036","DOIUrl":"10.1016/j.arbres.2024.05.036","url":null,"abstract":"<div><h3>Background</h3><div><span>Bronchiectasis is one of the most common comorbidities in </span>severe asthma. However, the mechanisms by which asthma promotes the development and progress of this condition are not well defined. This study aimed to analyze the inflammatory phenotypes and quantify the expression of proinflammatory and remodeling cytokines in asthma patients with and without bronchiectasis.</div></div><div><h3>Methods</h3><div><span>The study sample comprised individuals with severe asthma and bronchiectasis (group AB, </span><em>n</em> <!-->=<!--> <!-->55) and a control population of individuals with severe asthma without bronchiectasis (group AC, <em>n</em> <!-->=<!--> <span><span><span>45). Induced sputum<span> samples were obtained and cell types determined by differential cell count. Proinflammatory and bronchial remodeling cytokines (IL-8, neutrophilic </span></span>elastase, TGFβ1, VEGF, IFN-γ, TNF-α, and GM-CSF) were analyzed by </span>immunoassay<span> in sputum supernatant.</span></span></div></div><div><h3>Results</h3><div>Neutrophilic inflammation was the primary phenotype in both asthma groups. Higher levels of TGFβ1, VEGF and IFN-γ were observed in asthma patients with bronchiectasis (group AB) than in controls (group AC) (15 vs 24<!--> <!-->pg/ml, <em>p</em> <!-->=<!--> <!-->0.014; 183 vs 272<!--> <!-->pg/ml, <em>p</em> <!-->=<!--> <!-->0.048; 0.85 vs 19<!--> <!-->pg/ml, <em>p</em> <!--><<!--> <!-->0.001, respectively). Granulocyte-macrophage colony-stimulating factor (GM-CSF) levels were significantly lower in the AB group than in the AC group (1.2 vs 4.4<!--> <!-->pg/ml, <em>p</em> <!--><<!--> <span>0.001). IL-8, neutrophil elastase and TNF-α did not present significant differences between the groups.</span></div></div><div><h3>Conclusions</h3><div><span>Raised levels of TGFβ1 and VEGF cytokines may indicate airway remodeling activation in asthma patients with bronchiectasis. The type of inflammation in asthma patients did not differ according to the presence or </span>absence of bronchiectasis.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 682-689"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transbronchial Cryobiopsy Versus Transbronchial Forceps Biopsy for Acute Cellular Rejection Detection in Lung Transplantation: A Meta-Analysis","authors":"","doi":"10.1016/j.arbres.2024.06.006","DOIUrl":"10.1016/j.arbres.2024.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Transbronchial cryobiopsy (TBCB) provides larger tissue samples and improved sampling depth, but its role in diagnosing acute cellular rejection (ACR) in lung transplant patients is unclear due to limitations in existing studies. To address this, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of TBCB.</div></div><div><h3>Methods</h3><div>A thorough literature review was conducted to evaluate TBCB in post-lung transplant surveillance, assessing the quality of studies and conducting a meta-analysis comparing diagnostic yields of TBCB and transbronchial forceps biopsy (TBFB), as well as evaluating procedural complications.</div></div><div><h3>Results</h3><div>Our meta-analysis, incorporating 11 studies with a total of 915 patients, showed that TBCB had a diagnostic rate of 38.27% (225/588) for ACR post-lung transplantation, notably higher than the 35.65% (251/704) for TBFB. The inverse-variance weighted odds ratio was calculated at 2.32 (95% confidence interval: 1.24–4.32; <em>p</em> <!-->=<!--> <span>0.008). Funnel plot analysis indicated no major publication bias. Meta-analysis of 6 studies demonstrated that TBCB, compared to TBFB, significantly increased the diagnostic rate for chronic rejection post-transplantation (25.00% vs 10.93%, </span><em>p</em> <!-->=<!--> <!-->0.005). Our meta-analysis comparing the safety of TBCB and TBFB in post-lung transplant surveillance found no significant differences in moderate to severe bleeding (5.99% vs 6.31%, <em>p</em> <!-->=<!--> <!-->0.98), or pneumothorax incidence (3.90% vs 3.29%, <em>p</em> <!-->=<!--> <!-->0.75).</div></div><div><h3>Conclusions</h3><div>Our study indicates that TBCB may enhance the diagnosis of acute and chronic rejection post-lung transplantation with a safety profile comparable to TBFB. Further research and the development of standardized procedures are warranted to ensure the safe and effective application of TBCB in broader clinical practice.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 698-704"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BiPAP as a Possible Treatment in Patients With Diaphragmatic Flutter","authors":"","doi":"10.1016/j.arbres.2024.06.011","DOIUrl":"10.1016/j.arbres.2024.06.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 721-722"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fia Sabrina Boedijono , Verena Bood , Ilse A. Eichhorn , Philip M. Hansbro , Dirk-Jan Slebos , Maarten van den Berge , Alen Faiz , Simon D. Pouwels
{"title":"Identification of Genetic Factors Associated With DAMP Release in COPD Patients","authors":"Fia Sabrina Boedijono , Verena Bood , Ilse A. Eichhorn , Philip M. Hansbro , Dirk-Jan Slebos , Maarten van den Berge , Alen Faiz , Simon D. Pouwels","doi":"10.1016/j.arbres.2024.06.020","DOIUrl":"10.1016/j.arbres.2024.06.020","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 714-717"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiotypes in COPD: a pro/con debate","authors":"Alvar Agusti , Marc Miravitlles","doi":"10.1016/j.arbres.2024.08.002","DOIUrl":"10.1016/j.arbres.2024.08.002","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"60 11","pages":"Pages 678-681"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}