Giulia Raffaella De Luca, Stefano Diciotti, Mario Mascalchi
{"title":"The Pivotal Role of Baseline LDCT for Lung Cancer Screening in the Era of Artificial Intelligence.","authors":"Giulia Raffaella De Luca, Stefano Diciotti, Mario Mascalchi","doi":"10.1016/j.arbres.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.11.001","url":null,"abstract":"<p><p>In this narrative review, we address the ongoing challenges of lung cancer (LC) screening using chest low-dose computerized tomography (LDCT) and explore the contributions of artificial intelligence (AI), in overcoming them. We focus on evaluating the initial (baseline) LDCT examination, which provides a wealth of information relevant to the screening participant's health. This includes the detection of large-size prevalent LC and small-size malignant nodules that are typically diagnosed as LCs upon growth in subsequent annual LDCT scans. Additionally, the baseline LDCT examination provides valuable information about smoking-related comorbidities, including cardiovascular disease, chronic obstructive pulmonary disease, and interstitial lung disease (ILD), by identifying relevant markers. Notably, these comorbidities, despite the slow progression of their markers, collectively exceed LC as ultimate causes of death at follow-up in LC screening participants. Computer-assisted diagnosis tools currently improve the reproducibility of radiologic readings and reduce the false negative rate of LDCT. Deep learning (DL) tools that analyze the radiomic features of lung nodules are being developed to distinguish between benign and malignant nodules. Furthermore, AI tools can predict the risk of LC in the years following a baseline LDCT. AI tools that analyze baseline LDCT examinations can also compute the risk of cardiovascular disease or death, paving the way for personalized screening interventions. Additionally, DL tools are available for assessing osteoporosis and ILD, which helps refine the individual's current and future health profile. The primary obstacles to AI integration into the LDCT screening pathway are the generalizability of performance and the explainability.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Walking Assistance in a Patient with Chronic Obstructive Pulmonary Disease Using a Powered Exoskeleton: A Case Report.","authors":"Zhongkai Kuai, Fei Zhao, Dan Zeng","doi":"10.1016/j.arbres.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.012","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuel Casal-Guisande, Cristina Represas-Represas, Rafael Golpe, Alberto Fernández-García, Almudena González-Montaos, Alberto Comesaña-Campos, Alberto Ruano-Raviña, Alberto Fernández-Villar
{"title":"Clinical and Social Characterization of Patients Hospitalized for COPD Exacerbation Using Machine Learning Tools.","authors":"Manuel Casal-Guisande, Cristina Represas-Represas, Rafael Golpe, Alberto Fernández-García, Almudena González-Montaos, Alberto Comesaña-Campos, Alberto Ruano-Raviña, Alberto Fernández-Villar","doi":"10.1016/j.arbres.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.010","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to employ machine learning (ML) tools to cluster patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) based on their diverse social and clinical characteristics. This clustering is intended to facilitate the subsequent analysis of differences in clinical outcomes.</p><p><strong>Methods: </strong>We analysed a cohort of patients with severe COPD from two Pulmonary Departments in north-western Spain using the k-prototypes algorithm, incorporating demographic, clinical, and social data. The resulting clusters were correlated with metrics such as readmissions, mortality, and place of death. Additionally, we developed an intelligent clinical decision support system (ICDSS) using a supervised ML model (Random Forest) to assign new patients to these clusters based on a reduced set of variables.</p><p><strong>Results: </strong>The cohort consisted of 524 patients, with an average age of 70.30±9.35 years, 77.67% male, and an average FEV<sub>1</sub> of 44.43±15.4. Four distinct clusters (A-D) were identified with varying clinical-demographic and social profiles. Cluster D showed the highest levels of dependency, social isolation, and increased rates of readmissions and mortality. Cluster B was characterized by prevalent cardiovascular comorbidities. Cluster C included a younger demographic, with a higher proportion of women and significant psychosocial challenges. The ICDSS, using five key variables, achieved areas under the ROC curve of at least 0.91.</p><p><strong>Conclusions: </strong>ML tools effectively facilitate the social and clinical clustering of patients with severe COPD, closely related to resource utilization and prognostic profiles. The ICDSS enhances the ability to characterize new patients in clinical settings.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MeiLan K Han, Michal Shteinberg, Deborah Assayag, Florence Schleich, Martino Pengo, Victoria M Scicluna, Carolina Lombardi, Miriam Barrecheguren, Luis Jara-Palomares
{"title":"Respiratory Diseases in Women.","authors":"MeiLan K Han, Michal Shteinberg, Deborah Assayag, Florence Schleich, Martino Pengo, Victoria M Scicluna, Carolina Lombardi, Miriam Barrecheguren, Luis Jara-Palomares","doi":"10.1016/j.arbres.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.009","url":null,"abstract":"<p><p>Respiratory diseases exhibit diverse patterns in prevalence, clinical presentations, and outcomes between men and women. Historically, certain conditions were more prevalent in men, but trends have shifted, highlighting the need to understand sex disparities in respiratory health. Social, environmental, and healthcare changes have reshaped the landscape of respiratory diseases, complicating diagnosis and treatment. Moreover, the underrepresentation of women in clinical trials has limited our understanding of their specific needs. In this review, we explore the sex differences in the prevalence, clinical characteristics, and presentation of respiratory diseases, emphasizing the importance of tailored approaches to diagnosis and management. By recognizing and addressing these disparities, we can advance toward more equitable and effective respiratory healthcare for all individuals.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Gorospe, Rut Romera-Sánchez, Gemma María Muñoz-Molina
{"title":"A Thoracic Complication of an Abdominal Procedure: Massive Hemothorax Following Percutaneous Transhepatic Portal Vein Angioplasty.","authors":"Luis Gorospe, Rut Romera-Sánchez, Gemma María Muñoz-Molina","doi":"10.1016/j.arbres.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucia Cayuela, Anna Michela Gaeta, Remedios Otero, Luis Jara-Palomares, Isabel Mendo Pedrajas, Aurelio Cayuela
{"title":"Regional Disparities and Trends in Venous Thromboembolism Mortality in Spain (1999-2022).","authors":"Lucia Cayuela, Anna Michela Gaeta, Remedios Otero, Luis Jara-Palomares, Isabel Mendo Pedrajas, Aurelio Cayuela","doi":"10.1016/j.arbres.2024.10.015","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.015","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to analyze trends in venous thromboembolism (VTE) mortality in the Spanish Autonomous Communities (ACs) from 1999 to 2022, with a focus on identifying regional disparities and informing targeted public health interventions.</p><p><strong>Methods: </strong>Age-standardized mortality rates (ASMRs) were calculated using the European standard population as a reference. Joinpoint regression analysis was employed to identify significant changes in mortality trends, and geographical analysis was conducted using Bayesian inference to assess regional variations in mortality risk.</p><p><strong>Results: </strong>From 1999 to 2022, Spain recorded 59,515 VTE-related deaths, with a higher proportion in women (59.4%) compared to men (40.6%). On a nationwide scale, VTE ASMRs showed a general decline for both men and women, with rates decreasing from 11.0 to 5.1 per 100,000 in men and from 9.2 to 4.4 per 100,000 in women. However, this decline was not uniform across all regions or demographic groups. Notably, mortality rates among younger individuals, particularly men, increased during the study period, highlighting the need for targeted interventions. Analysis revealed significant regional disparities, with higher mortality risks observed in Extremadura, Aragon, Navarre, and Andalusia, particularly for women.</p><p><strong>Conclusions: </strong>This study provides valuable insights into the complex landscape of VTE mortality in Spain. While the overall decline in mortality is encouraging, persistent regional disparities and rising rates among younger individuals underscore the need for ongoing surveillance and targeted interventions.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Ignacio de Granda-Orive, Carlos A Jiménez-Ruiz, Mina Gaga
{"title":"The New Tobacco Companies Offensive: The Nicotine Pouches.","authors":"José Ignacio de Granda-Orive, Carlos A Jiménez-Ruiz, Mina Gaga","doi":"10.1016/j.arbres.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.017","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alba Naya-Prieto, María de Los Ángeles Zambrano, Maria Del Pilar Carballosa, Itziar Fernández Ormaechea, Carlos López Chang, Pablo Zazu López, Pedro Piñero Gutierrez, María Jesús Rodríguez-Nieto, Germán Peces-Barba Romero, Victoria Del Pozo, Sarah Heili-Frades
{"title":"A New Method Using Diaphragmatic Ultrasound to Monitor the Work of Breathing During Assisted and Controlled Non-Invasive Ventilation.","authors":"Alba Naya-Prieto, María de Los Ángeles Zambrano, Maria Del Pilar Carballosa, Itziar Fernández Ormaechea, Carlos López Chang, Pablo Zazu López, Pedro Piñero Gutierrez, María Jesús Rodríguez-Nieto, Germán Peces-Barba Romero, Victoria Del Pozo, Sarah Heili-Frades","doi":"10.1016/j.arbres.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.014","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonography-Guided Mediastinal Cryobiopsy in the Diagnosis of Mediastinal Diseases: Case Reports of 200 Cases.","authors":"Esperanza Salcedo Lobera, Mario Garcia Garcia, Macarena Arroyo Varela, Rocio Bautista Moreno","doi":"10.1016/j.arbres.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.arbres.2024.10.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}