Daniela I García Cortés, Irvin Ordoñez-González, Airam A Burboa Hernández, Marco A Murillo-Maldonado, Stanislaw Sadowinski-Pine, María A Escobar Sánchez
{"title":"Growing teratoma syndrome in pediatrics.","authors":"Daniela I García Cortés, Irvin Ordoñez-González, Airam A Burboa Hernández, Marco A Murillo-Maldonado, Stanislaw Sadowinski-Pine, María A Escobar Sánchez","doi":"10.5546/aap.2026-11069.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11069.eng","url":null,"abstract":"<p><p>Growing teratoma syndrome (GTS), described by Logothetis in 1982, is characterized by the appearance of benign tumor lesions during or after chemotherapy for germ cell tumors, with normalized tumor markers. It is rare in pediatrics; in Mexico, there have been no previous reports of this condition in girls. We present an 8-year-old girl with abdominal distension, colicky pain, and constipation; a CT scan revealed a mass in the right ovary, a liver lesion, and intra-abdominal fluid. Cytoreductive surgery revealed an immature teratoma with neuroglial implants. She was diagnosed with stage IV mixed germ cell tumor; chemotherapy was initiated. Given the persistence of a residual mass with normalized tumor markers, laparotomy confirmed mixed germ cell tumor. Since complete resection was not possible, close monitoring was decided upon; she remains stable at 11 months. GTS should be considered in pediatric germ cell tumors with tumor growth and normalized markers. Surveillance is a valid alternative in unresectable cases.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611069"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Social determinants of health and biological embedding: From the social gradient to epigenetics in the DOHaD context.","authors":"Laura G Strada","doi":"10.5546/aap.2026-11116.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11116.eng","url":null,"abstract":"<p><p>Current evidence shows that social and environmental conditions present from the earliest stages of life can influence health and disease trajectories. From the perspective of the DOHaD (developmental origins of health and disease) paradigm, the social determinants of health interact with nutritional, environmental, toxic, and psychosocial factors during periods of high biological plasticity, especially during the first 1000 days of life, modulating developmental programming processes. This view is supported by the social gradient in health, which shows a progressive worsening of morbidity and mortality as socioeconomic status declines. Based on these observations, the biological embedding hypothesis and social epigenetics have helped us understand how early-life experiences can influence human biology, providing evidence of molecular mechanisms linked to changes in DNA methylation patterns.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611116"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bibliometric analysis of publications in Archivos Argentinos de Pediatría (2021-2025).","authors":"Carina Goya, Solana Rapaport, María E Serra","doi":"10.5546/aap.2026-11149.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11149.eng","url":null,"abstract":"<p><p>A bibliometric study was conducted on the publications of Archivos Argentinos de Pediatría between 2021 and 2025 to describe its editorial output, the types of articles, the institutional composition of authorship and collaboration, the thematic distribution, and the impact of the publications as measured by citations. A total of 717 articles were included. Clinical case reports predominated, followed by original articles, which accounted for 25% of the publications. The original studies were primarily descriptive observational studies, with a low proportion of international funding and collaboration. The research output was concentrated mainly in the fields of infectious diseases, general pediatrics, and medical education. Citation analysis revealed generally modest levels. These results help characterize the journal's recent profile.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611149"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Liver involvement in hemolytic anemias.","authors":"Fernando Álvarez, Mirta Ciocca","doi":"10.5546/aap.2026-11059.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11059.eng","url":null,"abstract":"<p><p>Hemolytic anemias in childhood comprise a heterogeneous group of hereditary and acquired diseases that may be associated with liver involvement through multiple mechanisms. Chronic hemolysis leads to a sustained increase in unconjugated bilirubin, with a risk of pigmentary cholelithiasis; ineffective erythropoiesis and repeated transfusions contribute to iron overload and the development of chronic liver disease. In certain conditions, such as sickle cell anemia, vaso-occlusive events can cause acute and chronic liver damage. Furthermore, there are well-documented associations between autoimmune hemolytic anemias and immune-mediated liver diseases. This review analyzes the main types of hemolytic anemia associated with liver disease in children, including thalassemias, hereditary spherocytosis and elliptocytosis, sickle cell anemia, pyruvate kinase deficiency, and autoimmune hemolytic anemias. The review describes pathophysiological mechanisms, clinical and biochemical manifestations, diagnosis, treatment, and follow-up. Early recognition of liver involvement allows for optimized treatment and the prevention of potentially serious complications.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611059"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgina Pintado Tovar, Mireya Robledo Aceves, Alejandro Barrón Balderas, América A Corona Gutiérrez, Eva E Camarena Pulido
{"title":"Clinical and hematological predictors of severity in pediatric patients with Centruroides scorpion stings.","authors":"Georgina Pintado Tovar, Mireya Robledo Aceves, Alejandro Barrón Balderas, América A Corona Gutiérrez, Eva E Camarena Pulido","doi":"10.5546/aap.2026-11112.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11112.eng","url":null,"abstract":"<p><p>Introduction. In Mexico, scorpion stings are the leading cause of death from contact with venomous animals among children under 5 years of age. Despite a decline in mortality over the past 20 years, this remains a public health problem. The objective of this study was to describe the correlation between the severity of scorpion sting poisoning and the age, anthropometric profile, and hematological profile of pediatric patients treated in the emergency department. Population and methods. Descriptive, cross-sectional, analytical study. Variables such as age, sex, bite location, signs and symptoms, weight, height, body mass index, white blood cell count, and platelet count were analyzed, along with their correlation with the severity of poisoning using Spearman's correlation. Differences between severity groups were assessed using the Kruskal-Wallis test, and the strength of association of the independent variables was evaluated using ordinal logistic regression, with a significance level of p <0.05. Results. A total of 349 patients stung by scorpions of the genus Centruroides were analyzed over 10 years. A negative correlation was observed between age, weight, and height and the severity of poisoning (p = 0.001); that is, the younger the patient and the lower their weight and height, the greater the severity of poisoning. A positive correlation was also observed between an increase in white blood cell count and severity (p = 0.001). Conclusion. In the multivariate analysis, young age was confirmed as an independent determinant of the severity of poisoning. Leukocytosis is a marker of severe poisoning.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611112"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guillermo Kohn-Loncarica, Josefina Pérez, Gustavo A González, Roberto Jabornisky, Luis H Llano, Ana L Fustiñana
{"title":"Recommendations for the initial management of septic shock in children.","authors":"Guillermo Kohn-Loncarica, Josefina Pérez, Gustavo A González, Roberto Jabornisky, Luis H Llano, Ana L Fustiñana","doi":"10.5546/aap.2025-10926.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10926.eng","url":null,"abstract":"<p><p>We present an update on recommendations for managing septic shock in the emergency department during the \"golden hour,\" highlighting the importance of early recognition and rapid implementation of therapeutic measures to reduce morbidity and mortality. It includes specific diagnostic criteria (the Phoenix Sepsis Scale), which improve the identification of sepsis and septic shock, although their usefulness in the initial stage is limited. This update covers strategies for hemodynamic support, airway management, individualized ultrasound-guided fluid therapy, and the safe use of vasoactive drugs administered via peripheral routes. It emphasizes the importance of administering antibiotics within the first hour. Incorporating these elements into institutional protocols helps optimize initial treatment in the emergency department, even in settings with limited resources. It serves as a key tool for improving the prognosis in pediatric patients with sepsis.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510926"},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cystic hydatid disease of the liver and lungs in Peruvian children: Clinical and surgical profile and associated factors in 219 cases (2014-2023).","authors":"Oscar Pantoja-Rivera, Pedro Navarrete-Mejía","doi":"10.5546/aap.2026-11043.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11043.eng","url":null,"abstract":"<p><p>Introduction. Cystic echinococcosis is a major zoonotic disease from a public health perspective, with a high prevalence in rural areas of Peru. We analyzed the clinical characteristics and surgical treatment of hepatic and pulmonary cases in children from 2014 to 2023. Population and methods. This was a retrospective, cross-sectional study of 219 children diagnosed through imaging. The study evaluated sociodemographic variables (sex, rural origin, educational level, and parental occupation), clinical variables (symptoms, cyst location), surgical variables, and complications. Descriptive analysis, Pearson's chi-square test, and multivariate logistic regression were performed to assess location, independent predictive factors, and complications. Results. The disease predominantly affected males from rural or marginal urban areas. The most common symptoms were cough, abdominal pain, chest pain, and weight loss. In most cases, surgery was elective, with a short mean hospital stay and zero mortality. Complications were rare, such as biliary fistulas/liver abscesses and pneumothorax, with a higher risk in cases involving multiple cysts. Pulmonary involvement was associated with rural origin and contact with dogs. Contact with dogs, herding, and low socioeconomic status were identified as predictors of cystic echinococcosis; concurrent pulmonary and hepatic cysts and a diagnostic delay of >90 days were identified as predictors of complications. Conclusion. The disease is linked to rural poverty and zoonotic exposures (dogs, grazing), with clinical profiles that vary depending on the location of the cysts and higher morbidity in cases involving both the lungs and liver, with a predominance of pulmonary cysts. Zoonotic and social determinants are more significant than classic demographic factors. Surgical treatment combined with albendazole proved highly effective.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611043"},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between pediatric counseling and after school physical activity in children: A cross-sectional study.","authors":"Pablo G Dei-Cas, Ignacio J Dei-Cas","doi":"10.5546/aap.2026-11098.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11098.eng","url":null,"abstract":"<p><p>Introduction. Physical activity during childhood is essential for health; however, current recommendations are often not met. The effectiveness of pediatric advice in clinical practice is uncertain. Objective. To evaluate the association between pediatric advice and after-school physical activity in children, and to analyze the influence of demographic, anthropometric, and family factors. Population and methods. Observational, cross-sectional study. Children aged 7 to 14 years were included. The association between a history of pediatric counseling and the practice of after-school physical activity was evaluated. Pediatric counseling was defined as a history of receiving recommendations from a pediatrician aimed at promoting physical activity and was obtained through parental self-report. Univariate analysis and multivariate logistic regression were performed. The nonlinear relationship with body mass index (BMI) was explored, and a sensitivity analysis was conducted using 1:1 propensity score matching (PSM). Results. A total of 823 children (mean age 10.2 ± 2.3 years) were included; 35.2% engaged in physical activity. No significant association was observed between pediatric advice and physical activity (OR 1.38; 95%CI 0.98-1.94; p = 0.061). Male gender and parental physical activity during childhood were significantly associated with higher levels of physical activity. A nonlinear relationship between BMI and physical activity was observed. In the PSM analysis, the association remained nonsignificant (OR 1.49; 95%CI 0.99-2.22; p = 0.053). Conclusion. Pediatric counseling in routine clinical practice is not independently associated with physical activity in children. Structured, multi-component strategies are needed.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611098"},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast disorders in adolescence: Etiological, clinical, and therapeutic aspects.","authors":"Jessie N Zurita Cruz, Juana Serret Montoya, Ofelia Mendoza Rojas, Isabel Colunga Olvera, Guillermo Fojaco Villanueva, Mónica Zavala Serret","doi":"10.5546/aap.2025-10820.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10820.eng","url":null,"abstract":"<p><p>Introduction. Breast diseases in adolescents are rare and generally benign, although their treatment can be complex. Objective. To describe the etiology, clinical presentation, and therapeutic management of adolescents with breast conditions at a tertiary care hospital. Population and methods. Retrospective case series study. The study included patients aged 10 to 18 years with suspected breast pathology who were treated between 2020 and 2024. Clinical and treatment data, as well as information on comorbidities, were collected. Results. A total of 127 patients were analyzed (median age: 16 years); 80 were female. In females, benign tumors predominated, primarily fibroadenomas, and 29 required surgery. In males, pubertal gynecomastia was the most common finding (n = 33), and secondary cases associated with hypogonadism or medication use were identified; 11 required surgery. Conclusion. Fibroadenomas were most common in girls, and gynecomastia in boys. The identification of secondary causes underscores the need for a comprehensive evaluation and targeted treatment.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510820"},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana L Fustiñana, Tomás Giménez, Julia R Echeveste, María P Veiga, Danila A Curto, María G Yannuzzi, Sofía Piantanida, Leandro J Pastori, Gabriela S Hualde, Guillermo Kohn-Loncarica, Pedro B Rino
{"title":"Validation of the Canadian Pediatric Triage and Acuity Scale in the Emergency Department of a pediatric hospital in Argentina.","authors":"Ana L Fustiñana, Tomás Giménez, Julia R Echeveste, María P Veiga, Danila A Curto, María G Yannuzzi, Sofía Piantanida, Leandro J Pastori, Gabriela S Hualde, Guillermo Kohn-Loncarica, Pedro B Rino","doi":"10.5546/aap.2026-11032.eng","DOIUrl":"https://doi.org/10.5546/aap.2026-11032.eng","url":null,"abstract":"<p><p>Introduction. Overcrowding in pediatric emergency departments (PEDs) affects the quality of care. Triage is a strategy for optimizing this situation. Although validated systems exist, few have been validated in Latin America. This study evaluates the validity of the CPTAS (Canadian Pediatric Triage and Acuity Scale), as adapted for use in our center's PED, in predicting hospitalization and resource utilization. Materials and methods. A retrospective validation study of a randomized sample of visits classified by triage at the Emergency Department (from April 2021 to February 2022). The relationship between urgency level, hospital admission, and resource utilization was evaluated. Results. A total of 56 843 consultations were classified; 1500 were randomly selected, and 1159 were analyzed. The overall need for hospitalization was 15.27% and varied by urgency level: 100% for level 1, 61.48% for level 2, 13.67% for level 3, 3.38% for level 4, and 3.85% for level 5 (p <0.01). The odds ratio (OR) for admission was 49.15 (95%CI: 26.51-91.10) for levels 2 and 5, and 5.23 (95%CI: 2.97-9.19) for level 3 (p <0.01); AUC 0.83; five patients were admitted to the Intensive Care Unit, and no deaths were recorded. The use of ≥2 resources was 50% (level 1), 42.96% (level 2), 19.60% (level 3), 10.63% (level 4), and 1.92% (level 5) (p <0.01); and levels 2 and 3 showed a higher OR (p <0.01). Conclusion. The adapted CPTAS scale performed well in assessing urgency at our institution, and its use could be considered at other centers in the region.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611032"},"PeriodicalIF":0.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}