Voriconazole-associated peripheral polyneuropathy: A case report.

Abstract

Invasive fungal infections, especially aspergillosis, severely affect immunocompromised patients. The use of azoles, particularly voriconazole, has been considered an effective antifungal therapy for the treatment of these infections and prevention. However, cases of peripheral neuropathy have been reported in patients treated with this drug. We present two clinical cases of patients with immunocompromise (acute myeloblastic leukemia and primary immunodeficiency) who, during treatment with voriconazole, developed peripheral sensory motor axonal polyneuropathy, which completely resolved after discontinuation of the medication. Given the rapid resolution of the clinical manifestations after discontinuation of the drug, we consider it essential to keep this neurotoxicity in mind as a differential diagnosis in children exposed to multiple medications.