{"title":"Autoimmune hemolytic anemia due to biphasic Donath-Landsteiner hemolysin: a diagnostic challenge.","authors":"Laura Castro, Carolina Davenport","doi":"10.5546/aap.2024-10575.eng","DOIUrl":"https://doi.org/10.5546/aap.2024-10575.eng","url":null,"abstract":"<p><p>Autoimmune hemolytic anemia due to Donath-Landsteiner biphasic hemolysin represents a real diagnostic challenge due to its low frequency and the complex methodology involved in the test used to confirm it. It usually presents abruptly in previously healthy children, secondary to a viral infection. The symptoms derived from the intense intravascular hemolysis are often confused with sepsis. Although its evolution is self-limited and has a good prognosis, it usually causes prolonged hospitalization with potential morbidity due to the performance of complementary tests and unnecessary treatments. The case of a child diagnosed with autoimmune hemolytic anemia secondary to biphasic hemolysin is presented to highlight the importance of timely diagnosis for adequate treatment.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410575"},"PeriodicalIF":0.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Respiratory distress syndrome in preterm newborns: current recommendations.","authors":"Javier Meritano","doi":"10.5546/aap.2025-10721.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10721.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510721"},"PeriodicalIF":0.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of meconium-stained amniotic fluid from birth to childhood: Adverse or protective effects?","authors":"Norma E Rossato, Néstor E Vain","doi":"10.5546/aap.2025-10742.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10742.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510742"},"PeriodicalIF":0.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Alconcher, Lucas Lucarelli, Sabrina Bronfen, Fernanda Villarreal, Marcela Tombesi
{"title":"Predictors of spontaneous resolution of prenatally detected primary non-refluxing megaureter: A retrospective cohort study.","authors":"Laura Alconcher, Lucas Lucarelli, Sabrina Bronfen, Fernanda Villarreal, Marcela Tombesi","doi":"10.5546/aap.2024-10583.eng","DOIUrl":"https://doi.org/10.5546/aap.2024-10583.eng","url":null,"abstract":"<p><p>Introduction. Obstetric ultrasonography increased the detection of primary megaureters (PM); the most common type is non-refluxing, with a tendency to spontaneous resolution. Objectives. To determine predictors and time to spontaneous resolution and incidence of urinary tract infection (UTI) with and without antibiotic prophylaxis (AP). Population and methods. Retrospective cohort. The PM was defined as an anteroposterior diameter (APD) of the retrovesical ureter ≥7 mm, with or without pelvic dilatation (≥10 mm), at the first postnatal ultrasound. Spontaneous resolution was the absence of dilatation or a ureter APD <7 mm and pelvis <10 mm. Results. Seventy patients presented with PM, 15 bilateral. Of the 85 PM, 53 (62%) resolved spontaneously. In these patients, the ureter and pelvic APD at the first postnatal ultrasound were lower than those requiring surgery (p = 0.0001). A ureteral APD ≥10 mm and pelvic APD ≥15 mm increased the risk of surgery 2.63 and 4.57 times, respectively. The median time to spontaneous resolution was 6 and 33 months for ureters with APD < or ≥10 mm (p = 0.009) respectively. The incidence of UTI in the first year was 0.21. There were 7/22 children with AP and 7/44 without AP. Conclusion. Two-thirds of the MPs resolved spontaneously in a median of 6 months, with ureter and pelvic APD at birth being predictors. The incidence of UTI was 0.21; it was more frequent in more dilated ureters.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410583"},"PeriodicalIF":0.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent validity and reliability of the Pediatric Postural Balance Scale in Chilean preschool and school-aged children with typical development.","authors":"Stephanie Vanneste-Fierro, Mauricio Barramuño, Omar Andrade-Mayorga, Pamela Lavados-Romo","doi":"10.5546/aap.2024-10276.eng","DOIUrl":"https://doi.org/10.5546/aap.2024-10276.eng","url":null,"abstract":"<p><p>Introduction. The pediatric postural balance scale (PBS) is a valuable clinical tool for assessing postural balance in preschool and school-aged children with typical or atypical development. Objective. To assess the PBS's concurrent validity and inter-rater reliability in Chilean preschoolers and schoolchildren with typical development. Population and methods. Two hundred and three preschool and school children aged 4 to 11 (7.6 ± 2.1 years, 56.2% males) from public and private schools participated in a cross-sectional validation study. Postural balance was evaluated with PBS and postural oscillography, considering maximum lateral velocity (MLV), maximum anteroposterior velocity (MAPV), mean total velocity (MTV), mean radius (MR), and center of pressure area (COP area). Anthropometric parameters and socioeconomic level were measured. Results. The inter-rater reliability for the PBS with the intraclass correlation coefficient was 0.99 (95%CI: 0.990-0.997). There were weak inverse correlations between PBS total score and oscillography (MLV, MAPV, MTV, MR, and COP area) in the 4- to 6-year age group, standing out the correlations of mean radius (rho: -0.36; p 0.002) and COP area (Rho: -0.37; p 0.001). Conclusion. These results suggest that the PBS provides a very strong inter-rater reliability and a weak inverse correlation between the PBS total score and postural oscillography measures in the 4- to 6-yearold age group. Therefore, using PBS is recommended primarily in preschoolers and school children between 4 and 6 years of age.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410276"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Are Your Kidneys Ok?\"","authors":"Sandra Martin","doi":"10.5546/aap.2025-10707.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10707.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510707"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Cabanillas, María N Tahuil, Carolina Bouso, Astrid Schellnast Faure, Gabriela Belardinelli, Laura Del Pino, Celeste Ballester, Ileana Moreira, Laura Sasia, Elma Nievas, Lucía Tarquini, Luz Martin, Lucía Caputi, Denise Menard, Agostina Llarens, Lucía Peirano, Luciano Urdinez, Ignacio Uriarte, Daniela Di Giovanni, Andrea Gómez Raccio, Victor Skrie, Miguel Galicchio, Julio C Orellana, Lorena Regairaz, Diana Liberatore, Mariana Villa
{"title":"[Challenges in the evaluation of patients with inborn errors of immunity following the implementation of the 20-valent pneumococcal conjugate vaccine].","authors":"Diana Cabanillas, María N Tahuil, Carolina Bouso, Astrid Schellnast Faure, Gabriela Belardinelli, Laura Del Pino, Celeste Ballester, Ileana Moreira, Laura Sasia, Elma Nievas, Lucía Tarquini, Luz Martin, Lucía Caputi, Denise Menard, Agostina Llarens, Lucía Peirano, Luciano Urdinez, Ignacio Uriarte, Daniela Di Giovanni, Andrea Gómez Raccio, Victor Skrie, Miguel Galicchio, Julio C Orellana, Lorena Regairaz, Diana Liberatore, Mariana Villa","doi":"10.5546/aap.2024-10632","DOIUrl":"https://doi.org/10.5546/aap.2024-10632","url":null,"abstract":"<p><p>The advent of the 20-valent pneumococcal conjugate vaccine (PCV20) in Argentina is a tool to optimize the prevention of invasive pneumococcal disease. Nonetheless, this new vaccine has complicated the diagnosis of selective antibody deficiency (SAD), an inborn error of immunity characterized by an inadequate response to the polysaccharide antigens present in the 23-valent pneumococcal polysaccharide vaccine (PPSV23). The withdrawal of PPSV23 and the introduction of PCV20 hinder the evaluation of polysaccharide responses, given that PCV20 induces a T-dependent immune response. This review examines the current diagnostic criteria for SAD and the limitations of available diagnostic tests in the context of these vaccine changes. Alternative strategies for measuring polysaccharide antibodies are discussed, and the need to maintain PPSV23 availability for a specific patient cohort is emphasized.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410632"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Torres, Paula González Pannia, Manuel Rodríguez Tablado, María L Guerrero Giménez, María F Ossorio, Florencia Lucion, María N Pejito, Fernando Ferrero, Ángela Gentile
{"title":"Identification of healthcare visits due to respiratory syncytial virus infection in electronic medical records.","authors":"Fernando Torres, Paula González Pannia, Manuel Rodríguez Tablado, María L Guerrero Giménez, María F Ossorio, Florencia Lucion, María N Pejito, Fernando Ferrero, Ángela Gentile","doi":"10.5546/aap.2024-10618.eng","DOIUrl":"https://doi.org/10.5546/aap.2024-10618.eng","url":null,"abstract":"<p><p>Introduction. Acute lower respiratory infections (ALRI) due to respiratory syncytial virus (RSV) are a significant cause of disease. Most of them are treated outpatient without etiological investigation, making it difficult to estimate the disease burden. In 2020, an algorithm was developed to identify consultations for ALRI in electronic health records. We evaluated the algorithm's behavior in patients with RSV ALRI. Methods. The cross-sectional study included children under 5 years of age who consulted for ALRI with viral screening. The algorithm was applied to their health records, calculating diagnostic capacity to identify RSV ALRI. Results. We included 133 patients (age 4.9 ± 4.1 years). RSV was identified in 21.8%. The algorithm identified ALRI in 33.8% (95%CI: 26.3-42.2) and showed a limited ability to identify RSV infection (sensitivity: 55.2%, specificity: 72.1%). Conclusion. An algorithm for identifying ALRI consultations in electronic health records does not adequately distinguish those caused by RSV.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410618"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship of the Sociedad Argentina de Pediatría with the pharmaceutical industry and the producers of breastmilk substitutes.","authors":"Omar Tabacco","doi":"10.5546/aap.2025-10703.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10703.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510703"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Starting over.","authors":"Ernesto Alda","doi":"10.5546/aap.2025-10700.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10700.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510700"},"PeriodicalIF":0.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}