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A new hemoglobin cutoff value proposed by the World Health Organization: Its impact on the prevalence of anemia in children under 2 years of age. 世界卫生组织提出的新的血红蛋白临界值：其对2岁以下儿童贫血患病率的影响。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-10 DOI: 10.5546/aap.2025-10670.eng
Ana Varea, Liliana Disalvo, Marisa Sala, Natalia Matamoros, María V Fasano, Horacio F González
{"title":"A new hemoglobin cutoff value proposed by the World Health Organization: Its impact on the prevalence of anemia in children under 2 years of age.","authors":"Ana Varea, Liliana Disalvo, Marisa Sala, Natalia Matamoros, María V Fasano, Horacio F González","doi":"10.5546/aap.2025-10670.eng","DOIUrl":"10.5546/aap.2025-10670.eng","url":null,"abstract":"<p><p>Objective. Comparing the prevalence and severity of anemia according to the WHO 2011 and WHO 2024 cutoff points. Population and methods. Retrospective cross-sectional study. Hemoglobin data from children aged 6 to 24 months who underwent controls between 2017 and 2024 were analyzed. The prevalence and severity of anemia were established in all children, categorized by age group and sex. Results. A total of 1843 children were included, with 47.7% being girls. The prevalences of anemia were 46.9% (WHO, 2011) and 25.8% (WHO, 2024); they were higher in the 6-12 months group, with no differences according to sex. No child presented with severe anemia. Conclusion. Despite the decrease in the new cutoff point, anemia remains a significant public health issue affecting approximately 1 in 4 children aged 6 to 24 months who have accessed the public health system, in our region. Most of the cases were mild anemias.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510670"},"PeriodicalIF":0.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Musculoskeletal mucormycosis in a girl with acute lymphoblastic leukemia. 急性淋巴细胞白血病女孩的肌肉骨骼毛霉病。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-10 DOI: 10.5546/aap.2025-10681.eng
Daisi Vicentin, Eugenia Fernández Scotto
{"title":"Musculoskeletal mucormycosis in a girl with acute lymphoblastic leukemia.","authors":"Daisi Vicentin, Eugenia Fernández Scotto","doi":"10.5546/aap.2025-10681.eng","DOIUrl":"10.5546/aap.2025-10681.eng","url":null,"abstract":"<p><p>Mucormycosis is an aggressive fungal infection caused by fungi of the order Mucorales. Diagnosis is based on histopathological identification of microorganisms and culture confirmation. In case of suspicion, early surgical debridement and early antifungal therapy are recommended. The diagnosis and treatment of these infections pose a significant challenge, especially in pediatrics. Initial nonspecific clinical variability leads to late diagnosis. Their suspicion requires urgent intervention due to their rapid progression; late initiation of therapy is associated with higher mortality. We describe the case of a girl with acute lymphoblastic leukemia and steroid-induced diabetes who presented with a Rhizopus spp. infection in the deltoid muscle during the induction phase of oncologic treatment, with bone involvement.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510681"},"PeriodicalIF":0.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune liver disease in pediatrics: its association with extrahepatic autoimmune diseases. 儿科自身免疫性肝病：与肝外自身免疫性疾病的关系
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10672.eng
Emilia B Cepeda Calero, María B Pallitto, Gustavo Boldrini
{"title":"Autoimmune liver disease in pediatrics: its association with extrahepatic autoimmune diseases.","authors":"Emilia B Cepeda Calero, María B Pallitto, Gustavo Boldrini","doi":"10.5546/aap.2025-10672.eng","DOIUrl":"10.5546/aap.2025-10672.eng","url":null,"abstract":"<p><p>ntroduction. Autoimmune liver disease is a chronic and progressive inflammatory pathology; it often requires organ transplantation. In pediatrics, although the incidence is low, a significant percentage of patients also present with associated extrahepatic autoimmune diseases. Diagnosis is based on elevated transaminases and immunoglobulins, the presence of autoantibodies, and specific histological findings, with the absence of other known liver pathologies. Objective. To determine the prevalence of extrahepatic autoimmune diseases in pediatric patients with autoimmune liver disease, to describe the relationship between these entities, and to evaluate possible clinical and laboratory differences at diagnosis between patients with and without associated extrahepatic autoimmune diseases. Population and methods. Retrospective study that analyzed pediatric patients diagnosed with autoimmune liver disease between 2000 and 2022 in a tertiary-level hospital. Results. A total of 139 patients were included, with 62.6% being women. The median age at diagnosis was 7.3 years. The most frequent type of autoimmune hepatitis was type 1 (74.8%). An associated extrahepatic disease was present in 41.7% of patients; ulcerative colitis was the most common (39.7%), followed by celiac disease (20.7%) and hypothyroidism (12.1%). Ulcerative colitis was present in 73.3% of patients with autoimmune sclerosing cholangitis. Patients without associated autoimmune extrahepatic disease required liver transplantation more frequently (18.5%) than those with associated extrahepatic disease (5.2%). Conclusion. The study shows a high prevalence of extrahepatic autoimmune diseases in children with autoimmune liver disease. Ulcerative colitis is the most frequent, especially in cases of autoimmune sclerosing cholangitis.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510672"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference values for anti-Müllerian hormone measured by electrochemiluminescence in a pediatric population in Argentina. 用电化学发光法测定阿根廷儿童人群中抗<s:1>勒氏杆菌激素参考值。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10653.eng
Mariana Ochetti, Liliana K Silvano, Verónica Campi, Gabriela M Sobrero, Cintia S Tarifa, Silvia E Martin, Adriana Boyanovsky, Constanza Pelliza, Laura Castro, Noemí L Muñoz, Mirta B Miras
{"title":"Reference values for anti-Müllerian hormone measured by electrochemiluminescence in a pediatric population in Argentina.","authors":"Mariana Ochetti, Liliana K Silvano, Verónica Campi, Gabriela M Sobrero, Cintia S Tarifa, Silvia E Martin, Adriana Boyanovsky, Constanza Pelliza, Laura Castro, Noemí L Muñoz, Mirta B Miras","doi":"10.5546/aap.2025-10653.eng","DOIUrl":"10.5546/aap.2025-10653.eng","url":null,"abstract":"<p><p>Introduction. Anti-Müllerian hormone (AMH) is a specific marker of gonadal Sertoli cells, usually used for the diagnosis of disorders of sexual development. Currently, automated methods for measuring AMH are routinely incorporated into clinical laboratories. Objective. To obtain reference values of AMH in a population of healthy neonates and infants using an electrochemiluminescent immunoassay (ECLIA). Population and methods. We analyzed 599 serum samples from healthy neonates and infants (F = 296, M = 303) aged 2 to 291 days, with a distribution as follows: ≤15 days (n = 352) and >15 days (n = 247). An ECLIA-Roche™ assay determined AMH. AMH distribution percentiles were calculated using the Bootstrap method. Results. AMH values (ng/mL) in neonates and infants were: M: (≤15 days: P2.5: 27.5; P97.5: 118.3; >15 days: P2.5: 13.9; P97.5: 186.0. F: ≤15 days: P2.5: 0.03; P97.5: 4.00; >15 days: P2.5: 0.03; P97.5: 11.5. Conclusion. Our work provides reference values of AMH according to age and sex, facilitating its appropriate clinical use in the endocrinological evaluation of a population. The results obtained are consistent with previous studies, which show that AMH values are elevated at birth in males, reflecting the expression of Sertoli cell functionality.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510653"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterotopic brain tissue, an unexpected reason for feeding difficulty. 脑组织异位，意外导致进食困难。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10651.eng
Wei Mo, Shixi Liu, Hui Yang, Haiyang Wang
{"title":"Heterotopic brain tissue, an unexpected reason for feeding difficulty.","authors":"Wei Mo, Shixi Liu, Hui Yang, Haiyang Wang","doi":"10.5546/aap.2025-10651.eng","DOIUrl":"10.5546/aap.2025-10651.eng","url":null,"abstract":"<p><p>Feeding difficulty is common in the infant; the causes are varied and often multifactorial, resulting from a confluence of comorbid conditions. Heterotopic brain tissue is an unexpected reason for feeding difficulty, with approximately only 49 cases reported in the pharyngeal region. In this case report, we present a 2-month-old male infant with feeding difficulty, who was finally diagnosed as oropharyngeal heterotopic brain tissue. The patient underwent surgical excision; no functional disturbance of the oropharynx was found postoperatively. This study aims to enhance the comprehension, accurate diagnosis, and appropriate treatment of of feeding difficulty and pharyngeal heterotopic brain tissue by presenting an unusual case.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510651"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodevelopmental disorder with variable motor and language impairment (NEDMIAL): first case reported in Argentina. 神经发育障碍伴可变运动和语言障碍（NEDMIAL）：阿根廷首例报告病例。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10669.eng
Manuel Linares, Micaela Lambertucci, Mateo Castellani
{"title":"Neurodevelopmental disorder with variable motor and language impairment (NEDMIAL): first case reported in Argentina.","authors":"Manuel Linares, Micaela Lambertucci, Mateo Castellani","doi":"10.5546/aap.2025-10669.eng","DOIUrl":"10.5546/aap.2025-10669.eng","url":null,"abstract":"<p><p>Neurodevelopmental disorder with variable motor and language impairment (NEDMIAL) is a rare condition associated with mutations in the DHX30 gene, which encodes an RNA helicase involved in regulating the translation and stability of messenger RNA. Fewer than 110 cases worldwide have been documented, with no previous reports in Argentina. We present the case of an 11-month-old girl who was admitted to the hospital for acute gastroenteritis in the context of axial hypotonia since the first months of life, significant motor delay, and swallowing difficulties. After three years of multidisciplinary follow-up and after ruling out common causes of infantile hypotonia, a de novo mutation in DHX30 was confirmed, and the diagnosis of NEDMIAL was established. This case underscores the importance of early diagnosis and an interdisciplinary approach in the management of rare neurological diseases.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510669"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy-associated nephrotoxicity: a persistent clinical challenge. 化疗相关肾毒性：一个持续的临床挑战。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10666.eng
Miguel Liern
{"title":"Chemotherapy-associated nephrotoxicity: a persistent clinical challenge.","authors":"Miguel Liern","doi":"10.5546/aap.2025-10666.eng","DOIUrl":"10.5546/aap.2025-10666.eng","url":null,"abstract":"<p><p>In the last two years, the Nephrology Unit of our hospital recorded an increasing percentage of consultations corresponding to renal damage related to chemotherapy treatments. This increase could be attributed to more precise diagnoses, the development of targeted therapies, and improved survival rates. Chemotherapy prolongs and improves the lives of people with cancer, but it can also negatively affect renal function. Therefore, it is essential to detect predisposing nephrotoxic factors early, such as pre-existing renal damage, neoplastic renal infiltration, the presence of toxic metabolites, and the tubular transport system used by these drugs, with their consequent accumulation in the renal interstitium. It is essential to implement the renal prevention measures recommended in the context of chemotherapy treatment, to administer these drugs at the recommended doses, and to conduct strict clinical monitoring.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510666"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of medical students with children before taking the Pediatrics course. 医学生在上儿科学课程前与儿童的互动。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-07-03 DOI: 10.5546/aap.2025-10682.eng
Paula Domínguez, Alfredo Eymann, Fernando Torres, Alberto Rodríguez Pérez, Fernando Ferrero
{"title":"Interaction of medical students with children before taking the Pediatrics course.","authors":"Paula Domínguez, Alfredo Eymann, Fernando Torres, Alberto Rodríguez Pérez, Fernando Ferrero","doi":"10.5546/aap.2025-10682.eng","DOIUrl":"10.5546/aap.2025-10682.eng","url":null,"abstract":"<p><p>Introduction. In Pediatrics, communication involves children and their families. Students with the highest interaction with children can approach this subject with greater confidence. Objective. To assess the interaction with children of medical students in their daily lives and its correlation with confidence at the start of the Pediatrics course. Methods. A self-administered survey study of pediatric students of the School of Medicine of the Universidad de Buenos Aires inquired about the frequency of interaction with children under 12 years of age and confidence in this interaction. Results. A total of 286/450 responses were obtained. Only 27 students lived with children, and 14 were parents. Most had little interaction (1-2 times a year or less) with children (64% infants, 64.3% preschoolers, 54.6% schoolchildren). A positive correlation was found between interaction level and confidence (p < 0.01). Conclusion. Medical students have limited interaction with minors in their daily lives, which affects their confidence in taking a Pediatrics course.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510682"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insufficient physical activity in adolescents. 青少年身体活动不足。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-06-19 DOI: 10.5546/aap.2024-10518.eng
Paula Weissbrod, María I Peñalva, Ariela Slarner, Patricia Jáuregui Leyes
{"title":"Insufficient physical activity in adolescents.","authors":"Paula Weissbrod, María I Peñalva, Ariela Slarner, Patricia Jáuregui Leyes","doi":"10.5546/aap.2024-10518.eng","DOIUrl":"https://doi.org/10.5546/aap.2024-10518.eng","url":null,"abstract":"<p><p>Introduction. Insufficient physical activity (IPA) affects a significant number of children and adolescents. Understanding its associated factors is key to improving their health. This study aimed to determine the prevalence and characteristics associated with IPA in adolescents. Population and methods. Adolescents aged 13 to 18 years who attended health checkups at two primary care centers during August and September 2023. A survey was applied to determine the physical activity level and its associated factors. Results. A total of 111 adolescents were included in the study. Of the total, 61.26% (68) considered themselves to have not done enough physical activity; 88% (98) had an IPA. The only factor significantly associated with greater physical activity was having to work or help around the house. Conclusion. The prevalence of IPA was 88%, and the need to work or help at home was associated with higher levels of physical activity.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410518"},"PeriodicalIF":0.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudo oculomotor palsy associated with Parry-Romberg syndrome. 伴有Parry-Romberg综合征的假性动眼性麻痹。
IF 0.7 4区 医学
Archivos argentinos de pediatria Pub Date : 2025-06-19 DOI: 10.5546/aap.2025-10650.eng
Alejandra Antacle, Macarena Nougues, Graciela Espada, Milagros Martino, Margarita Larralde
{"title":"Pseudo oculomotor palsy associated with Parry-Romberg syndrome.","authors":"Alejandra Antacle, Macarena Nougues, Graciela Espada, Milagros Martino, Margarita Larralde","doi":"10.5546/aap.2025-10650.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10650.eng","url":null,"abstract":"<p><p>Parry-Romberg syndrome is a rare form of localized scleroderma that can affect deep tissues, including muscles and the central nervous system. Early and appropriate treatment during the inflammatory phase is essential to prevent serious sequelae. We present the case of an 11-year-old patient whose first manifestation was a palpebral hypochromia, followed by pseudo paralysis of the third cranial nerve with ptosis and hypotropia, whose late diagnosis delayed the start of treatment and conditioned an unfavorable evolution. This work emphasizes the significance of early diagnosis in enhancing prognosis and preventing permanent sequelae.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510650"},"PeriodicalIF":0.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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