Mariana Ochetti, Liliana K Silvano, Verónica Campi, Gabriela M Sobrero, Cintia S Tarifa, Silvia E Martin, Adriana Boyanovsky, Constanza Pelliza, Laura Castro, Noemí L Muñoz, Mirta B Miras
{"title":"Reference values for anti-Müllerian hormone measured by electrochemiluminescence in a pediatric population in Argentina.","authors":"Mariana Ochetti, Liliana K Silvano, Verónica Campi, Gabriela M Sobrero, Cintia S Tarifa, Silvia E Martin, Adriana Boyanovsky, Constanza Pelliza, Laura Castro, Noemí L Muñoz, Mirta B Miras","doi":"10.5546/aap.2025-10653.eng","DOIUrl":"10.5546/aap.2025-10653.eng","url":null,"abstract":"<p><p>Introduction. Anti-Müllerian hormone (AMH) is a specific marker of gonadal Sertoli cells, usually used for the diagnosis of disorders of sexual development. Currently, automated methods for measuring AMH are routinely incorporated into clinical laboratories. Objective. To obtain reference values of AMH in a population of healthy neonates and infants using an electrochemiluminescent immunoassay (ECLIA). Population and methods. We analyzed 599 serum samples from healthy neonates and infants (F = 296, M = 303) aged 2 to 291 days, with a distribution as follows: ≤15 days (n = 352) and >15 days (n = 247). An ECLIA-Roche™ assay determined AMH. AMH distribution percentiles were calculated using the Bootstrap method. Results. AMH values (ng/mL) in neonates and infants were: M: (≤15 days: P2.5: 27.5; P97.5: 118.3; >15 days: P2.5: 13.9; P97.5: 186.0. F: ≤15 days: P2.5: 0.03; P97.5: 4.00; >15 days: P2.5: 0.03; P97.5: 11.5. Conclusion. Our work provides reference values of AMH according to age and sex, facilitating its appropriate clinical use in the endocrinological evaluation of a population. The results obtained are consistent with previous studies, which show that AMH values are elevated at birth in males, reflecting the expression of Sertoli cell functionality.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510653"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofía H Rigou, María F Lución, Vanesa E Castellano, Sofía Diana Menéndez, Ángela Gentile
{"title":"Characterization of outpatient respiratory syncytial virus infection in children under 5 years of age in a tertiary-level hospital.","authors":"Sofía H Rigou, María F Lución, Vanesa E Castellano, Sofía Diana Menéndez, Ángela Gentile","doi":"10.5546/aap.2025-10692.eng","DOIUrl":"10.5546/aap.2025-10692.eng","url":null,"abstract":"<p><p>Introduction. Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections. This study aimed to characterize outpatient RSV cases in children under 5 years of age who attended a public pediatric hospital. Population and methods. Cross-sectional study between 2022 and 2024. We analyzed 102 ambulatory cases of acute respiratory infection due to RSV diagnosed in the Ambulatory Monitoring Unit. Results: The median age was 16.4 months; 70% were younger than 24 months, and 54.9% were male. Most of the patients belonged to the middle class, and 62.5% of the mothers had a secondary education or higher; 88.7% were born at term, 54% by cesarean section, and 43.2% were exclusively breastfed until six months; 19.6% had some comorbidity. The most common manifestations were cough (99%), fever (86%), rhinorrhea (84%), and respiratory distress (32%). The primary diagnoses were bronchiolitis or obstructive bronchial syndrome (50.9%) and influenza-like illness (30.4%). Antibiotics were administered to 21.6% of the patients. Of the working caregivers, 62.5% had to be absent from work, with a median absence of 1.5 days. Conclusion. In patients attended on an outpatient basis, RSV presented seasonally, affecting mainly healthy children aged 13-24 months, with bronchiolitis being the most common diagnosis.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510692"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gonzalo Ortiz, Mabel Mora, María Del C Toca, Marina Orsi, Raquel Furnes, Néstor Litwin, Marta Wagener, Luciana Guzmán, Cinthia Bastianelli, Graciela Martín, Alejandro Guouman, Silvia Cóccolo, Adriana Botero, Florencia Ursino, Lorena Menéndez, Adriana Oviedo, Verónica Kahane, María T. García de Dávila, Juliana González, Patricia Sosa, Laura Levy
{"title":"[Pediatric guidelines for coeliac disease: Treatment and follow-up].","authors":"Gonzalo Ortiz, Mabel Mora, María Del C Toca, Marina Orsi, Raquel Furnes, Néstor Litwin, Marta Wagener, Luciana Guzmán, Cinthia Bastianelli, Graciela Martín, Alejandro Guouman, Silvia Cóccolo, Adriana Botero, Florencia Ursino, Lorena Menéndez, Adriana Oviedo, Verónica Kahane, María T. García de Dávila, Juliana González, Patricia Sosa, Laura Levy","doi":"10.5546/aap.2024-10526","DOIUrl":"10.5546/aap.2024-10526","url":null,"abstract":"<p><p>The goal of the treatment is to relieve symptoms, achieve duodenal mucosal healing, avoid long term complications, and ensure children´s appropriate growth, for which it´s necessary to follow a lifelong, nutritionally complete and healthy gluten free diet (GFD).\u0000The Celiac Disease Working Group of the Gastroenterology Committee of the Sociedad Argentina de Pediatría developed this guide based on expert consensus, aimed at gastroenterologists, pediatricians and primary care physicians with the objective of updating the following topics: Treatment. Definition of gluten free food. Nutritional approach to children with celiac disease. Clinical, nutritional aspects and laboratory tests that should be monitored at initial controls. The importance of follow up visits, their frequency, which professionals should make up the monitoring team and what should be assessed. How to assess adherence to the GFD and other recommendations.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410526"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pseudo oculomotor palsy associated with Parry-Romberg syndrome.","authors":"Alejandra Antacle, Macarena Nougues, Graciela Espada, Milagros Martino, Margarita Larralde","doi":"10.5546/aap.2025-10650.eng","DOIUrl":"10.5546/aap.2025-10650.eng","url":null,"abstract":"<p><p>Parry-Romberg syndrome is a rare form of localized scleroderma that can affect deep tissues, including muscles and the central nervous system. Early and appropriate treatment during the inflammatory phase is essential to prevent serious sequelae. We present the case of an 11-year-old patient whose first manifestation was a palpebral hypochromia, followed by pseudo paralysis of the third cranial nerve with ptosis and hypotropia, whose late diagnosis delayed the start of treatment and conditioned an unfavorable evolution. This work emphasizes the significance of early diagnosis in enhancing prognosis and preventing permanent sequelae.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510650"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martín O Escudero, María F Kuspiel, Alfredo M Eymann, Paola X De la Iglesia Niveyro, Guillermo Alonso
{"title":"Atypical parathyroid tumor: A rare cause of primary hyperparathyroidism in an adolescent.","authors":"Martín O Escudero, María F Kuspiel, Alfredo M Eymann, Paola X De la Iglesia Niveyro, Guillermo Alonso","doi":"10.5546/aap.2024-10589.eng","DOIUrl":"10.5546/aap.2024-10589.eng","url":null,"abstract":"<p><p>Hyperparathyroidism is a rare entity in pediatrics. It is defined as the increased production of parathyroid hormone. It may be due to a primary defect of the parathyroid glands (primary hyperparathyroidism) or to a compensatory parathyroid hormone production to correct hypocalcemia states of various origins (secondary hyperparathyroidism). We describe the case of a 15-year-old adolescent girl with a history of several months of deteriorating school performance, anxiety crises, weight loss, and tachycardia. Laboratory results showed hypercalcemia, hypophosphatemia, increased parathyroid hormones, and hypovitaminosis D; imaging studies showed generalized bone involvement and parathyroid nodular formation. A parathyroidectomy and right hemithyroidectomy were performed, after which she presented persistent hungry bone syndrome. The anatomopathological diagnosis was an atypical parathyroid tumor. We describe the form of presentation, the results of the different complementary tests performed, and the short- and long-term evolution.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410589"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejo Seminara, Guillermo T Newkirk, Consuelo Durand
{"title":"Recurrent rhabdomyolysis as a presenting feature of glycogenosis IX (GSD IX): a case report.","authors":"Alejo Seminara, Guillermo T Newkirk, Consuelo Durand","doi":"10.5546/aap.2024-10578.eng","DOIUrl":"10.5546/aap.2024-10578.eng","url":null,"abstract":"<p><p>Rhabdomyolysis is the clinical picture characterized by the destruction of skeletal muscle. It is associated with the consequent elevation of serum creatine kinase above five times its standard value or greater than 1,000 U/L. Its most frequent causes are acquired. However, less frequent causes, such as congenital metabolic diseases, should be considered when the rhabdomyolysis event recurs. We describe the case of a pediatric patient with recurrent rhabdomyolysis, which triggered by a type IX glycogenosis with a PHKA1 gene mutation. This pathogenic variant generates muscle phosphorylase kinase enzyme deficiency, hindering the use of glycogen as an energy source during prolonged fasting or metabolic demands. We consider it essential to increase knowledge about these entities in the face of recurrent rhabdomyolysis in the pediatric age for early detection and timely referral to a specialist.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410578"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a comprehensive improvement in pediatric post-surgical care.","authors":"Analía Solari Moro","doi":"10.5546/aap.2024-10634.eng","DOIUrl":"10.5546/aap.2024-10634.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410634"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Are Your Kidneys Ok?\"","authors":"Sandra Martin","doi":"10.5546/aap.2025-10707.eng","DOIUrl":"10.5546/aap.2025-10707.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510707"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cinthia Bastianelli, Mariana Araujo, Luis Cataldi, Alberto Aleman, Constanza Olleta, Mariana Pineda, Estefanía Bracamonte, Daniel Romero
{"title":"Scientific societies in health education and promotion in the school setting.","authors":"Cinthia Bastianelli, Mariana Araujo, Luis Cataldi, Alberto Aleman, Constanza Olleta, Mariana Pineda, Estefanía Bracamonte, Daniel Romero","doi":"10.5546/aap.2024-10603.eng","DOIUrl":"10.5546/aap.2024-10603.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410603"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agustín Bernatzky, Maria F Conzi, Marco A Belzu, Gonzalo L Mariani, Milton H Miyoshi, Maria F de Almeida, Ruth Guinsburg, Juan P Berazategui
{"title":"Laryngeal mask in the delivery room for neonates with difficult airway: a randomized clinical simulation study.","authors":"Agustín Bernatzky, Maria F Conzi, Marco A Belzu, Gonzalo L Mariani, Milton H Miyoshi, Maria F de Almeida, Ruth Guinsburg, Juan P Berazategui","doi":"10.5546/aap.2024-10631.eng","DOIUrl":"10.5546/aap.2024-10631.eng","url":null,"abstract":"<p><p>Introduction. Endotracheal intubation is one of the most important technical skills in neonatal resuscitation. However, it can be challenging in various situations. The use of the laryngeal mask (LM) may be an alternative. However, its use is not yet standardized in current neonatal resuscitation algorithms. The study aimed to evaluate whether the standardized use of an LM in difficult airway (DAW) situations reduces the time to achieve effective ventilation (EVT) in a clinical simulation setting. Population and methods. This was a blinded, randomized, simulation-based study. A modified algorithm was developed that emphasized the early use of LM in cases of DAW. Two groups of neonatologists were randomly assigned to receive training in two different resuscitation algorithms (standard and modified). After training, the physicians participated in two simulation scenarios, one with a normal airway and one with a difficult airway. Results. Sixty-nine neonatologists participated in the study, 36 in the intervention group. No significant differences in EVT were observed between the two groups. However, when we analyzed those participants who used the LM on the first attempt, regardless of the training received, a shorter time was observed: 9.5 seconds (IQR 7-11) versus 63 seconds (IQR 42-89); p <0.01. Conclusions. Standardized use of LM in DAW situations could reduce the time to achieve effective ventilation.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410631"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}