{"title":"Curricular changes in pediatric residency: Gains, losses, and the need for balance.","authors":"Fernando Ferrero","doi":"10.5546/aap.2026-11135.eng","DOIUrl":"10.5546/aap.2026-11135.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611135"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gustavo H Izbizky, Gonzalo Sevillano, Rocío M Abramor, María V Borroni, Guillermo Izbizky, Lucas Trinchero, María E Carducci
{"title":"Obstetric and perinatal outcomes in twin pregnancies conceived through assisted reproduction: A retrospective cohort study.","authors":"Gustavo H Izbizky, Gonzalo Sevillano, Rocío M Abramor, María V Borroni, Guillermo Izbizky, Lucas Trinchero, María E Carducci","doi":"10.5546/aap.2025-10997.eng","DOIUrl":"10.5546/aap.2025-10997.eng","url":null,"abstract":"<p><p>Introduction. Multiple pregnancies are more frequently associated with adverse maternal and neonatal outcomes. The incidence of multiple pregnancies has increased with the use of assisted reproductive technologies (ART): they account for between 15% and 25% of twin births. ART has also been associated with adverse outcomes in both singleton and multiple pregnancies, although the available evidence is limited and heterogeneous. Objective. To evaluate maternal and perinatal outcomes in spontaneously conceived twin pregnancies and compare them with those conceived through ART. Population and methods. Patients aged 18 years or older with twin pregnancies who reached a gestational age of 24.0 weeks and who underwent first-trimester screening, follow-up, and delivery at the Hospital Italiano de Buenos Aires between January 2014 and December 2022. A composite outcome of maternal and neonatal adverse events was analyzed. Neurological development was monitored until age 2. Results. A total of 243 twin pregnancies were included (148 ART; 95 spontaneous). The ART group had a higher prevalence of advanced maternal age, nulliparity, obesity, and chronic diseases, with statistically significant differences (p <0.001). There were no significant differences in primary maternal outcomes (29% vs. 23%; p = 0.347) or neonatal outcomes (16% vs. 19%; p = 0.371). We found an increased frequency of autism spectrum disorders in pregnancies conceived through ART. Conclusion. Twin pregnancies resulting from ART showed similar maternal and neonatal outcomes to those resulting from spontaneous conception, despite significant differences in baseline maternal characteristics. Long-term follow-up studies are needed.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510997"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Estefanía Rossetti, Silvia Eandi Eberle, Fernando Aguirre, Leandro Nieto, Diego Fernández, María F Mininni, Berenice Milanesio, Eugenia Masegosa, Carolina Pepe, Vanesa Ávalos
{"title":"Clinical clues to recognizing hereditary dehydrated stomatocytosis (DHSt) in children.","authors":"Estefanía Rossetti, Silvia Eandi Eberle, Fernando Aguirre, Leandro Nieto, Diego Fernández, María F Mininni, Berenice Milanesio, Eugenia Masegosa, Carolina Pepe, Vanesa Ávalos","doi":"10.5546/aap.2025-10777.eng","DOIUrl":"10.5546/aap.2025-10777.eng","url":null,"abstract":"<p><p>Dehydrated hereditary stomatocytosis (DHSt) is a heterogeneous group of rare hemolytic disorders with autosomal dominant inheritance. A series of 20 cases demonstrates that early identification of DHSt can prevent unnecessary interventions and improve the management of anemia, iron overload, and other complications in pediatric and adult patients. The presence of elevated mean corpuscular hemoglobin concentration (MCHC) with resistant erythrocytes suggested a possible association with variants in PIEZO1. Patients with KCNN4 variants showed no clear signs of erythrocyte dehydration, but, as with PIEZO1, macrocytosis, hemolytic anemia, and iron overload were common manifestations.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510777"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabrina Merenzon, Paula C Luna, María E Abad, Anabel Panizzardi, Ramiro Cano, Margarita Larralde
{"title":"Biologic therapies in pediatric psoriasis: A single-center experience.","authors":"Sabrina Merenzon, Paula C Luna, María E Abad, Anabel Panizzardi, Ramiro Cano, Margarita Larralde","doi":"10.5546/aap.2026-11081.eng","DOIUrl":"10.5546/aap.2026-11081.eng","url":null,"abstract":"<p><p>Pediatric psoriasis accounts for approximately 2% of dermatological conditions in children under 16 years of age. The objective of this study is to describe the clinical characteristics, treatment regimens, and observed efficacy and safety profiles in a real-world cohort. This retrospective study analyzed 15 pediatric patients treated with biologics in Argentina between 2010 and 2024. The median age at treatment initiation was 8 years, with a predominance of female patients. The biologics used were primarily adalimumab, followed by secukinumab, etanercept, and ixekizumab. Five patients experienced treatment failure secondary to adalimumab. The therapy was well tolerated, with no adverse events reported.The data suggest that early intervention can alter the course of the disease and prevent long-term complications.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611081"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond neonatal intensive care: Challenges in the follow-up of bronchopulmonary dysplasia.","authors":"Manuela Dicembrino, Gisela Martinchuk Migliazza","doi":"10.5546/aap.2026-11134.eng","DOIUrl":"10.5546/aap.2026-11134.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611134"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafael Fraire, Josefina Polizzi, Josefina Castro Méndez, Thomas Iolster, Christian Kreutzer, Alejandro Siaba Serrate, Pablo Longo, Silvio F Torres
{"title":"Extracorporeal membrane oxygenation as a pre-transplant rescue therapy in a patient with an oncohematological condition.","authors":"Rafael Fraire, Josefina Polizzi, Josefina Castro Méndez, Thomas Iolster, Christian Kreutzer, Alejandro Siaba Serrate, Pablo Longo, Silvio F Torres","doi":"10.5546/aap.2025-10832.eng","DOIUrl":"10.5546/aap.2025-10832.eng","url":null,"abstract":"<p><p>The use of extracorporeal membrane oxygenation (ECMO) in pediatrics poses a significant clinical and ethical challenges due to its high costs and associated morbidity and mortality. We present the case of a 2-year-old boy with severe bone marrow aplasia and septic shock who required ECMO as a bridge to hematopoietic stem cell transplantation. High-flow venoarterial support was initiated, initially without anticoagulation, due to marked thrombocytopenia and a high risk of bleeding. A multidisciplinary discussion was held involving the treating medical team and the institutional Ethics Committee. The patient was successfully weaned from support, showed favorable clinical progress until receiving the transplant, and achieved effective hematopoietic recovery. This case illustrates the complexity of decision-making regarding ECMO use in oncohematological patients, highlighting the importance of individualized assessment, family involvement, and the need to avoid futile therapeutic intervention.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510832"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of sports-related concussion in children and adolescents.","authors":"Nelly Testa, Juliana Pochetti, María J Russo","doi":"10.5546/aap.2025-10833.eng","DOIUrl":"10.5546/aap.2025-10833.eng","url":null,"abstract":"<p><p>Advances in research on sports-related concussions have led to updates in diagnostic and management protocols. This article reviews the recommendations from the Sixth International Consensus Conference on Concussion in Sport (Amsterdam, 2022), focusing on children (ages 8-12) and adolescents (ages 13-18). It highlights preventive strategies, such as identifying risk factors, using protective equipment, implementing regulatory changes, and engaging in neuromuscular training. Up-to-date clinical tools are recommended for identification and monitoring. Initial management includes relative rest for 24-48 hours, with limited screen time, followed by subthreshold physical exercise. Specific rehabilitation is indicated if symptoms persist. This comprehensive, evidence-based approach optimizes recovery and minimizes long-term effects, promoting the safety and well-being of young athletes.The proposed protocol aims to guide pediatricians and sports professionals in clinical decision-making.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510833"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolle D Becerra Páez, Dubán S Hernández Rodríguez, Leidy A Forero Cisneros, Gustavo A Contreras García, Víctor C Mendoza Rojas
{"title":"Sotos syndrome: Report of a new pathogenic variant in the NSD1 gene in an adolescent.","authors":"Nicolle D Becerra Páez, Dubán S Hernández Rodríguez, Leidy A Forero Cisneros, Gustavo A Contreras García, Víctor C Mendoza Rojas","doi":"10.5546/aap.2025-10877.eng","DOIUrl":"10.5546/aap.2025-10877.eng","url":null,"abstract":"<p><p>Sotos syndrome is a genetic disorder characterized by distinctive facial features, intellectual disability, and excessive growth. It is associated with pathogenic variants in the NSD1 gene, most of which are de novo.We present the case of an 11-year-old girl with overgrowth (height more than 2 standard deviations above the mean), typical craniofacial dysmorphisms, global neurodevelopmental delay, and borderline intelligence. A de novo nonsense variant was detected in the NSD1 gene [NM_022455.5:c.1782dup p.(Glu595Ter)], confirmed by family segregation analysis, which has not been previously described in the literature. The patient also presented with hypotonia, hypoglycemia, neonatal jaundice, strabismus, scoliosis, seizures, and attention-deficit disorder. This report contributes to our understanding of the phenotypic spectrum of Sotos syndrome in Latin America and highlights the importance of a multidisciplinary approach, as well as timely access to genetic testing to confirm the diagnosis and guide comprehensive patient care.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510877"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José M Vera García, Patricia Streitenberger, Lucía Pérez, Vanina Pagotto
{"title":"Pneumocystis jirovecii Infection in children with solid tumors: Incidence and clinical characteristics in a retrospective cohort (2010-2023).","authors":"José M Vera García, Patricia Streitenberger, Lucía Pérez, Vanina Pagotto","doi":"10.5546/aap.2025-10972.eng","DOIUrl":"10.5546/aap.2025-10972.eng","url":null,"abstract":"<p><p>Introduction. Pneumocystis jirovecii pneumonia (PJP) is a life-threatening infection that affects patients with impaired immunity (primarily cellular immunity). Given that few studies have evaluated the incidence of PJP in pediatric patients with solid tumors, the objective of this study was to estimate the incidence of PJP among pediatric patients with solid tumors treated at a general hospital. Population and methods. A retrospective cohort study of 251 patients under 18 years of age with a confirmed diagnosis of solid organ cancer treated at a general hospital. Clinical, oncological, and infectious disease characteristics were evaluated. The cumulative incidence and incidence density of PJP were calculated, along with their respective 95% confidence intervals. Results. The cumulative incidence of PJP was 2.4% (95%CI 0.9-5.1), with an incidence rate of 8.4 cases per 1000 person-years (95%CI 3.8-18.6), and a median time from cancer diagnosis to infection of 2.7 months (IQR 2-4.5)-most patients presented with moderate symptoms. Conclusion. PJP can occur in children and adolescents with solid tumors, although its incidence is low and the prognosis is generally favorable in this cohort. These findings provide important insights into the risk profile in this population and highlight the need for further studies to determine its clinical impact and the role of prophylaxis.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510972"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agostina Llarens, Diana Cabanillas, María P Tejada, Daniela Di Giovanni, Gisela D'Angelo, Astrid Schellnast Faure, María P Martínez, María I Gaillard, Víctor C Skrie, Julio C Orellana, Laura Del Pino, Débora B Velázquez, Lucia Spossito, Miguel Galicchio, Daniel Solis, Mariana Villa, Silvia Pizzi, Mariana Roizen, Danila Labonia
{"title":"[Clinical and immunological evaluation of patients with inborn errors of immunity after hematopoietic cell transplantation].","authors":"Agostina Llarens, Diana Cabanillas, María P Tejada, Daniela Di Giovanni, Gisela D'Angelo, Astrid Schellnast Faure, María P Martínez, María I Gaillard, Víctor C Skrie, Julio C Orellana, Laura Del Pino, Débora B Velázquez, Lucia Spossito, Miguel Galicchio, Daniel Solis, Mariana Villa, Silvia Pizzi, Mariana Roizen, Danila Labonia","doi":"10.5546/aap.2026-11024","DOIUrl":"10.5546/aap.2026-11024","url":null,"abstract":"<p><p>Inborn errors of immunity (IEI) are genetic disorders that impair the development and/or function of the immune system. Hematopoietic stem cell transplantation (HSCT) represents a key and potentially curative treatment option for selected patients with IEI. Nevertheless, HSCT is a complex procedure associated with clinical and immunological complications that may arise at different stages during post-transplant follow-up. This article summarizes the consensus recommendations developed by the Pediatric Immunology Work Group of the Sociedad Argentina de Pediatría, in collaboration with transplant specialists, regarding the essential principles for clinical and immunological evaluation of patients with IEI after HSCT. Key aspects of post-transplant care are addressed, including the identification and management of infectious and non infectious complications, monitoring of immune reconstitution, assessment of chimerism, and guidance for long-term clinical follow-up.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202611024"},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}