The Journal of respiratory diseases最新文献_第3页

Results of Bronchoscopic Lung Volume Reduction With One-way Valve in Patients With Severe Emphysema in Vietnam 越南支气管镜下单向阀肺减容治疗严重肺气肿的效果

The Journal of respiratory diseases Pub Date : 2018-03-03 DOI: 10.14302/ISSN.2642-9241.JRD-18-1958

T. Taba, H. DongKhac, Q. Do, B. DaoNgoc, L. NguyễnHuy, N. NguyenViet

引用次数: 0

Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap 分次呼气一氧化氮引导治疗哮喘-慢性阻塞性肺疾病重叠患者的有效性

The Journal of respiratory diseases Pub Date : 2018-02-07 DOI: 10.4236/OJRD.2018.81001

T. Akamatsu, T. Shirai, Yuko Tanaka, Hirofumi Watanabe, Y. Endo, Y. Shimoda, Takahito Suzuki, Rie Noguchi, M. Saigusa, A. Yamamoto, Y. Shishido, T. Akita, S. Morita, K. Asada

{"title":"Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap","authors":"T. Akamatsu, T. Shirai, Yuko Tanaka, Hirofumi Watanabe, Y. Endo, Y. Shimoda, Takahito Suzuki, Rie Noguchi, M. Saigusa, A. Yamamoto, Y. Shishido, T. Akita, S. Morita, K. Asada","doi":"10.4236/OJRD.2018.81001","DOIUrl":"https://doi.org/10.4236/OJRD.2018.81001","url":null,"abstract":"Background: Some patients present clinical features of both asthma and chronic obstructive pulmonary disease (COPD), which has led to the recent proposal of asthma-COPD overlap (ACO) as a diagnosis. Fractional exhaled nitric oxide (FeNO) is a candidate biomarker to diagnose ACO. We assessed the effect of an add-on treatment with budesonide/formoterol (BUD/FM) combination in patients with ACO, which was diagnosed by FeNO. Methods: This was a prospective, single-arm, open-label, before and after comparison study. Subjects included 83 patients with COPD who attended outpatient clinics for routine checkups at Shizuoka General Hospital between June and November 2016. All patients fulfilled the GOLD definition of COPD and were receiving long-acting muscarinic antagonist (LAMA) or LAMA/long-acting β2 agonist (LABA) combinations. After an 8-week run-in period, BUD/FM was added to the patients with FeNO levels of ≥35 ppb, defined as having ACO. For patients receiving LAMA/LABA, BUD/FM was added after the discontinuation of LABA. The modified British Medical Research Council (mMRC) score, COPD assessment test (CAT) score, spirometric indices, forced oscillation parameters, and FeNO were assessed before and after 8 weeks of BUD/ FM add-on treatment. Results: Twenty-four patients (28.9%) had FeNO levels ≥ 35 ppb, and 17 patients completed the study (mean age: 73 years and GOLD I/II/III/IV, 5/10/1/1). The mean CAT scores significantly improved (9.2 to 5.4, p = 0.015) and 10 patients (58.8%) showed ≥2 points improvement, a minimal clinically important difference. The mean FeNO levels significantly decreased from 63.0 to 34.3 ppb (p < 0.006). However, there were no changes in mMRC scores, spirometric indices, or forced oscillation parameters. Conclusions: FeNO-guided treatment with BUD/FM improves symptoms in patients with ACO.","PeriodicalId":83134,"journal":{"name":"The Journal of respiratory diseases","volume":"08 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2018-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43116602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Study on ColdZyme® Mouth Spray against Rhinovirus-Induced Common Cold ColdZyme®口腔喷雾剂治疗鼻病毒引起的普通感冒的随机、双盲、安慰剂对照试验临床研究

The Journal of respiratory diseases Pub Date : 2017-10-16 DOI: 10.4236/OJRD.2017.74013

Mats Clarsund, Marcus Fornbacke, L. Uller, S. Johnston, C. A. Emanuelsson

{"title":"A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Study on ColdZyme® Mouth Spray against Rhinovirus-Induced Common Cold","authors":"Mats Clarsund, Marcus Fornbacke, L. Uller, S. Johnston, C. A. Emanuelsson","doi":"10.4236/OJRD.2017.74013","DOIUrl":"https://doi.org/10.4236/OJRD.2017.74013","url":null,"abstract":"Common colds incur significant costs in terms of sick leave and personal discomfort for affected individuals. This study investigated the performance of ColdZyme® Mouth Spray (ColdZyme), a protective barrier against common cold, in rhinovirus-inoculated healthy volunteers. This randomized, doubleblind, placebo-controlled pilot study was conducted on 46 healthy volunteers inoculated with rhinovirus 16 via the nose. Subjects self-administered ColdZyme or placebo 6 times daily for 11 days. Symptoms were recorded daily in a diary. Rhinovirus 16 in nasal and oropharyngeal samples at days 0, 3, 4, 6, 7 and 10 were quantified by RT-qPCR. The primary outcome measure was the reduction in viral load in oropharyngeal samples. Rhinovirus 16 was only detected in 35 out of 46 inoculated subjects. Exploratory analysis measuring the total viral load (i.e., area under the curve (AUC)) for days 3 - 10 in successfully inoculated subjects found that ColdZyme treatment resulted in a lower total viral load in the oropharynx (p = 0.023). In subjects who experienced symptomatic common cold, irrespectively, if virus were detected, treatment with ColdZyme resulted in a reduction in the number of days with common cold symptoms from 6.5 to 3.0 days (p = 0.014) in comparison to placebo. ColdZyme reduced virus infection in the oropharynx and reduced the number of days with common cold symptoms and highlights the possible importance of the oropharynx in common cold infections. Suitable outcome measures for a feasible study on ColdZyme are total viral load in the oropharynx in subjects having detectable virus present in nasal or oropharyngeal samples.","PeriodicalId":83134,"journal":{"name":"The Journal of respiratory diseases","volume":"7 1","pages":"125-135"},"PeriodicalIF":0.0,"publicationDate":"2017-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46790516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Correlation of Self-Reported Breathlessness with Post Exercise Dyspnea in Obesity 肥胖患者自述呼吸困难与运动后呼吸困难的相关性

The Journal of respiratory diseases Pub Date : 2017-10-16 DOI: 10.4236/OJRD.2017.74015

M. Agustin, Hong-yan Chang, J. Unterborn, A. Andoh-Duku

{"title":"Correlation of Self-Reported Breathlessness with Post Exercise Dyspnea in Obesity","authors":"M. Agustin, Hong-yan Chang, J. Unterborn, A. Andoh-Duku","doi":"10.4236/OJRD.2017.74015","DOIUrl":"https://doi.org/10.4236/OJRD.2017.74015","url":null,"abstract":"Background: Dyspnea in obesity is common and dyspnea questionnaires are mostly validated for chronic respiratory diseases. The study aims to assess how modified Medical Research Council (mMRC) dyspnea scale correlates with post exercise dyspnea Borg scale in 6-minute walk test of the obese population. Methods: We performed a retrospective observational study on 342 obese patients with 6 MWT tests from February 2008 to November 2014 at a single tertiary hospital. Linear regression analysis was used to assess the relationship between mMRC and Borg dyspnea score. Fractional polynomial regression was used to analyze the relationship of mMRC and Borg scores with BMI. Results: MMRC dyspnea score was a strong predictor of post exercise dyspnea Borg score in the obese population in a univariate regression model (coefficient = 0.764, p ≤ 0.001). When adjusted to age, BMI, 6 MWT distance and PFT parameters in a multivariate regression model, the relationship remained statistically significant (coefficient = 0.587, p ≤ 0.001). The relationship was stronger in obese group with no airflow obstruction. Conclusion: In obese population, pre-exercise mMRC dyspnea score correlates significantly with post exercise dyspnea Borg score regardless of airflow obstruction. This is the first validity study regarding mMRC scale in assessing dyspnea in the obese population.","PeriodicalId":83134,"journal":{"name":"The Journal of respiratory diseases","volume":"07 1","pages":"141-149"},"PeriodicalIF":0.0,"publicationDate":"2017-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43983856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of ColdZyme Mouth Spray against Common Cold in Preschool Staff ColdZyme口腔喷雾剂对幼儿园工作人员普通感冒的评价

The Journal of respiratory diseases Pub Date : 2017-10-16 DOI: 10.4236/OJRD.2017.74014

Mats Clarsund

{"title":"Evaluation of ColdZyme Mouth Spray against Common Cold in Preschool Staff","authors":"Mats Clarsund","doi":"10.4236/OJRD.2017.74014","DOIUrl":"https://doi.org/10.4236/OJRD.2017.74014","url":null,"abstract":"The common cold is one of the most frequently encountered infectious diseases in humans and, despite the modest severity in most cases; it presents a significant economic burden upon society and individuals. ColdZyme® Mouth Spray (ColdZyme®, Enzymatica AB, Lund, Sweden) is a mouth spray intended to reduce the probability of catching a cold and can also help shorten the duration of a cold if used at an early stage of the infection, by forming a barrier on the oropharyngeal mucous membrane. This study evaluated the effect of ColdZyme® on common cold related sick-leave in preschool (kindergarten) staff. Fifteen preschool staff members were evaluated over a 6-month period and ColdZyme® was used according to instructions. Sick-leave days were recorded and compared to historical data. The number of average sick leave days decreased during the period from 7.4 days to 4.1 days (p = 0.04). It is notable that, if occurring, the majority of subjects perceived a common cold infection as milder than usual. Conclusion: Using ColdZyme® to apply a barrier to the pharyngeal mucous membrane may be an easy and practical way to prevent or reduce infections and corresponding sick leave in personnel from the preschool environment.","PeriodicalId":83134,"journal":{"name":"The Journal of respiratory diseases","volume":"07 1","pages":"136-140"},"PeriodicalIF":0.0,"publicationDate":"2017-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45349369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of A Waterproof Device in the Noninvasive Ventilation Circuit On Patient-machine Synchronization 无创通气回路中防水装置对人机同步的影响

The Journal of respiratory diseases Pub Date : 2017-09-28 DOI: 10.14302/ISSN.2642-9241.JRD-17-1683

Hu Jieying, Zheng Ze-guang, Yang Feng, Zhong Lihong, Chen Rongchang

{"title":"Effect of A Waterproof Device in the Noninvasive Ventilation Circuit On Patient-machine Synchronization","authors":"Hu Jieying, Zheng Ze-guang, Yang Feng, Zhong Lihong, Chen Rongchang","doi":"10.14302/ISSN.2642-9241.JRD-17-1683","DOIUrl":"https://doi.org/10.14302/ISSN.2642-9241.JRD-17-1683","url":null,"abstract":"Objective: Investigate the effect of connecting a waterproof device at the front end of the piezometric tube on pressure transmission and patient-machine synchronization during the noninvasive ventilation. Method: In test 1, the waterproof device was connected to the piezometric tube and put into a closed container, the pressure inside the container was varied to observe the corresponding pressure change in the piezometric tube. In test 2, a waterproof device was connected in front of the piezometric tube during noninvasive ventilation.12 subjects were received noninvasive ventilator so that dynamic changes of the pressure inside the mask (Pmask) and piezometric tube (Ptube) could be measured. Results: In test 1, when the pressure in the container was gradually increased to 50 cmH2O and then decreased to 0, the pressure inside the piezometric tube changed synchronously with the pressure inside the container, with no statistically significant difference between the pressures (0.009 ± 0.138) cmH2O. In test 2, there was no significant increase in triggering time, pressure, and power after connecting the waterproof device at the front end of the piezometric tube. There was no significant difference in the platform pressure and baseline pressure as measured by Pmask, before and after connecting the waterproof device. Finally, there was no significant difference in the platform pressure and baseline pressure between Pmask and Ptube after connecting the waterproof device. Conclusion: Connecting the waterproof device at the front end of the piezometric tube can prevent condensate from entering the tube without affecting pressure transmission . DOI : COMING SOON Corresponding author: Zheng Zeguang , First Affiliated Hospital of Guangzhou Medical University (State Key Laboratory of Respiratory Disease), Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong 510120, China","PeriodicalId":83134,"journal":{"name":"The Journal of respiratory diseases","volume":"1 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46792589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of ColdZyme Mouth Spray for the Protection against Common Cold in Elite Athletes to Reduce Unwanted Absence from Training and Competition ColdZyme口腔喷雾剂对优秀运动员预防感冒的效果评价

The Journal of respiratory diseases Pub Date : 2017-06-19 DOI: 10.4236/OJRD.2017.73010

Mats Clarsund

引用次数: 3

A Human T Lymphotropic Virus Type 1 Carrier Coinfected with Mycobacterium intracellulare and Pneumocystis jirovecii with a Characteristic Compositional Change of Bone Marrow Cells 细胞内分枝杆菌和吉氏肺孢子虫共同感染具有骨髓细胞组成特征性变化的人T淋巴细胞性1型病毒携带者

The Journal of respiratory diseases Pub Date : 2017-06-19 DOI: 10.4236/OJRD.2017.73011

S. Uda, S. Shiotsu, Ayaka Omura, Ryosuke Hamashima, A. Yoshimura, Naoko Kurisu, T. Sagawa, Koichi Hasegawa, T. Yuba, Chieko Takumi, Seiko Ono, Noriya Hiraoka

引用次数: 0

Pulmonary Fibrosis Due to Nitrofurantoin Therapy: A Case Report 呋喃妥因治疗肺纤维化1例报告

The Journal of respiratory diseases Pub Date : 2017-06-19 DOI: 10.4236/OJRD.2017.73012

L. Grigorakos, G. Poulakou, D. Lazarescu, P. Myrianthefs, N. Markou, Maria Bikou, A. Petineli, K. Kokkinis

引用次数: 1

Testing Low Doses of Caffeine on Respiratory Resistance Using the Airflow Perturbation Device 用气流扰动装置测试低剂量咖啡因对呼吸阻力的影响

The Journal of respiratory diseases Pub Date : 2017-05-09 DOI: 10.4236/OJRD.2017.72006

M. Montgomery, Allen Luk, A. Johnson, J. Vossoughi

引用次数: 2