Archives of oto-rhino-laryngology最新文献_第8页

An experimental study of vancomycin-induced cochlear damage. 万古霉素致耳蜗损伤的实验研究。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00457456

R A Tange, H L Kieviet, J von Marle, D Bagger-Sjöbäck, W Ring

引用次数: 15

A comparison of initial and permanent surface changes to guinea pig hair cells after acoustic overstimulation. 声学过度刺激后豚鼠毛细胞初始和永久表面变化的比较。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00454127

A Pye, L Ulehlova

{"title":"A comparison of initial and permanent surface changes to guinea pig hair cells after acoustic overstimulation.","authors":"A Pye, L Ulehlova","doi":"10.1007/BF00454127","DOIUrl":"https://doi.org/10.1007/BF00454127","url":null,"abstract":"Groups of pigmented guinea pigs were exposed unilaterally to a 15 kHz pure tone at 133 dB SPL for 7.5 min. The inner ears of one group were examined by light microscopy to count damaged hair cells 3 weeks after exposure. Four other groups were investigated using scanning electron microscopy to assess the progression of initial surface changes after sound exposure. Hair cells were examined at 0, 10 and 30 min and compared with those seen at 3 weeks. Drastic stereociliary disturbances were present immediately after this short sound stimulation. Changes initially affected the first row of outer hair cells, followed by the inner hair cell row, and then spread to all rows at the centre of a damaged area. These changes appeared more advanced in specimens from the later groups. At 3 weeks, primarily phalangeal scars were seen at the main damaged area, with partially degenerating cells at the periphery. The latter still showed stereociliary disturbances, but the types predominating were different from those seen initially. However, no differences were found in the extens of damage when the various exposure groups were compared. No changes due to overstimulation were present in the contralateral ears.","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00454127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13875371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The effects of auditory deprivation on morphological maturation of the ventral cochlear nucleus. 听觉剥夺对耳蜗腹侧核形态成熟的影响。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00454133

M Anniko, B Sjöström, D Webster

引用次数: 7

Hematoporphyrin uptake by experimentally induced cholesteatomas in an animal model. 实验诱导的动物模型胆脂瘤对血卟啉的摄取。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00454135

G P Teatini, C Perria, G Iori, F Meloni, F Tanda

{"title":"Hematoporphyrin uptake by experimentally induced cholesteatomas in an animal model.","authors":"G P Teatini, C Perria, G Iori, F Meloni, F Tanda","doi":"10.1007/BF00454135","DOIUrl":"https://doi.org/10.1007/BF00454135","url":null,"abstract":"Photodynamic therapy is based on the production of a cytotoxic factor by porphyrins, particularly hematoporphyrin (HP), when exposed to light of a suitable wavelength and intensity. The uptake of HP is notably large in tissues with a high mitotic index. Although cholesteatomas are not malignant tumors, our working hypothesis was that their high lipid content might result in their exhibiting a remarkable affinity to HP, which is normally carried in the blood by lipoproteins. Cholesteatomas were induced in rabbits using the Tübingen procedure (closure of the auditory canal by sutures). Animals were killed 30-40 days later at intervals of 1, 3, 6, 12, and 24 h following intravenous HP administration (5 mg/kg). Specimens were divided into two portions, one for histological examination and the other for biochemical study. The latter revealed that HP accumulates in experimental cholesteatomas, with a maximum uptake after 3 h. The level then gradually decreases, although at a lower rate than in the liver, but remains considerably high even after 24 h. These results suggest that the photodynamic treatment of cholesteatomas should be feasible in our animal model, although such treatment is still speculative in man.","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 1","pages":"53-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00454135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13875375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The involvement of the cochlear nerve in neurinomas of the eighth cranial nerve. 耳蜗神经在第八脑神经神经瘤中的受累。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00456658

G Forton, L Moeneclaey, F Declau, J Marquet

引用次数: 9

Laryngeal electromyography. 喉肌电图。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463604

R L Blair

引用次数: 0

In vivo and in vitro suppression of lymphocyte function in Aspergillus sinusitis. 曲霉菌性鼻窦炎淋巴细胞功能的体内外抑制。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00463585

D Loidolt, H Mangge, M Wilders-Truschnig, F Beaufort, K Schauenstein

{"title":"In vivo and in vitro suppression of lymphocyte function in Aspergillus sinusitis.","authors":"D Loidolt, H Mangge, M Wilders-Truschnig, F Beaufort, K Schauenstein","doi":"10.1007/BF00463585","DOIUrl":"https://doi.org/10.1007/BF00463585","url":null,"abstract":"In about 10% of patients who are operated on for chronic sinusitis, an aspergilloma is found in the affected paranasal sinus. In order to detect possible underlying immune defects, 25 patients with aspergillomas were subjected to an immunological screening program. The data obtained were compared with those of patients with non-mycotic chronic sinusitis and healthy controls. Total lymphocyte counts and immunoglobulin levels were normal in both groups with sinusitis. However, leukocyte subset analyses using membrane fluorescence revealed a significant decrease of CD11+ cells (macrophages, monocytes and natural killer-cells) in both types of sinusitis. Furthermore, a markedly enhanced frequency of CD25+ cells (interleukin 2-receptor-bearing cells), was observed in patients with the aspergillomas. Additionally, peripheral blood lymphocytes in both groups of patients showed a significant reduction in the proliferative response to both T- and B-cell mitogens, with the values for the mitogens ConA and PHA being significantly lower in the aspergilloma patients as compared to those with non-mycotic sinusitis. This lack of lymphocyte stimulation in the aspergilloma group was also manifest in skin tests to recall antigens. These first data suggest that there is an immune deficiency in patients with chronic sinusitis caused by Aspergillus fumigatus. Further studies are needed to clarify if this defect is the cause or the result of the mycotic infection.","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"321-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Use of the subrenal capsule assay to measure antibody-dependent, cell-mediated cytotoxicity against head and neck tumors. 使用肾下包膜试验测量抗体依赖，细胞介导的头颈部肿瘤细胞毒性。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00456660

R Kau, C Kürten, H Kumazawa, P Koldovsky

引用次数: 0

Pure-tone hearing thresholds in otologically healthy 5-year-old children in Finland. 芬兰耳科健康5岁儿童的纯音听力阈值。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00456654

T Rahko, P Karma

引用次数: 10

Chemically induced esthesioneuroepithelioma: a cytogenetic, cell culture and biochemical investigation with implications for tumor histogenesis. 化学诱导的感觉神经上皮瘤:与肿瘤组织发生相关的细胞遗传学、细胞培养和生化研究。

Archives of oto-rhino-laryngology Pub Date : 1989-01-01 DOI: 10.1007/BF00457457

M Vollrath

引用次数: 2